| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E F Espejo, F J Miñan. Prefrontocortical dopamine depletion induces antidepressant-like effects in rats and alters the profile of desipramine during Porsolt's test. Neuroscience. vol 88. issue 2. 1999-06-01. PMID:10197779. |
in conclusion, the results indicate that: (i) dopamine neurotransmission within the medial prefrontal cortex is a factor involved in depression, since dopamine reduction led to a low depression tonus; (ii) desipramine induces antidepression not only by enhancing prefrontocortical noradrenaline and serotonin neurotransmission, but also by blocking the normal increase in dopamine neurotransmission during a depressant situation; (iii) a selective enhancement of prefrontocortical serotonin neurotransmission mediates swimming; and (iv) a selectively augmented prefrontocortical noradrenaline activity mediates climbing during porsolt's test. |
1999-06-01 |
2023-08-12 |
rat |
| A J Dun. Brain catecholaminergic and tryptophan responses to restraint are attenuated by nitric oxide synthase inhibition. Neurochemistry international. vol 33. issue 6. 1999-05-06. PMID:10098725. |
restraint caused increases in concentrations of tryptophan and the catabolites of dopamine (da), norepinephrine (ne) and 5-ht in the medial prefrontal cortex, hypothalamus, and brain stem. |
1999-05-06 |
2023-08-12 |
mouse |
| J C Chen, J Y Li, K W Liang, Y K Huan. Neuropeptide FF potentiates the behavioral sensitization to amphetamine and alters the levels of neurotransmitters in the medial prefrontal cortex. Brain research. vol 816. issue 1. 1999-03-25. PMID:9878747. |
further, the treatment with npff decreased the levels of serotonin, and increased the glutamate and gaba content in the medial prefrontal cortex of amphetamine-sensitized rats. |
1999-03-25 |
2023-08-12 |
rat |
| V N Luine, S T Richards, V Y Wu, K D Bec. Estradiol enhances learning and memory in a spatial memory task and effects levels of monoaminergic neurotransmitters. Hormones and behavior. vol 34. issue 2. 1999-01-08. PMID:9799625. |
in medial prefrontal cortex, levels of ne, da, and 5-ht were decreased but glutamate and gaba levels were not affected following chronic estrogen treatment. |
1999-01-08 |
2023-08-12 |
rat |
| S D Friedman, E Castañeda, G K Hodg. Long-term monoamine depletion, differential recovery, and subtle behavioral impairment following methamphetamine-induced neurotoxicity. Pharmacology, biochemistry, and behavior. vol 61. issue 1. 1998-11-05. PMID:9715805. |
initially, 5-ht within medial prefrontal cortex (mpfc), caudate (cdn), and hippocampus (hpc) was reduced to 30% of control levels. |
1998-11-05 |
2023-08-12 |
rat |
| J Ichikawa, T Kuroki, J Dai, H Y Meltze. Effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens. European journal of pharmacology. vol 351. issue 2. 1998-10-26. PMID:9686999. |
effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens. |
1998-10-26 |
2023-08-12 |
rat |
| J Ichikawa, T Kuroki, J Dai, H Y Meltze. Effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens. European journal of pharmacology. vol 351. issue 2. 1998-10-26. PMID:9686999. |
we studied the effect of these five proven antipsychotic drugs and one putative (amperozide) antipsychotic drug on extracellular 5-ht levels in the medial prefrontal cortex and the nucleus accumbens of awake, freely-moving rats, using in vivo microdialysis with dual probe implantation. |
1998-10-26 |
2023-08-12 |
rat |
| J Ichikawa, T Kuroki, J Dai, H Y Meltze. Effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens. European journal of pharmacology. vol 351. issue 2. 1998-10-26. PMID:9686999. |
risperidone (1 mg/kg) and clozapine (20 mg/kg) significantly increased extracellular 5-ht levels in the medial prefrontal cortex and the nucleus accumbens, respectively. |
1998-10-26 |
2023-08-12 |
rat |
| J Ichikawa, T Kuroki, J Dai, H Y Meltze. Effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens. European journal of pharmacology. vol 351. issue 2. 1998-10-26. PMID:9686999. |
thus, the ability to increase extracellular 5-ht levels in the medial prefrontal cortex and the nucleus accumbens by these antipsychotic drugs is not directly related to their affinity for 5-ht2a receptors since olanzapine and mdl-100,907 had no significant effect on extracellular 5-ht levels. |
1998-10-26 |
2023-08-12 |
rat |
| J Ichikawa, T Kuroki, J Dai, H Y Meltze. Effect of antipsychotic drugs on extracellular serotonin levels in rat medial prefrontal cortex and nucleus accumbens. European journal of pharmacology. vol 351. issue 2. 1998-10-26. PMID:9686999. |
the increase in extracellular 5-ht levels in the medial prefrontal cortex or nucleus accumbens following amperozide, clozapine, or risperidone administration may not be related to the effect on psychotic symptoms but could be related to effects on other types of psychopathology such as depression, negative symptoms, or cognition. |
1998-10-26 |
2023-08-12 |
rat |
| M Hajós, C D Richards, A D Székely, T Shar. An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat. Neuroscience. vol 87. issue 1. 1998-10-26. PMID:9722144. |
in an initial study, electrical stimulation of the ventral medial prefrontal cortex caused a post-stimulus inhibition in the majority (49/56) of dorsal raphe 5-hydroxytryptamine neurons tested (mean duration of inhibition, 200+/-17 ms); in some cases (8/56) the inhibition was preceded by short-latency (26 +/-3 ms) orthodromic activation, and a small number of cells was antidromically activated (6/56). |
1998-10-26 |
2023-08-12 |
rat |
| M Hajós, C D Richards, A D Székely, T Shar. An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat. Neuroscience. vol 87. issue 1. 1998-10-26. PMID:9722144. |
the effects of stimulation of the dorsal and ventral medial prefrontal cortex were compared on the same raphe 5-hydroxytryptamine neurons (n=17): ventral medial prefrontal cortex stimulation inhibited 16/17 of these neurons while only 8/17 were inhibited by dorsal medial prefrontal cortex stimulation. |
1998-10-26 |
2023-08-12 |
rat |
| M Hajós, C D Richards, A D Székely, T Shar. An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat. Neuroscience. vol 87. issue 1. 1998-10-26. PMID:9722144. |
finally, the inhibitory effect of ventral medial prefrontal cortex stimulation on 5-hydroxytryptamine cell-firing was not altered by 5-hydroxytryptamine depletion with p-chlorophenylalanine or by systemic administration of the selective 5-hydroxytryptamine1a receptor antagonist way 100635. |
1998-10-26 |
2023-08-12 |
rat |
| M Hajós, C D Richards, A D Székely, T Shar. An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat. Neuroscience. vol 87. issue 1. 1998-10-26. PMID:9722144. |
our results show that stimulation of the ventral medial prefrontal cortex causes a marked post-stimulus inhibition in the vast majority of midbrain raphe 5-hydroxytryptamine neurons tested. |
1998-10-26 |
2023-08-12 |
rat |
| M Hajós, C D Richards, A D Székely, T Shar. An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat. Neuroscience. vol 87. issue 1. 1998-10-26. PMID:9722144. |
it seems likely that the projection from ventral medial prefrontal cortex to the midbrain raphe nuclei mediates the responses of 5-hydroxytryptamine neurons to cortical stimulation. |
1998-10-26 |
2023-08-12 |
rat |
| L E Rueter, C de Montigny, P Blie. In vivo electrophysiological assessment of the agonistic properties of flibanserin at pre- and postsynaptic 5-HT1A receptors in the rat brain. Synapse (New York, N.Y.). vol 29. issue 4. 1998-09-24. PMID:9661257. |
in addition, as determined by the concurrent microiontophoretic application of flibanserin and 5-ht, flibanserin behaved as a full agonist in the dorsal raphe nucleus (drn) and the medial prefrontal cortex (mpfc), but as a partial agonist in the ca3 region of the hippocampus. |
1998-09-24 |
2023-08-12 |
rat |
| X Liang, V L Arvanov, R Y Wan. Inhibition of NMDA-receptor mediated response in the rat medial prefrontal cortical pyramidal cells by the 5-HT3 receptor agonist SR 57227A and 5-HT: intracellular studies. Synapse (New York, N.Y.). vol 29. issue 3. 1998-08-20. PMID:9635896. |
the techniques of intracellular recording and single-electrode voltage-clamp were used to study the effect of serotonin (5-ht) and the selective 5-ht3 receptor agonist sr 57227a on n-methyl-d-aspartic acid (nmda)-evoked responses in pyramidal cells of the rat medial prefrontal cortex (mpfc) in in vitro brain slice preparations. |
1998-08-20 |
2023-08-12 |
rat |
| J Bolte Taylor, M C Cunningham, F M Bene. Neonatal raphe lesions increase dopamine fibers in prefrontal cortex of adult rats. Neuroreport. vol 9. issue 8. 1998-08-13. PMID:9665606. |
in order to characterize how the dopamine (da) and serotonin (5ht) systems may be interacting in medial prefrontal cortex (mpfc) during postnatal development, the specific toxin 5,7-dihydroxytryptamine (5,7-dht) was used to induce lesions of the nucleus raphe dorsalis (nrd) in neonatal rats and the density of tyrosine hydroxylase-immunoreactive varicosities (th-irv) was assessed. |
1998-08-13 |
2023-08-12 |
rat |
| J Bolte Taylor, M C Cunningham, F M Bene. Neonatal raphe lesions increase dopamine fibers in prefrontal cortex of adult rats. Neuroreport. vol 9. issue 8. 1998-08-13. PMID:9665606. |
these results suggest that postnatal development in medial prefrontal cortex may be associated with a competitive interaction between cortical monoaminergic systems, such that an early disturbance in the development of the 5ht innervation can potentially induce a hyperinnervation of da fibres. |
1998-08-13 |
2023-08-12 |
rat |
| N Lindefors, S Barati, W T O'Conno. Differential effects of single and repeated ketamine administration on dopamine, serotonin and GABA transmission in rat medial prefrontal cortex. Brain research. vol 759. issue 2. 1997-10-28. PMID:9221938. |
differential effects of single and repeated ketamine administration on dopamine, serotonin and gaba transmission in rat medial prefrontal cortex. |
1997-10-28 |
2023-08-12 |
rat |