| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Meller, H Li, K D Carr, J M Hille. 5-Hydroxytryptamine(1A) receptor-stimulated [(35)S]GTPgammaS binding in rat brain: absence of regional differences in coupling efficiency. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640306. |
in autoradiographic sections, r-(+)-8-oh-dpat stimulated [(35)s]gtpgammas binding in 5-ht(1a) receptor-rich regions (dorsal hippocampus, 123%; lateral septum, 111%; midhippocampus, 110%; dorsal raphe nucleus, 83%; medial prefrontal cortex, approximately 60%). |
2000-02-22 |
2023-08-12 |
rat |
| G J Marek, R A Wright, D D Schoepp, J A Monn, G K Aghajania. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 292. issue 1. 2000-01-27. PMID:10604933. |
in this study, we tested the ability of the selective mglu2/3 agonist (1s,2s,5r, 6s)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate monohydrate (ly354740) and the selective mglu2/3 antagonist 2s-2-amino-2-(1s, 2s-2-carboxycycloprop-1-yl)-3(xanthy-9-yl)propanoic acid (ly341495) to modulate serotonin(5-ht)-induced epsps and electrically evoked epsps by using intracellular recording from layer v pyramidal cells in medial prefrontal cortex. |
2000-01-27 |
2023-08-12 |
Not clear |
| G J Marek, R A Wright, D D Schoepp, J A Monn, G K Aghajania. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 292. issue 1. 2000-01-27. PMID:10604933. |
conversely, the mglu2/3 agonist ly354740 was highly effective and potent (ec(50) = 89 nm) in suppressing glutamate release induced by 5-ht(2a) receptor activation in the medial prefrontal cortex, probably via a presynaptic mechanism. |
2000-01-27 |
2023-08-12 |
Not clear |
| G J Marek, R A Wright, D D Schoepp, J A Monn, G K Aghajania. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 292. issue 1. 2000-01-27. PMID:10604933. |
autoradiography with the radioligands [(3)h]ly354740 and [(125)i](+/-)-1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane showsa striking overlap of the laminar distribution of mglu2/3 and 5-ht(2a) receptors in the medial prefrontal cortex that is not apparent in other cortical regions. |
2000-01-27 |
2023-08-12 |
Not clear |
| J Ichikawa, H Y Meltze. R(+)-8-OH-DPAT, a serotonin(1A) receptor agonist, potentiated S(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum. The Journal of pharmacology and experimental therapeutics. vol 291. issue 3. 1999-12-20. PMID:10565846. |
r(+)-8-oh-dpat, a serotonin(1a) receptor agonist, potentiated s(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum. |
1999-12-20 |
2023-08-12 |
rat |
| J Ichikawa, H Y Meltze. R(+)-8-OH-DPAT, a serotonin(1A) receptor agonist, potentiated S(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum. The Journal of pharmacology and experimental therapeutics. vol 291. issue 3. 1999-12-20. PMID:10565846. |
the serotonin (5-ht)(2a/2c) receptor antagonist ritanserin has been reported to potentiate the dopamine (da) d(2/3) receptor antagonist raclopride-induced da release in medial prefrontal cortex (mpfc) and nucleus accumbens (nac) but not striatum (str). |
1999-12-20 |
2023-08-12 |
rat |
| E Hajós-Korcsok, T Shar. Effect of 5-HT(1A) receptor ligands on Fos-like immunoreactivity in rat brain: evidence for activation of noradrenergic transmission. Synapse (New York, N.Y.). vol 34. issue 2. 1999-11-09. PMID:10502313. |
taken together, the present findings provide immunocytochemical evidence that 5-ht(1a) receptor agonists activate noradrenergic neurones in the lc and that this leads to increased noradrenergic transmission at postsynaptic sites in the forebrain (specifically medial prefrontal cortex). |
1999-11-09 |
2023-08-12 |
rat |
| S Hashimoto, T Inoue, T Koyam. Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats. European journal of pharmacology. vol 378. issue 1. 1999-10-21. PMID:10478561. |
in an attempt to clarify the role of the brain serotonergic system in the psychopathology of anxiety, we examined the effect of a psychological stress, conditioned fear stress, on extracellular serotonin (5-hydroxytryptamine, 5-ht) concentrations in the rat medial prefrontal cortex using the method of in vivo microdialysis, while simultaneously observing conditioned fear stress-induced freezing behavior, an index of anxiety. |
1999-10-21 |
2023-08-12 |
rat |
| S Hashimoto, T Inoue, T Koyam. Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats. European journal of pharmacology. vol 378. issue 1. 1999-10-21. PMID:10478561. |
conditioned fear stress increased extracellular 5-ht levels in the medial prefrontal cortex, and this 5-ht level increase was followed by a resolution of the freezing behavior. |
1999-10-21 |
2023-08-12 |
rat |
| G Juckel, A Mendlin, B L Jacob. Electrical stimulation of rat medial prefrontal cortex enhances forebrain serotonin output: implications for electroconvulsive therapy and transcranial magnetic stimulation in depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 3. 1999-10-19. PMID:10457536. |
electrical stimulation of rat medial prefrontal cortex enhances forebrain serotonin output: implications for electroconvulsive therapy and transcranial magnetic stimulation in depression. |
1999-10-19 |
2023-08-12 |
rat |
| J M Casanovas, I Hervás, F Artiga. Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex. Neuroreport. vol 10. issue 7. 1999-09-16. PMID:10380960. |
postsynaptic 5-ht1a receptors control 5-ht release in the rat medial prefrontal cortex. |
1999-09-16 |
2023-08-12 |
rat |
| J M Casanovas, I Hervás, F Artiga. Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex. Neuroreport. vol 10. issue 7. 1999-09-16. PMID:10380960. |
using in vivo microdialysis in unanesthetized rats, we show that the local application of the selective 5-ht1a receptor agonist 8-oh-dpat decreased the 5-ht output to approximately 50% of controls in medial prefrontal cortex (mpfc) but not in dorsal hippocampus. |
1999-09-16 |
2023-08-12 |
rat |
| V L Arvanov, X Liang, P Magro, R Roberts, R Y Wan. A pre- and postsynaptic modulatory action of 5-HT and the 5-HT2A, 2C receptor agonist DOB on NMDA-evoked responses in the rat medial prefrontal cortex. The European journal of neuroscience. vol 11. issue 8. 1999-09-10. PMID:10457188. |
a pre- and postsynaptic modulatory action of 5-ht and the 5-ht2a, 2c receptor agonist dob on nmda-evoked responses in the rat medial prefrontal cortex. |
1999-09-10 |
2023-08-12 |
rat |
| V L Arvanov, X Liang, P Magro, R Roberts, R Y Wan. A pre- and postsynaptic modulatory action of 5-HT and the 5-HT2A, 2C receptor agonist DOB on NMDA-evoked responses in the rat medial prefrontal cortex. The European journal of neuroscience. vol 11. issue 8. 1999-09-10. PMID:10457188. |
intracellular recordings were made from pyramidal neurons in layers v and vi of the rat medial prefrontal cortex in slice preparations to investigate the effect of the serotonin 5-ht2a,2c receptor agonist (-)-1-2,5-dimethoxy-4-bromophenol-2-aminopropane (dob) and 5-hydroxytryptamine (5-ht) on n-methyl-d-aspartate (nmda)-induced responses. |
1999-09-10 |
2023-08-12 |
rat |
| C P Stephenson, G E Hunt, A N Topple, I S McGrego. The distribution of 3,4-methylenedioxymethamphetamine "Ecstasy"-induced c-fos expression in rat brain. Neuroscience. vol 92. issue 3. 1999-09-09. PMID:10426541. |
expression was pronounced in 5-hydroxytryptamine terminal regions including the medial prefrontal cortex, caudate-putamen, nucleus accumbens, olfactory tubercle, islands of calleja, lateral septum, paraventricular hypothalamus and paraventricular thalamus. |
1999-09-09 |
2023-08-12 |
human |
| M Hajós, E Hajós-Korcsok, T Shar. Role of the medial prefrontal cortex in 5-HT1A receptor-induced inhibition of 5-HT neuronal activity in the rat. British journal of pharmacology. vol 126. issue 8. 1999-07-29. PMID:10372816. |
role of the medial prefrontal cortex in 5-ht1a receptor-induced inhibition of 5-ht neuronal activity in the rat. |
1999-07-29 |
2023-08-12 |
rat |
| D Nakahara, M Nakamur. Differential effect of immobilization stress on in vivo synthesis rate of monoamines in medial prefrontal cortex and nucleus accumbens of conscious rats. Synapse (New York, N.Y.). vol 32. issue 3. 1999-07-15. PMID:10340633. |
the results suggest that in vivo catecholamine synthesis is heterogenous, whereas in vivo serotonin synthesis is homogenous, with respect to responsiveness to stress in the medial prefrontal cortex and nucleus accumbens. |
1999-07-15 |
2023-08-12 |
rat |
| J Wu, G L Kramer, M Kram, M Steciuk, I L Crawford, F Pett. Serotonin and learned helplessness: a regional study of 5-HT1A, 5-HT2A receptors and the serotonin transport site in rat brain. Journal of psychiatric research. vol 33. issue 1. 1999-06-22. PMID:10094235. |
using quantitative autoradiography, we measured the density of 5-ht1a and 5-ht2a receptors and of 5-ht transport sites in medial prefrontal cortex, dorsal hippocampus, septum, hypothalamus, and amygdala in learned helpless rats, and in rats that were nonhelpless after inescapable stress, as well as in shuttlebox-tested and nonhandled controls. |
1999-06-22 |
2023-08-12 |
rat |
| J Wu, G L Kramer, M Kram, M Steciuk, I L Crawford, F Pett. Serotonin and learned helplessness: a regional study of 5-HT1A, 5-HT2A receptors and the serotonin transport site in rat brain. Journal of psychiatric research. vol 33. issue 1. 1999-06-22. PMID:10094235. |
in medial prefrontal cortex, the serotonin transport sites showed decreased density in helpless rats as compared to controls but not to nonhelpless rats. |
1999-06-22 |
2023-08-12 |
rat |
| P Martin, M L Carlsson, S Hjort. Systemic PCP treatment elevates brain extracellular 5-HT: a microdialysis study in awake rats. Neuroreport. vol 9. issue 13. 1999-06-07. PMID:9804302. |
we here report for the first time that systemically administered pcp (5 mg/kg, s.c.) increases extracellular 5-ht levels in the rat medial prefrontal cortex (to 322%) and dorsal hippocampus (to 233%). |
1999-06-07 |
2023-08-12 |
rat |