| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Mogha, S R Guariglia, P R Debata, G Y Wen, P Banerje. Serotonin 1A receptor-mediated signaling through ERK and PKCα is essential for normal synaptogenesis in neonatal mouse hippocampus. Translational psychiatry. vol 2. 2013-03-04. PMID:22832728. |
the elucidated signaling cascade explains how 5-ht(1a)-r regulates hippocampal sculpting and function, which may determine the affective phenotype of an adult. |
2013-03-04 |
2023-08-12 |
mouse |
| Catherine E Hagan, Ross A McDevitt, Yusha Liu, Amy R Furay, John F Neumaie. 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse (New York, N.Y.). vol 66. issue 12. 2013-02-21. PMID:22961814. |
furthermore, sert activity varies as a function of 5-ht(1b) receptor expression-specifically, genetic deletion of 5-ht(1b) decreased sert function, while viral-mediated overexpression of 5-ht(1b) autoreceptors in rat raphe neurons increased sert activity in rat hippocampal synaptosomes. |
2013-02-21 |
2023-08-12 |
mouse |
| J C Shaw, Ø Øverl. Brain-encysting trematodes and altered monoamine activity in naturally infected killifish Fundulus parvipinnis. Journal of fish biology. vol 81. issue 7. 2013-02-21. PMID:23252735. |
a parasite density-associated decrease in serotonergic activity occurred in the hippocampus of naturally infected fish, as well as a decrease in dopaminergic activity in the raphe nuclei, suggesting that e. californiensis inhibits serotonin and dopamine signaling in naturally infected f. parvipinnis. |
2013-02-21 |
2023-08-12 |
Not clear |
| Sunoh Kwon, Dongsoo Kim, Hyemee Park, Doyoung Yoo, Hi-Joon Park, Dae-Hyun Hahm, Hyejung Lee, Seung-Tae Ki. Prefrontal-limbic change in dopamine turnover by acupuncture in maternally separated rat pups. Neurochemical research. vol 37. issue 10. 2013-02-19. PMID:22714092. |
the present study investigated the possible role of acupuncture in alleviating depression-like behavioral changes and examined changes in the levels of serotonin (5-ht), dopamine (da), and their metabolites in the hippocampus (hp) and prefrontal cortex (pfc) of maternally separated rat pups. |
2013-02-19 |
2023-08-12 |
rat |
| Saida Haider, Saima Khaliq, Saiqa Tabassum, Darakhshan J Halee. Role of somatodendritic and postsynaptic 5-HT₁A receptors on learning and memory functions in rats. Neurochemical research. vol 37. issue 10. 2013-02-19. PMID:22814880. |
among the 5-ht receptors subtypes, 5-ht(1a) receptors are of special interest because these receptors are present in the brain areas involved in learning and memory functions such as hippocampus and cortex. |
2013-02-19 |
2023-08-12 |
rat |
| Hudu G Mikail, Christina Dalla, Nikolaos Kokras, Vasilios Kafetzopoulos, Z Papadopoulou-Daifot. Sertraline behavioral response associates closer and dose-dependently with cortical rather than hippocampal serotonergic activity in the rat forced swim stress. Physiology & behavior. vol 107. issue 2. 2013-02-15. PMID:22771833. |
serotonin and its metabolite 5-hiaa were assayed in the hippocampus and the prefrontal cortex with the use of high-performance liquid chromatography (hplc-ed) and their ratio 5-hiaa/5-ht was calculated. |
2013-02-15 |
2023-08-12 |
rat |
| Hudu G Mikail, Christina Dalla, Nikolaos Kokras, Vasilios Kafetzopoulos, Z Papadopoulou-Daifot. Sertraline behavioral response associates closer and dose-dependently with cortical rather than hippocampal serotonergic activity in the rat forced swim stress. Physiology & behavior. vol 107. issue 2. 2013-02-15. PMID:22771833. |
serotonergic activity was not altered by the 2-day swim stress in either brain region, while subchronic sertraline treatment enhanced 5-ht levels and decreased 5-hiaa/5-ht in the hippocampus and the prefrontal cortex. |
2013-02-15 |
2023-08-12 |
rat |
| Hudu G Mikail, Christina Dalla, Nikolaos Kokras, Vasilios Kafetzopoulos, Z Papadopoulou-Daifot. Sertraline behavioral response associates closer and dose-dependently with cortical rather than hippocampal serotonergic activity in the rat forced swim stress. Physiology & behavior. vol 107. issue 2. 2013-02-15. PMID:22771833. |
in the prefrontal cortex, but not in the hippocampus, immobility duration was negatively correlated with 5-ht tissue levels, whereas swimming duration was positively correlated with 5-ht. |
2013-02-15 |
2023-08-12 |
rat |
| Jia Zhang, Yan Fan, Ying Li, Hobart Zhu, Liang Wang, Meng-Yang Zh. Chronic social defeat up-regulates expression of the serotonin transporter in rat dorsal raphe nucleus and projection regions in a glucocorticoid-dependent manner. Journal of neurochemistry. vol 123. issue 6. 2013-02-14. PMID:23061525. |
protein levels of the serotonin transporter (sert) in the dorsal raphe nucleus (drn), hippocampus, frontal cortex, and amygdala were examined by western blotting or immunofluorescence staining. |
2013-02-14 |
2023-08-12 |
rat |
| A Bacq, L Balasse, G Biala, B Guiard, A M Gardier, A Schinkel, F Louis, V Vialou, M-P Martres, C Chevarin, M Hamon, B Giros, S Gautro. Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response. Molecular psychiatry. vol 17. issue 9. 2013-01-23. PMID:21769100. |
in vivo clearance of ne and 5-ht evaluated using microiontophoretic electrophysiology was diminished in the hippocampus of oct2(-/-) mice in the presence of venlafaxine, thereby affecting postsynaptic neuronal activity. |
2013-01-23 |
2023-08-12 |
mouse |
| Valeria Paola Carlini, María Belén Poretti, Mathias Rask-Andersen, Rohit A Chavan, Marina F Ponzio, Rahul S Sawant, Susana Rubiales de Barioglio, Helgi B Schiöth, Marta Fiol de Cune. Differential effects of fluoxetine and venlafaxine on memory recognition: possible mechanisms of action. Progress in neuro-psychopharmacology & biological psychiatry. vol 38. issue 2. 2013-01-21. PMID:22449479. |
considering that the changes in gene expression involved in the action of antidepressant drugs on memory have not been identified, in this study we investigated the impact of chronic treatment with a ssri (fluoxetine) and a snri (venlafaxine) on the mrna expression of genes related to memory cascade in the mouse hippocampus, namely, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa), nitric oxide synthase 1 (nos1), neurotrophic tyrosine kinase receptor type 2 (trkb), mitogen-activated protein kinases (mapk/erk) and serotonin transporter (sert). |
2013-01-21 |
2023-08-12 |
mouse |
| Jardel Gomes Villarinho, Roselei Fachinetto, Francielle de Vargas Pinheiro, Gabriela da Silva Sant'Anna, Pablo Machado, Patrícia Andréia Dombrowski, Cláudio da Cunha, Daniela de Almeida Cabrini, Marcos Antônio Pinto Martins, Helio Gauze Bonacorso, Nilo Zanatta, Maribel Antonello Rubin, Juliano Ferreir. Antidepressant-like effect of the novel MAO inhibitor 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 39. issue 1. 2013-01-21. PMID:22525823. |
2-dmpi (300 μmol/kg, s.c.) decreased serotonin turnover in the cerebral cortex, hippocampus and striatum, whereas dopamine turnover was diminished only in the striatum, and norepinephrine turnover was not changed. |
2013-01-21 |
2023-08-12 |
mouse |
| Naoki Takamura, Takahiro Masuda, Takeshi Inoue, Shin Nakagawa, Tsukasa Koyam. The effects of the co-administration of the α₁-adrenoreceptor antagonist prazosin on the anxiolytic effect of citalopram in conditioned fear stress in the rat. Progress in neuro-psychopharmacology & biological psychiatry. vol 39. issue 1. 2013-01-21. PMID:22658980. |
the administration of the α₁-adrenoreceptor antagonist prazosin was shown to decrease extracellular serotonin levels in the hippocampus, the prefrontal cortex and the raphe nucleus, while the administration of the α₁-adrenoreceptor agonist cirazoline was shown to increase serotonin levels. |
2013-01-21 |
2023-08-12 |
rat |
| Li-Tao Yi, Jing Li, Huo-Chen Li, Dong-Xue Su, Xia-Bo Quan, Xiao-Cheng He, Xiao-Hong Wan. Antidepressant-like behavioral, neurochemical and neuroendocrine effects of naringenin in the mouse repeated tail suspension test. Progress in neuro-psychopharmacology & biological psychiatry. vol 39. issue 1. 2013-01-21. PMID:22709719. |
moreover, administration of naringenin for 14 days (20 mg/kg) increased hippocampal serotonin (5-ht), norepinephrine (ne) and gr levels, and reduced serum corticosterone levels in mice exposed to the repeated tst. |
2013-01-21 |
2023-08-12 |
mouse |
| Yan Li, Alan L Pehrson, David P Budac, Connie Sánchez, Maria Gulinell. A rodent model of premenstrual dysphoria: progesterone withdrawal induces depression-like behavior that is differentially sensitive to classes of antidepressants. Behavioural brain research. vol 234. issue 2. 2013-01-21. PMID:22789402. |
however, progesterone withdrawal did not alter serotonin levels in the cortex or hippocampus. |
2013-01-21 |
2023-08-12 |
Not clear |
| Soo-Jeong Kim, Hyojung Lee, Gihyun Lee, Sei-Joong Oh, Min-Kyu Shin, Insop Shim, Hyunsu Ba. CD4+CD25+ regulatory T cell depletion modulates anxiety and depression-like behaviors in mice. PloS one. vol 7. issue 7. 2013-01-14. PMID:22860054. |
furthermore, the non stressed anti-cd25 ab-treated group displayed decreased 5-ht levels within the hippocampus when compared with the non stressed wild-type group. |
2013-01-14 |
2023-08-12 |
mouse |
| Therese M Eriksson, Sarah Holst, Tiberiu L Stan, Torben Hager, Benita Sjögren, Sven Öve Ogren, Per Svenningsson, Oliver Stied. 5-HT1A and 5-HT7 receptor crosstalk in the regulation of emotional memory: implications for effects of selective serotonin reuptake inhibitors. Neuropharmacology. vol 63. issue 6. 2013-01-10. PMID:22801295. |
the putative 5-ht(7)r agonists lp-44 when administered systemically and as19 when administered both systemically and into the dorsal hippocampus failed to facilitate memory. |
2013-01-10 |
2023-08-12 |
mouse |
| Therese M Eriksson, Sarah Holst, Tiberiu L Stan, Torben Hager, Benita Sjögren, Sven Öve Ogren, Per Svenningsson, Oliver Stied. 5-HT1A and 5-HT7 receptor crosstalk in the regulation of emotional memory: implications for effects of selective serotonin reuptake inhibitors. Neuropharmacology. vol 63. issue 6. 2013-01-10. PMID:22801295. |
dorsohippocampal infusion of 8-oh-dpat impaired passive avoidance retention through hippocampal 5-ht(1a)r activation, while 5-ht(7)rs appear to facilitate memory processes in a broader cortico-limbic network and not the hippocampus alone. |
2013-01-10 |
2023-08-12 |
mouse |
| John H Anneken, Gary A Gudelsk. MDMA produces a delayed and sustained increase in the extracellular concentration of glutamate in the rat hippocampus. Neuropharmacology. vol 63. issue 6. 2013-01-10. PMID:22842073. |
treatment with the 5-ht reuptake inhibitor fluoxetine prevented the increase in extracellular glutamate in the hippocampus following the systemic administration of mdma, as did treatment with the serotonin 5-ht2a/c receptor antagonist ketanserin. |
2013-01-10 |
2023-08-12 |
rat |
| John H Anneken, Gary A Gudelsk. MDMA produces a delayed and sustained increase in the extracellular concentration of glutamate in the rat hippocampus. Neuropharmacology. vol 63. issue 6. 2013-01-10. PMID:22842073. |
these data support the view that stimulation of 5-ht2a/2c receptors on non-neuronal cells by 5-ht released by mdma promotes glutamate efflux in the hippocampus. |
2013-01-10 |
2023-08-12 |
rat |