| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong-Mei Jia, Yu-Fei Feng, Yue-Tao Liu, Xing Chang, Lin Chen, Hong-Wu Zhang, Gang Ding, Zhong-Mei Zo. Integration of ¹H NMR and UPLC-Q-TOF/MS for a comprehensive urinary metabonomics study on a rat model of depression induced by chronic unpredictable mild stress. PloS one. vol 8. issue 5. 2014-02-18. PMID:23696839. |
moreover, the results of western blot analysis of aromatic l-amino acid decarboxylase (ddc) and indoleamine 2, 3-dioxygenase (ido) in the hippocampus of cums-treated rats indicated that depletion of 5-ht and tryptophan, production of 5-mt and altered expression of ddc and ido together played a key role in the initiation and progression of depression. |
2014-02-18 |
2023-08-12 |
rat |
| Masanori Ookubo, Hirohiko Kanai, Harusuke Aoki, Naoto Yamad. Antidepressants and mood stabilizers effects on histone deacetylase expression in C57BL/6 mice: Brain region specific changes. Journal of psychiatric research. vol 47. issue 9. 2014-02-14. PMID:23777937. |
to determine whether treatment with various antidepressants or mood stabilizers leads to region-specific changes, we investigated the effects of their subchronic (14 days of intraperitoneal injection) administration on the tissue concentration of monoamines, dopamine, serotonin, and norepinephrine, and the protein expression of acetylated histone h3 (ach3) and histone deacetylases (hdacs) in the mouse striatum (st), nucleus accumbens (acb), hippocampus (hip), cingulate cortex (cg), and amygdala (amy). |
2014-02-14 |
2023-08-12 |
mouse |
| Winanda W Ursinus, J Elizabeth Bolhuis, Johan J Zonderland, T Bas Rodenburg, Adriana S de Souza, Rudie E Koopmanschap, Bas Kemp, Gerdien A H Korte-Bouws, S Mechiel Korte, Cornelis G van Reene. Relations between peripheral and brain serotonin measures and behavioural responses in a novelty test in pigs. Physiology & behavior. vol 118. 2014-02-12. PMID:23685231. |
levels of serotonin, its metabolite and serotonin turnover were determined at 19weeks of age in the frontal cortex, hypothalamus and hippocampus. |
2014-02-12 |
2023-08-12 |
Not clear |
| Winanda W Ursinus, J Elizabeth Bolhuis, Johan J Zonderland, T Bas Rodenburg, Adriana S de Souza, Rudie E Koopmanschap, Bas Kemp, Gerdien A H Korte-Bouws, S Mechiel Korte, Cornelis G van Reene. Relations between peripheral and brain serotonin measures and behavioural responses in a novelty test in pigs. Physiology & behavior. vol 118. 2014-02-12. PMID:23685231. |
platelet serotonin level and brain serotonergic parameters in the hippocampus were interrelated. |
2014-02-12 |
2023-08-12 |
Not clear |
| Winanda W Ursinus, J Elizabeth Bolhuis, Johan J Zonderland, T Bas Rodenburg, Adriana S de Souza, Rudie E Koopmanschap, Bas Kemp, Gerdien A H Korte-Bouws, S Mechiel Korte, Cornelis G van Reene. Relations between peripheral and brain serotonin measures and behavioural responses in a novelty test in pigs. Physiology & behavior. vol 118. 2014-02-12. PMID:23685231. |
notably, the time spent exploring the test arena was significantly correlated with both platelet serotonin level and right hippocampal serotonin activity (turnover and concentration). |
2014-02-12 |
2023-08-12 |
Not clear |
| Lawrence S Own, Rimsha Iqbal, Paresh D Pate. Maternal separation alters serotonergic and HPA axis gene expression independent of separation duration in mice. Brain research. vol 1515. 2014-02-11. PMID:23548594. |
as adults, pups that experienced ms15 or ms180 demonstrated decreases in tryptophan hydroxylase 2 and serotonin transporter mrna in the dorsal raphe dorsalis and ventralis, and increases in glucocorticoid receptor mrna in the dentate gyrus of the hippocampus. |
2014-02-11 |
2023-08-12 |
mouse |
| Nicole A Northrop, Bryan K Yamamot. Cyclooxygenase activity contributes to the monoaminergic damage caused by serial exposure to stress and methamphetamine. Neuropharmacology. vol 72. 2014-02-11. PMID:23643743. |
the enhanced da and 5-ht depletions in the striatum, but not the hippocampus, were prevented by pretreatment with cox inhibitor, ketoprofen, during stress or during meth; however, ketoprofen did not attenuate the monoaminergic damage caused by meth alone. |
2014-02-11 |
2023-08-12 |
Not clear |
| Francesca Zoratto, Amanda L Tringle, Giancarlo Bellenchi, Luisa Speranza, Domenica Travaglini, Umberto di Porzio, Carla Perrone-Capano, Giovanni Laviola, Jean-Luc Dreyer, Walter Adrian. Impulsivity and home-cage activity are decreased by lentivirus-mediated silencing of serotonin transporter in the rat hippocampus. Neuroscience letters. vol 548. 2014-02-07. PMID:23769733. |
impulsivity and home-cage activity are decreased by lentivirus-mediated silencing of serotonin transporter in the rat hippocampus. |
2014-02-07 |
2023-08-12 |
rat |
| Francesca Zoratto, Amanda L Tringle, Giancarlo Bellenchi, Luisa Speranza, Domenica Travaglini, Umberto di Porzio, Carla Perrone-Capano, Giovanni Laviola, Jean-Luc Dreyer, Walter Adrian. Impulsivity and home-cage activity are decreased by lentivirus-mediated silencing of serotonin transporter in the rat hippocampus. Neuroscience letters. vol 548. 2014-02-07. PMID:23769733. |
this phenotype is consistent with available data both on 5-ht manipulations and hippocampal lesions. |
2014-02-07 |
2023-08-12 |
rat |
| Hosung Lee, Makoto Ohno, Shigeo Ohta, Toshio Mikam. Regular moderate or intense exercise prevents depression-like behavior without change of hippocampal tryptophan content in chronically tryptophan-deficient and stressed mice. PloS one. vol 8. issue 7. 2014-02-03. PMID:23861751. |
regular exercise, whether moderate or intense, prevents depression-like behavior with an improvement of adult hippocampal cell proliferation and survival and without the recovery of 5-ht. |
2014-02-03 |
2023-08-12 |
mouse |
| Simon Trent, Rachel Dean, Bonnie Veit, Tommaso Cassano, Gaurav Bedse, Obah A Ojarikre, Trevor Humby, William Davie. Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology. vol 38. issue 8. 2014-01-31. PMID:23276394. |
hyperactivity), elevated hippocampal serotonin (5-ht) levels, and reduced serum levels of dehydroepiandrosterone (dhea). |
2014-01-31 |
2023-08-12 |
mouse |
| Simon Trent, Rachel Dean, Bonnie Veit, Tommaso Cassano, Gaurav Bedse, Obah A Ojarikre, Trevor Humby, William Davie. Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology. vol 38. issue 8. 2014-01-31. PMID:23276394. |
subsequently, to specify potential behavioural correlates of elevated hippocampal 5-ht arising due to the genetic lesion, we compared 39,x(y*)o mf1 mice to 40,xy mf1 mice on behavioural tasks taxing hippocampal and/or 5-ht function (a 'foraging' task, an object-location task, and the 1-choice serial reaction time task of impulsivity). |
2014-01-31 |
2023-08-12 |
mouse |
| Simon Trent, Rachel Dean, Bonnie Veit, Tommaso Cassano, Gaurav Bedse, Obah A Ojarikre, Trevor Humby, William Davie. Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology. vol 38. issue 8. 2014-01-31. PMID:23276394. |
although sts/asmt deficiency did not influence foraging behaviour, reactivity to familiar objects in novel locations, or 'ability to wait', it did result in markedly increased response rates; these rates correlated with hippocampal 5-ht levels and are likely to index behavioural perseveration, a frequent feature of neurodevelopmental disorders. |
2014-01-31 |
2023-08-12 |
mouse |
| Simon Trent, Rachel Dean, Bonnie Veit, Tommaso Cassano, Gaurav Bedse, Obah A Ojarikre, Trevor Humby, William Davie. Biological mechanisms associated with increased perseveration and hyperactivity in a genetic mouse model of neurodevelopmental disorder. Psychoneuroendocrinology. vol 38. issue 8. 2014-01-31. PMID:23276394. |
additionally, we show that whilst there was no systematic relationship between serum dhea levels and hippocampal 5-ht levels across 39,x(y*)o and 40,xy mice, there was a significant inverse linear correlation between serum dhea levels and activity. |
2014-01-31 |
2023-08-12 |
mouse |
| Shinsuke Uchihashi, Miyu Nishikawa, Toshiyuki Sakaki, Shin-ichi Ikushir. Comparison of serotonin glucuronidation activity of UDP-glucuronosyltransferase 1a6a (Ugt1a6a) and Ugt1a6b: evidence for the preferential expression of Ugt1a6a in the mouse brain. Drug metabolism and pharmacokinetics. vol 28. issue 3. 2014-01-30. PMID:23089803. |
however, the difference in expression levels between ugt1a6a and ugt1a6b in the hippocampus led us to speculate that ugt1a6a is likely the predominant catalyst of serotonin glucuronidation in the mouse brain. |
2014-01-30 |
2023-08-12 |
mouse |
| Yinghua Yu, Yizhen Wu, Craig Patch, Zhixiang Wu, Alexander Szabo, Duo Li, Xu-Feng Huan. DHA prevents altered 5-HT1A, 5-HT2A, CB1 and GABAA receptor binding densities in the brain of male rats fed a high-saturated-fat diet. The Journal of nutritional biochemistry. vol 24. issue 7. 2014-01-29. PMID:23337348. |
in the hippocampus, the 5-ht(1a), cb1 and gaba(a) receptor binding densities significantly increased in response to an hf diet, while in the hypothalamus, 5-ht(1a) and cb1 binding densities significantly increased in hf-fed rats. |
2014-01-29 |
2023-08-12 |
rat |
| E Venzala, A L García-García, N Elizalde, R M Torder. Social vs. environmental stress models of depression from a behavioural and neurochemical approach. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 7. 2014-01-23. PMID:22743048. |
subsequently, we examined glutamate, gaba, 5-ht and dopamine levels in the prefrontal cortex, hippocampus and brainstem. |
2014-01-23 |
2023-08-12 |
mouse |
| Shingo Matsuda, Daisuke Matsuzawa, Daisuke Ishii, Haruna Tomizawa, Junko Sajiki, Eiji Shimiz. Perinatal exposure to bisphenol A enhances contextual fear memory and affects the serotoninergic system in juvenile female mice. Hormones and behavior. vol 63. issue 5. 2014-01-17. PMID:23567477. |
bpa enhanced fear memory and increased serotonin metabolite (5-hiaa) levels and 5-hiaa/5-ht in the hippocampus, the striatum, the midbrain, the pons, and the medulla oblongata of juvenile female mice. |
2014-01-17 |
2023-08-12 |
mouse |
| Shingo Matsuda, Daisuke Matsuzawa, Daisuke Ishii, Haruna Tomizawa, Junko Sajiki, Eiji Shimiz. Perinatal exposure to bisphenol A enhances contextual fear memory and affects the serotoninergic system in juvenile female mice. Hormones and behavior. vol 63. issue 5. 2014-01-17. PMID:23567477. |
furthermore, bpa induced increases in the expression levels of tph2, slc6a4, and maoa mrna in the hippocampus of juvenile females, indicating that bpa induces hyper 5-ht turnover in the hippocampus. |
2014-01-17 |
2023-08-12 |
mouse |
| Dasiel O Borroto-Escuela, Fidel Corrales, Manuel Narvaez, Julia Oflijan, Luigi F Agnati, Miklós Palkovits, Kjell Fux. Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2. Biochemical and biophysical research communications. vol 441. issue 2. 2014-01-17. PMID:24157794. |
new findings show that neurotrophic and antidepressant effects of 5-ht in brain can, in part, be mediated by activation of the 5-ht1a receptor protomer in the hippocampal and raphe fgfr1-5-ht1a heteroreceptor complexes enhancing the fgfr1 signaling. |
2014-01-17 |
2023-08-12 |
Not clear |