| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mauritz Frederick Herselman, Larisa Bobrovskay. The Effects of Chronic Unpredictable Mild Stress and Semi-Pure Diets on the Brain, Gut and Adrenal Medulla in C57BL6 Mice. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834073. |
cums induced anxiety-like behaviour, dysregulated the tryptophan and serotonin metabolic pathways in the hippocampus, prefrontal cortex, and colon, and altered the composition of the gut microbiota. |
2023-10-14 |
2023-10-15 |
mouse |
| Hanan H Ahmed, Reham M Essam, Muhammed F El-Yamany, Kawkab A Ahmed, Ayman E El-Saha. Unleashing lactoferrin's antidepressant potential through the PI3K/Akt/mTOR pathway in chronic restraint stress rats. Food & function. 2023-09-28. PMID:37767889. |
this effect was also accompanied by reduced gsh and serotonin levels and elevated lipid peroxidation and corticosterone levels in the hippocampus. |
2023-09-28 |
2023-10-07 |
rat |
| Te-Hsuan Tung, Wen-De Lai, Hsiu-Chuan Lee, Kuan-Pin Su, Binar Panunggal, Shih-Yi Huan. Attenuation of Chronic Stress-Induced Depressive-like Symptoms by Fish Oil via Alleviating Neuroinflammation and Impaired Tryptophan Metabolism in Aging Rats. Journal of agricultural and food chemistry. 2023-09-28. PMID:37769277. |
thus, fish oil intervention could ameliorate abnormal neurobehaviors and neuroinflammation and elevate the serotonin level in the hippocampus. |
2023-09-28 |
2023-10-07 |
rat |
| Min-Kyung Joo, Yoon-Jung Shin, Dong-Hyun Ki. Cefaclor causes vagus nerve-mediated depression-like symptoms with gut dysbiosis in mice. Scientific reports. vol 13. issue 1. 2023-09-19. PMID:37726354. |
cefaclor reduced serotonin levels and fluctuated 5-ht receptor mrna expressions such as htr1a, htr1b, and htr6 in the hippocampus. |
2023-09-19 |
2023-10-07 |
mouse |
| Sharmin Aktar, Farhana Ferdousi, Shinji Kondo, Tamami Kagawa, Hiroko Isod. Transcriptomics and biochemical evidence of trigonelline ameliorating learning and memory decline in the senescence-accelerated mouse prone 8 (SAMP8) model by suppressing proinflammatory cytokines and elevating neurotransmitter release. GeroScience. 2023-09-18. PMID:37721682. |
finally, elisa test showed that tg treatment significantly decreased proinflammatory cytokines- tnfα and il6 and increased neurotransmitters- dopamine, noradrenaline, and serotonin in mouse hippocampus. |
2023-09-18 |
2023-10-07 |
mouse |
| Su Hyun Lee, Nicholas I Cilz, Sarah K Williams Avram, Adi Cymerblit-Sabba, June Song, Karis Courey, Austin Howley, Michaela E Cooke, W Scott Youn. Stimulation of median raphe terminals in dorsal CA2 reduces social investigation in male mice specifically investigating social stimulus of ovariectomized female mice. bioRxiv : the preprint server for biology. 2023-09-11. PMID:37693526. |
a functional role of median raphe (mr) - ca2 projection is supported by the mr to ca2 projections and 82% reduction of hippocampal serotonin (5-ht) levels following mr lesions. |
2023-09-11 |
2023-10-07 |
mouse |
| Francesco Tortora, Abed L Hadipour, Simone Battaglia, Alessandra Falzone, Alessio Avenanti, Carmelo M Vicari. The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies. Brain sciences. vol 13. issue 8. 2023-08-26. PMID:37626553. |
accumulating evidence from both animal and human studies suggests that brain regions involved in fc, such as the amygdala, hippocampus, and prefrontal cortex, possess a high density of 5-ht receptors, implicating the crucial involvement of serotonin in aversive learning. |
2023-08-26 |
2023-09-07 |
human |
| Hasan S Alamri, Rana Mufti, Deema Kamal Sabir, Abdulwahab A Abuderman, Amal F Dawood, Asmaa M ShamsEldeen, Mohamed A Haidara, Esma R Isenovic, Mahmoud H El-Bidaw. Forced Swimming-Induced Depressive-like Behavior and Anxiety Are Reduced by Chlorpheniramine via Suppression of Oxidative and Inflammatory Mediators and Activating the Nrf2-BDNF Signaling Pathway. Current issues in molecular biology. vol 45. issue 8. 2023-08-25. PMID:37623226. |
brain neurotransmitters (cortisol, serotonin, and noradrenaline), oxidative stress (sod and mda), inflammatory (il-6 and il-1) biomarkers, and the nrf2-bdnf signaling pathway in the hippocampus and cerebral cortex tissues was determined. |
2023-08-25 |
2023-09-07 |
rat |
| Yujuan Zhao, You Kang, Zijian Zhao, Ge Yang, Yansong Gao, Lei Gao, Chao Wang, Shengyu L. Lacticaseibacillus rhamnosus TF318 prevents depressive behavior in rats by inhibiting HPA-axis hyperactivity and upregulating BDNF expression. Neuroscience letters. 2023-08-24. PMID:37619699. |
administration of l. rhamnosus tf318 resulted in lower hippocampal levels of adrenocorticotropic hormone and corticotropin-releasing factor and serum levels of cort and restoration of hippocampal levels of 5-hydroxytryptamine, dopamine, and norepinephrine. |
2023-08-24 |
2023-09-07 |
rat |
| Fiona A Wilkes, David Jakabek, Mark Walterfang, Dennis Velakoulis, Govinda R Poudel, Julie C Stout, Phyllis Chua, Gary F Egan, Jeffrey C L Looi, Nellie Georgiou-Karistiani. Hippocampal morphology in Huntington's disease, implications for plasticity and pathogenesis: The IMAGE-HD study. Psychiatry research. Neuroimaging. vol 335. 2023-08-20. PMID:37598529. |
interestingly we found decreased bilateral hippocampal volume in people with symptomatic-hd who took selective serotonin reuptake inhibitors compared to those who did not, despite no significant differences in anxiety, depressive symptoms, or motor incapacity between the two groups. |
2023-08-20 |
2023-09-07 |
Not clear |
| Alina Díez-Solinska, Garikoitz Azkona, Maider Muñoz-Culla, Garikoitz Beitia Oyarzabal, Olatz Goñi Balentziaga, Eneritz Gómez-Lazaro, Oscar Vega. The role of sociability in social instability stress: behavioral, neuroendocrine and monoaminergic effects. Physiology & behavior. 2023-07-29. PMID:37516231. |
csis increased serotonin levels in both the hippocampus and striatum. |
2023-07-29 |
2023-08-14 |
mouse |
| Xiaomei Yang, Yue Yang, Feng Gao, Kangping Lu, Chunling Wan. N-Acetyl Serotonin Provides Neuroprotective Effects by Inhibiting Ferroptosis in the Neonatal Rat Hippocampus Following Hypoxic Brain Injury. Molecular neurobiology. 2023-07-14. PMID:37452222. |
n-acetyl serotonin provides neuroprotective effects by inhibiting ferroptosis in the neonatal rat hippocampus following hypoxic brain injury. |
2023-07-14 |
2023-08-14 |
rat |
| Haoxing Cai, Mingyue Chen, Yang Gao, Jinpeng Ruan, Chengyong He, Zhenghong Zu. Transgenerational Effects and Mechanisms of Tributyltin Exposure on Neurodevelopment in the Male Offspring of Rats. Environmental science & technology. 2023-07-05. PMID:37406193. |
additionally, f1-f3 males exhibited increased serotonin and dopamine levels and a loose arrangement of neurons in the hippocampus. |
2023-07-05 |
2023-08-14 |
rat |
| Huiwen Kang, Wei Zhang, Jiaru Jing, Danyang Huang, Lei Zhang, Jingyu Wang, Lin Han, Ziyan Liu, Ziyan Wang, Ai Ga. The gut-brain axis involved in polystyrene nanoplastics-induced neurotoxicity via reprogramming the circadian rhythm-related pathways. Journal of hazardous materials. vol 458. 2023-07-01. PMID:37392641. |
we found that 80 nm ps-nps could reach and cause neuronal damage in the hippocampus, and alter the expression of neuroplasticity-related molecules (5-ht, ache, gaba, bdnf and creb), and even affect the learning and memory ability of mice. |
2023-07-01 |
2023-08-14 |
mouse |
| Ruixi Yang, Suzhen Ye, Shuping Zhang, Hanjin Huang, Yun Zhang, Yao Yang, Shu Xie, Lin He, Yuwei Yang, Jian Sh. Serotonin and dopamine depletion in distinct brain regions may cause anxiety in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice as a model of early Parkinson's disease. Neuroreport. vol 34. issue 11. 2023-06-29. PMID:37384936. |
in our murine model, mptp induced a decreased level of 5-hydroxytryptamine and its metabolite 5-hydroxyindoleacetic acid (5-hiaa) in the prefrontal cortex, hippocampus, and striatum (all p < 0.05); however, it only induced a decreased level of dopamine and its metabolite homovanillic acid (hva) in the striatum (both p < 0.001), with a negative correlation in the hippocampus and a positive correlation in the cortex and striatum. |
2023-06-29 |
2023-08-14 |
mouse |
| Junxi Fu, Wentian Song, Xiaobing Song, Li Fang, Xiyan Wang, Yue Leng, Ji Wang, Chunlei Liu, Weihong Mi. Synergistic Effect of Combined Walnut Peptide and Ginseng Extracts on Memory Improvement in C57BL/6 Mice and Potential Mechanism Exploration. Foods (Basel, Switzerland). vol 12. issue 12. 2023-06-28. PMID:37372540. |
improvement in the morphology of hippocampal neurons, dendritic spines, and synaptic plasticity and upregulation of neurotransmitters ache, ach, chat, glu, da, and 5-ht supported the memory improvement effects of wnp + gse. |
2023-06-28 |
2023-08-14 |
mouse |
| Kun Zhang, Yanfei Han, Peng Zhang, Yuqiong Zheng, Aobing Chen. Comparison of fluorescence biosensors and whole-cell patch clamp recording in detecting ACh, NE, and 5-HT. Frontiers in cellular neuroscience. vol 17. 2023-06-19. PMID:37333890. |
in this study, a multiplexed method was developed to measure acetylcholine (ach), norepinephrine (ne), and serotonin (5-ht) in cultured rat hippocampal slices using simultaneous whole-cell patch clamp recordings and genetically encoded fluorescence sensor imaging. |
2023-06-19 |
2023-08-14 |
rat |
| Min-Kyung Joo, Dong-Hyun Ki. Vagus nerve-dependent effects of fluoxetine on anxiety- and depression-like behaviors in mice. European journal of pharmacology. 2023-06-18. PMID:37331682. |
the vagotomy also inhibited the effect of fluoxetine to attenuate restraint stress- or cefaclor-induced reduction in serotonin levels and htr1a mrna expression in the hippocampus. |
2023-06-18 |
2023-08-14 |
mouse |
| Sharafuddin Khairuddin, Wei Ling Lim, Luca Aquili, Ka Chun Tsui, Anna Chung-Kwan Tse, Shehani Jayalath, Ruhani Varma, Trevor Sharp, Abdelhamid Benazzouz, Harry Steinbusch, Arjan Blokland, Yasin Temel, Lee Wei Li. Prelimbic Cortical Stimulation Induces Antidepressant-like Responses through Dopaminergic-Dependent and -Independent Mechanisms. Cells. vol 12. issue 11. 2023-06-11. PMID:37296570. |
hfs prl in both the cus-susceptible and cus-resilient animals significantly increased hedonia, reduced anxiety, decreased forced swim immobility, enhanced hippocampal da and serotonin levels, and reduced corticosterone levels when compared with the respective sham groups. |
2023-06-11 |
2023-08-14 |
rat |
| Shufang Xia, Gusonghan Maitiniyazi, Yuan Liu, Yue Chen, Mengting Guo, Jianyun He, Wei Tao, Ziyuan L. Whey protein isolate attenuates depression-like behavior developed in a mouse model of breast tumor. Food research international (Ottawa, Ont.). vol 169. 2023-05-31. PMID:37254425. |
increasing evidence indicates that tryptophan (trp) metabolism disturbance controls hippocampal 5-hydroxytryptamine (5-ht) and thereby affecting depression-like behavior, in which the gut microbiota (gm) might be involved. |
2023-05-31 |
2023-08-14 |
mouse |