| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia-Ning Xu, Li-Fang Chen, Jun Su, Zhi-Li Liu, Jie Chen, Qing-Fen Lin, Wei-Dong Mao, Dong She. The anxiolytic-like effects of ginsenoside Rg3 on chronic unpredictable stress in rats. Scientific reports. vol 8. issue 1. 2019-10-24. PMID:29773855. |
in addition, the decreased levels on progesterone, allopregnanolone, serotonin (5-ht) in the prefrontal cortex and hippocampus of chronic unpredictable stress (cus) were blocked by grg3 (20 and 40 mg/kg, i.g). |
2019-10-24 |
2023-08-13 |
rat |
| Xiao-Ming Si, Yu-Hua Tian, Sha-Sha Zhang, Hua Gao, Kun Liu, Jing-Yu Ji. Low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress-induced depression-like behavior in mice. Acta pharmaceutica (Zagreb, Croatia). vol 68. issue 3. 2019-10-21. PMID:31259700. |
further, there was a significant reduction of 5-ht level in the hippocampus region of depressed mice. |
2019-10-21 |
2023-08-13 |
mouse |
| Xiao-Ming Si, Yu-Hua Tian, Sha-Sha Zhang, Hua Gao, Kun Liu, Jing-Yu Ji. Low molecular mass chondroitin sulfate suppresses chronic unpredictable mild stress-induced depression-like behavior in mice. Acta pharmaceutica (Zagreb, Croatia). vol 68. issue 3. 2019-10-21. PMID:31259700. |
these novel results suggest that lmmcs produces an antidepressant-like effect in mice subjected to cums, which might be related, at least in part, to the increase of 5-ht concentration in the hippocampus. |
2019-10-21 |
2023-08-13 |
mouse |
| R Feio-Azevedo, V M Costa, D J Barbosa, A Teixeira-Gomes, I Pita, S Gomes, F C Pereira, M Duarte-Araújo, J A Duarte, F Marques, E Fernandes, M L Bastos, F Carvalho, J P Capel. Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity. Archives of toxicology. vol 92. issue 7. 2019-10-07. PMID:29869127. |
mdma promoted serotonergic neurotoxicity only in the hippocampus of aged, but not in the adolescents' brain, and did not change the levels of dopamine or serotonin metabolite in the striatum of both groups. |
2019-10-07 |
2023-08-13 |
rat |
| Laura Micheli, Manuela Ceccarelli, Giorgio D'Andrea, Felice Tiron. Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise. Brain research bulletin. vol 143. 2019-09-30. PMID:30236533. |
similarly, the antidepressant action of running also correlates with an increase of hippocampal neurogenesis and plasticity, although the gene pathways involved are only partially coincident with those of fluoxetine, such as those involved in serotonin metabolism and synapse formation. |
2019-09-30 |
2023-08-13 |
human |
| Satoko Hattori, Keizo Takao, Hiroshi Funakoshi, Tsuyoshi Miyakaw. Comprehensive behavioral analysis of tryptophan 2,3-dioxygenase (Tdo2) knockout mice. Neuropsychopharmacology reports. vol 38. issue 2. 2019-09-18. PMID:30106261. |
it has been reported that targeted deletion of the tdo2 gene in mice resulted in reduced anxiety-like behavior, enhanced exploratory activity and cognitive performance, and increased levels of trp and 5-ht in the hippocampus and midbrain. |
2019-09-18 |
2023-08-13 |
mouse |
| David D Kim, Alasdair M Barr, William G Honer, Ric M Procyshy. Exercise-induced hippocampal neurogenesis: 5-HT Molecular psychiatry. vol 23. issue 12. 2019-09-17. PMID:29422519. |
exercise-induced hippocampal neurogenesis: 5-ht |
2019-09-17 |
2023-08-13 |
Not clear |
| Rutuja Yawalkar, Harish Changotra, Girdhari Lal Gupt. Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats. Neurochemistry international. vol 118. 2019-09-16. PMID:29704590. |
serotonin concentrations were measured in the plasma, hippocampus and pre-frontal cortex using the rat elisa kit. |
2019-09-16 |
2023-08-13 |
rat |
| Rutuja Yawalkar, Harish Changotra, Girdhari Lal Gupt. Protective influences of N-acetylcysteine against alcohol abstinence-induced depression by regulating biochemical and GRIN2A, GRIN2B gene expression of NMDA receptor signaling pathway in rats. Neurochemistry international. vol 118. 2019-09-16. PMID:29704590. |
the significant reversal effect of nac on the serotonin level following alcohol abstinence was greater in the hippocampus as compared to the third-day alcohol withdrawal group. |
2019-09-16 |
2023-08-13 |
rat |
| Francisca Taciana Sousa Rodrigues, Marcos Romário Matos de Souza, Camila Nayane de Carvalho Lima, Francisco Eliclécio Rodrigues da Silva, Deiziane Viana da Silva Costa, Cláudio Costa Dos Santos, Fábio Miyajima, Francisca Cléa F de Sousa, Silvânia Maria Mendes Vasconcelos, Tatiana Barichello, João Quevedo, Michael Maes, David F de Lucena, Danielle Maced. Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations. Journal of psychiatric research. vol 107. 2019-09-12. PMID:30326340. |
six weeks after the last lps-exposure, we assessed behavioral despair and anhedonia, microglial activation, alterations in tryptophan, 5-ht, kynurenine, quinolinic acid (quin) levels and spermidine/spermine n1-acetyltransferase (sat1) expression in the hippocampus, both with and without fluoxetine administration. |
2019-09-12 |
2023-08-13 |
mouse |
| Lei Tang, Fei You, Xing Hu, Yun-Fei L. [Electroacupuncture improves insomnia by down-regulating peripheral benzodiazepine receptor expression in hippocampus, and up-regulating 5-HT, 5-HIAA, TNF-α and IL-1β contents in hypothalamus in insomnia rats]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 8. 2019-09-10. PMID:31475488. |
[electroacupuncture improves insomnia by down-regulating peripheral benzodiazepine receptor expression in hippocampus, and up-regulating 5-ht, 5-hiaa, tnf-α and il-1β contents in hypothalamus in insomnia rats]. |
2019-09-10 |
2023-08-13 |
rat |
| Lei Tang, Fei You, Xing Hu, Yun-Fei L. [Electroacupuncture improves insomnia by down-regulating peripheral benzodiazepine receptor expression in hippocampus, and up-regulating 5-HT, 5-HIAA, TNF-α and IL-1β contents in hypothalamus in insomnia rats]. Zhen ci yan jiu = Acupuncture research. vol 44. issue 8. 2019-09-10. PMID:31475488. |
to observe the therapeutic effect of electroacupuncture (ea) at five back-shu points on sleep, hippocampal peripheral benzodiazepine receptor (pbr) expression and hypothalamic 5-hydroxytryptamine (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), tumor necrosis factor alpha (tnf-α) and interleukin (il)-1β contents in insomnia rats, so as to explore its mechanisms underlying improvement of insomnia. |
2019-09-10 |
2023-08-13 |
rat |
| Pei-Yang Sun, Rong-Lin Cai, Pei-Fang Li, Yan Zhu, Tao Wang, Jie Wu, Nan Li, Hui Liu, Hao-Ran Ch. [Protective effects on hippocampal neurons and the influence on hippocampal monoamine neurotransmitters with acupuncture for promoting the circulation of the governor vessel and regulating the mental state in rats with post-stroke depression]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 39. issue 7. 2019-09-06. PMID:31286737. |
to observe the effects on hippocampal neuronal structure and hippocampal monoamine neurotransmitters such as norepinephrine (ne), 5-hydroxytryptamine (5-ht) and dopamine (da) with acupuncture for promoting the circulation of the governor vessel and regulating the mental state ( |
2019-09-06 |
2023-08-13 |
rat |
| María-Aránzazu Martínez, Irma Ares, José-Luis Rodríguez, Marta Martínez, María-Rosa Martínez-Larrañaga, Arturo Anadó. Neurotransmitter changes in rat brain regions following glyphosate exposure. Environmental research. vol 161. 2019-08-28. PMID:29156344. |
after last dose of glyphosate, serotonin (5-ht), dopamine (da) and norepinephrine (ne) and its metabolites levels were determined in the brain regions striatum, hippocampus, prefrontal, cortex, hypothalamus and midbrain, by hplc. |
2019-08-28 |
2023-08-13 |
rat |
| María-Aránzazu Martínez, Irma Ares, José-Luis Rodríguez, Marta Martínez, María-Rosa Martínez-Larrañaga, Arturo Anadó. Neurotransmitter changes in rat brain regions following glyphosate exposure. Environmental research. vol 161. 2019-08-28. PMID:29156344. |
moreover, glyphosate, dose-dependent, evoked a statistically significant increase in 5-ht turnover in striatum and hypothalamus and in da turnover in prefrontal cortex and hippocampus, and a statistically significant decrease in ne turnover in prefrontal cortex and hypothalamus. |
2019-08-28 |
2023-08-13 |
rat |
| Xiong-Jun Mou, Hao Ming, Le-Si Xu, Ying-Ying Yue, Yu Chen, Xin Chen, Song-Lin Li. [Active substance fractions and effects of Shugan Hewei Tang on hippocampal meurotransmitters in rat model of chronic stress-induced depression]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 3. 2019-08-08. PMID:30989918. |
after modeling for 3 weeks and administration for 1 week, the effective substance fractions were selected according to the body mass and behavioral performance of sd rats in each group; several neurotransmitters in hippocampus of rats were determined by lc-ms/ms method, including norepinephrine(ne), serotonin(5-ht), 5-indoleacetic acid(5-hiaa), r-aminobutyric acid(gaba), and glutamic acid(glu). |
2019-08-08 |
2023-08-13 |
rat |
| Xiong-Jun Mou, Hao Ming, Le-Si Xu, Ying-Ying Yue, Yu Chen, Xin Chen, Song-Lin Li. [Active substance fractions and effects of Shugan Hewei Tang on hippocampal meurotransmitters in rat model of chronic stress-induced depression]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 3. 2019-08-08. PMID:30989918. |
the levels of ne, 5-ht and gaba in the hippocampus of the model group were significantly lower than those in the blank group(p<0.01), and the levels of 5-hiaa and glu were significantly increased(p<0.01). |
2019-08-08 |
2023-08-13 |
rat |
| M Neus Fullana, Albert Ferrés-Coy, Jorge E Ortega, Esther Ruiz-Bronchal, Verónica Paz, J Javier Meana, Francesc Artigas, Analia Bortolozz. Selective Knockdown of TASK3 Potassium Channel in Monoamine Neurons: a New Therapeutic Approach for Depression. Molecular neurobiology. vol 56. issue 4. 2019-08-06. PMID:30088175. |
moreover, ser-task3-sirna induced robust antidepressant-like behaviors, enhanced the hippocampal plasticity, and potentiated the fluoxetine-induced increase on extracellular 5-ht. |
2019-08-06 |
2023-08-13 |
mouse |
| Catia M Teixeira, Zev B Rosen, Deepika Suri, Qian Sun, Marc Hersh, Derya Sargin, Iva Dincheva, Ashlea A Morgan, Stephen Spivack, Anne C Krok, Tessa Hirschfeld-Stoler, Evelyn K Lambe, Steven A Siegelbaum, Mark S Ansorg. Hippocampal 5-HT Input Regulates Memory Formation and Schaffer Collateral Excitation. Neuron. vol 98. issue 5. 2019-08-05. PMID:29754752. |
hippocampal 5-ht input regulates memory formation and schaffer collateral excitation. |
2019-08-05 |
2023-08-13 |
mouse |
| Catia M Teixeira, Zev B Rosen, Deepika Suri, Qian Sun, Marc Hersh, Derya Sargin, Iva Dincheva, Ashlea A Morgan, Stephen Spivack, Anne C Krok, Tessa Hirschfeld-Stoler, Evelyn K Lambe, Steven A Siegelbaum, Mark S Ansorg. Hippocampal 5-HT Input Regulates Memory Formation and Schaffer Collateral Excitation. Neuron. vol 98. issue 5. 2019-08-05. PMID:29754752. |
while the modulatory transmitter serotonin (5-ht) plays an important role in implicit forms of memory in the invertebrate aplysia, its function in explicit memory mediated by the mammalian hippocampus is less clear. |
2019-08-05 |
2023-08-13 |
mouse |