| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Monika Fleshner, Benjamin N Greenwood, Raz Yirmiy. Neuronal-glial mechanisms of exercise-evoked stress robustness. Current topics in behavioral neurosciences. vol 18. 2019-11-20. PMID:24481547. |
specifically, we propose that sedentary animals respond to an intense acute uncontrollable stressor with excessive serotonin (5-ht) and noradrenergic (ne) activity and/or prolonged down-regulation of the cx3cl1-cx3cr1 axis resulting in activation and proliferation of hippocampal microglia in the absence of pathogenic signals and consequent hippocampal-dependent memory deficits and reduced neurogenesis. |
2019-11-20 |
2023-08-12 |
Not clear |
| Yu Ohmura, Takayuki Yoshida, Kohtarou Konno, Masabumi Minami, Masahiko Watanabe, Mitsuhiro Yoshiok. Serotonin 5-HT7 Receptor in the Ventral Hippocampus Modulates the Retrieval of Fear Memory and Stress-Induced Defecation. The international journal of neuropsychopharmacology. vol 19. issue 6. 2019-11-20. PMID:26647382. |
serotonin 5-ht7 receptor in the ventral hippocampus modulates the retrieval of fear memory and stress-induced defecation. |
2019-11-20 |
2023-08-13 |
Not clear |
| Hyun-Sun Park, Arum Han, Hye-Lim Yeo, Min-Jung Park, Min-Jung You, Hyun Jin Choi, Chang-Won Hong, Sang-Hyuk Lee, Seung Hyun Kim, Borah Kim, Min-Soo Kwo. Chronic high dose of captopril induces depressive-like behaviors in mice: possible mechanism of regulatory T cell in depression. Oncotarget. vol 8. issue 42. 2019-11-20. PMID:29069807. |
however, chc did not affect to hippocampal kynurenine pathway, serotonin level, hypothalamic corticotropin-releasing hormone mrna level, or serum corticosterone level. |
2019-11-20 |
2023-08-13 |
mouse |
| Michael H Baumann, Mario A Ayestas, Richard B Rothma. In Vivo Correlates of Central Serotonin Function after High-Dose Fenfluramine Administration. Annals of the New York Academy of Sciences. vol 844. issue 1. 2019-11-20. PMID:29090811. |
the repeated fen dosing regimen dramatically reduced (>50%) postmortem 5-ht levels in the mediobasal hypothalamus, basolateral amygdala, and hippocampus, while the lateral hypothalamus was unaffected. |
2019-11-20 |
2023-08-13 |
human |
| David L Frederick, Syed F Ali, Michael P Gillam, Jeff Gossett, William Slikker, Merle G Paul. Acute Effects of Dexfenfluramine (d-FEN) and Methylenedioxymethamphetamine (MDMA) before and after Short-Course, High-Dose Treatment. Annals of the New York Academy of Sciences. vol 844. issue 1. 2019-11-20. PMID:29090816. |
50% in serotonin in frontal cortex and hippocampus) were observed in all monkeys approximately six months after short-course, high-dose mdma or d-fen treatment. |
2019-11-20 |
2023-08-13 |
monkey |
| Rong-Xia Liu, You-Yan Xian, Sha Liu, Fei Yu, Hong-Jie Mu, Kao-Xiang Sun, Wan-Hui Li. Development, validation and comparison of surrogate matrix and surrogate analyte approaches with UHPLC-MS/MS to simultaneously quantify dopamine, serotonin and γ-aminobutyric acid in four rat brain regions. Biomedical chromatography : BMC. 2019-11-20. PMID:29727024. |
both approaches satisfied fda and ema validation criterias after an appropriate parallelism assessment, and they were used to further quantify the three endogenous neurotransmitters, including dopamine (da), serotonin (5-ht) and γ-aminobutyric acid (gaba) in rat brain four regions (cortex, striatum, hypothalamus and hippocampus) which represent the catecholamines, indolamines, and amino acids, respectively. |
2019-11-20 |
2023-08-13 |
rat |
| Rong-Xia Liu, You-Yan Xian, Sha Liu, Fei Yu, Hong-Jie Mu, Kao-Xiang Sun, Wan-Hui Li. Development, validation and comparison of surrogate matrix and surrogate analyte approaches with UHPLC-MS/MS to simultaneously quantify dopamine, serotonin and γ-aminobutyric acid in four rat brain regions. Biomedical chromatography : BMC. 2019-11-20. PMID:29727024. |
the concentrations of da and gaba were highest in striatum and hypothalamus, respectively, and the levels of 5-ht were paralleled in striatum and hippocampus almost 2-fold higher than other regions. |
2019-11-20 |
2023-08-13 |
rat |
| Katsuya Sakimura, Tatsuya Maekawa, Kazuo Sasagawa, Yukihito Ishii, Shin-Ichi Kume, Takeshi Oht. Depression-related behavioural and neuroendocrine changes in the Spontaneously Diabetic Torii (SDT) fatty rat, an animal model of type 2 diabetes mellitus. Clinical and experimental pharmacology & physiology. 2019-11-20. PMID:29757463. |
in addition, serotonin (5-hydroxytryptamine; 5-ht), noradrenaline, glutamate and γ-aminobutyric acid (gaba) concentrations in the frontal cortex, hippocampus and brain stem were measured. |
2019-11-20 |
2023-08-13 |
rat |
| Katsuya Sakimura, Tatsuya Maekawa, Kazuo Sasagawa, Yukihito Ishii, Shin-Ichi Kume, Takeshi Oht. Depression-related behavioural and neuroendocrine changes in the Spontaneously Diabetic Torii (SDT) fatty rat, an animal model of type 2 diabetes mellitus. Clinical and experimental pharmacology & physiology. 2019-11-20. PMID:29757463. |
furthermore, there were significant changes in 5-ht concentrations in the prefrontal cortex, and in gaba and glutamate concentrations in the hippocampus in sdt fatty compared with controls. |
2019-11-20 |
2023-08-13 |
rat |
| P Tharyan, K Kuruvilla, S Prabhaka. Prolactin in the diagnosis of epilepsy. The National medical journal of India. vol 4. issue 5. 2019-11-20. PMID:29783610. |
evidence from these studies indicates that post-ictal hyperprolactinaemia is caused by involvement of medial temporal structures, especially the amygdala and hippocampus, by ictal discharges and the resultant disruption of tonic dopaminergic inhibition of prolactin release and/or stimulation of serotonin, rather than due to non-specific influences. |
2019-11-20 |
2023-08-13 |
Not clear |
| Sonia Verma, Pavitra Ranawat, Neha Sharma, Bimla Nehr. Ginkgo biloba attenuates aluminum lactate-induced neurotoxicity in reproductive senescent female rats: behavioral, biochemical, and histopathological study. Environmental science and pollution research international. vol 26. issue 26. 2019-11-19. PMID:31321719. |
based on the above results, gbe prevented the neuronal loss in the hippocampus and cortex, hence caused significant improvement in the learning and memory of the animals in terms of ache activity, serotonin levels, morris water maze, and active and passive avoidance tests. |
2019-11-19 |
2023-08-13 |
rat |
| Giacomo Maddaloni, Sara Migliarini, Francesco Napolitano, Andrea Giorgi, Serena Nazzi, Daniele Biasci, Alessia De Felice, Marta Gritti, Anna Cavaccini, Alberto Galbusera, Sara Franceschi, Francesca Lessi, Marco La Ferla, Paolo Aretini, Chiara Maria Mazzanti, Raffaella Tonini, Alessandro Gozzi, Alessandro Usiello, Massimo Pasqualett. Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress. Scientific reports. vol 8. issue 1. 2019-11-18. PMID:30087403. |
serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress. |
2019-11-18 |
2023-08-13 |
mouse |
| Giacomo Maddaloni, Sara Migliarini, Francesco Napolitano, Andrea Giorgi, Serena Nazzi, Daniele Biasci, Alessia De Felice, Marta Gritti, Anna Cavaccini, Alberto Galbusera, Sara Franceschi, Francesca Lessi, Marco La Ferla, Paolo Aretini, Chiara Maria Mazzanti, Raffaella Tonini, Alessandro Gozzi, Alessandro Usiello, Massimo Pasqualett. Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress. Scientific reports. vol 8. issue 1. 2019-11-18. PMID:30087403. |
this work tests the hypothesis that the neurotransmitter serotonin (5-ht) is a key determinant of hippocampal neuroplasticity, and its absence leads to maladaptive behaviour relevant for bd. |
2019-11-18 |
2023-08-13 |
mouse |
| Giacomo Maddaloni, Sara Migliarini, Francesco Napolitano, Andrea Giorgi, Serena Nazzi, Daniele Biasci, Alessia De Felice, Marta Gritti, Anna Cavaccini, Alberto Galbusera, Sara Franceschi, Francesca Lessi, Marco La Ferla, Paolo Aretini, Chiara Maria Mazzanti, Raffaella Tonini, Alessandro Gozzi, Alessandro Usiello, Massimo Pasqualett. Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress. Scientific reports. vol 8. issue 1. 2019-11-18. PMID:30087403. |
these findings delineate 5-ht as a critical determinant in bd associated maladaptive emotional responses and aberrant hippocampal neuroplasticity, and support the use of tph2-/- mice as a new research tool for mechanistic and therapeutic research in bipolar disorder. |
2019-11-18 |
2023-08-13 |
mouse |
| Amal Ahmed Abd El-Fattah, Atef Tadros Fahim, Nermin Abdel Hamid Sadik, Bassam Mohamed Al. Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress. Brain research. vol 1701. 2019-11-04. PMID:30244113. |
the depressive-like behaviour of rats induced by cums was revealed by an elevated serum corticosterone level and decreased serum and hippocampal serotonin levels. |
2019-11-04 |
2023-08-13 |
rat |
| Marcelo Gomes de Gomes, Leandro Cattelan Souza, André Rossito Goes, Lucian Del Fabbro, Carlos Borges Filho, Franciele Donato, Marina Prigol, Cristiane Luchese, Silvane Souza Roman, Robson Luiz Puntel, Silvana Peterini Boeira, Cristiano Ricardo Jess. Fish oil ameliorates sickness behavior induced by lipopolysaccharide in aged mice through the modulation of kynurenine pathway. The Journal of nutritional biochemistry. vol 58. 2019-10-28. PMID:29870875. |
moreover, we evaluated the ability of fo treatment on the regulation of neuroinflammation (levels of interleukin-1β, interleukin-6, tumor factor necrosis-α and interferon-γ), kp biomarkers (levels of tryptophan, kynurenine, kynurenic acid, 3-hydroxykynurenine and quinolinic acid and activities of indoleamine-2,3-dioxygenase, kynurenine monooxygenase and kynurenine aminotransferase) and serotonergic system (levels of serotonin and 5-hydroxyindoleactic acid) in the hippocampus, striatum and prefrontal cortex of lps-treated mice. |
2019-10-28 |
2023-08-13 |
mouse |
| Jenna L N Sprowles, Robyn M Amos-Kroohs, Amanda A Braun, Chiho Sugimoto, Charles V Vorhees, Michael T William. Developmental manganese, lead, and barren cage exposure have adverse long-term neurocognitive, behavioral and monoamine effects in Sprague-Dawley rats. Neurotoxicology and teratology. vol 67. 2019-10-25. PMID:29631003. |
pb altered neostriatal serotonin and norepinephrine, mn increased hippocampal serotonin in males, mn + barren-rearing increased neostriatal serotonin, and barren-rearing decreased neostriatal dopamine in males. |
2019-10-25 |
2023-08-13 |
rat |
| Vishnu N Thakare, Rajesh R Patil, Rajesh J Oswal, Valmik D Dhakane, Manoj K Aswar, Bhoomika M Pate. Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice. Journal of psychopharmacology (Oxford, England). vol 32. issue 2. 2019-10-24. PMID:29215318. |
in addition, neurobiochemical alterations, mainly monoamines, 5-ht, ne, da, neurotrophic factor bdnf, and cytokines, il-6, tnf-α, oxidant-antioxidant parameters by determining the malondialdehyde formation (an index of lipid peroxidation process), superoxide dismutase (sod) and catalase (cat) activity in hippocampus and cerebral cortex along with serum corticosterone were investigated. |
2019-10-24 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Rajesh R Patil, Rajesh J Oswal, Valmik D Dhakane, Manoj K Aswar, Bhoomika M Pate. Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice. Journal of psychopharmacology (Oxford, England). vol 32. issue 2. 2019-10-24. PMID:29215318. |
our findings reveal that mice subjected to cums exhibited lower sucrose preference, increase immobility time without affecting general locomotion of the animals, and reduce bdnf, 5-ht, ne, and da level, increased serum corticosterone, il-6 and tnf-α along with an oxidant-antioxidant imbalance in the hippocampus and cerebral cortex. |
2019-10-24 |
2023-08-13 |
mouse |
| Vishnu N Thakare, Rajesh R Patil, Rajesh J Oswal, Valmik D Dhakane, Manoj K Aswar, Bhoomika M Pate. Therapeutic potential of silymarin in chronic unpredictable mild stress induced depressive-like behavior in mice. Journal of psychopharmacology (Oxford, England). vol 32. issue 2. 2019-10-24. PMID:29215318. |
thus, the possible mechanism involved in the antidepressant-like activity of silymarin is correlated to the alleviation of monoaminergic, neurogenesis (enhancing 5-ht, ne, and bdnf levels), and attenuation of inflammatory cytokines system and oxidative stress by modulation of corticosterone response, restoration of antioxidant defense system in cerebral cortex and hippocampus. |
2019-10-24 |
2023-08-13 |
mouse |