| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J B Mitchell, K Betito, W Rowe, P Boksa, M J Meane. Serotonergic regulation of type II corticosteroid receptor binding in hippocampal cell cultures: evidence for the importance of serotonin-induced changes in cAMP levels. Neuroscience. vol 48. issue 3. 1992-07-16. PMID:1318518. |
camp, but not cgmp, levels in cultured hippocampal cells were significantly increased by the addition of 5-hydroxytryptamine to the medium. |
1992-07-16 |
2023-08-11 |
rat |
| Y Odagak. [Effects of lithium and antidepressants on monoaminergic receptors and receptor-coupled adenylate cyclase system in rat brain]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. vol 67. issue 2. 1992-07-09. PMID:1317819. |
with regard to 5-hydroxytryptamine (5-ht) receptor subtypes, lithium treatment reduced the maximum number of 5-ht1a receptors in rat hippocampus but not in cerebral cortex, whereas repetitive injections with imipramine or desipramine did not. |
1992-07-09 |
2023-08-11 |
rat |
| E B Erdtsieck-Ernste, M G Feenstra, M H Botterblom, J De Barrios, G J Boe. Changes in adrenoceptors and monoamine metabolism in neonatal and adult rat brain after postnatal exposure to the antihypertensive labetalol. British journal of pharmacology. vol 105. issue 1. 1992-07-07. PMID:1596689. |
a slight increase in 5-ht metabolism (20%) was induced by the chronic labetalol treatment in the hippocampus and meso-limbic system. |
1992-07-07 |
2023-08-11 |
rat |
| H D Li, X C Li, B Y Zha. [Changes of the 5-HT content in hippocampus, midbrain-pons, spinal cord and concentration of blood glucose after intraperitoneal injection of ACTH in rats]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 13. issue 2. 1992-07-06. PMID:1317987. |
[changes of the 5-ht content in hippocampus, midbrain-pons, spinal cord and concentration of blood glucose after intraperitoneal injection of acth in rats]. |
1992-07-06 |
2023-08-11 |
rat |
| H D Li, X C Li, B Y Zha. [Changes of the 5-HT content in hippocampus, midbrain-pons, spinal cord and concentration of blood glucose after intraperitoneal injection of ACTH in rats]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 13. issue 2. 1992-07-06. PMID:1317987. |
effects of acth on the content of 5-ht in the hippocampus, midbrain-pons, and spinal cord and the concentration of blood glucose in rats by spectrofluorometric assay and glucose oxidase method were studied. |
1992-07-06 |
2023-08-11 |
rat |
| H D Li, X C Li, B Y Zha. [Changes of the 5-HT content in hippocampus, midbrain-pons, spinal cord and concentration of blood glucose after intraperitoneal injection of ACTH in rats]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 13. issue 2. 1992-07-06. PMID:1317987. |
acth ip 10 iu.kg-1 or 20 iu.kg-1 significantly increased the content of 5-ht in the hippocampus, midbrain-pons and spinal cord and blood glucose level, both in a dose-dependent manner; para-chloroaphetamine, p-cpa 4 mg icv markedly reduced the 5-ht in these brain regions and spinal cord and the blood glucose level (p less than 0.01); the level of 5-ht and blood glucose were not significantly altered after icv p-cpa+ip acth; adrenalectomy+ip acth markedly increased the 5-ht content in the brain regions and spinal cord, but the blood glucose was decreased (p less than 0.01); and 5-ht was markedly decreased by sc alloxan tetrahydrate+ip acth, but blood glucose did not decrease (p greater than 0.05). |
1992-07-06 |
2023-08-11 |
rat |
| N Andrews, A Zharkovsky, S E Fil. Raised [3H]-5-HT release and 45Ca2+ uptake in diazepam withdrawal: inhibition by baclofen. Pharmacology, biochemistry, and behavior. vol 41. issue 4. 1992-06-30. PMID:1594636. |
the effect of diazepam withdrawal (2 mg/kg/day) on release of [3h]-5-hydroxytryptamine(5-ht) and [14c]-gaba from rat cortical and hippocampal slices was studied. |
1992-06-30 |
2023-08-11 |
rat |
| M P Johnson, X M Huang, D E Nichol. Serotonin neurotoxicity in rats after combined treatment with a dopaminergic agent followed by a nonneurotoxic 3,4-methylenedioxymethamphetamine (MDMA) analogue. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1726189. |
more importantly, if a subacute dosing regimen (every 12 hours for 4 days) was utilized, the combination of s-amphetamine with mdai resulted in a marked long-term decrease in the levels of cortical, hippocampal and striatal 5-ht, 5-hiaa and the number of 5-ht uptake sites. |
1992-06-30 |
2023-08-11 |
rat |
| N K Popova, N N Voitenko, A V Kulikov, D F Avgustinovic. Evidence for the involvement of central serotonin in mechanism of domestication of silver foxes. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1816562. |
silver foxes selected for more than 30 years for tame behavior and displaying no defensive reaction to human contact were shown to have a higher serotonin level in midbrain and hypothalamus, and a higher 5-hydroxyindole acetic acid (5-hiaa) content in midbrain, hypothalamus and hippocampus in comparison to nonselected wild silver foxes bred in captivity over the same time span. |
1992-06-30 |
2023-08-11 |
human |
| N Ropert, N Gu. Serotonin facilitates GABAergic transmission in the CA1 region of rat hippocampus in vitro. The Journal of physiology. vol 441. 1992-06-26. PMID:1687746. |
serotonin facilitates gabaergic transmission in the ca1 region of rat hippocampus in vitro. |
1992-06-26 |
2023-08-11 |
rat |
| J C Lacaille, S Cloutier, T A Reade. Lithium reduced synaptic transmission and increased neuronal excitability without altering endogenous serotonin, norepinephrine and dopamine in rat hippocampal slices in vitro. Progress in neuro-psychopharmacology & biological psychiatry. vol 16. issue 3. 1992-06-24. PMID:1350356. |
lithium reduced synaptic transmission and increased neuronal excitability without altering endogenous serotonin, norepinephrine and dopamine in rat hippocampal slices in vitro. |
1992-06-24 |
2023-08-11 |
rat |
| J Weidenfeld, S Feldma. Effect of 6-hydroxydopamine and 5,7-dihydroxytryptamine on tissue uptake and cell nuclear retention of corticosterone in the rat hypothalamus. Brain research. vol 566. issue 1-2. 1992-06-23. PMID:1667607. |
previous studies have shown that norepinephrine and serotonin can modulate the glucocorticoid (gc) binding capacity in the hippocampus. |
1992-06-23 |
2023-08-11 |
rat |
| G Richter-Levin, M Sega. Restoration of serotonergic innervation underlies the behavioral effects of raphe grafts. Brain research. vol 566. issue 1-2. 1992-06-23. PMID:1814537. |
it has been previously demonstrated that an embryonic raphe grafted into a serotonin-depleted hippocampus restores normal serotonin innervation of the hippocampus and behaviors associated with serotonin. |
1992-06-23 |
2023-08-11 |
rat |
| L A Mamounas, C A Mullen, E O'Hearn, M E Mollive. Dual serotoninergic projections to forebrain in the rat: morphologically distinct 5-HT axon terminals exhibit differential vulnerability to neurotoxic amphetamine derivatives. The Journal of comparative neurology. vol 314. issue 3. 1992-06-23. PMID:1814975. |
moreover, beaded 5-ht axons exhibit a highly characteristic regional distribution which is the same in control as in mda- and pca-treated rats: these axons innervate specific zones or layers within parietal and occipital cortex, hippocampus, cingulate cortex, entorhinal cortex, and the olfactory bulb, among other forebrain areas, and they form a dense plexus lining the ventricular system. |
1992-06-23 |
2023-08-11 |
rat |
| Z Y Zhao, N Castagnoli, G A Ricaurte, T Steele, M Martell. Synthesis and neurotoxicological evaluation of putative metabolites of the serotonergic neurotoxin 2-(methylamino)-1-[3,4-(methylenedioxy)phenyl] propane [(methylenedioxy)methamphetamine]. Chemical research in toxicology. vol 5. issue 1. 1992-06-18. PMID:1349835. |
systemic, intracerebroventricular, and intraparenchymal (intrastriatal and intracortical) administration of 4 led to no detectable alterations of hippocampal or cortical serotonin or striatal dopamine levels in the rat under conditions that caused significant biogenic amine depletions by established neurotoxins. |
1992-06-18 |
2023-08-11 |
rat |
| A Biegon, K Dillon, N D Volkow, R J Hitzemann, J S Fowler, A P Wol. Quantitative autoradiography of cocaine binding sites in human brain postmortem. Synapse (New York, N.Y.). vol 10. issue 2. 1992-06-18. PMID:1585256. |
preliminary competition experiments with several drugs indicate that dopamine uptake inhibitors completely block cocaine binding to the basal ganglia, while serotonin uptake inhibitors were more effective in the hippocampus. |
1992-06-18 |
2023-08-11 |
human |
| S G Bec. 5-Hydroxytryptamine increases excitability of CA1 hippocampal pyramidal cells. Synapse (New York, N.Y.). vol 10. issue 4. 1992-06-18. PMID:1585262. |
in the presence of spiperone to block the 5-ht1a-mediated inhibition of pyramidal cell activity, 5-hydroxytryptamine (serotonin, 5-ht) produces a rapid transient increase in amplitude of the extracellularly recorded population spike from area ca1 of the hippocampus. |
1992-06-18 |
2023-08-11 |
rat |
| S G Bec. 5-Hydroxytryptamine increases excitability of CA1 hippocampal pyramidal cells. Synapse (New York, N.Y.). vol 10. issue 4. 1992-06-18. PMID:1585262. |
intracellular recording techniques in area ca1 of rat hippocampal slices were used to identify the ionic mechanism and to characterize the 5-ht receptor mediating this excitatory response to 5-ht. |
1992-06-18 |
2023-08-11 |
rat |
| H Kido, M Hasegawa, H Sakamoto, N Yamaguchi, K Kurata, M Kurach. Effects of clomipramine on the concentrations of catecholamines, indoleamines and their metabolites in 11 rat brain regions. The Japanese journal of psychiatry and neurology. vol 45. issue 4. 1992-06-18. PMID:1725996. |
a long-term cmp treatment (14 days, 10 mg/kg/day) decreased the concentrations of dopamine (da), 5-hydroxytryptamine and 5hiaa in the mesencephalon, and increased the da concentrations in the hippocampus. |
1992-06-18 |
2023-08-11 |
rat |
| A J Dekker, F H Gage, L J Tha. Delayed treatment with nerve growth factor improves acquisition of a spatial task in rats with lesions of the nucleus basalis magnocellularis: evaluation of the involvement of different neurotransmitter systems. Neuroscience. vol 48. issue 1. 1992-06-12. PMID:1374860. |
there was no significant difference in the levels of norepinephrine, dopamine, serotonin or their metabolites in the cortex or hippocampus between nerve growth factor-treated animals and lesioned control animals. |
1992-06-12 |
2023-08-11 |
human |