| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M el Mansari, P Blie. Functional characterization of 5-HT1D autoreceptors on the modulation of 5-HT release in guinea-pig mesencephalic raphe, hippocampus and frontal cortex. British journal of pharmacology. vol 118. issue 3. 1997-02-14. PMID:8762094. |
taken together with our previous results, this suggests that, in addition to the 5-ht1d autoreceptor activated by sumatriptan, another subtype of 5-ht autoreceptor is activated by 5-meot in the hippocampus. |
1997-02-14 |
2023-08-12 |
Not clear |
| M el Mansari, P Blie. Functional characterization of 5-HT1D autoreceptors on the modulation of 5-HT release in guinea-pig mesencephalic raphe, hippocampus and frontal cortex. British journal of pharmacology. vol 118. issue 3. 1997-02-14. PMID:8762094. |
following a 3-week treatment with the selective 5-ht reuptake inhibitor, paroxetine (10 mg kg-1 day-1) and a 48 h washout period, the electrically evoked release of [3h]-5-ht was enhanced in mesencephalic raphe, hippocampus and frontal cortex slices. |
1997-02-14 |
2023-08-12 |
Not clear |
| M el Mansari, P Blie. Functional characterization of 5-HT1D autoreceptors on the modulation of 5-HT release in guinea-pig mesencephalic raphe, hippocampus and frontal cortex. British journal of pharmacology. vol 118. issue 3. 1997-02-14. PMID:8762094. |
the enhancement of [3h]-5-ht release by long-term paroxetine treatment is possibly due to a desensitization of 5-ht1d autoreceptors activated by sumatriptan in mesencephalic raphe and by terminal 5-ht autoreceptors activated by 5-meot in hippocampus. |
1997-02-14 |
2023-08-12 |
Not clear |
| G Griebel, D C Blanchard, M C Rettori, B Guardiola-Lemaître, R J Blanchar. Preclinical profile of the mixed 5-HT1A/5-HT2A receptor antagonist S 21,357. Pharmacology, biochemistry, and behavior. vol 54. issue 2. 1997-02-12. PMID:8743616. |
the drug behaved as antagonist at both 5-ht1a autoreceptors and postsynaptic 5-ht1a receptors, as it prevented the inhibitory effect of lesopitron on the electrical discharge of the dorsal raphé nucleus (drn) 5-ht neurons and the activity of forskolin-stimulated adenylate cyclase in hippocampal homogenates. |
1997-02-12 |
2023-08-12 |
mouse |
| M B Assié, W Koe. Effects of 5-HT1A receptor antagonists on hippocampal 5-hydroxytryptamine levels: (S)-WAY100135, but not WAY100635, has partial agonist properties. European journal of pharmacology. vol 304. issue 1-3. 1997-02-12. PMID:8813579. |
effects of 5-ht1a receptor antagonists on hippocampal 5-hydroxytryptamine levels: (s)-way100135, but not way100635, has partial agonist properties. |
1997-02-12 |
2023-08-12 |
rat |
| M B Assié, W Koe. Effects of 5-HT1A receptor antagonists on hippocampal 5-hydroxytryptamine levels: (S)-WAY100135, but not WAY100635, has partial agonist properties. European journal of pharmacology. vol 304. issue 1-3. 1997-02-12. PMID:8813579. |
in vivo microdialysis measuring 5-hydroxytryptamine (5-ht) levels in the ventral hippocampus of chloral hydrate-anaesthetised rats was used to characterise further the recently described 5-ht1a receptor antagonists (s)-way100135 ((s)-n-tert-butyl-3-(4-(2-methoxyphenyl)piperazine-1-yl)-2- phenylpropanamide) and way100635 (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-n-(2-pyridinyl)cyclohexanecarboxamide). |
1997-02-12 |
2023-08-12 |
rat |
| R Li, G Bao, R S el-Mallakh, E C Fletche. Effects of chronic episodic hypoxia on monoamine metabolism and motor activity. Physiology & behavior. vol 60. issue 4. 1997-02-05. PMID:8884935. |
norepinephrine, dopamine, serotonin, and their metabolites in the hypothalamus, hippocampus, and adrenal glands were measured by high-performance liquid chromatography (hplc). |
1997-02-05 |
2023-08-12 |
rat |
| Y Levkovitz, V Greenberger, M Sega. The effects of raphe grafts on hippocampal electrophysiology in aged rats. Brain research. vol 719. issue 1-2. 1997-02-04. PMID:8782888. |
in previous studies we have demonstrated that raphe grafts, implanted into serotonin-depleted rat hippocampus can restore behavioral and physiological functions impaired by serotonin depletion. |
1997-02-04 |
2023-08-12 |
rat |
| M Gobbi, L Mancini, M L Presti, T Mennin. Down-regulation of rat brain 5-HT uptake carriers after treatment with high doses of D-fenfluramine. Brain research. vol 730. issue 1-2. 1997-01-28. PMID:8883900. |
five days later there was a strong reduction (70-100%) in the bmax of [3h]citalopram binding and the vmax of [3h]5-ht uptake in cortical and hippocampal synaptosomes; 2 months after the treatment these parameters were reduced by 40-70%. |
1997-01-28 |
2023-08-12 |
rat |
| J A Harder, M E Kelly, C H Cheng, B Costal. Combined pCPA and muscarinic antagonist treatment produces a deficit in rat water maze acquisition. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870039. |
a 3-day treatment with p-chlorophenylalanine (pcpa, 100 mg/kg/day) produced a significant decrease (63-89%) in 5-ht levels in both the hippocampus and the cortex of rats, while noradrenaline, adrenaline, and dopamine levels were unaffected. |
1997-01-23 |
2023-08-12 |
rat |
| A M Andrews, B Ladenheim, C J Epstein, J L Cadet, D L Murph. Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminals. Molecular pharmacology. vol 50. issue 6. 1997-01-23. PMID:8967972. |
administration of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) analog 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-nh2-mptp; 4 x 15 mg/kg) to cd-1 mice was found to cause substantial decreases in cortical and hippocampal 5-hydroxytryptamine (5-ht) and norepinephrine (ne) to 20-30% of control 3 weeks after treatment. |
1997-01-23 |
2023-08-12 |
mouse |
| A M Andrews, B Ladenheim, C J Epstein, J L Cadet, D L Murph. Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminals. Molecular pharmacology. vol 50. issue 6. 1997-01-23. PMID:8967972. |
in 2'-nh2-mptp-treated heterozygous sod mice, which showed an average 3-fold increase in brain sod activity, only moderate depletions in cortical and hippocampal 5-ht (50-60% of control) and ne (30-40% of control) were observed. |
1997-01-23 |
2023-08-12 |
mouse |
| A M Andrews, B Ladenheim, C J Epstein, J L Cadet, D L Murph. Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminals. Molecular pharmacology. vol 50. issue 6. 1997-01-23. PMID:8967972. |
in various cortical and hippocampal subregions of nontransgenic mice, 5-ht uptake sites were reduced to 20-35% of control after 2'-nh2-mptp treatment, in comparison with homozygous sod mice, which were affected only minimally by 2'-nh2-mptp administration, and heterozygous sod mice, which showed intermediate reductions in 5-ht uptake site density on the order of 55-80% of control. |
1997-01-23 |
2023-08-12 |
mouse |
| M Yamazaki, N Matsuoka, N Maeda, Y Ohkubo, I Yamaguch. FK960 N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate ameliorates the memory deficits in rats through a novel mechanism of action. The Journal of pharmacology and experimental therapeutics. vol 279. issue 3. 1997-01-23. PMID:8968337. |
dose-dependently increased both serotonin and 5-hydroxyindoleacetic acid levels in the brain areas examined and significantly increased hippocampal somatostatin contents at the smaller doses. |
1997-01-23 |
2023-08-12 |
rat |
| D F Papolos, Y M Yu, E Rosenbaum, H M Lachma. Modulation of learned helplessness by 5-hydroxytryptamine2A receptor antisense oligodeoxynucleotides. Psychiatry research. vol 63. issue 2-3. 1997-01-16. PMID:8878316. |
these data support the view that central 5ht, mediated by the 5ht2a receptor, participates in regulating behaviors that are affected by inescapable stress, and that the induction of behavioral depression may be specifically regulated via serotonergic pathways that terminate in this hippocampal subfield. |
1997-01-16 |
2023-08-12 |
rat |
| T de Boe. The effects of mirtazapine on central noradrenergic and serotonergic neurotransmission. International clinical psychopharmacology. vol 10 Suppl 4. 1997-01-08. PMID:8930006. |
it increases serotonergic cell-firing in the dorsal raphe and 5-ht release in the hippocampus as measured by microdialysis. |
1997-01-08 |
2023-08-12 |
Not clear |
| T de Boe. The effects of mirtazapine on central noradrenergic and serotonergic neurotransmission. International clinical psychopharmacology. vol 10 Suppl 4. 1997-01-08. PMID:8930006. |
these effects are explained by noradrenergic enhancement of 5-ht cell-firing and blockade of noradrenaline-mediated inhibition of hippocampal 5-ht release. |
1997-01-08 |
2023-08-12 |
Not clear |
| R Tao, S B Auerbac. Differential effect of NMDA on extracellular serotonin in rat midbrain raphe and forebrain sites. Journal of neurochemistry. vol 66. issue 3. 1997-01-07. PMID:8769868. |
infusion of nmda into the mrn also produced a significant increase in hippocampal 5-ht. |
1997-01-07 |
2023-08-12 |
rat |
| R Tao, S B Auerbac. Differential effect of NMDA on extracellular serotonin in rat midbrain raphe and forebrain sites. Journal of neurochemistry. vol 66. issue 3. 1997-01-07. PMID:8769868. |
in contrast, infusion of nmda into the nucleus accumbens, frontal cortex, or hippocampus produced small decreases in 5-ht in these forebrain sites. |
1997-01-07 |
2023-08-12 |
rat |
| L Molinengo, I Scordo, B Pastorello, M Orsetti, P Gh. Behavioral and neurochemical effects induced by chronic L-DOPA administration. Pharmacology, biochemistry, and behavior. vol 54. issue 4. 1997-01-06. PMID:8853203. |
a decrease in levels of dopamine in the olfactory system and dopac in the striatum was seen at all tested doses of l-dopa, while an increase in 5-ht levels was seen in the hippocampus and in the striatum. |
1997-01-06 |
2023-08-12 |
rat |