| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Berg, L G Larsson, L Rényi, S B Ross, S O Thorberg, G Thorell-Svantesso. (R)-(+)-2-[[[3-(Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl] morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine1B receptor antagonist. Journal of medicinal chemistry. vol 41. issue 11. 1998-06-15. PMID:9599242. |
(r)-25 at 20 mg/kg sc enhanced the 5-ht turnover in four rat brain regions (hypothalamus, hippocampus, striatum, and frontal cortex) with about 40% measured as the 5-htp accumulation after decarboxylase inhibition with 3-hydroxybenzylhydrazine. |
1998-06-15 |
2023-08-12 |
rat |
| T Itoh, S Murai, H Saito, Y Masud. Effects of single and repeated administrations of Toki-shakuyaku-san on the concentrations of brain neurotransmitters in mice. Methods and findings in experimental and clinical pharmacology. vol 20. issue 1. 1998-06-11. PMID:9575477. |
the amounts of monoamine-related substances (ne, mhpg, da, dopac, hva, 5-ht, and 5-hiaa and acetylcholine (ach) in the cerebral cortex, corpus striatum and hippocampus of mice treated orally with a powdered extract of toki-shakuyaku-san (tss) were measured using the hplc-ecd method. |
1998-06-11 |
2023-08-12 |
mouse |
| J A Morón, V Perez, E Fernández-Alvarez, J L Marco, M Unzet. "In vitro" effect of some 5-hydroxy-indolalkylamine derivatives on monoamine uptake system. Journal of neural transmission. Supplementum. vol 52. 1998-06-10. PMID:9564637. |
the ic50 values for fa 102, fa 69, fa 70, respectively, were: 17 microm, 60 microm, 18 microm for 5ht uptake in cortex and 37 microm, 55 microm and 20 microm in hippocampus; 70 microm, 385 microm for na uptake in cortex and 315 microm, 255 microm and 600 microm in hypothalamus; 270 microm, 160 microm, 40 microm for da uptake in striatum. |
1998-06-10 |
2023-08-12 |
rat |
| R H Alper, D L Nelso. Characterization of 5-HT1A receptor-mediated [35S]GTPgammaS binding in rat hippocampal membranes. European journal of pharmacology. vol 343. issue 2-3. 1998-06-09. PMID:9570480. |
stimulation of [35s]gtpgammas binding by serotonin (5-hydroxytryptamine, 5-ht) receptor ligands was characterized in rat hippocampal membranes. |
1998-06-09 |
2023-08-12 |
rat |
| L E Rueter, C De Montigny, P Blie. Electrophysiological characterization of the effect of long-term duloxetine administration on the rat serotonergic and noradrenergic systems. The Journal of pharmacology and experimental therapeutics. vol 285. issue 2. 1998-06-08. PMID:9580577. |
in the present in vivo electrophysiological study, the changes in the function of the rat 5-ht and ne systems after 2- and 21-day administration of duloxetine (20 mg/kg/day) were assessed in the dorsal hippocampus and the dorsal raphe nucleus (drn). |
1998-06-08 |
2023-08-12 |
rat |
| L E Rueter, C De Montigny, P Blie. Electrophysiological characterization of the effect of long-term duloxetine administration on the rat serotonergic and noradrenergic systems. The Journal of pharmacology and experimental therapeutics. vol 285. issue 2. 1998-06-08. PMID:9580577. |
way 100635 increased hippocampal firing rates in 21-day treated rats to a greater extent than in 2-day treated or control rats, suggesting that long-term administration induced an increase in endogenous levels of 5-ht in postsynaptic regions. |
1998-06-08 |
2023-08-12 |
rat |
| R Y Shen, R Andrad. 5-Hydroxytryptamine2 receptor facilitates GABAergic neurotransmission in rat hippocampus. The Journal of pharmacology and experimental therapeutics. vol 285. issue 2. 1998-06-08. PMID:9580630. |
5-hydroxytryptamine (5-ht; serotonin) administration enhances gabaergic synaptic activity recorded in pyramidal neurons of the ca1 region of hippocampus. |
1998-06-08 |
2023-08-12 |
rat |
| D Schmitz, T Gloveli, R M Empson, A Draguhn, U Heineman. Serotonin reduces synaptic excitation in the superficial medial entorhinal cortex of the rat via a presynaptic mechanism. The Journal of physiology. vol 508 ( Pt 1). 1998-05-29. PMID:9490827. |
the superficial layers ii and iii of the entorhinal cortex, which form the main cortical input to the hippocampus, receive a large serotonergic projection from the raphe nuclei and express 5-ht receptors at high density. |
1998-05-29 |
2023-08-12 |
rat |
| G Skuza, Z Rogóz, K Gołembiowsk. EMD 57445, the selective sigma receptor ligand, has no effect on the 5-hydroxytryptamine system. Polish journal of pharmacology. vol 49. issue 6. 1998-05-28. PMID:9566054. |
in biochemical studies, no changes in the 5-ht and 5-hiaa levels in rat brain cortex, nucleus accumbens, striatum, hypothalamus and hippocampus were found. |
1998-05-28 |
2023-08-12 |
mouse |
| Y Odagaki, N Nishi, T Koyam. Receptor-mediated and receptor-independent activation of G-proteins in rat brain membranes. Life sciences. vol 62. issue 17-18. 1998-05-26. PMID:9585132. |
receptor-mediated high-affinity gtpase activity was detectable preferentially for the gi subfamily associated with adenylyl cyclase inhibition mediated by group ii metabotropic glutamate, pirenzepine-insensitive muscarinic acetylcholine, gaba(b), adenosine a1, dopamine d2-like (striatum), and serotonin 5-ht1a (hippocampus) receptors. |
1998-05-26 |
2023-08-12 |
rat |
| L Lima, M Urbin. Serotonergic projections to the retina of rat and goldfish. Neurochemistry international. vol 32. issue 2. 1998-05-19. PMID:9542725. |
the administration of 5,7-dihydroxytryptamine into the central or the lateral area of the rat dorsal raphe nucleus decreased serotonin levels in the raphe area and in the hippocampus, but only the bilateral injection into the dorsal raphe nucleus decreased it in the retina. |
1998-05-19 |
2023-08-12 |
mouse |
| C C Wilson, K M Faber, J H Harin. Serotonin regulates synaptic connections in the dentate molecular layer of adult rats via 5-HT1a receptors: evidence for a glial mechanism. Brain research. vol 782. issue 1-2. 1998-05-14. PMID:9519268. |
reduction of hippocampal 5-ht with para-chloroamphetamine (pca) resulted in a significant decline in the synaptic density of the dentate molecular layer. |
1998-05-14 |
2023-08-12 |
rat |
| S E Gartside, R McQuade, T Shar. Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on 5-HT cell firing and release: comparison between dorsal and median raphe 5-HT systems. Neuropharmacology. vol 36. issue 11-12. 1998-05-05. PMID:9517441. |
microdialysis measurements were made in the frontal cortex and dorsal hippocampus, regions which receive a drn- and an mrn-selective 5-ht innervation, respectively. |
1998-05-05 |
2023-08-12 |
Not clear |
| S E Gartside, R McQuade, T Shar. Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on 5-HT cell firing and release: comparison between dorsal and median raphe 5-HT systems. Neuropharmacology. vol 36. issue 11-12. 1998-05-05. PMID:9517441. |
mdma increased extracellular 5-ht 3-fold in both the frontal cortex and dorsal hippocampus. |
1998-05-05 |
2023-08-12 |
Not clear |
| W Hesen, Y J Karten, S V van de Witte, M Joël. Serotonin and carbachol induced suppression of synaptic excitability in rat CA1 hippocampal area: effects of corticosteroid receptor activation. Journal of neuroendocrinology. vol 10. issue 1. 1998-04-30. PMID:9510054. |
serotonin and carbachol induced suppression of synaptic excitability in rat ca1 hippocampal area: effects of corticosteroid receptor activation. |
1998-04-30 |
2023-08-12 |
rat |
| L Romero, B Jernej, N Bel, L Cicin-Sain, R Cortés, F Artiga. Basal and stimulated extracellular serotonin concentration in the brain of rats with altered serotonin uptake. Synapse (New York, N.Y.). vol 28. issue 4. 1998-04-30. PMID:9517840. |
compared to controls, lesioned rats had a reduced cortical concentration of 5-hydroxyindoles (45%), unchanged basal extracellular 5-ht in the drn and ventral hippocampus (vhpc), and reduced basal 5-hydroxyindoleacetic acid (5-hiaa) concentrations (46%, drn; 22%, vhpc). |
1998-04-30 |
2023-08-12 |
rat |
| S Sarre, I Smolders, K Thorré, G Ebinger, Y Michott. Biotransformation of locally applied precursors of dopamine, serotonin and noradrenaline in striatum and hippocampus: a microdialysis study. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 11-12. 1998-04-29. PMID:9503267. |
biotransformation of locally applied precursors of dopamine, serotonin and noradrenaline in striatum and hippocampus: a microdialysis study. |
1998-04-29 |
2023-08-12 |
rat |
| S Sarre, I Smolders, K Thorré, G Ebinger, Y Michott. Biotransformation of locally applied precursors of dopamine, serotonin and noradrenaline in striatum and hippocampus: a microdialysis study. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 11-12. 1998-04-29. PMID:9503267. |
the extracellular concentrations of 5ht (in hippocampus) were only 60% ttx-sensitive. |
1998-04-29 |
2023-08-12 |
rat |
| S Rose, J G Hindmarsh, P Collins, P Jenne. The effect of fenfluramine dosage regimen and reduced food intake on levels of 5-HT in rat brain. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 11-12. 1998-04-29. PMID:9503280. |
additionally, pair-feeding transiently decreased hippocampal 5-ht levels. |
1998-04-29 |
2023-08-12 |
rat |
| L Vyklický, H Knotková-Urbancová, Z Vitásková, V Vlachová, M Kress, P W Ree. Inflammatory mediators at acidic pH activate capsaicin receptors in cultured sensory neurons from newborn rats. Journal of neurophysiology. vol 79. issue 2. 1998-04-14. PMID:9463430. |
whole cell membrane currents induced by the inflammatory mediators, bradykinin, 5-hydroxytryptamine (5-ht) and prostaglandin e2, were investigated in capsaicin-sensitive dorsal root ganglion (drg) neurons from newborn rats grown on a monolayer of hippocampal glia without nerve growth factor (ngf). |
1998-04-14 |
2023-08-12 |
rat |