| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P A Broderic. Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia. Progress in neuro-psychopharmacology & biological psychiatry. vol 21. issue 7. 1998-01-28. PMID:9421826. |
alprazolam increased hippocampal 5-ht release, whereas diazepam decreased hippocampal 5-ht release. |
1998-01-28 |
2023-08-12 |
rat |
| P A Broderic. Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia. Progress in neuro-psychopharmacology & biological psychiatry. vol 21. issue 7. 1998-01-28. PMID:9421826. |
time course studies showed that the alpha 2-adrenergic antagonist, yohimbine, an anxiogenic agent, increased both ne and 5-ht release in ca1 region of hippocampus; the alpha 2-adrenergic agonist, clonidine, decreased ne release and increased 5-ht release in the same region. |
1998-01-28 |
2023-08-12 |
rat |
| P A Broderic. Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia. Progress in neuro-psychopharmacology & biological psychiatry. vol 21. issue 7. 1998-01-28. PMID:9421826. |
interestingly, alprazolam's hippocampal 5-ht/ne interaction is similar to clonidine's 5-ht/ne action at alpha 2-adrenergic autoreceptors, resulting in enhanced 5-ht release. |
1998-01-28 |
2023-08-12 |
rat |
| P A Broderic. Alprazolam, diazepam, yohimbine, clonidine: in vivo CA1 hippocampal norepinephrine and serotonin release profiles under chloral hydrate anesthesia. Progress in neuro-psychopharmacology & biological psychiatry. vol 21. issue 7. 1998-01-28. PMID:9421826. |
enhanced 5-ht release in hippocampus, exhibited by the atypical tbzd, alprazolam, and not by the typical bzd, diazepam, may be an underlying mechanism for the antidepressant activity exhibited by alprazolam. |
1998-01-28 |
2023-08-12 |
rat |
| M B Assié, C Cosi, W Koe. 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine. European journal of pharmacology. vol 334. issue 2-3. 1998-01-22. PMID:9369342. |
here, 5-ht1a receptor activation was examined in vitro, by measuring forskolin-stimulated camp accumulation in hela cells expressing human 5-ht1a receptors, and in vivo, by using microdialysis to measure the extracellular concentration of hippocampal 5-hydroxytryptamine (5-ht) in rats. |
1998-01-22 |
2023-08-12 |
human |
| R Hu, M Wei, X Din. [Changes in brain monoamine neurotransmitter in iron deficiency nonanemic rats]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. vol 30. issue 6. 1998-01-20. PMID:9388911. |
results showed that iron contents and activities of mao in brain tissues of iron deficiency nonanemic rats reduced significantly, and contents of norepinephrine (ne) and 5-hydroxytryptamine (5-ht) in cerebral cortex were significantly higher than those of controls, while 5-hydroxydroxytryptamine acid (5-hiaa) metabolite of 5-ht in the hippocampus was lower than that of controls. |
1998-01-20 |
2023-08-12 |
rat |
| D C Chugani, O Muzik, P Chakraborty, T Mangner, H T Chugan. Human brain serotonin synthesis capacity measured in vivo with alpha-[C-11]methyl-L-tryptophan. Synapse (New York, N.Y.). vol 28. issue 1. 1998-01-20. PMID:9414016. |
high serotonin synthesis capacity values were measured in putamen, caudate, thalamus, and hippocampus. |
1998-01-20 |
2023-08-12 |
human |
| J E Smith, J M Lakosk. Electrophysiological study of the effects of the reuptake inhibitor duloxetine on serotonergic responses in the aging hippocampus. Pharmacology. vol 55. issue 2. 1998-01-09. PMID:9323306. |
the pharmacological effects of the dual serotonin (5-hydroxy-tryptamine, 5-ht) and norepinephrine reuptake inhibitor, duloxetine, on serotonergic function in the aging hippocampus were studied using an in vivo chloral hydrate-anesthetized preparation in the female fischer 344 rate across the life-span (3-8, 11-14, 18-22 and 24-27 months). |
1998-01-09 |
2023-08-12 |
Not clear |
| R Tao, Z Ma, S B Auerbac. Influence of AMPA/kainate receptors on extracellular 5-hydroxytryptamine in rat midbrain raphe and forebrain. British journal of pharmacology. vol 121. issue 8. 1998-01-05. PMID:9283707. |
extracellular 5-ht was measured in the dorsal raphe nucleus (drn), median raphe nucleus (mrn), nucleus accumbens, hypothalamus, frontal cortex, dorsal and ventral hippocampus. |
1998-01-05 |
2023-08-12 |
rat |
| J M Casanovas, M Lésourd, F Artiga. The effect of the selective 5-HT1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain. British journal of pharmacology. vol 122. issue 4. 1998-01-02. PMID:9375971. |
we have examined the effects of the systemic administration of the selective 5-ht1a agonist alnespirone (s-20499) on in vivo 5-hydroxytryptamine (5-ht) release in the dorsal raphe nucleus, the median raphe nucleus and four forebrain areas innervated differentially by both (dorsal striatum, frontal cortex, ventral hippocampus and dorsal hippocampus). |
1998-01-02 |
2023-08-12 |
rat |
| J M Casanovas, M Lésourd, F Artiga. The effect of the selective 5-HT1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain. British journal of pharmacology. vol 122. issue 4. 1998-01-02. PMID:9375971. |
8-oh-dpat (0.025, 0.1 and 0.3 mg kg(-1), s.c.) also reduced extracellular 5-ht in a regionally-selective manner (e.g., to 32% of baseline in striatum and to 69% in dorsal hippocampus at 0.1 mg kg(-1), s.c.). |
1998-01-02 |
2023-08-12 |
rat |
| J J Mejía, F Díaz-Barriga, J Calderón, C Ríos, M E Jiménez-Capdevill. Effects of lead-arsenic combined exposure on central monoaminergic systems. Neurotoxicology and teratology. vol 19. issue 6. 1997-12-30. PMID:9392784. |
although these alterations were similar to those produced by arsenic alone, the mixture provoked a 38% decrease of ne in the hippocampus and increases of 5-ht in midbrain and frontal cortex (100 and 90%, respectively) over control values, alterations that were not elicited by either metal alone. |
1997-12-30 |
2023-08-12 |
mouse |
| L L McMahon, J A Kaue. Hippocampal interneurons are excited via serotonin-gated ion channels. Journal of neurophysiology. vol 78. issue 5. 1997-12-22. PMID:9356400. |
as our results indicate that 5-ht may mediate fast excitatory synaptic transmission onto these interneurons, serotonergic inputs can simultaneously modulate the output of both hippocampus and dentate gyrus. |
1997-12-22 |
2023-08-12 |
Not clear |
| M C Scorza, C Carrau, R Silveira, G Zapata-Torres, B K Cassels, M Reyes-Parad. Monoamine oxidase inhibitory properties of some methoxylated and alkylthio amphetamine derivatives: structure-activity relationships. Biochemical pharmacology. vol 54. issue 12. 1997-12-17. PMID:9393679. |
injection, the compounds induced an increase of serotonin and a decrease of 5-hydroxyindoleacetic acid in the raphe nuclei and hippocampus, confirming the in vitro results. |
1997-12-17 |
2023-08-12 |
rat |
| M J Druse, N F Tajuddin, J D Ricke. Effects of chronic ethanol consumption and aging on 5-HT2A receptors and 5-HT reuptake sites. Alcoholism, clinical and experimental research. vol 21. issue 7. 1997-12-16. PMID:9347073. |
in contrast, 5-ht reuptake sites were increased in older rats in the frontal cortex, nucleus accumbens, amygdala, and ca3 region of the hippocampus. |
1997-12-16 |
2023-08-12 |
rat |
| K Muneoka, M Mikuni, T Ogawa, K Kitera, K Kamei, M Takigawa, K Takahash. Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring. The American journal of physiology. vol 273. issue 5. 1997-12-16. PMID:9374808. |
in this study, it has been clearly demonstrated that prenatal dexamethasone treatment (dex; 0.05 mg/kg on gestational days 17, 18, and 19) resulted in the significant reductions of 5-hydroxytryptamine (5-ht) turnover in four brain regions, including the neocortex, hippocampus, hypothalamus, and midbrain + pons-medulla (m + p-m) but not in the striatum in the offspring at 3 and 14 wk of life, as well as dopamine turnover in the hypothalamus. |
1997-12-16 |
2023-08-12 |
rat |
| A Zangen, D H Overstreet, G Yadi. High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment. Journal of neurochemistry. vol 69. issue 6. 1997-12-12. PMID:9375680. |
in the nucleus accumbens, prefrontal cortex, hippocampus, and hypothalamus of fsl rats, the levels of 5-ht and 5-hiaa were three- to eightfold higher than in control sprague-dawley rats. |
1997-12-12 |
2023-08-12 |
rat |
| M Okada, Y Kawata, K Kiryu, K Mizuno, K Wada, H Tasaki, S Kanek. Effects of adenosine receptor subtypes on hippocampal extracellular serotonin level and serotonin reuptake activity. Journal of neurochemistry. vol 69. issue 6. 1997-12-12. PMID:9375692. |
effects of adenosine receptor subtypes on hippocampal extracellular serotonin level and serotonin reuptake activity. |
1997-12-12 |
2023-08-12 |
rat |
| M Okada, Y Kawata, K Kiryu, K Mizuno, K Wada, H Tasaki, S Kanek. Effects of adenosine receptor subtypes on hippocampal extracellular serotonin level and serotonin reuptake activity. Journal of neurochemistry. vol 69. issue 6. 1997-12-12. PMID:9375692. |
to clarify the effects of adenosine receptor subtypes (a1, a2, and a3) on hippocampal serotoninergic function, hippocampal extracellular serotonin (5-ht) levels were determined by in vivo microdialysis in freely moving rats under various conditions. |
1997-12-12 |
2023-08-12 |
rat |
| M Okada, Y Kawata, K Kiryu, K Mizuno, K Wada, H Tasaki, S Kanek. Effects of adenosine receptor subtypes on hippocampal extracellular serotonin level and serotonin reuptake activity. Journal of neurochemistry. vol 69. issue 6. 1997-12-12. PMID:9375692. |
when the adenosine a1 receptor was blocked by cpt, the hippocampal extracellular 5-ht level was increased by adenosine, cgs-21680, and pd-125944, and decreased by caffeine, dmpx, and apnea. |
1997-12-12 |
2023-08-12 |
rat |