| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L C Daws, G M Toney, D J Davis, G A Gerhardt, A Fraze. In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrus. Journal of neuroscience methods. vol 78. issue 1-2. 1998-04-14. PMID:9497010. |
similarly, signals produced by locally applied 5-ht in the dentate gyrus of rats following destruction of hippocampal serotonergic innervation with 5,7-dihydroxytryptamine (5,7-dht), were significantly enhanced compared to those observed in control animals. |
1998-04-14 |
2023-08-12 |
rat |
| S R Hansson, E Mezey, B J Hoffma. Serotonin transporter messenger RNA in the developing rat brain: early expression in serotonergic neurons and transient expression in non-serotonergic neurons. Neuroscience. vol 83. issue 4. 1998-04-14. PMID:9502257. |
septum, olfactory areas and the developing hippocampus contained serotonin transporter messenger rna early in the developing brain. |
1998-04-14 |
2023-08-12 |
rat |
| J De Vry, R Schohe-Loop, H G Heine, J M Greuel, F Mauler, B Schmidt, H Sommermeyer, T Glase. Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist. The Journal of pharmacology and experimental therapeutics. vol 284. issue 3. 1998-04-09. PMID:9495870. |
the aminomethylchroman derivative bay x 3702 (r-(-)-2-[4-[(chroman-2-ylmethyl)-amino]-butyl]-1,1-dioxo-benzo[d] isothiazolone hydrochloride) is a new high affinity 5-hydroxytryptamine (5-ht)1a receptor ligand [calf hippocampus: ki: 0.19 nm; reference compounds 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat) and ipsapirone: 0.98 and 2.56, respectively; rat cortex: 0.24 nm; rat hippocampus: 0.58 nm; human cortex and recombinant 5-ht1a receptors: 0.25 and 0.4 nm, respectively]. |
1998-04-09 |
2023-08-12 |
human |
| A A Harrison, B J Everitt, T W Robbin. Doubly dissociable effects of median- and dorsal-raphé lesions on the performance of the five-choice serial reaction time test of attention in rats. Behavioural brain research. vol 89. issue 1-2. 1998-04-03. PMID:9475622. |
analysis of tissue monoamine content demonstrated that the mrn lesion profoundly depleted hippocampal 5-ht (by about 90%) without affecting noradrenaline and dopamine, whereas the drn lesion primarily depleted (by about 80%) nucleus accumbens and caudate-putamen 5-ht. |
1998-04-03 |
2023-08-12 |
rat |
| I Shim, J Javaid, D Wirtshafte. Dissociation of hippocampal serotonin release and locomotor activity following pharmacological manipulations of the median raphe nucleus. Behavioural brain research. vol 89. issue 1-2. 1998-04-03. PMID:9475626. |
dissociation of hippocampal serotonin release and locomotor activity following pharmacological manipulations of the median raphe nucleus. |
1998-04-03 |
2023-08-12 |
rat |
| I Shim, J Javaid, D Wirtshafte. Dissociation of hippocampal serotonin release and locomotor activity following pharmacological manipulations of the median raphe nucleus. Behavioural brain research. vol 89. issue 1-2. 1998-04-03. PMID:9475626. |
intra-mr injections of the gaba(a) agonist muscimol (25 ng) resulted in a pronounced increase in locomotor activity which was accompanied by a 42% decrease in hippocampal serotonin release during the first hour following injection. |
1998-04-03 |
2023-08-12 |
rat |
| I Shim, J Javaid, D Wirtshafte. Dissociation of hippocampal serotonin release and locomotor activity following pharmacological manipulations of the median raphe nucleus. Behavioural brain research. vol 89. issue 1-2. 1998-04-03. PMID:9475626. |
intra-mr injections of the gaba(b) agonist baclofen (125 ng) induced hyperactivity of a similar magnitude, but failed to affect hippocampal serotonin release. |
1998-04-03 |
2023-08-12 |
rat |
| I Shim, J Javaid, D Wirtshafte. Dissociation of hippocampal serotonin release and locomotor activity following pharmacological manipulations of the median raphe nucleus. Behavioural brain research. vol 89. issue 1-2. 1998-04-03. PMID:9475626. |
in contrast, the serotonin (5-ht1a) agonist 8-ohdpat (5 microg) produced only a small effect on locomotor activity but reduced hippocampal serotonin output by 51%. |
1998-04-03 |
2023-08-12 |
rat |
| I Shim, J Javaid, D Wirtshafte. Dissociation of hippocampal serotonin release and locomotor activity following pharmacological manipulations of the median raphe nucleus. Behavioural brain research. vol 89. issue 1-2. 1998-04-03. PMID:9475626. |
these findings demonstrate that it is possible to dissociate the effects of intra-mr drug injections on locomotor activity and hippocampal 5-ht release and strongly support the view that nonserotonergic neurons in the paramedian tegmentum are importantly involved in the control of behavioral arousal. |
1998-04-03 |
2023-08-12 |
rat |
| M Y Li, M E Reit. Effect of quinine on autoreceptor-regulated serotonin release in the rat hippocampus. European journal of pharmacology. vol 340. issue 2-3. 1998-04-03. PMID:9537808. |
effect of quinine on autoreceptor-regulated serotonin release in the rat hippocampus. |
1998-04-03 |
2023-08-12 |
rat |
| M Y Li, M E Reit. Effect of quinine on autoreceptor-regulated serotonin release in the rat hippocampus. European journal of pharmacology. vol 340. issue 2-3. 1998-04-03. PMID:9537808. |
the involvement of k+ channels in the autoregulation of terminal serotonin (5-hydroxytryptamine, 5-ht) release was investigated by microdialysis in the hippocampus of conscious rats. |
1998-04-03 |
2023-08-12 |
rat |
| M Y Li, M E Reit. Effect of quinine on autoreceptor-regulated serotonin release in the rat hippocampus. European journal of pharmacology. vol 340. issue 2-3. 1998-04-03. PMID:9537808. |
the 5-ht1/2/6 receptor antagonist methiothepin (50 microm) increased dialysate 5-ht, most likely through 5-ht1b autoreceptors tonically activated in the hippocampus of awake rats as opposed to the previously reported lack of effect 5-ht1b autoreceptor blockade in anesthetized rats. |
1998-04-03 |
2023-08-12 |
rat |
| M Y Li, M E Reit. Effect of quinine on autoreceptor-regulated serotonin release in the rat hippocampus. European journal of pharmacology. vol 340. issue 2-3. 1998-04-03. PMID:9537808. |
the effect of methiothepin was greatly reduced by preperfusion with quinine (100 microm), consonant with a role for quinine-sensitive k+ channels in the autoregulation of 5-ht release in the hippocampus by 5-ht receptor antagonism. |
1998-04-03 |
2023-08-12 |
rat |
| A J Fulford, C A Marsde. Conditioned release of 5-hydroxytryptamine in vivo in the nucleus accumbens following isolation-rearing in the rat. Neuroscience. vol 83. issue 2. 1998-03-12. PMID:9460756. |
the isolation-induced increase in presynaptic serotonergic function in the medial nucleus accumbens contrasts with previous reports of reduced 5-hydroxytryptamine release in the hippocampus and therefore suggests that isolation-rearing differentially affects the function of serotonergic neurons in the brain. |
1998-03-12 |
2023-08-12 |
rat |
| b' T Puumala, J Sirvi\\xc3\\xb. Changes in activities of dopamine and serotonin systems in the frontal cortex underlie poor choice accuracy and impulsivity of rats in an attention task. Neuroscience. vol 83. issue 2. 1998-03-12. PMID:9460757.' |
levels of dopamine, noradrenaline, 5-hydroxytryptamine, the dopamine metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid and the 5-hydroxytryptamine metabolite, 5-hydroxyindoleacetic acid were determined in the frontal cortex, nucleus accumbens, dorsal striatum and hippocampus. |
1998-03-12 |
2023-08-12 |
human |
| C M Brown, P J Fletcher, D V Coscin. Acute amino acid loads that deplete brain serotonin fail to alter behavior. Pharmacology, biochemistry, and behavior. vol 59. issue 1. 1998-03-09. PMID:9443545. |
although 5-ht levels were decreased in the hippocampus (-23.3%) and 5-hydroxyindoleacetic acid (5-hiaa) levels were decreased in the striatum (-35.1%) and hippocampus (-38.5%), there were no effects of the try-deficient load on any of the behavioral tests. |
1998-03-09 |
2023-08-12 |
human |
| P Tagliaferro, A J Ramos, E M López, J Pecci Saavedra, A Brusc. Neural and astroglial effects of a chronic parachlorophenylalanine-induced serotonin synthesis inhibition. Molecular and chemical neuropathology. vol 32. issue 1-3. 1998-02-26. PMID:9437667. |
the effectiveness of the pcpa treatment was tested by the use of specific anti-5ht antibodies that showed absence of 5ht fibers in 5ht innervation areas like frontal cortex and hippocampus. |
1998-02-26 |
2023-08-12 |
rat |
| E Bagdy, S Solyom, L G Harsin. Feedback stimulation of somatodendritic serotonin release: a 5-HT3 receptor-mediated effect in the raphe nuclei of the rat. Brain research bulletin. vol 45. issue 2. 1998-02-26. PMID:9443841. |
slices from rat midbrain containing the raphe nuclei and from hippocampus were prepared, loaded with [3h]5-ht and superfused and the resting and the electrically stimulated [3h]5-ht release was measured. |
1998-02-26 |
2023-08-12 |
rat |
| E Bagdy, S Solyom, L G Harsin. Feedback stimulation of somatodendritic serotonin release: a 5-HT3 receptor-mediated effect in the raphe nuclei of the rat. Brain research bulletin. vol 45. issue 2. 1998-02-26. PMID:9443841. |
2-methyl-5-ht in lower concentration increased the electrically induced tritium overflow from raphe nuclei slices (ec50 0.56 micromol/l) and also from hippocampal slices preloaded with [3h]5-ht. |
1998-02-26 |
2023-08-12 |
rat |
| E Gur, B Lerer, M E Newma. Chronic electroconvulsive shock and 5-HT autoreceptor activity in rat brain: an in vivo microdialysis study. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 8-9. 1998-02-26. PMID:9451712. |
in vivo microdialysis was used to determine the effects of chronic electroconvulsive shock (ecs), given daily for 10 days, on basal 5-ht levels in rat frontal cortex and hippocampus and on the effect of systemic administration of the 5-ht-la receptor agonist, 8-oh-dpat (0.2 mg/kg), to reduce 5-ht levels in these areas by activation of somatodendritic autoreceptors. |
1998-02-26 |
2023-08-12 |
rat |