| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L W Maines, B J Keck, J E Smith, J M Lakosk. Corticosterone regulation of serotonin transporter and 5-HT1A receptor expression in the aging brain. Synapse (New York, N.Y.). vol 32. issue 1. 1999-06-01. PMID:10188639. |
similarly, quantitative autoradiography using the radiolabeled 5-ht(1a) receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin demonstrated a significant decline in receptor density in 3- and 13-month mc and hc groups as compared to age-matched lc groups in the hippocampus. |
1999-06-01 |
2023-08-12 |
rat |
| L W Maines, B J Keck, J E Smith, J M Lakosk. Corticosterone regulation of serotonin transporter and 5-HT1A receptor expression in the aging brain. Synapse (New York, N.Y.). vol 32. issue 1. 1999-06-01. PMID:10188639. |
these hormone treatments (mc or hc), however, failed to alter hippocampal 5-ht(1a) binding site density in the 18-month groups as compared to the age-matched lc group. |
1999-06-01 |
2023-08-12 |
rat |
| L E Rueter, P Blie. Electrophysiological examination of the effects of sustained flibanserin administration on serotonin receptors in rat brain. British journal of pharmacology. vol 126. issue 3. 1999-05-27. PMID:10188973. |
the responsiveness of postsynaptic 5-ht1a receptors located on ca3 hippocampus pyramidal neurons and mpfc neurons, examined using microiontophoretically-applied 5-ht and gepirone, was unchanged following a 7-day flibanserin treatment. |
1999-05-27 |
2023-08-12 |
rat |
| T Uz, H Mane. Chronic fluoxetine administration increases the serotonin N-acetyltransferase messenger RNA content in rat hippocampus. Biological psychiatry. vol 45. issue 2. 1999-05-24. PMID:9951564. |
chronic fluoxetine administration increases the serotonin n-acetyltransferase messenger rna content in rat hippocampus. |
1999-05-24 |
2023-08-12 |
rat |
| B S Shankaranarayana Rao, T R Raju, B L Met. Self-stimulation of lateral hypothalamus and ventral tegmentum increases the levels of noradrenaline, dopamine, glutamate, and AChE activity, but not 5-hydroxytryptamine and GABA levels in hippocampus and motor cortex. Neurochemical research. vol 23. issue 8. 1999-05-21. PMID:9704594. |
self-stimulation of lateral hypothalamus and ventral tegmentum increases the levels of noradrenaline, dopamine, glutamate, and ache activity, but not 5-hydroxytryptamine and gaba levels in hippocampus and motor cortex. |
1999-05-21 |
2023-08-12 |
rat |
| B S Shankaranarayana Rao, T R Raju, B L Met. Self-stimulation of lateral hypothalamus and ventral tegmentum increases the levels of noradrenaline, dopamine, glutamate, and AChE activity, but not 5-hydroxytryptamine and GABA levels in hippocampus and motor cortex. Neurochemical research. vol 23. issue 8. 1999-05-21. PMID:9704594. |
self-stimulation experience resulted in a significant (p < 0.001) increase in the levels of noradrenaline, dopamine, glutamate and ache activity but not 5-hydroxytryptamine and gaba levels in hippocampus and motor cortex. |
1999-05-21 |
2023-08-12 |
rat |
| S Lacosta, Z Merali, H Anisma. Behavioral and neurochemical consequences of lipopolysaccharide in mice: anxiogenic-like effects. Brain research. vol 818. issue 2. 1999-05-06. PMID:10082815. |
as well, lps induced increased turnover of norepinephrine (ne), dopamine (da) and serotonin (5-ht) in the paraventricular nucleus (pvn), median eminence plus arcuate nucleus, hippocampus, as well as ne turnover within the locus coeruleus and da turnover within the nucleus accumbens. |
1999-05-06 |
2023-08-12 |
mouse |
| P J Harriso. The neuropathology of schizophrenia. A critical review of the data and their interpretation. Brain : a journal of neurology. vol 122 ( Pt 4). 1999-05-06. PMID:10219775. |
a case can be made for impairment of hippocampal and corticocortical excitatory pathways, but in general the relationship between neurochemical findings (which centre upon dopamine, 5-hydroxytryptamine, glutamate and gaba systems) and the neuropathology of schizophrenia is unclear. |
1999-05-06 |
2023-08-12 |
Not clear |
| C L Barton, P H Hutso. Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025679. |
inhibition of hippocampal 5-ht synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-ht1a and 5-ht1b/d autoreceptors. |
1999-05-04 |
2023-08-12 |
rat |
| C L Barton, P H Hutso. Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025679. |
hippocampal serotonin (5-hydroxytryptamine, 5-ht) synthesis, as determined by the accumulation of 5-hydroxytryptophan (5-htp) following inhibition of l-aromatic amino acid decarboxylase with nsd 1015, was inhibited by systemic administration of the selective serotonin reuptake inhibitors fluoxetine (10 mg/kg i.p.) |
1999-05-04 |
2023-08-12 |
rat |
| C L Barton, P H Hutso. Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025679. |
pretreatment of rats with the selective 5-ht1a receptor antagonist way 100635 for a period of 7 days using subcutaneously implanted osmotic minipumps (1 mg/kg/day) was sufficient to block the inhibition of 5-ht synthesis following the 5-ht 1a receptor agonist 8-oh-dpat (0.3 mg/kg s.c.), but failed to inhibit the decrease of hippocampal 5-ht synthesis by fluoxetine (10 mg/kg i.p.) |
1999-05-04 |
2023-08-12 |
rat |
| C L Barton, P H Hutso. Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025679. |
), an antagonist with high affinity for 5-ht1b/d receptors, blocked the reduction of hippocampal 5-ht synthesis following the 5-ht receptor agonist tfmpp (3 mg/kg s.c.) without affecting the reduction of hippocampal 5-ht synthesis by either fluoxetine or paroxetine. |
1999-05-04 |
2023-08-12 |
rat |
| C L Barton, P H Hutso. Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025679. |
significantly attenuated the decrease of hippocampal 5-ht synthesis by both fluoxetine and paroxetine. |
1999-05-04 |
2023-08-12 |
rat |
| C L Barton, P H Hutso. Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025679. |
these results indicate that both 5-ht1a and 5-ht1b/1d receptors, which function in the rat as inhibitory somatodendritic and nerve terminal autoreceptors, independently regulate hippocampal 5-ht synthesis and must be simultaneously blocked to prevent the inhibition of 5-ht synthesis by selective serotonin reuptake inhibitors which increase 5-ht availability at both nerve terminals in hippocampus and 5-ht cell bodies in the raphe nuclei. |
1999-05-04 |
2023-08-12 |
rat |
| S Y Ye. N-tert-butyl-alpha-phenylnitrone protects against 3,4-methylenedioxymethamphetamine-induced depletion of serotonin in rats. Synapse (New York, N.Y.). vol 31. issue 3. 1999-05-04. PMID:10029234. |
levels of 5-ht and 5-hiaa in the frontal cortex, hippocampus, striatum, and brain stem of rats decreased significantly after mdma or mdma plus ethanol, but not after mdma plus pbn, pbn plus ethanol (pbn dissolved in ethanol), or ethanol as compared to the saline controls. |
1999-05-04 |
2023-08-12 |
rat |
| S Y Ye. N-tert-butyl-alpha-phenylnitrone protects against 3,4-methylenedioxymethamphetamine-induced depletion of serotonin in rats. Synapse (New York, N.Y.). vol 31. issue 3. 1999-05-04. PMID:10029234. |
similar results were observed in the density of 5-ht transporters in the frontal cortex and hippocampus. |
1999-05-04 |
2023-08-12 |
rat |
| M Nishi, E C Azmiti. Agonist- and antagonist-induced plasticity of rat 5-HT1A receptor in hippocampal cell culture. Synapse (New York, N.Y.). vol 31. issue 3. 1999-05-04. PMID:10029236. |
we examined the response and regulation of 5-ht1a receptor on hippocampal cultured fetal neurons grown in the absence of serotonin and steroids using three experimental designs: 1) functional response using an antibody against phosphorylated cyclic adenosine monophosphate response element binding protein (pcreb); 2) transcriptional regulation using in situ hybridization; and 3) translational expression using antipeptide 5-ht1a receptor antibody. |
1999-05-04 |
2023-08-12 |
rat |
| M Nishi, E C Azmiti. Agonist- and antagonist-induced plasticity of rat 5-HT1A receptor in hippocampal cell culture. Synapse (New York, N.Y.). vol 31. issue 3. 1999-05-04. PMID:10029236. |
our results indicate that the 5-ht1a receptor is sensitive to both agonists (downregulation) and antagonists (upregulation) in hippocampal fetal neurons grown in the absence of serotonin and steroids. |
1999-05-04 |
2023-08-12 |
rat |
| E Eriksson, G Engberg, O Bing, H Nissbrand. Effects of mCPP on the extracellular concentrations of serotonin and dopamine in rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 20. issue 3. 1999-05-03. PMID:10063489. |
intravenous administration of m-chloro-phenylpiperazine (mcpp) (0.25 or 2.5 mg/kg) induced a marked and dose-related increase in extracellular concentrations of serotonin in hippocampus (300-1,400% of baseline) as measured using in vivo microdialysis in awake male wistar rats of the spontaneously hypertensive (sh) strain. |
1999-05-03 |
2023-08-12 |
rat |
| A C Trillat, I Malagié, M Bourin, C Jacquot, R Hen, A M Gardie. [Homozygote mice deficient in serotonin 5-HT1B receptor and antidepressant effect of selective serotonin reuptake inhibitors]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 192. issue 6. 1999-05-03. PMID:10101609. |
using microdialysis in awake 129/sv mice, we show that the absence of the 5-ht1b receptor in mutant mice (ko 1b -/-) potentiated the effect of paroxetine on extracellular 5-ht levels in the ventral hippocampus, but not in the frontal cortex compared to wild-type mice (wt). |
1999-05-03 |
2023-08-12 |
mouse |