| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Balse, R Suhr, A Haaf, C Kelche, R Jackisch, J C Casse. The potentiation of amphetamine-induced hyperlocomotion by fimbria-fornix lesions in rats is abolished by intrahippocampal grafts rich in serotonergic neurons. Neuroscience letters. vol 265. issue 2. 1999-06-29. PMID:10327173. |
the effects of the lesions and grafts were assessed by measuring the accumulation of [3h]-choline or [3h]-5-hydroxytryptamine (5-ht) by hippocampal slices, and the electrically-evoked release of tritium. |
1999-06-29 |
2023-08-12 |
rat |
| N Haddjeri, P Blier, C de Montign. Acute and long-term actions of the antidepressant drug mirtazapine on central 5-HT neurotransmission. Journal of affective disorders. vol 51. issue 3. 1999-06-28. PMID:10333981. |
sustained administration of mirtazapine for 21 days (5 mg/kg/day, s.c., using minipumps) lead to a marked increase in the firing rate of 5-ht neurons (75%) but a more modest increase in the firing rate of ne neurons (30%), as well as to a desensitization of alpha 2-adrenergic heteroreceptors on 5-ht terminals in the hippocampus. |
1999-06-28 |
2023-08-12 |
rat |
| E Hajós-Korcsok, R McQuade, T Shar. Influence of 5-HT1A receptors on central noradrenergic activity: microdialysis studies using (+/-)-MDL 73005EF and its enantiomers. Neuropharmacology. vol 38. issue 2. 1999-06-24. PMID:10218872. |
measurements of extracellular 5-ht in hippocampus of anaesthetised rats confirmed that the 5-ht1a receptor agonist action of (+/-)-mdl 73005ef resides in the s(-)- enantiomer. |
1999-06-24 |
2023-08-12 |
rat |
| J Wu, G L Kramer, M Kram, M Steciuk, I L Crawford, F Pett. Serotonin and learned helplessness: a regional study of 5-HT1A, 5-HT2A receptors and the serotonin transport site in rat brain. Journal of psychiatric research. vol 33. issue 1. 1999-06-22. PMID:10094235. |
using quantitative autoradiography, we measured the density of 5-ht1a and 5-ht2a receptors and of 5-ht transport sites in medial prefrontal cortex, dorsal hippocampus, septum, hypothalamus, and amygdala in learned helpless rats, and in rats that were nonhelpless after inescapable stress, as well as in shuttlebox-tested and nonhandled controls. |
1999-06-22 |
2023-08-12 |
rat |
| I Thiblin, A Finn, S B Ross, C Stenfor. Increased dopaminergic and 5-hydroxytryptaminergic activities in male rat brain following long-term treatment with anabolic androgenic steroids. British journal of pharmacology. vol 126. issue 6. 1999-06-22. PMID:10217522. |
the 5-hiaa/5-ht ratio was increased in all treatment groups in the hippocampus, in the frontal cortex in the methandrostenolone-treated animals and in the hypothalamus in the testosterone- and oxymetholone-treated rats, while the 5-ht synthesis rate was not affected by the aas-treatments. |
1999-06-22 |
2023-08-12 |
rat |
| M Okada, T Hirano, Y Kawata, T Murakami, K Wada, K Mizuno, T Kondo, S Kanek. Biphasic effects of zonisamide on serotonergic system in rat hippocampus. Epilepsy research. vol 34. issue 2-3. 1999-06-17. PMID:10210034. |
to study the mechanisms of antiepileptic action of zonisamide (zns), we determined the effects of zns on extracellular, total levels and re-uptake activity of serotonin (5-ht) in rat striatum and hippocampus. |
1999-06-17 |
2023-08-12 |
rat |
| M Okada, T Hirano, Y Kawata, T Murakami, K Wada, K Mizuno, T Kondo, S Kanek. Biphasic effects of zonisamide on serotonergic system in rat hippocampus. Epilepsy research. vol 34. issue 2-3. 1999-06-17. PMID:10210034. |
zns concentrations of 30-1000 microm did not affect hippocampal 5ht re uptake activity in vitro. |
1999-06-17 |
2023-08-12 |
rat |
| J D Bremne. Does stress damage the brain? Biological psychiatry. vol 45. issue 7. 1999-06-14. PMID:10202566. |
the mechanism involves glucocorticoids and possibly serotonin acting through excitatory amino acids to mediate hippocampal atrophy. |
1999-06-14 |
2023-08-12 |
Not clear |
| J F López, I Liberzon, D M Vázquez, E A Young, S J Watso. Serotonin 1A receptor messenger RNA regulation in the hippocampus after acute stress. Biological psychiatry. vol 45. issue 7. 1999-06-14. PMID:10202584. |
serotonin 1a receptor messenger rna regulation in the hippocampus after acute stress. |
1999-06-14 |
2023-08-12 |
rat |
| J F López, I Liberzon, D M Vázquez, E A Young, S J Watso. Serotonin 1A receptor messenger RNA regulation in the hippocampus after acute stress. Biological psychiatry. vol 45. issue 7. 1999-06-14. PMID:10202584. |
when rats are subjected to chronic stress for 2 weeks, a significant decrease in hippocampal serotonin (5-ht)1a messenger rna (mrna) is observed. |
1999-06-14 |
2023-08-12 |
rat |
| M I Colado, B Esteban, E O'Shea, R Granados, A R Gree. Studies on the neuroprotective effect of pentobarbitone on MDMA-induced neurodegeneration. Psychopharmacology. vol 142. issue 4. 1999-06-10. PMID:10229068. |
administration of a dose of 15 mg/kg of the recreationally used drug 3,4-methylenedioxymethamphetamine (mdma or "ecstasy") to dark agouti rats resulted in an acute hyperthermic response which was followed 7 days later by a marked (approximately 45%) loss of 5-ht and its metabolite 5-hiaa in cortex, hippocampus and striatum and a similar loss of [3h]-paroxetine binding in cortex. |
1999-06-10 |
2023-08-12 |
rat |
| P Martin, M L Carlsson, S Hjort. Systemic PCP treatment elevates brain extracellular 5-HT: a microdialysis study in awake rats. Neuroreport. vol 9. issue 13. 1999-06-07. PMID:9804302. |
we here report for the first time that systemically administered pcp (5 mg/kg, s.c.) increases extracellular 5-ht levels in the rat medial prefrontal cortex (to 322%) and dorsal hippocampus (to 233%). |
1999-06-07 |
2023-08-12 |
rat |
| J L Yau, P A Kelly, T Olsson, J Noble, J R Seck. Chronic amitriptyline administration increases serotonin transporter binding sites in the hippocampus of aged rats. Neuroscience letters. vol 261. issue 3. 1999-06-07. PMID:10081979. |
chronic amitriptyline administration increases serotonin transporter binding sites in the hippocampus of aged rats. |
1999-06-07 |
2023-08-12 |
rat |
| J L Yau, P A Kelly, T Olsson, J Noble, J R Seck. Chronic amitriptyline administration increases serotonin transporter binding sites in the hippocampus of aged rats. Neuroscience letters. vol 261. issue 3. 1999-06-07. PMID:10081979. |
the effects of ageing and of chronic antidepressant treatment upon 5-ht transporter sites ([3h]paroxetine binding) in the rat hippocampus was examined. |
1999-06-07 |
2023-08-12 |
rat |
| J L Yau, P A Kelly, T Olsson, J Noble, J R Seck. Chronic amitriptyline administration increases serotonin transporter binding sites in the hippocampus of aged rats. Neuroscience letters. vol 261. issue 3. 1999-06-07. PMID:10081979. |
these data indicate an age-related decrease in hippocampal serotonin transporter sites and upregulation of these sites following 10 weeks of amitriptyline. |
1999-06-07 |
2023-08-12 |
rat |
| R Jackisch, A Haaf, H Jeltsch, C Lazarus, C Kelche, J C Casse. Modulation of 5-hydroxytryptamine release in hippocampal slices of rats: effects of fimbria-fornix lesions on 5-HT1B-autoreceptor and alpha2-heteroreceptor function. Brain research bulletin. vol 48. issue 1. 1999-06-03. PMID:10210167. |
modulation of 5-hydroxytryptamine release in hippocampal slices of rats: effects of fimbria-fornix lesions on 5-ht1b-autoreceptor and alpha2-heteroreceptor function. |
1999-06-03 |
2023-08-12 |
rat |
| R Jackisch, A Haaf, H Jeltsch, C Lazarus, C Kelche, J C Casse. Modulation of 5-hydroxytryptamine release in hippocampal slices of rats: effects of fimbria-fornix lesions on 5-HT1B-autoreceptor and alpha2-heteroreceptor function. Brain research bulletin. vol 48. issue 1. 1999-06-03. PMID:10210167. |
since 5-hydroxytryptamine (5-ht) release in the hippocampus is modulated by 5-ht1b auto- and alpha2-heteroreceptors, we investigated whether such lesions may alter these presynaptic mechanisms. |
1999-06-03 |
2023-08-12 |
rat |
| R Jackisch, A Haaf, H Jeltsch, C Lazarus, C Kelche, J C Casse. Modulation of 5-hydroxytryptamine release in hippocampal slices of rats: effects of fimbria-fornix lesions on 5-HT1B-autoreceptor and alpha2-heteroreceptor function. Brain research bulletin. vol 48. issue 1. 1999-06-03. PMID:10210167. |
hippocampal slices of sham-operated (sham) and fimbria-fornix-lesioned (les) rats (14 months after surgery) were preincubated with [3h]5-ht, superfused continuously, and stimulated electrically using two stimulation conditions: either (a) 360 pulses 3 hz, or (b) 20 pulses 100 hz (2 ms, 28 ma, 4 v/chamber). |
1999-06-03 |
2023-08-12 |
rat |
| R Jackisch, A Haaf, H Jeltsch, C Lazarus, C Kelche, J C Casse. Modulation of 5-hydroxytryptamine release in hippocampal slices of rats: effects of fimbria-fornix lesions on 5-HT1B-autoreceptor and alpha2-heteroreceptor function. Brain research bulletin. vol 48. issue 1. 1999-06-03. PMID:10210167. |
in les rats, hippocampal 5-ht content was reduced to about 45% of sham levels, whereas that of noradrenaline was increased by about 30% (high-performance liquid chromatography). |
1999-06-03 |
2023-08-12 |
rat |
| M Koprowska, M Krotewicz, A Romaniuk, M Strzelczuk, M Wieczore. Behavioral and neurochemical alterations evoked by p-Chlorophenylalanine application in rats examined in the light-dark crossing test. Acta neurobiologiae experimentalis. vol 59. issue 1. 1999-06-03. PMID:10230072. |
the aim of the present study is to examine the effects of serotonin synthesis inhibition with p-chlorophenylalanine (p-cpa) in rats on (1) anxiety behavior examined in the light-dark crossing test and, (2) regional brain concentration of monoamines (na, da and 5-ht) and their metabolites (mhpg, dopac, hva and 5-hiaa) as well as gaba in the hypothalamus, amygdala, hippocampus, midbrain central gray matter and the frontal cortex. |
1999-06-03 |
2023-08-12 |
rat |