| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhicheng Jin, Jianer Ling, Jing Yu, Mengzi He, Pingping Ni, Fang Zhang, Yizhen Wan. Serotonin 2A receptor function and depression-like behavior in rats model of hypothyroidism. Experimental brain research. vol 239. issue 8. 2021-08-12. PMID:34106297. |
tt[formula: see text] and tt[formula: see text] levels were measured after the behavior tests and the expression levels of 5-ht[formula: see text] receptor and 5-ht[formula: see text] receptor proteins were analyzed in the hippocampus and prefrontal cortex. |
2021-08-12 |
2023-08-13 |
rat |
| Rachel E Martin, Madison T Green, Jessica A Kinkade, Robert R Schmidt, Tess E Willemse, A Katrin Schenk, Jiude Mao, Cheryl S Rosenfel. Maternal Oxycodone Treatment Results in Neurobehavioral Disruptions in Mice Offspring. eNeuro. vol 8. issue 4. 2021-08-12. PMID:34312305. |
in the hippocampus, prenatal exposure to oxy caused sex-dependent differences in expression of genes encoding opioid receptors and those involved in serotonin signaling. |
2021-08-12 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
this study aims to evaluate maternal hfd effects, during pregnancy and lactation, upon dams/mice offspring nutritional status, protein and gene expression of inflammatory pathway (jnk, pjnk and tnf-α), serotonin system molecules (tryptophan hydroxylase 2 (tph2), key-enzyme of serotonin synthesis, serotonin transporter (sert); 5-ht1a serotonergic receptor (5-ht1a)) and brain derived neurotrophic factor (bdnf) on recently weaned mice offspring hippocampus. |
2021-08-11 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
however, the tph2 increase in hfd-offspring did not alter hippocampal serotonin levels quantified through elisa. |
2021-08-11 |
2023-08-13 |
mouse |
| Francesca Zoratto, Clelia Buccheri, Romina Mura, Luisa Altabella, Marion Vanneste, Marie Villotte, Giovanni Laviola, Francois Dauphin, Eleni Paizanis, Walter Adriani, Rossella Canes. Anatomical and behavioral impact of a lentiviral tool tapping onto hippocampal serotonin reuptake in rats. Synapse (New York, N.Y.). vol 74. issue 4. 2021-08-10. PMID:31587367. |
anatomical and behavioral impact of a lentiviral tool tapping onto hippocampal serotonin reuptake in rats. |
2021-08-10 |
2023-08-13 |
rat |
| Melinda Hersey, Jennifer L Woodruff, Nicholas Maxwell, Alia T Sadek, Maria K Bykalo, Ian Bain, Claudia A Grillo, Gerardo G Piroli, Parastoo Hashemi, Lawrence P Reaga. High-fat diet induces neuroinflammation and reduces the serotonergic response to escitalopram in the hippocampus of obese rats. Brain, behavior, and immunity. vol 96. 2021-08-06. PMID:34010713. |
obesity, a condition of chronic mild inflammation including obesity-induced neuroinflammation, is proposed to contribute to decreases in synaptic concentrations of neurotransmitters like serotonin (5ht) by decreasing 5ht synthesis in the dorsal raphe nucleus (drn) and/or affecting 5ht reuptake in drn target regions like the hippocampus. |
2021-08-06 |
2023-08-13 |
human |
| Melinda Hersey, Jennifer L Woodruff, Nicholas Maxwell, Alia T Sadek, Maria K Bykalo, Ian Bain, Claudia A Grillo, Gerardo G Piroli, Parastoo Hashemi, Lawrence P Reaga. High-fat diet induces neuroinflammation and reduces the serotonergic response to escitalopram in the hippocampus of obese rats. Brain, behavior, and immunity. vol 96. 2021-08-06. PMID:34010713. |
in real time using fast scan cyclic voltammetry (fscv), we observed no changes in basal levels of hippocampal 5ht; however responses to escitalopram were significantly impaired in the hippocampus of obese rats compared to diet resistant rats and control rats. |
2021-08-06 |
2023-08-13 |
human |
| Melinda Hersey, Jennifer L Woodruff, Nicholas Maxwell, Alia T Sadek, Maria K Bykalo, Ian Bain, Claudia A Grillo, Gerardo G Piroli, Parastoo Hashemi, Lawrence P Reaga. High-fat diet induces neuroinflammation and reduces the serotonergic response to escitalopram in the hippocampus of obese rats. Brain, behavior, and immunity. vol 96. 2021-08-06. PMID:34010713. |
further studies revealed that these neurochemical observations could be explained by increases in serotonin transporter (sert) expression in the hippocampus driven by elevated neuroinflammation. |
2021-08-06 |
2023-08-13 |
human |
| Margherita Tassan Mazzocco, Fabrizia Claudia Guarnieri, Elena Monzani, Fabio Benfenati, Flavia Valtorta, Stefano Coma. Dysfunction of the serotonergic system in the brain of synapsin triple knockout mice is associated with behavioral abnormalities resembling synapsin-related human pathologies. Progress in neuro-psychopharmacology & biological psychiatry. vol 105. 2021-07-19. PMID:33058959. |
levels of 5-ht and da in the frontal cortex and hippocampus of wt and tko mice were also assessed using a high-performance liquid chromatography. |
2021-07-19 |
2023-08-13 |
mouse |
| Margherita Tassan Mazzocco, Fabrizia Claudia Guarnieri, Elena Monzani, Fabio Benfenati, Flavia Valtorta, Stefano Coma. Dysfunction of the serotonergic system in the brain of synapsin triple knockout mice is associated with behavioral abnormalities resembling synapsin-related human pathologies. Progress in neuro-psychopharmacology & biological psychiatry. vol 105. 2021-07-19. PMID:33058959. |
finally, hippocampal 5-ht levels were lower in tko than in wt mice. |
2021-07-19 |
2023-08-13 |
mouse |
| Margherita Tassan Mazzocco, Fabrizia Claudia Guarnieri, Elena Monzani, Fabio Benfenati, Flavia Valtorta, Stefano Coma. Dysfunction of the serotonergic system in the brain of synapsin triple knockout mice is associated with behavioral abnormalities resembling synapsin-related human pathologies. Progress in neuro-psychopharmacology & biological psychiatry. vol 105. 2021-07-19. PMID:33058959. |
overall, syns deletion in mice leads to a reduction in drn 5-ht firing activity and hippocampal 5-ht levels along with behavioral alterations reminiscent of human neuropsychiatric conditions associated with syn dysfunction. |
2021-07-19 |
2023-08-13 |
mouse |
| Basem H Elesawy, Walaa F Alsanie, Mubarak Ali Algahtany, Jawaher M Al-Ashkhari, Aya K Alyarobi, Hussein F Sak. Whole and refined grains change behavior and reduce brain derived neurotrophic factor and neurotrophin-3 in rats. Journal of food biochemistry. 2021-07-19. PMID:34278588. |
after 12 weeks, we measured the hippocampal and prefrontal cortical brain derived neurotrophic factor (bdnf), neurotrophin-3 (nt-3), 5-hydroxytryptamine, dopamine, norepinephrine, malondialdehyde (mda) and reduced glutathione (gsh) levels. |
2021-07-19 |
2023-08-13 |
rat |
| Basem H Elesawy, Walaa F Alsanie, Mubarak Ali Algahtany, Jawaher M Al-Ashkhari, Aya K Alyarobi, Hussein F Sak. Whole and refined grains change behavior and reduce brain derived neurotrophic factor and neurotrophin-3 in rats. Journal of food biochemistry. 2021-07-19. PMID:34278588. |
the rats on a diet of whole and refined grains had low bdnf, nt-3, norepinephrine, dopamine and serotonin significantly (p < .01) in both the hippocampus and prefrontal cortex as compared to control rats. |
2021-07-19 |
2023-08-13 |
rat |
| Kate Beecher, Joshua Wang, Angela Jacques, Nicholas Chaaya, Fatemeh Chehrehasa, Arnauld Belmer, Selena E Bartlet. Sucrose Consumption Alters Serotonin/Glutamate Co-localisation Within the Prefrontal Cortex and Hippocampus of Mice. Frontiers in molecular neuroscience. vol 14. 2021-07-16. PMID:34262435. |
although serotonin and glutamate co-localisation has been implicated in reward processing, it is still unknown how chronic sucrose consumption changes this transmission in regions associated with executive control over feeding-such as the prefrontal cortex (pfc) and dentate gyrus (dg) of the hippocampus. |
2021-07-16 |
2023-08-13 |
mouse |
| Barbara Dos Santos, Ariana Ern Schmitz, Gudrian Ricardo Lopes de Almeida, Luiz Felipe de Souza, Jozimar Carlos Szczepanik, Everson Araújo Nunes, Henver Simionato Brunetta, Josiel Mileno Mack, Rui Daniel Prediger, Maurício Peña Cunha, Alcir Luiz Dafr. Fructose Intake Impairs Cortical Antioxidant Defenses Allied to Hyperlocomotion in Middle-Aged C57BL/6 Female Mice. Neurochemical research. vol 45. issue 12. 2021-07-12. PMID:32968860. |
fru intake did not alter serotonin, dopamine, and norepinephrine levels in the hippocampus, prefrontal cortex, and striatum. |
2021-07-12 |
2023-08-13 |
mouse |
| Eman Soliman, Nariman Essmat, Mona F Mahmoud, Amr A A Mahmou. Impact of some oral hypoglycemic agents on type 2 diabetes-associated depression and reserpine-induced depression in rats: the role of brain oxidative stress and inflammation. Naunyn-Schmiedeberg's archives of pharmacology. vol 393. issue 8. 2021-07-06. PMID:32077986. |
antidiabetic agents reduced diabetes-associated depression as indicated by the reduction in the immobility time in the forced swim test, elevation of cortical and hippocampal serotonin and brain-derived neurotrophic factor (bdnf), and the increase in serum β-amyloid 1-42 (aβ1-42) levels. |
2021-07-06 |
2023-08-13 |
rat |
| Eva Florensa-Zanuy, Emilio Garro-Martínez, Albert Adell, Elena Castro, Álvaro Díaz, Ángel Pazos, Karina S Mac-Dowell, David Martín-Hernández, Fuencisla Pilar-Cuélla. Cannabidiol antidepressant-like effect in the lipopolysaccharide model in mice: Modulation of inflammatory pathways. Biochemical pharmacology. vol 185. 2021-07-01. PMID:33513342. |
the precursor tryptophan (trp), and its metabolites kynurenine (kyn) and serotonin (5-ht) were measured in hippocampus and cortex by hplc. |
2021-07-01 |
2023-08-13 |
mouse |
| Romain Troubat, Pascal Barone, Samuel Leman, Thomas Desmidt, Arnaud Cressant, Boriana Atanasova, Bruno Brizard, Wissam El Hage, Alexandre Surget, Catherine Belzung, Vincent Camu. Neuroinflammation and depression: A review. The European journal of neuroscience. vol 53. issue 1. 2021-06-28. PMID:32150310. |
some recent clinical and preclinical evidence suggests that neuroinflammation is a key factor that interacts with the three neurobiological correlates of major depressive disorder: depletion of brain serotonin, dysregulation of the hypothalamus-pituitary-adrenal (hpa) axis and alteration of the continuous production of adult-generated neurons in the dentate gyrus of the hippocampus. |
2021-06-28 |
2023-08-13 |
Not clear |
| Ke Xu, Mingyang Wang, Wei Zhou, Juncai Pu, Haiyang Wang, Peng Xi. Chronic D-ribose and D-mannose overload induce depressive/anxiety-like behavior and spatial memory impairment in mice. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33531473. |
association analysis of the metabolome and transcriptome suggested that the anxiety-like behavior and spatial memory impairment induced by rib and man may be attributed to the changes in four metabolites and 81 genes in the hippocampus, which is involved in amino acid metabolism and serotonin transport. |
2021-06-28 |
2023-08-13 |
mouse |
| Karina Festerling, Karolina Can, Sebastian Kügler, Michael Mülle. Overshooting Subcellular Redox-Responses in Rett-Mouse Hippocampus during Neurotransmitter Stimulation. Cells. vol 9. issue 12. 2021-06-22. PMID:33255426. |
the rogfp redox sensor was expressed in either the cytosol or the mitochondrial matrix of cultured mouse hippocampal neurons, and the responses to transient stimulation by glutamate, serotonin, dopamine and norepinephrine were characterized. |
2021-06-22 |
2023-08-13 |
mouse |