| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lynette C Daws, Sylvia Montañez, W Anthony Owens, Georgianna G Gould, Alan Frazer, Glenn M Toney, Greg A Gerhard. Transport mechanisms governing serotonin clearance in vivo revealed by high-speed chronoamperometry. Journal of neuroscience methods. vol 143. issue 1. 2005-06-30. PMID:15763136. |
in hippocampal regions of intact rats, local application of the selective serotonin reuptake inhibitor, fluvoxamine, inhibited 5-ht clearance most robustly when the extracellular concentration of 5-ht was less than the k(t) value. |
2005-06-30 |
2023-08-12 |
rat |
| Lynette C Daws, Sylvia Montañez, W Anthony Owens, Georgianna G Gould, Alan Frazer, Glenn M Toney, Greg A Gerhard. Transport mechanisms governing serotonin clearance in vivo revealed by high-speed chronoamperometry. Journal of neuroscience methods. vol 143. issue 1. 2005-06-30. PMID:15763136. |
these data indicate that hippocampal uptake of 5-ht may be mediated by two processes, one with high affinity but low capacity (i.e. |
2005-06-30 |
2023-08-12 |
rat |
| Ralph Clinckers, Sarah Gheuens, Ilse Smolders, Alfred Meurs, Guy Ebinger, Yvette Michott. In vivo modulatory action of extracellular glutamate on the anticonvulsant effects of hippocampal dopamine and serotonin. Epilepsia. vol 46. issue 6. 2005-06-30. PMID:15946324. |
in vivo modulatory action of extracellular glutamate on the anticonvulsant effects of hippocampal dopamine and serotonin. |
2005-06-30 |
2023-08-12 |
Not clear |
| Ralph Clinckers, Sarah Gheuens, Ilse Smolders, Alfred Meurs, Guy Ebinger, Yvette Michott. In vivo modulatory action of extracellular glutamate on the anticonvulsant effects of hippocampal dopamine and serotonin. Epilepsia. vol 46. issue 6. 2005-06-30. PMID:15946324. |
our recent work (clinckers et al., j neurochem 2004;89:834-43) demonstrated that intrahippocampal perfusion of 2 nm dopamine or serotonin via a microdialysis probe offered complete protection against focal pilocarpine-induced limbic seizures and did not influence basal extracellular hippocampal glutamate levels. |
2005-06-30 |
2023-08-12 |
Not clear |
| Zoë A Hughes, Kathryn R Starr, Christopher J Langmead, Matthew Hill, Gerd D Bartoszyk, James J Hagan, Derek N Middlemiss, Lee A Dawso. Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone. European journal of pharmacology. vol 510. issue 1-2. 2005-06-28. PMID:15740724. |
dose-dependently displaced in vivo [3h]dasb (n,n-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine) binding from rat cortex and hippocampus, indicating that vilazodone occupies 5-ht transporters in vivo. |
2005-06-28 |
2023-08-12 |
rat |
| Zoë A Hughes, Kathryn R Starr, Christopher J Langmead, Matthew Hill, Gerd D Bartoszyk, James J Hagan, Derek N Middlemiss, Lee A Dawso. Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone. European journal of pharmacology. vol 510. issue 1-2. 2005-06-28. PMID:15740724. |
in summary, vilazodone behaved as a high efficacy partial agonist at the rat hippocampal 5-ht1a receptors in vitro and occupied 5-ht transporters in vivo. |
2005-06-28 |
2023-08-12 |
rat |
| Moonkyu Kang, Kwang-Ho Pyun, Choon-Gon Jang, Hyuntaek Kim, Hyunsu Bae, Insop Shi. Nelumbinis Semen reverses a decrease in hippocampal 5-HT release induced by chronic mild stress in rats. The Journal of pharmacy and pharmacology. vol 57. issue 5. 2005-06-28. PMID:15901354. |
nelumbinis semen reverses a decrease in hippocampal 5-ht release induced by chronic mild stress in rats. |
2005-06-28 |
2023-08-12 |
rat |
| Moonkyu Kang, Kwang-Ho Pyun, Choon-Gon Jang, Hyuntaek Kim, Hyunsu Bae, Insop Shi. Nelumbinis Semen reverses a decrease in hippocampal 5-HT release induced by chronic mild stress in rats. The Journal of pharmacy and pharmacology. vol 57. issue 5. 2005-06-28. PMID:15901354. |
recently, several lines of evidence have suggested that a very important evoking factor in depression may be a serotonin deficit in the hippocampus. |
2005-06-28 |
2023-08-12 |
rat |
| Moonkyu Kang, Kwang-Ho Pyun, Choon-Gon Jang, Hyuntaek Kim, Hyunsu Bae, Insop Shi. Nelumbinis Semen reverses a decrease in hippocampal 5-HT release induced by chronic mild stress in rats. The Journal of pharmacy and pharmacology. vol 57. issue 5. 2005-06-28. PMID:15901354. |
ns and fluoxetine significantly increased serotonin in normal conditions and reversed a cms-induced decrease in serotonin release in the hippocampus (p<0.05 compared with normal group or control group under cms). |
2005-06-28 |
2023-08-12 |
rat |
| Laurent Galineau, Catherine Belzung, Ercem Kodas, Sylvie Bodard, Denis Guilloteau, Sylvie Chalo. Prenatal 3,4-methylenedioxymethamphetamine (ecstasy) exposure induces long-term alterations in the dopaminergic and serotonergic functions in the rat. Brain research. Developmental brain research. vol 154. issue 2. 2005-06-27. PMID:15707670. |
prenatally mdma-exposed rats showed (i) a two-fold decrease of whole brain levels of 5-ht and 5-hiaa at p0; (ii) no effect on the dat and sert density; (iii) a strongly reduced pharmacologically induced release of da and 5-ht at p70 in the striatum and hippocampus; and (iv) a significant 20% decrease in sucrose preference at p70. |
2005-06-27 |
2023-08-12 |
rat |
| Yuji Odagaki, Ryoichi Toyoshima, Toshio Yamauch. Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding. Journal of psychopharmacology (Oxford, England). vol 19. issue 3. 2005-06-27. PMID:15888508. |
these effects were replicated in the 5-ht(1a) receptor-mediated [(35)s]gtpgamma(s) binding assay in native rat brain membranes (at least in hippocampal membranes), although the intrinsic activities of the compounds were low and differently ranked compared to those in cho/h5-ht(1a) cell membranes. |
2005-06-27 |
2023-08-12 |
human |
| S Djalali, M Höltje, G Grosse, T Rothe, T Stroh, J Grosse, D R Deng, R Hellweg, R Grantyn, H Hörtnagl, G Ahnert-Hilge. Effects of brain-derived neurotrophic factor (BDNF) on glial cells and serotonergic neurones during development. Journal of neurochemistry. vol 92. issue 3. 2005-06-24. PMID:15659231. |
in bdnf-/- mice, the number of serotonin-immunoreactive neuronal somata, the amount of the serotonin transporter, the serotonin content in the striatum and the hippocampus, and the content of 5-hydroxyindoleacetic acid in all brain regions analysed were increased. |
2005-06-24 |
2023-08-12 |
mouse |
| Shagufta Ahmad, Leslie J Fowler, Peter S Whitto. Lamotrigine, carbamazepine and phenytoin differentially alter extracellular levels of 5-hydroxytryptamine, dopamine and amino acids. Epilepsy research. vol 63. issue 2-3. 2005-06-24. PMID:15777732. |
we have studied the effects of treatment with the anticonvulsants lamotrigine (ltg), phenytoin (phn) and carbamazepine (cbz) on basal and stimulated extracellular aspartate (asp), glutamate (glu), taurine (tau), gaba, 5-hydroxytryptamine (5-ht) and dopamine (da) in the hippocampus of freely moving rats using microdialysis. |
2005-06-24 |
2023-08-12 |
rat |
| Izuru Matsumoto, Yuki Inoue, Takeshi Iwazaki, Geoff Pavey, Brian Dea. 5-HT2A and muscarinic receptors in schizophrenia: a postmortem study. Neuroscience letters. vol 379. issue 3. 2005-06-24. PMID:15843056. |
no significant difference was observed in the density of 5ht(2a) receptors in the hippocampus or caudate/putamen between the two groups. |
2005-06-24 |
2023-08-12 |
human |
| Claus Normann, Kristin Clar. Selective modulation of Ca(2+) influx pathways by 5-HT regulates synaptic long-term plasticity in the hippocampus. Brain research. vol 1037. issue 1-2. 2005-06-16. PMID:15777768. |
selective modulation of ca(2+) influx pathways by 5-ht regulates synaptic long-term plasticity in the hippocampus. |
2005-06-16 |
2023-08-12 |
human |
| Claus Normann, Kristin Clar. Selective modulation of Ca(2+) influx pathways by 5-HT regulates synaptic long-term plasticity in the hippocampus. Brain research. vol 1037. issue 1-2. 2005-06-16. PMID:15777768. |
in patch-clamp experiments on hippocampal brain slices, we tested the modulation of different forms of synaptic plasticity by the neurotransmitter serotonin (5-ht) which is known to inhibit high-voltage activated ca(2+) channels. |
2005-06-16 |
2023-08-12 |
human |
| L Descarries, N Aznavour, E Hame. The acetylcholine innervation of cerebral cortex: new data on its normal development and its fate in the hAPP(SW,IND) mouse model of Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 1. 2005-06-07. PMID:15599613. |
a selective, widespread, plaque independent cholinergic denervation was thus demonstrated, first in hippocampus and then neocortex, in addition to a non-selective, plaque-dependent, local neurotoxic effect of aggregated beta-amyloid on ach and 5-ht axons. |
2005-06-07 |
2023-08-12 |
mouse |
| Romina Soledad Almirón, Oscar Angel Ramíre. Participation of dorsal raphe nucleus in the behavioral alteration observed after discontinuation of chronic diazepam administration: possible neural circuitry involved. Synapse (New York, N.Y.). vol 56. issue 2. 2005-06-06. PMID:15714479. |
in the present study, we investigated the involvement of the serotonergic (5-ht) system in the possible neural circuitry recruited during dz withdrawal and in the increased hippocampal synaptic plasticity associated with the discontinuation of chronic dz administration. |
2005-06-06 |
2023-08-12 |
Not clear |
| Klaus Lieb, Lisa Biersack, Anne Waschbisch, Sonja Orlikowski, Ravi Shankar Akundi, Eduardo Candelario-Jalil, Michael Hüll, Bernd L Fiebic. Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells. Journal of neurochemistry. vol 93. issue 3. 2005-06-03. PMID:15836614. |
previously, it has been demonstrated that 5-ht may induce interleukin (il)-6 expression in primary rat hippocampal astrocytes. |
2005-06-03 |
2023-08-12 |
human |
| Anna Pittaluga, Daniela Segantini, Marco Feligioni, Maurizio Raiter. Extracellular protons differentially potentiate the responses of native AMPA receptor subtypes regulating neurotransmitter release. British journal of pharmacology. vol 144. issue 2. 2005-05-31. PMID:15665865. |
the effects of ph changes on the basal and evoked release of [(3)h]noradrenaline ([(3)h]na) and [(3)h]5-hydrohytryptamine ([(3)h]5-ht) from hippocampal synaptosomes and of [(3)h]dopamine ([(3)h]da) and [(3)h]acetylcholine ([(3)h]ach) from striatal and cortical synaptosomes were investigated in rat brain. |
2005-05-31 |
2023-08-12 |
rat |