| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Procaccini, M Maksimovic, T Aitta-Aho, E R Korpi, A-M Linde. Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740. Neuroscience. vol 250. 2014-04-04. PMID:23867766. |
as a putative model for these disorders, a mouse line lacking the glua1 subunit (glua1-ko) of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) glutamate receptor displays a robust novelty-induced hyperlocomotion associated with excessive neuronal activation in the hippocampus. |
2014-04-04 |
2023-08-12 |
mouse |
| C Procaccini, M Maksimovic, T Aitta-Aho, E R Korpi, A-M Linde. Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740. Neuroscience. vol 250. 2014-04-04. PMID:23867766. |
agonists of metabotropic glutamate 2/3 receptors (mglur2/3) inhibit glutamate release in various brain regions and they have been shown to inhibit neuronal activation in the hippocampus. |
2014-04-04 |
2023-08-12 |
mouse |
| Elizabeth D Moore, Mitra Kooshki, Kenneth T Wheeler, Linda J Metheny-Barlow, Mike E Robbin. Differential expression of Homer1a in the hippocampus and cortex likely plays a role in radiation-induced brain injury. Radiation research. vol 181. issue 1. 2014-04-04. PMID:24377717. |
two months after fractionated whole-brain irradiation, these changes in homer1a expression correlated with a down-regulation of the hippocampal glutamate receptor 1 and protein kinase cγ, and an up-regulation of cortical glutamate receptor 1 and protein kinase cγ. |
2014-04-04 |
2023-08-12 |
rat |
| Elizabeth D Moore, Mitra Kooshki, Kenneth T Wheeler, Linda J Metheny-Barlow, Mike E Robbin. Differential expression of Homer1a in the hippocampus and cortex likely plays a role in radiation-induced brain injury. Radiation research. vol 181. issue 1. 2014-04-04. PMID:24377717. |
two drugs that prevent radiation-induced cognitive impairment in rats, the angiotensin type-1 receptor blocker, l-158,809, and the angiotensin converting enzyme inhibitor, ramipril, reversed the fractionated whole-brain irradiation-induced homer1a expression at 48 h in the hippocampus and cortex and restored glutamate receptor 1 and protein kinase cγ to the levels in sham-irradiated controls at 2 months after fractionated whole-brain irradiation. |
2014-04-04 |
2023-08-12 |
rat |
| Niels G Nørager, Christel B Jensen, Mette Rathje, Jacob Andersen, Kenneth L Madsen, Anders S Kristensen, Kristian Strømgaar. Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons. ACS chemical biology. vol 8. issue 9. 2014-04-03. PMID:23838571. |
development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons. |
2014-04-03 |
2023-08-12 |
spider |
| Joshua G Jackson, John C O'Donnell, Hajime Takano, Douglas A Coulter, Michael B Robinso. Neuronal activity and glutamate uptake decrease mitochondrial mobility in astrocytes and position mitochondria near glutamate transporters. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 5. 2014-04-01. PMID:24478345. |
we imaged organotypic hippocampal slice cultures of rat, in which astrocytes maintain their highly branched morphologies and express glutamate transporters. |
2014-04-01 |
2023-08-12 |
rat |
| Jordan Marrocco, Marie-Line Reynaert, Eleonora Gatta, Cecilia Gabriel, Elisabeth Mocaër, Silvia Di Prisco, Elisa Merega, Anna Pittaluga, Ferdinando Nicoletti, Stefania Maccari, Sara Morley-Fletcher, Jérôme Mairess. The effects of antidepressant treatment in prenatally stressed rats support the glutamatergic hypothesis of stress-related disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 6. 2014-04-01. PMID:24501344. |
we have recently demonstrated a causal link between the reduction of glutamate release in the ventral hippocampus and anxiety-like behavior in prs rats. |
2014-04-01 |
2023-08-12 |
rat |
| Jordan Marrocco, Marie-Line Reynaert, Eleonora Gatta, Cecilia Gabriel, Elisabeth Mocaër, Silvia Di Prisco, Elisa Merega, Anna Pittaluga, Ferdinando Nicoletti, Stefania Maccari, Sara Morley-Fletcher, Jérôme Mairess. The effects of antidepressant treatment in prenatally stressed rats support the glutamatergic hypothesis of stress-related disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 6. 2014-04-01. PMID:24501344. |
for 21 d. both treatments reversed the reduction in depolarization-evoked glutamate release and in the expression of synaptic vesicle-associated proteins in the ventral hippocampus of prs rats. |
2014-04-01 |
2023-08-12 |
rat |
| Ying Ouyang, Ziwei Chen, Min Tan, Anmin Liu, Meihui Chen, Jun Liu, Rongbiao Pi, Jianpei Fan. Carvedilol, a third-generation β-blocker prevents oxidative stress-induced neuronal death and activates Nrf2/ARE pathway in HT22 cells. Biochemical and biophysical research communications. vol 441. issue 4. 2014-03-31. PMID:24216104. |
here we investigated the effect of carvedilol on oxidative stress-induced cell death (glutamate 2mm and h2o2 600 μm) and the activity of nrf2/are pathway in ht22 hippocampal cells. |
2014-03-31 |
2023-08-12 |
Not clear |
| Xoan Thi Le, Hang Thi Nguyet Pham, Phuong Thi Do, Hironori Fujiwara, Ken Tanaka, Feng Li, Tai Van Nguyen, Khoi Minh Nguyen, Kinzo Matsumot. Bacopa monnieri ameliorates memory deficits in olfactory bulbectomized mice: possible involvement of glutamatergic and cholinergic systems. Neurochemical research. vol 38. issue 10. 2014-03-28. PMID:23949198. |
obx downregulated phosphorylation of synaptic plasticity-related signaling proteins: nr1 subunit of n-methyl-d-aspartate receptor, glutamate receptor 1 (glur1), and calmodulin-dependent kinase ii but not cyclic amp-responsive element binding protein (creb), and reduced brain-derived neurotrophic factor (bdnf) mrna in the hippocampus. |
2014-03-28 |
2023-08-12 |
mouse |
| Yuri Ikeda-Matsu. [The role of prostaglandin E2 in stroke-reperfusion injury]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 133. issue 9. 2014-03-20. PMID:23995802. |
the induction of mpges-1 was also observed after glutamate exposure in cultured hippocampal slices. |
2014-03-20 |
2023-08-12 |
mouse |
| Monika Mishra, Rameshwar Singh, Somnath Mukherjee, Deepak Sharm. Dehydroepiandrosterone's antiepileptic action in FeCl3-induced epileptogenesis involves upregulation of glutamate transporters. Epilepsy research. vol 106. issue 1-2. 2014-03-19. PMID:23891458. |
levels of glutamate transporters mrnas expression were measured using quantitative pcr in the hippocampus during the chronic phase of iron-induced epileptogenesis. |
2014-03-19 |
2023-08-12 |
rat |
| Ana F Oliveira, Ryohei Yasud. Neurofibromin is the major ras inactivator in dendritic spines. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 3. 2014-03-13. PMID:24431436. |
here, using a fluorescence resonance energy transfer/fluorescence lifetime imaging microscopy-based ras imaging technique in combination with 2-photon glutamate uncaging, we show that neurofibromin, in which loss-of-function mutations cause neurofibromatosis type 1 (nf1), contributes to the majority (∼90%) of ras inactivation in dendritic spines of pyramidal neurons in the ca1 region of the rat hippocampus. |
2014-03-13 |
2023-08-12 |
rat |
| Mark Turlington, Meredith J Noetzel, Aspen Chun, Ya Zhou, Rocco D Gogliotti, Elizabeth D Nguyen, Karen J Gregory, Paige N Vinson, Jerri M Rook, Kiran K Gogi, Zixiu Xiang, Thomas M Bridges, J Scott Daniels, Carrie Jones, Colleen M Niswender, Jens Meiler, P Jeffrey Conn, Craig W Lindsley, Shaun R Stauffe. Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254). Journal of medicinal chemistry. vol 56. issue 20. 2014-03-10. PMID:24050755. |
pam 38t, a low glutamate fold-shift allosteric ligand (maximum fold-shift ~ 3.0), was selected as a potent pam with no agonism in the in vitro system used for compound characterization and in two native electrophysiological systems using rat hippocampal slices. |
2014-03-10 |
2023-08-12 |
rat |
| Katsuro Iwase, Akinori Ishihara, Shuntaro Yoshimura, Yoshio Andoh, Masaki Kato, Naohiko Seki, Eriko Matsumoto, Takaki Hiwasa, Dominique Muller, Kohji Fukunaga, Masaki Takiguch. The secretogranin II gene is a signal integrator of glutamate and dopamine inputs. Journal of neurochemistry. vol 128. issue 2. 2014-03-07. PMID:24111984. |
following cdna microarray analysis for genes regulated by ca(2+) or camp, we found that the secretogranin ii gene (scg2) was cooperatively activated by glutamate and dopamine in primary cultured mouse hippocampal neurons. |
2014-03-07 |
2023-08-12 |
mouse |
| Wyatt B Potter, Trina Basu, Kenneth J O'Riordan, Allison Kirchner, Paul Rutecki, Corinna Burger, Avtar Roopr. Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling. PLoS biology. vol 11. issue 8. 2014-03-06. PMID:23966835. |
we find that although reduced ltd is a feature of the juvenile mutant hippocampus, heightened expression of metabotropic glutamate receptor 5 and constitutively activated erk signaling in the adult hippocampus drives wild-type levels of ltd. |
2014-03-06 |
2023-08-12 |
mouse |
| Hea-Jo Yoon, Young-Jin Lim, Zhiyi Zuo, Wonseok Hur, Sang-Hwan D. Nicotine decreases the activity of glutamate transporter type 3. Toxicology letters. vol 225. issue 1. 2014-03-06. PMID:24355585. |
in the hippocampus, the origin of nicotine-induced seizures, most glutamate uptake could be performed primarily by excitatory amino acid transporter type 3 (eaat3). |
2014-03-06 |
2023-08-12 |
xenopus_laevis |
| Felipe Vasconcelos Torres, Fernanda Hansen, Lucas Doridio Locks-Coelh. Increase of extracellular glutamate concentration increases its oxidation and diminishes glucose oxidation in isolated mouse hippocampus: reversible by TFB-TBOA. Journal of neuroscience research. vol 91. issue 8. 2014-03-05. PMID:23359514. |
increase of extracellular glutamate concentration increases its oxidation and diminishes glucose oxidation in isolated mouse hippocampus: reversible by tfb-tboa. |
2014-03-05 |
2023-08-12 |
mouse |
| Andrea Pedroni, Do Duc Minh, Antonello Mallamaci, Enrico Cherubin. Electrophysiological characterization of granule cells in the dentate gyrus immediately after birth. Frontiers in cellular neuroscience. vol 8. 2014-03-04. PMID:24592213. |
in addition, most spiking neurons showed spontaneous synchronized network activity, reminiscent of giant depolarizing potentials (gdps) generated in the hippocampus by the synergistic action of glutamate and gaba, both depolarizing and excitatory. |
2014-03-04 |
2023-08-12 |
rat |
| Guilherme Neves, Mala M Shah, Petros Liodis, Angeliki Achimastou, Myrto Denaxa, Grant Roalfe, Abdul Sesay, Matthew C Walker, Vassilis Pachni. The LIM homeodomain protein Lhx6 regulates maturation of interneurons and network excitability in the mammalian cortex. Cerebral cortex (New York, N.Y. : 1991). vol 23. issue 8. 2014-02-26. PMID:22710612. |
consistent with a selective deficit in the differentiation of sst(+) interneurons in the ca1 subfield of the hippocampus, we observed reduced expression of metabotropic glutamate receptor 1 in the stratum oriens and characteristic changes in dendritic inhibition, but normal inhibitory input onto the somatic compartment of ca1 pyramidal cells. |
2014-02-26 |
2023-08-12 |
mouse |