| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nina V Kraguljac, David M White, Meredith A Reid, Adrienne C Laht. Increased hippocampal glutamate and volumetric deficits in unmedicated patients with schizophrenia. JAMA psychiatry. vol 70. issue 12. 2014-02-24. PMID:24108440. |
increased hippocampal glutamate and volumetric deficits in unmedicated patients with schizophrenia. |
2014-02-24 |
2023-08-12 |
Not clear |
| L Ferraro, A Loche, S Beggiato, M C Tomasini, T Antonelli, G Colombo, C Lobina, M A M Carai, A Porcu, M P Castelli, F Clerici, A C Borelli, R Cacciaglia, S Tanganell. The new compound GET73, N-[(4-trifluoromethyl)benzyl]4-methoxybutyramide, Regulates hippocampal Aminoacidergic transmission possibly via an allosteric modulation of mGlu5 receptor. Behavioural evidence of its "anti-alcohol" and anxiolytic properties. Current medicinal chemistry. vol 20. issue 27. 2014-02-20. PMID:23862615. |
particular emphasis is given to findings obtained in vivo and in vitro suggesting that an allosteric modulation of metabotropic glutamate receptor 5 (mglu5 receptor) by get73 may represent the mechanism underlying the effects of the compound produced on rat hippocampal glutamate and gaba transmission. |
2014-02-20 |
2023-08-12 |
rat |
| S-Y Loke, N J Siddiqi, A S Alhomida, H-C Kim, W-Y On. Expression and localization of duodenal cytochrome b in the rat hippocampus after kainate-induced excitotoxicity. Neuroscience. vol 245. 2014-02-19. PMID:23597830. |
the iron transport protein, divalent metal transporter 1 (dmt1) is found in reactive astrocytes of the lesioned hippocampal ca fields after excitotoxicity induced by the glutamate analog kainate (ka), but in order for iron to be transported by dmt1, it must be converted from the ferric to the ferrous form. |
2014-02-19 |
2023-08-12 |
rat |
| Adriana Medina, Sharon Burke, Robert C Thompson, William Bunney, Richard M Myers, Alan Schatzberg, Huda Akil, Stanley J Watso. Glutamate transporters: a key piece in the glutamate puzzle of major depressive disorder. Journal of psychiatric research. vol 47. issue 9. 2014-02-14. PMID:23706640. |
we hypothesize that the decreased expression of the membrane glutamate transporters and the increased expression of the vesicular transporter in the hippocampus would affect the balance of the glutamatergic circuitry of the hippocampus, and that this effect may be a major contributor to depressive symptoms. |
2014-02-14 |
2023-08-12 |
human |
| Phu V Tran, Srikanth Dakoji, Kathryn H Reise, Kathleen K Storey, Michael K Georgief. Fetal iron deficiency alters the proteome of adult rat hippocampal synaptosomes. American journal of physiology. Regulatory, integrative and comparative physiology. vol 305. issue 11. 2014-02-10. PMID:24089371. |
western analysis was used to confirm findings for selected proteins in the glutamate receptor signaling pathway, which regulates hippocampal synaptic plasticity, a cellular process critical for learning and memory. |
2014-02-10 |
2023-08-12 |
rat |
| Rongqing Chen, Jian Zhang, Ni Fan, Zhao-Qian Teng, Yan Wu, Hongwei Yang, Ya-Ping Tang, Hao Sun, Yunping Song, Chu Che. Δ9-THC-caused synaptic and memory impairments are mediated through COX-2 signaling. Cell. vol 155. issue 5. 2014-02-10. PMID:24267894. |
pharmacological or genetic inhibition of cox-2 blocks downregulation and internalization of glutamate receptor subunits and alterations of the dendritic spine density of hippocampal neurons induced by repeated Δ(9)-thc exposures. |
2014-02-10 |
2023-08-12 |
Not clear |
| Paul F Smith, Yiwen Zhen. Principal component analysis suggests subtle changes in glutamate receptor subunit expression in the rat hippocampus following bilateral vestibular deafferentation. Neuroscience letters. vol 548. 2014-02-07. PMID:23721785. |
principal component analysis suggests subtle changes in glutamate receptor subunit expression in the rat hippocampus following bilateral vestibular deafferentation. |
2014-02-07 |
2023-08-12 |
rat |
| Paul F Smith, Yiwen Zhen. Principal component analysis suggests subtle changes in glutamate receptor subunit expression in the rat hippocampus following bilateral vestibular deafferentation. Neuroscience letters. vol 548. 2014-02-07. PMID:23721785. |
given the importance of glutamate as a neurotransmitter in the hippocampus, it was predicted that bilateral vestibular deafferentation (bvd) would alter the expression of nmda and ampa receptors in this area of the brain. |
2014-02-07 |
2023-08-12 |
rat |
| Paul F Smith, Yiwen Zhen. Principal component analysis suggests subtle changes in glutamate receptor subunit expression in the rat hippocampus following bilateral vestibular deafferentation. Neuroscience letters. vol 548. 2014-02-07. PMID:23721785. |
in this study, we performed principal component analysis (pca) on the expression of the nr1, nr2b, glur1, glur2 and glur3 glutamate receptor subunits, as well as calmodulin kinase iiα (camkiiα) and phosphorylated camkiiα (pcamkiiα), in the rat ca1, ca2/3 and dentate gyrus (dg) subregions of the hippocampus, at 6 months following bvd, using western blotting. |
2014-02-07 |
2023-08-12 |
rat |
| Masashi Okada, Yasukazu Hozumi, Toshiaki Tanaka, Yusuke Suzuki, Mitsuaki Yanagida, Yoshihiko Araki, Camilla Evangelisti, Hitoshi Yagisawa, Matthew K Topham, Alberto M Martelli, Kaoru Got. DGKζ is degraded through the cytoplasmic ubiquitin-proteasome system under excitotoxic conditions, which causes neuronal apoptosis because of aberrant cell cycle reentry. Cellular signalling. vol 24. issue 8. 2014-01-30. PMID:22516102. |
collectively, these results suggest that 1) glutamate excitotoxicity induces nucleocytoplasmic translocation of dgkζ followed by its degradation through the cytoplasmic ups in hippocampal neurons and that 2) dgkζ-deficient neurons do not succumb directly to apoptosis, although they are more vulnerable to excitotoxicity because of aberrant cell cycle reentry. |
2014-01-30 |
2023-08-12 |
mouse |
| Yaroslav S Ermolyuk, Felicity G Alder, Rainer Surges, Ivan Y Pavlov, Yulia Timofeeva, Dimitri M Kullmann, Kirill E Volynsk. Differential triggering of spontaneous glutamate release by P/Q-, N- and R-type Ca2+ channels. Nature neuroscience. vol 16. issue 12. 2014-01-27. PMID:24185424. |
we found that stochastic opening of p/q-, n- and r-type vgccs accounts for ∼50% of all spontaneous glutamate release at rat cultured hippocampal synapses, and that r-type channels have a far greater role in spontaneous than in action potential-evoked exocytosis. |
2014-01-27 |
2023-08-12 |
rat |
| E Venzala, A L García-García, N Elizalde, R M Torder. Social vs. environmental stress models of depression from a behavioural and neurochemical approach. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 7. 2014-01-23. PMID:22743048. |
subsequently, we examined glutamate, gaba, 5-ht and dopamine levels in the prefrontal cortex, hippocampus and brainstem. |
2014-01-23 |
2023-08-12 |
mouse |
| L K Friedman, J Mancuso, A Patel, V Kudur, J R Leheste, S Iacobas, J Botta, D A Iacobas, D C Spra. Transcriptome profiling of hippocampal CA1 after early-life seizure-induced preconditioning may elucidate new genetic therapies for epilepsy. The European journal of neuroscience. vol 38. issue 1. 2014-01-15. PMID:23551718. |
the observed differential transcriptional responses may contribute to early-life seizure-induced pre-conditioning and neuroprotection by reducing glutamate receptor-mediated ca(2+) permeability of the hippocampus and redirecting inflammatory and apoptotic pathways. |
2014-01-15 |
2023-08-12 |
cat |
| Qian Bu, Lei Lv, Guangyan Yan, Pengchi Deng, Yanli Wang, Jiaqing Zhou, Yanzhu Yang, Yan Li, Xiaobo Ce. NMR-based metabonomic in hippocampus, nucleus accumbens and prefrontal cortex of methamphetamine-sensitized rats. Neurotoxicology. vol 36. 2014-01-13. PMID:23462569. |
the neurotransmitters glutamate, glutamine and gaba significantly decreased in hippocampus, nac and pfc. |
2014-01-13 |
2023-08-12 |
rat |
| Manickavasagom Alkondon, Edson X Albuquerque, Edna F R Pereir. Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices. Neurotoxicology. vol 36. 2014-01-13. PMID:23511125. |
acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to ca1 stratum radiatum interneurons in hippocampal slices. |
2014-01-13 |
2023-08-12 |
rat |
| Manickavasagom Alkondon, Edson X Albuquerque, Edna F R Pereir. Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices. Neurotoxicology. vol 36. 2014-01-13. PMID:23511125. |
to test the hypothesis that ache inhibition builds sufficient acetylcholine (ach) in the brain and facilitates nachr-dependent glutamate transmission, we used whole-cell patch-clamp technique to record spontaneous glutamate excitatory postsynaptic currents (epscs) from ca1 stratum radiatum interneurons (sri) in hippocampal slices. |
2014-01-13 |
2023-08-12 |
rat |
| Manickavasagom Alkondon, Edson X Albuquerque, Edna F R Pereir. Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices. Neurotoxicology. vol 36. 2014-01-13. PMID:23511125. |
these results support the concept that ache inhibition is able to recruit nachr-dependent glutamate transmission in the hippocampus and such a mechanism can contribute to the acute neurotoxicological actions of soman. |
2014-01-13 |
2023-08-12 |
rat |
| F Yeganeh, F Nikbakht, S Bahmanpour, K Rastegar, R Namava. Neuroprotective effects of NMDA and group I metabotropic glutamate receptor antagonists against neurodegeneration induced by homocysteine in rat hippocampus: in vivo study. Journal of molecular neuroscience : MN. vol 50. issue 3. 2014-01-10. PMID:23564299. |
neuroprotective effects of nmda and group i metabotropic glutamate receptor antagonists against neurodegeneration induced by homocysteine in rat hippocampus: in vivo study. |
2014-01-10 |
2023-08-12 |
rat |
| Laurent Ladepeche, Julien P Dupuis, Delphine Bouchet, Evelyne Doudnikoff, Luting Yang, Yohan Campagne, Erwan Bézard, Eric Hosy, Laurent Gro. Single-molecule imaging of the functional crosstalk between surface NMDA and dopamine D1 receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 44. 2014-01-08. PMID:24127604. |
using a combination of single-molecule detection imaging and electrophysiology in live hippocampal neurons, we demonstrate here that dopamine d1 receptors (d1rs) and nmdars form dynamic surface clusters in the vicinity of glutamate synapses. |
2014-01-08 |
2023-08-12 |
Not clear |
| Chadi G Abdallah, Jeremy D Coplan, Andrea Jackowski, João R Sato, Xiangling Mao, Dikoma C Shungu, Sanjay J Mathe. A pilot study of hippocampal volume and N-acetylaspartate (NAA) as response biomarkers in riluzole-treated patients with GAD. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 4. 2014-01-06. PMID:22739126. |
anxiolytic benefit following chronic treatment with the glutamate modulating agent riluzole in patients with generalized anxiety disorder (gad) was previously associated with differential changes in hippocampal naa concentrations. |
2014-01-06 |
2023-08-12 |
human |