| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Li, Jia Li, Shanshan Li, Yi Li, Xiangxiang Wang, Baolin Liu, Qiang Fu, Shiping M. Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Toxicology and applied pharmacology. vol 286. issue 1. 2015-08-05. PMID:25791922. |
this study aims to investigate the action of curcumin in the hippocampus subjected to glutamate neurotoxicity. |
2015-08-05 |
2023-08-13 |
rat |
| Ying Li, Jia Li, Shanshan Li, Yi Li, Xiangxiang Wang, Baolin Liu, Qiang Fu, Shiping M. Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Toxicology and applied pharmacology. vol 286. issue 1. 2015-08-05. PMID:25791922. |
glutamate stimulation induced reactive oxygen species (ros), endoplasmic reticulum stress (er stress) and txnip/nlrp3 inflammasome activation, leading to damage in the hippocampus. |
2015-08-05 |
2023-08-13 |
rat |
| Ying Li, Jia Li, Shanshan Li, Yi Li, Xiangxiang Wang, Baolin Liu, Qiang Fu, Shiping M. Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Toxicology and applied pharmacology. vol 286. issue 1. 2015-08-05. PMID:25791922. |
together, these results showed that curcumin attenuated glutamate neurotoxicity by inhibiting er stress-associated txnip/nlrp3 inflammasome activation via the regulation of ampk, and thereby protected the hippocampus from ischemic insult. |
2015-08-05 |
2023-08-13 |
rat |
| Renshi Xu, Yiyi Zhou, Xin Fang, Yi Lu, Jiao Li, Jie Zhang, Xia Deng, Shujuan L. The possible mechanism of Parkinson's disease progressive damage and the preventive effect of GM1 in the rat model induced by 6-hydroxydopamine. Brain research. vol 1592. 2015-07-27. PMID:25285892. |
our study investigated the content of glutamate, mitochondria calcium, calmodulin, malonaldehyde and trace elements in striatum, cerebral cortex and hippocampus tissues; and the expression of bcl-2, bax and neuronal nitric oxide synthase (nnos) in substantia nigra and striatum; and the change of apomorphine induced rotation behavior; and the treatmental effect of monosialotetrahexosylganglioside (gm1) intraperitoneal administration for 14 days in a pd rat model induced by 6-hydroxydopamine. |
2015-07-27 |
2023-08-13 |
rat |
| Renshi Xu, Yiyi Zhou, Xin Fang, Yi Lu, Jiao Li, Jie Zhang, Xia Deng, Shujuan L. The possible mechanism of Parkinson's disease progressive damage and the preventive effect of GM1 in the rat model induced by 6-hydroxydopamine. Brain research. vol 1592. 2015-07-27. PMID:25285892. |
the results revealed that the content of glutamate significantly decreased, and that of mitochondria calcium, calmodulin, malonaldehyde and ferrum significantly increased in striatum, cerebral cortex and hippocampus tissues; the content of magnesium significantly decreased, and that of cuprum and zinc significantly increased in cerebral cortex; the expression of bcl-2 significantly decreased, and that of bax and nnos significantly increased in substantia nigra and striatum in pd rat. |
2015-07-27 |
2023-08-13 |
rat |
| Rebecca Klar, Adam G Walker, Dipanwita Ghose, Brad A Grueter, Darren W Engers, Corey R Hopkins, Craig W Lindsley, Zixiu Xiang, P Jeffrey Conn, Colleen M Niswende. Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 19. 2015-07-27. PMID:25972184. |
activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at sc-ca1 synapses in the hippocampus. |
2015-07-27 |
2023-08-13 |
mouse |
| Rebecca Klar, Adam G Walker, Dipanwita Ghose, Brad A Grueter, Darren W Engers, Corey R Hopkins, Craig W Lindsley, Zixiu Xiang, P Jeffrey Conn, Colleen M Niswende. Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 19. 2015-07-27. PMID:25972184. |
of the eight metabotropic glutamate (mglu) receptor subtypes, only mglu7 is expressed presynaptically at the schaffer collateral (sc)-ca1 synapse in the hippocampus in adult animals. |
2015-07-27 |
2023-08-13 |
mouse |
| Hye-Hyun Kim, Kyu-Hee Lee, Doyun Lee, Young-Eun Han, Suk-Ho Lee, Jong-Woo Sohn, Won-Kyung H. Costimulation of AMPA and metabotropic glutamate receptors underlies phospholipase C activation by glutamate in hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 16. 2015-07-16. PMID:25904792. |
costimulation of ampa and metabotropic glutamate receptors underlies phospholipase c activation by glutamate in hippocampus. |
2015-07-16 |
2023-08-13 |
rat |
| Hye-Hyun Kim, Kyu-Hee Lee, Doyun Lee, Young-Eun Han, Suk-Ho Lee, Jong-Woo Sohn, Won-Kyung H. Costimulation of AMPA and metabotropic glutamate receptors underlies phospholipase C activation by glutamate in hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 16. 2015-07-16. PMID:25904792. |
in this study, we found that group i mglur-specific agonist (rs)-3,5-dihydroxyphenylglycine (dhpg) alone is not sufficient to activate phospholipase c (plc) in rat hippocampus, while glutamate robustly activates plc. |
2015-07-16 |
2023-08-13 |
rat |
| Mauro Cunha Xavier Pinto, Isabel Vieira de Assis Lima, Flávia Lage Pessoa da Costa, Daniela Valadão Rosa, Vânia Aparecida Mendes-Goulart, Rodrigo Ribeiro Resende, Marco Aurélio Romano-Silva, Antônio Carlos Pinheiro de Oliveira, Marcus Vinícius Gomez, Renato Santiago Gome. Glycine transporters type 1 inhibitor promotes brain preconditioning against NMDA-induced excitotoxicity. Neuropharmacology. vol 89. 2015-07-15. PMID:25312280. |
the amino acids (glycine and glutamate) uptake and content were increased in hippocampus of animals treated with nfps 5.0 mg/kg, which were associated to an increased expression of type-2 glycine transporter (glyt2) and glutamate transporters (eaat1, eaat2 and eaat3). |
2015-07-15 |
2023-08-13 |
mouse |
| Catherine R Wasser, Irene Masiulis, Murat S Durakoglugil, Courtney Lane-Donovan, Xunde Xian, Uwe Beffert, Anandita Agarwala, Robert E Hammer, Joachim Her. Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning. Science signaling. vol 7. issue 353. 2015-07-14. PMID:25429077. |
mice expressing apoer2 lacking the ols domain had increased apoer2 abundance in the brain, hippocampal spine density, and glutamate receptor abundance, but decreased synaptic efficacy. |
2015-07-14 |
2023-08-13 |
mouse |
| Catherine R Wasser, Irene Masiulis, Murat S Durakoglugil, Courtney Lane-Donovan, Xunde Xian, Uwe Beffert, Anandita Agarwala, Robert E Hammer, Joachim Her. Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning. Science signaling. vol 7. issue 353. 2015-07-14. PMID:25429077. |
mice expressing a form of apoer2 lacking the ols domain and containing an alternatively spliced cytoplasmic tail region that promotes glutamate receptor signaling showed enhanced hippocampal long-term potentiation (ltp), a phenomenon associated with learning and memory. |
2015-07-14 |
2023-08-13 |
mouse |
| Sanjeev K Bhardwaj, Yiu Chung Tse, Richard Ryan, Tak Pan Wong, Lalit K Srivastav. Impaired adrenergic-mediated plasticity of prefrontal cortical glutamate synapses in rats with developmental disruption of the ventral hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 13. 2015-07-07. PMID:24917197. |
impaired adrenergic-mediated plasticity of prefrontal cortical glutamate synapses in rats with developmental disruption of the ventral hippocampus. |
2015-07-07 |
2023-08-13 |
rat |
| Isabel Vieira de Assis Lima, Alline Cristina Campos, Aline Silva Miranda, Érica Leandro Marciano Vieira, Flávia Amaral-Martins, Juliana Priscila Vago, Rebeca Priscila de Melo Santos, Lirlândia Pires Sousa, Luciene Bruno Vieira, Mauro Martins Teixeira, Bernd L Fiebich, Márcio Flávio Dutra Moraes, Antonio Lucio Teixeira, Antonio Carlos Pinheiro de Oliveir. PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine. Experimental neurology. vol 267. 2015-07-06. PMID:25749189. |
in hippocampal synaptosomes, genetic or pharmacological blockade of pi3kγ enhanced the release of glutamate and the cytosolic calcium concentration induced by kcl. |
2015-07-06 |
2023-08-13 |
mouse |
| André Quincozes-Santos, Larissa Daniele Bobermin, Ana Carolina Tramontina, Krista Minéia Wartchow, Bárbara Tagliari, Diogo Onofre Souza, Angela T S Wyse, Carlos-Alberto Gonçalve. Oxidative stress mediated by NMDA, AMPA/KA channels in acute hippocampal slices: neuroprotective effect of resveratrol. Toxicology in vitro : an international journal published in association with BIBRA. vol 28. issue 4. 2015-06-29. PMID:24412540. |
this study sought to determine the neuroprotective effect of resveratrol against glutamate toxicity in acute hippocampal slices, using specific inhibitors of glutamate channels, and to investigate the targets of glutamate excitotoxicity, such as mitochondrial membrane potential (ΔΨ(m)), na(+)k(+)-atpase and glutamine synthetase (gs) activity. |
2015-06-29 |
2023-08-12 |
Not clear |
| Camille Belzil, Tim Ramos, Kamon Sanada, Michael A Colicos, Minh Dang Nguye. p600 stabilizes microtubules to prevent the aggregation of CaMKIIα during photoconductive stimulation. Cellular & molecular biology letters. vol 19. issue 3. 2015-06-26. PMID:25034033. |
the large microtubule-associated/ca(2+)-signalling protein p600 (also known as ubr4) is required for hippocampal neuronal survival upon ca(2+) dyshomeostasis induced by glutamate treatment. |
2015-06-26 |
2023-08-13 |
Not clear |
| E Hernández-Andrade, A J Cortés-Camberos, N F Díaz, H Flores-Herrera, G García-López, M González-Jiménez, A Santamaría, A Molina-Hernánde. Altered levels of brain neurotransmitter from new born rabbits with intrauterine restriction. Neuroscience letters. vol 584. 2015-06-23. PMID:25304540. |
the aim of this study was to evaluate the levels of gamma-aminobutyric acid, glutamate, dopamine and serotonin in three structures of the brain related to the above-mentioned function such as the cerebral cortex, the striatum, and the hippocampus in the chronic hypoxic newborn rabbit model. |
2015-06-23 |
2023-08-13 |
rabbit |
| Rosamund E Combs-Bachmann, Jeffreys Nate Johnson, Devaiah Vytla, Amanda M Hussey, Maria L Kilfoil, James J Chamber. Ligand-directed delivery of fluorophores to track native calcium-permeable AMPA receptors in neuronal cultures. Journal of neurochemistry. vol 133. issue 3. 2015-06-22. PMID:25640258. |
we used a small molecule, ligand-directed probe to deliver synthetic fluorophores to endogenously expressed glutamate receptors for the purpose of tracking these receptors on live, hippocampal neurons. |
2015-06-22 |
2023-08-13 |
rat |
| Shoufang Jiang, Jing Su, Sanqiao Yao, Yanshu Zhang, Fuyuan Cao, Fei Wang, Huihui Wang, Jun Li, Shuhua X. Fluoride and arsenic exposure impairs learning and memory and decreases mGluR5 expression in the hippocampus and cortex in rats. PloS one. vol 9. issue 4. 2015-06-19. PMID:24759735. |
the present study was conducted to explore the effects on spatial learning, memory, glutamate levels, and group i metabotropic glutamate receptors (mglurs) expression in the hippocampus and cortex after subchronic exposure to fluoride, arsenic, and a fluoride and arsenic combination in rats. |
2015-06-19 |
2023-08-13 |
rat |
| Shoufang Jiang, Jing Su, Sanqiao Yao, Yanshu Zhang, Fuyuan Cao, Fei Wang, Huihui Wang, Jun Li, Shuhua X. Fluoride and arsenic exposure impairs learning and memory and decreases mGluR5 expression in the hippocampus and cortex in rats. PloS one. vol 9. issue 4. 2015-06-19. PMID:24759735. |
compared with controls, glutamate levels decreased in the hippocampus and cortex of rats exposed to fluoride and combined fluoride and arsenic, and in cortex of arsenic-exposed rats. |
2015-06-19 |
2023-08-13 |
rat |