| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shoufang Jiang, Jing Su, Sanqiao Yao, Yanshu Zhang, Fuyuan Cao, Fei Wang, Huihui Wang, Jun Li, Shuhua X. Fluoride and arsenic exposure impairs learning and memory and decreases mGluR5 expression in the hippocampus and cortex in rats. PloS one. vol 9. issue 4. 2015-06-19. PMID:24759735. |
the mechanism may be associated with changes of glutamate level and mglur5 expression in cortex and hippocampus. |
2015-06-19 |
2023-08-13 |
rat |
| Keifer P Walsh, Laurie S Minamide, Sarah J Kane, Alisa E Shaw, David R Brown, Bruce Pulford, Mark D Zabel, J David Lambeth, Thomas B Kuhn, James R Bambur. Amyloid-β and proinflammatory cytokines utilize a prion protein-dependent pathway to activate NADPH oxidase and induce cofilin-actin rods in hippocampal neurons. PloS one. vol 9. issue 4. 2015-06-19. PMID:24760020. |
rods form rapidly (5-30 min) in >80% of cultured hippocampal or cortical neurons treated with excitotoxic levels of glutamate or energy depleted (hypoxia/ischemia or mitochondrial inhibitors). |
2015-06-19 |
2023-08-13 |
mouse |
| Sofya Abazyan, Eun Ju Yang, Bagrat Abazyan, Meng Xia, Chunxia Yang, Camilo Rojas, Barbara Slusher, Rita Sattler, Mikhail Pletniko. Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism. Journal of neuroscience research. vol 92. issue 12. 2015-06-19. PMID:25131692. |
although mutant disc1 had no significant effects on astrocyte proliferation, glu reuptake, glutaminase, or glutamate carboxypeptidase ii activity, expression of mutant disc1 was associated with increased levels of alanine-serine-cysteine transporter 2, vesicular glutamate transporters 1 and 3 in primary astrocytes and in the hippocampus, and elevated expression of the nr1 subunit and diminished expression of the nr2a subunit of n-methyl-d-aspartate (nmda) receptors in the hippocampus, at postnatal day 21. |
2015-06-19 |
2023-08-13 |
mouse |
| Mônica R Favre, Deborah La Mendola, Julie Meystre, Dimitri Christodoulou, Melissa J Cochrane, Henry Markram, Kamila Markra. Predictable enriched environment prevents development of hyper-emotionality in the VPA rat model of autism. Frontiers in neuroscience. vol 9. 2015-06-19. PMID:26089770. |
animals were tested for sociability, nociception, stereotypy, fear conditioning and anxiety, and for tissue content of glutamate signaling proteins in the primary somatosensory cortex, hippocampus and amygdala, and of corticosterone in plasma, amygdala and hippocampus. |
2015-06-19 |
2023-08-13 |
rat |
| Eduardo R Zimmer, Vitor R Torrez, Eduardo Kalinine, Marina C Augustin, Kamila C Zenki, Roberto F Almeida, Gisele Hansel, Alexandre P Muller, Diogo O Souza, Rodrigo Machado-Vieira, Luis V Portel. Long-term NMDAR antagonism correlates reduced astrocytic glutamate uptake with anxiety-like phenotype. Frontiers in cellular neuroscience. vol 9. 2015-06-19. PMID:26089779. |
we then evaluated glutamate uptake activity and the immunocontents of glutamate transporters in the frontoparietal cortex and hippocampus. |
2015-06-19 |
2023-08-13 |
mouse |
| Eduardo R Zimmer, Vitor R Torrez, Eduardo Kalinine, Marina C Augustin, Kamila C Zenki, Roberto F Almeida, Gisele Hansel, Alexandre P Muller, Diogo O Souza, Rodrigo Machado-Vieira, Luis V Portel. Long-term NMDAR antagonism correlates reduced astrocytic glutamate uptake with anxiety-like phenotype. Frontiers in cellular neuroscience. vol 9. 2015-06-19. PMID:26089779. |
additionally, the administration of memantine decreased glutamate uptake activity in both the frontoparietal cortex and hippocampus without altering the immunocontent of either glt-1 or glast. |
2015-06-19 |
2023-08-13 |
mouse |
| Débora K Rieger, Rodrigo M S Cunha, Mark William Lopes, Ana Paula Costa, Josiani Budni, Ana Lúcia S Rodrigues, Roger Walz, Edson H Teixeira, Kyria S Nascimento, Benildo S Cavada, Rodrigo B Lea. ConBr, a lectin from Canavalia brasiliensis seeds, modulates signaling pathways and increases BDNF expression probably via a glycosylated target. Journal of molecular recognition : JMR. vol 27. issue 12. 2015-06-18. PMID:25319623. |
we have previously shown that conbr, a lectin purified from canavalia brasiliensis seeds, produced antidepressant-like effect and blocked hippocampal neurotoxicity induced by quinolinic acid and glutamate. |
2015-06-18 |
2023-08-13 |
mouse |
| Angelika Mennecke, Andrea Gossler, Thilo Hammen, Arnd Dörfler, Andreas Stadlbauer, Julie Rösch, Johannes Kornhuber, Stefan Bleich, Marc Dölken, Norbert Thürau. Physiological effects of cigarette smoking in the limbic system revealed by 3 tesla magnetic resonance spectroscopy. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 10. 2015-06-16. PMID:24643301. |
12 smokers and 12 non-smokers were measured with single voxel proton magnetic resonance spectroscopy for total n-acetyl aspartate, glutamate and glutamine, choline-containing compounds, myo-inositol and total creatine in the right and the left hippocampus and in the right and the left dorsal anterior cingulate cortex. |
2015-06-16 |
2023-08-12 |
human |
| Matthias K Auer, Markus Sack, Jenny N Lenz, Mira Jakovcevski, Sarah V Biedermann, Claudia Falfán-Melgoza, Jan Deussing, Jörg Steinle, Maximilian Bielohuby, Martin Bidlingmaier, Frederik Pfister, Günter K Stalla, Gabriele Ende, Wolfgang Weber-Fahr, Johannes Fuss, Peter Gas. Effects of a high-caloric diet and physical exercise on brain metabolite levels: a combined proton MRS and histologic study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 4. 2015-06-16. PMID:25564238. |
it also induced several changes in cns metabolites such as reduced hippocampal glutamate (glu), choline-containing compounds (tcho) and n-acetylaspartate (naa)+n-acetyl-aspartyl-glutamic acid (naag) (tnaa) levels, whereas opposite effects were seen for running. |
2015-06-16 |
2023-08-13 |
mouse |
| Hardy Hagena, Denise Manahan-Vaugha. mGlu5 acts as a switch for opposing forms of synaptic plasticity at mossy fiber-CA3 and commissural associational-CA3 synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 12. 2015-06-15. PMID:25810529. |
given its crucial role in enabling persistent synaptic plasticity in other hippocampal subfields, we speculated that the metabotropic glutamate receptor mglu5 may regulate information encoding at mf and ac synapses. |
2015-06-15 |
2023-08-13 |
rat |
| A E Gareeva, E K Khusnutdinov. [Glutamate receptors genes polymorphism and the risk of paranoid schizophrenia in Russians and tatars from the Republic of Bashkortostan]. Molekuliarnaia biologiia. vol 48. issue 5. 2015-06-03. PMID:25842862. |
post mortem studies have found changes in the degree of affinity glutamate receptors, their transcription, and altered expression of their subunits in the prefrontal cortex, hippocampus, and thalamus in patients with schizophrenia. |
2015-06-03 |
2023-08-13 |
Not clear |
| Nan Wang, Guang-Fen Zhang, Xiao-Yu Liu, He-Liang Sun, Xing-Ming Wang, Li-Li Qiu, Chun Yang, Jian-Jun Yan. Downregulation of neuregulin 1-ErbB4 signaling in parvalbumin interneurons in the rat brain may contribute to the antidepressant properties of ketamine. Journal of molecular neuroscience : MN. vol 54. issue 2. 2015-05-28. PMID:24633675. |
the results showed that ketamine reduced the immobility time and latency to feed of rats receiving the fst, downregulated the levels of nrg1, phosphorylated erbb4 (p-erbb4), parvalbumin, 67-kda isoform of glutamic acid decarboxylase (gad67), gamma-aminobutyric acid (gaba), and upregulated the levels of glutamate in the rat prefrontal cortex and hippocampus. |
2015-05-28 |
2023-08-12 |
rat |
| Rachelle Crescenzi, Catherine DeBrosse, Ravi Prakash Reddy Nanga, Sanjana Reddy, Mohammed Haris, Hari Hariharan, Michiyo Iba, Virginia M Y Lee, John A Detre, Arijitt Borthakur, Ravinder Redd. In vivo measurement of glutamate loss is associated with synapse loss in a mouse model of tauopathy. NeuroImage. vol 101. 2015-05-27. PMID:25003815. |
glutamate was significantly decreased by 29% in the ca sub-region of the ps19 hippocampus, and by 15% in the thalamus, where synapse loss was also measured. |
2015-05-27 |
2023-08-13 |
mouse |
| Rachelle Crescenzi, Catherine DeBrosse, Ravi Prakash Reddy Nanga, Sanjana Reddy, Mohammed Haris, Hari Hariharan, Michiyo Iba, Virginia M Y Lee, John A Detre, Arijitt Borthakur, Ravinder Redd. In vivo measurement of glutamate loss is associated with synapse loss in a mouse model of tauopathy. NeuroImage. vol 101. 2015-05-27. PMID:25003815. |
glutamate levels and synapse density remained high in the dentate gyrus sub-region of the hippocampus, where neurogenesis is known to occur. |
2015-05-27 |
2023-08-13 |
mouse |
| Hanaa S Sallam, Batbayar Tumurbaatar, Wen-Ru Zhang, Demidmaa Tuvdendorj, Manisha Chandalia, Filippo Tempia, Fernanda Laezza, Giulio Taglialatela, Nicola Abat. Peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses. Journal of neurochemistry. vol 133. issue 1. 2015-05-27. PMID:25640170. |
these changes were associated with impaired basal synaptic transmission at the schaffer collaterals to hippocampal cornu ammonis 1 (ca1) synapses, decreased phosphorylation of the glun1 glutamate receptor subunit, down-regulation of insulin receptor expression, and up-regulation of the free fatty acid receptor 1. |
2015-05-27 |
2023-08-13 |
mouse |
| Phil-Ok Ko. Estradiol alleviates the ischemic brain injury-induced decrease of neuronal calcium sensor protein hippocalcin. Neuroscience letters. vol 582. 2015-05-26. PMID:25192982. |
in cultured hippocampal cells, glutamate exposure increased the intracellular ca(2+) concentration, which was rescued by the presence of estradiol. |
2015-05-26 |
2023-08-13 |
rat |
| Zhi Wang, Sang-Hon Park, Huijuan Zhao, Shuling Peng, Zhiyi Zu. A critical role of glutamate transporter type 3 in the learning and memory of mice. Neurobiology of learning and memory. vol 114. 2015-05-22. PMID:24818563. |
the expression of eaat3, glutamate receptor (glur)1 and glur2 in the plasma membrane and of phospho-glur1 (at ser 831) and phospho-camkii in the hippocampus of the wild-type mice was increased at 30 min after the fear conditioning stimulation. |
2015-05-22 |
2023-08-13 |
mouse |
| S Maccari, H J Krugers, S Morley-Fletcher, M Szyf, P J Brunto. The consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations. Journal of neuroendocrinology. vol 26. issue 10. 2015-05-20. PMID:25039443. |
for example, there is evidence for impaired glucocorticoid negative-feedback control of the hypothalamic-pituitary-adrenal axis, altered glutamate neurotransmission and reduced hippocampal neurogenesis in both prenatally stressed rats and rats that experienced deficient maternal care. |
2015-05-20 |
2023-08-13 |
rat |
| Ana Paula dos S C L da Silva, Joselma S L Lopes, Priscila de S Vieira, Emanuelly E A Pinheiro, Mirna L de G da Silva, José Carlos C L Silva Filho, Joaquim S da Costa, Jorge M David, Rivelilson M de Freita. Behavioral and neurochemical studies in mice pretreated with garcinielliptone FC in pilocarpine-induced seizures. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24911645. |
in aspartate, glutamine and glutamate levels detected a decrease of 5.21%, 13.55% and 21.80%, respectively in mice hippocampus treated with gfc75 plus p400 when compared with seized mice. |
2015-05-19 |
2023-08-13 |
mouse |
| Ana Paula dos S C L da Silva, Joselma S L Lopes, Priscila de S Vieira, Emanuelly E A Pinheiro, Mirna L de G da Silva, José Carlos C L Silva Filho, Joaquim S da Costa, Jorge M David, Rivelilson M de Freita. Behavioral and neurochemical studies in mice pretreated with garcinielliptone FC in pilocarpine-induced seizures. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24911645. |
in conclusion, our data suggest that gfc may influence in epileptogenesis and promote anticonvulsant actions in pilocarpine model by modulating the gaba and glutamate contents and of ache activity in seized mice hippocampus. |
2015-05-19 |
2023-08-13 |
mouse |