| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eric T Winzenried, Anna C Everett, Erin R Saito, Roxanne M Miller, Taylor Johnson, Eliza Neal, Zachary Boyce, Calvin Smith, Chloe Jensen, Spencer Kimball, Adam Brantley, Gabriel Melendez, Devin Moffat, Erin Davis, Lyndsey Aponik, Tyler Crofts, Bryson Dabney, Jeffrey G Edward. Effects of a True Prophylactic Treatment on Hippocampal and Amygdala Synaptic Plasticity and Gene Expression in a Rodent Chronic Stress Model of Social Defeat. International journal of molecular sciences. vol 24. issue 13. 2023-07-14. PMID:37446371. |
using competitive elisas on plasma, field electrophysiology at ca1 of the ventral hippocampus (vh) and the basolateral amygdala (bla), quantitative rt-pcr, and behavior assays, we demonstrate that our sd stress increased anxiety-like behavior, elevated long-term potentiation (ltp) in the vh and bla, and altered the expression of mineralocorticoid, glucocorticoid, and glutamate receptors. |
2023-07-14 |
2023-08-14 |
rat |
| Ana Belén Sanz-Martos, Esmeralda Fuentes-Verdugo, Beatriz Merino, Lidia Morales, Vicente Pérez, Roberto Capellán, Ricardo Pellón, Miguel Miguéns, Nuria Del Olm. SCHEDULE-INDUCED ALCOHOL INTAKE DURING ADOLESCENCE SEX DEPENDENTLY IMPAIRS HIPPOCAMPAL SYNAPTIC PLASTICITY AND SPATIAL MEMORY. Behavioural brain research. 2023-07-09. PMID:37423317. |
in contrast, alcohol did not modify hippocampal gene expression of ampa and nmda glutamate receptor subunits, although there are differences in the expression levels of several genes relevant to synaptic plasticity mechanisms underlying learning and memory processes, related to alcohol consumption as ephb2, sex differences as pi3k or the interaction of both factors such as pten. |
2023-07-09 |
2023-08-14 |
rat |
| Manolia R Ghouli, Carrie R Jonak, Rajan Sah, Todd A Fiacco, Devin K Binde. Regulation of the Volume-Regulated Anion Channel Pore-Forming Subunit LRRC8A in the Intrahippocampal Kainic Acid Model of Mesial Temporal Lobe Epilepsy. ASN neuro. vol 15. 2023-07-06. PMID:37410995. |
the timepoint-dependent upregulation of total hippocampal lrrc8a and the possible subsequent increased efflux of glutamate in the epileptic hippocampus suggest that the dysregulation of astrocytic vrac may play an important role in the development of epilepsy. |
2023-07-06 |
2023-08-14 |
Not clear |
| Marcelo Florencio Passos Silva, Christian Pereira Rafael, Jeferson Rubens Mamona Silva, Tiago Guardia de Souza E Silva, Rafaela Fadoni Alponti, Patricia Lucio Alves, Maria Regina Lopes Sandoval, Fernando Maurício Francis Abdall. The M1-muscarinic acetylcholine receptor subtype may play a role in learning and memory performance in the hippocampus of neonatal monosodium glutamate-obese rats. Behavioural pharmacology. 2023-07-04. PMID:37401396. |
here, we investigate the effects of obesity induced by monosodium glutamate (msg) on cognitive impairment and whether this model induces any alteration in the affinity, density, and subtypes of muscarinic acetylcholine receptors (machrs) in rat hippocampus. |
2023-07-04 |
2023-08-14 |
human |
| Karen K Szumlinski, Jessica N Herbert, Brenda Mejia Espinoza, Lauren E Madory, Samantha L Scudde. Alcohol-drinking during later life by C57BL/6J mice induces sex- and age-dependent changes in hippocampal and prefrontal cortex expression of glutamate receptors and neuropathology markers. Addiction neuroscience. vol 7. 2023-07-03. PMID:37396410. |
alcohol-drinking during later life by c57bl/6j mice induces sex- and age-dependent changes in hippocampal and prefrontal cortex expression of glutamate receptors and neuropathology markers. |
2023-07-03 |
2023-08-14 |
mouse |
| Attilio Iemolo, Maria De Risi, Nadia Giordano, Giulia Torromino, Cristina Somma, Diletta Cavezza, Martina Colucci, Maria Mancini, Antonio de Iure, Rocco Granata, Barbara Picconi, Paolo Calabresi, Elvira De Leonibu. Synaptic mechanisms underlying onset and progression of memory deficits caused by hippocampal and midbrain synucleinopathy. NPJ Parkinson's disease. vol 9. issue 1. 2023-06-16. PMID:37328503. |
in contrast, human α-syn overexpression in the hippocampus leads to early memory impairment, altered synaptic transmission and plasticity, and decreased expression of glua1 ampa-type glutamate receptors. |
2023-06-16 |
2023-08-14 |
human |
| A Alhowail, M Aldubaya. Mechanisms underlying cognitive impairment induced by prenatal cannabinoid exposure: a literature review. European review for medical and pharmacological sciences. vol 27. issue 11. 2023-06-15. PMID:37318470. |
the findings from the studies reviewed revealed that the cognitive impairment associated with prenatal cannabinoid exposure is caused by alterations in the expression and function of endocannabinoid receptor 1 (cb1r), decreased glutamate transmission, reduced neurogenesis, alterations in protein kinase b (pkb/akt) and extracellular signal‑regulated kinase 1 and 2 (erk1/2) activity, and increased mitochondrial function in the hippocampus, cortex, and cerebellum. |
2023-06-15 |
2023-08-14 |
human |
| Li-Zhe Liu, Shu-Juan Fan, Jun-Xia Gao, Wen-Bin Li, Xiao-Hui Xia. Ceftriaxone ameliorates hippocampal synapse loss by inhibiting microglial/macrophages activation in glial glutamate transporter-1 dependent manner in the APP/PS1 mouse model of Alzheimer's disease. Brain research bulletin. 2023-06-10. PMID:37301482. |
ceftriaxone ameliorates hippocampal synapse loss by inhibiting microglial/macrophages activation in glial glutamate transporter-1 dependent manner in the app/ps1 mouse model of alzheimer's disease. |
2023-06-10 |
2023-08-14 |
mouse |
| Erika Vazquez-Juarez, Ipsit Srivastava, Maria Lindsko. The effect of ketamine on synaptic mistuning induced by impaired glutamate reuptake. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-06-10. PMID:37301901. |
by recording evoked field postsynaptic potentials in the ca1 area in hippocampal slices, we found that inhibiting glutamate transporters using dl-tboa causes retuning of synaptic transmission, resulting in a new steady state with reduced synaptic strength and a lower threshold for inducing long-term synaptic potentiation (ltp). |
2023-06-10 |
2023-08-14 |
rat |
| Sebastiano A Torrisi, Silvia Rizzo, Samuele Laudani, Alessandro Ieraci, Filippo Drago, Gian Marco Leggi. Acute stress alters recognition memory and AMPA/NMDA receptor subunits in a sex-dependent manner. Neurobiology of stress. vol 25. 2023-06-09. PMID:37293561. |
because ionotropic glutamate receptors-mediated neurotransmission is essential for shaping recognition memory, we further tested the hypothesis that post training acute stress could induce sex-dependent transcriptional changes of ionotropic glutamate receptor subunits in the dorsal hippocampus. |
2023-06-09 |
2023-08-14 |
mouse |
| Elham Sajadi, Javad Sajedianfard, Saeid Hosseinzadeh, Mahnaz Taherianfar. Effect of insulin and cinnamon extract on spatial memory and gene expression of GLUT1, 3, and 4 in streptozotocin-induced Alzheimer's model in rats. Iranian journal of basic medical sciences. vol 26. issue 6. 2023-06-06. PMID:37275760. |
the effect of intracerebroventricular injection of insulin (ins) and oral cinnamon extract (cinn) on glucose transporter (glut) 1, 3, and 4 gene expressions in the hippocampus and spatial memory in a streptozotocin (stz)-induced ad rat model was investigated in the present study. |
2023-06-06 |
2023-08-14 |
rat |
| Jiaxin Zheng, Sisi Peng, Lingling Cui, Xi Liu, Tian Li, Zhenyu Zhao, Yaqing Li, Yuan Hu, Miao Zhang, Linling Xu, JunJian Zhan. Enriched environment attenuates hippocampal theta and gamma rhythms dysfunction in chronic cerebral hypoperfusion via improving imbalanced neural afferent levels. Frontiers in cellular neuroscience. vol 17. 2023-06-02. PMID:37265581. |
the results showed that ee significantly improved the balance of three classical neurotransmitters (acetylcholine, glutamate, and gaba) in the hippocampus, enhanced the strength of theta and slow-gamma (sg) rhythms, and dramatically improved neural coupling across frequency bands in cch rats. |
2023-06-02 |
2023-08-14 |
rat |
| Pablo Martínez San Segundo, Beatrice Terni, Artur Llobe. Multivesicular release favors short term synaptic depression in hippocampal autapses. Frontiers in cellular neuroscience. vol 17. 2023-06-02. PMID:37265578. |
here, we took advantage of the expression of sf-iglusnfr.s72a in the astrocytic feeder layer of autaptic hippocampal neuronal cultures to associate the liberation of glutamate to excitatory postsynaptic currents. |
2023-06-02 |
2023-08-14 |
Not clear |
| Siddhartha Datta, Zubin Rashid, Saptarnab Naskar, Sumantra Chattarj. Administration of the glutamate-modulating drug, riluzole, after stress prevents its delayed effects on the amygdala in male rats. PNAS nexus. vol 2. issue 6. 2023-06-02. PMID:37266396. |
riluzole, an fda-approved drug known to modulate glutamate release and facilitate glutamate clearance, prevents stress-induced deficits in the hippocampus. |
2023-06-02 |
2023-08-14 |
rat |
| Mario Díaz, Daniel Pereda de Pablo, Catalina Valdés-Baizabal, Guido Santos, Raquel Mari. Molecular and biophysical features of hippocampal "lipid rafts aging" are modified by dietary n-3 long-chain polyunsaturated fatty acids. Aging cell. 2023-05-31. PMID:37254617. |
in the present study, we have analyzed, in vivo, the effects of dietary supplementation of n-3 lcpufa on the lipid structure, membrane microviscosity, domain organization, and partitioning of ionotropic and metabotropic glutamate receptors in hippocampal lipid raffs in female mice. |
2023-05-31 |
2023-08-14 |
mouse |
| Mario Díaz, Daniel Pereda de Pablo, Catalina Valdés-Baizabal, Guido Santos, Raquel Mari. Molecular and biophysical features of hippocampal "lipid rafts aging" are modified by dietary n-3 long-chain polyunsaturated fatty acids. Aging cell. 2023-05-31. PMID:37254617. |
unexpectedly, this diet also modified the lipidome and dimension of lipid rafts, as well as the domain redistribution of glutamate receptors and acid-sensing ion channels involved in hippocampal synaptic plasticity, likely modulating functionality of lipid rafts in memory formation and reluctance to age-associated cognitive decline. |
2023-05-31 |
2023-08-14 |
mouse |
| Balázs Simon, András Buzás, Péter Bokor, Krisztina Csabafi, Katalin Eszter Ibos, Éva Bodnár, László Török, Imre Földesi, Andrea Siska, Zsolt Bagos. The Effects of Alcohol Intoxication and Withdrawal on Hypothalamic Neurohormones and Extrahypothalamic Neurotransmitters. Biomedicines. vol 11. issue 5. 2023-05-27. PMID:37238959. |
the aim of the present study was to determine the effects of alcohol intoxication and withdrawal on hypothalamic neurohormones such as corticotropin-releasing factor (crf) and arginine vasopressin (avp), and extrahypothalamic neurotransmitters such as striatal dopamine (da), amygdalar gamma aminobutyric acid (gaba), and hippocampal glutamate (glu). |
2023-05-27 |
2023-08-14 |
rat |
| Ghallab Alotaibi, Amna Khan, Patrick J Ronan, Kabirullah Lutfy, Shafiqur Rahma. Glial Glutamate Transporter Modulation Prevents Development of Complete Freund's Adjuvant-Induced Hyperalgesia and Allodynia in Mice. Brain sciences. vol 13. issue 5. 2023-05-27. PMID:37239279. |
glial glutamate transporter (glt-1) modulation in the hippocampus and anterior cingulate cortex (acc) is critically involved in nociceptive pain. |
2023-05-27 |
2023-08-14 |
mouse |
| Do-Wan Lee, Jae-Im Kwon, Hwon Heo, Chul-Woong Woo, Na Hee Yu, Kyung Won Kim, Dong-Cheol Wo. Cerebral Glutamate Alterations Using Chemical Exchange Saturation Transfer Imaging in a Rat Model of Lipopolysaccharide-Induced Sepsis. Metabolites. vol 13. issue 5. 2023-05-26. PMID:37233677. |
this study aimed to visualize and quantitatively evaluate hippocampal glutamate alterations in a rat model of sepsis-induced brain injury using glucest and proton magnetic resonance spectroscopy ( |
2023-05-26 |
2023-08-14 |
rat |
| Alexander Maltsev, Sergei Funikov, Alexander Rezvykh, Ekaterina Teterina, Vladimir Nebogatikov, Alexander Burov, Natalia Bal, Aleksey Ustyugov, Vadim Karpov, Alexey Morozo. Chronic Administration of Non-Constitutive Proteasome Inhibitor Modulates Long-Term Potentiation and Glutamate Signaling-Related Gene Expression in Murine Hippocampus. International journal of molecular sciences. vol 24. issue 9. 2023-05-14. PMID:37175876. |
chronic administration of non-constitutive proteasome inhibitor modulates long-term potentiation and glutamate signaling-related gene expression in murine hippocampus. |
2023-05-14 |
2023-08-14 |
Not clear |