| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhen Zeng, Jing He, Tao Ya. Characteristic early changes of Glu and Cho in brain regions affected by different types of subjective cognitive decline and their clinical significance. Medicine. vol 102. issue 49. 2023-12-08. PMID:38065860. |
using the bilateral hippocampus, left posterior cingulate gyrus (pcg), and frontal lobe as regions of interest, the scope under the peak of n-acetylaspartate (naa), choline complex (cho), glutamate (glu), metabolic images (mi), and creatine (cr) was tested. |
2023-12-08 |
2023-12-17 |
human |
| Mudan Cai, Hee Ra Park, Eun Jin Yan. Electroacupuncture modulates glutamate neurotransmission to alleviate PTSD-like behaviors in a PTSD animal model. Translational psychiatry. vol 13. issue 1. 2023-11-24. PMID:37993441. |
additionally, ea treatment decreased glutamate levels and glutamate neurotransmission-related proteins (pnr1 and nr2b) in the hippocampus of a ptsd model. |
2023-11-24 |
2023-11-28 |
mouse |
| Ming-Shang Pai, Kaw-Chen Wang, Kun-Chieh Yeh, Su-Jane Wan. Stabilization of mitochondrial function by chlorogenic acid protects against kainic acid-induced seizures and neuronal cell death in rats. European journal of pharmacology. 2023-11-24. PMID:38000721. |
chlorogenic acid pretreatment also resulted in a significant reduction in glutamate elevation and neuronal death in the hippocampus of kainic acid-treated rats. |
2023-11-24 |
2023-11-28 |
rat |
| Ming-Shang Pai, Kaw-Chen Wang, Kun-Chieh Yeh, Su-Jane Wan. Stabilization of mitochondrial function by chlorogenic acid protects against kainic acid-induced seizures and neuronal cell death in rats. European journal of pharmacology. 2023-11-24. PMID:38000721. |
additionally, the levels of mitochondrial function-related proteins, including sirtuin 3, complex i, glutamate dehydrogenase 1 and atp synthase, were increased, and the level of the mitochondrial damage marker cytochrome c was decreased in the hippocampus of chlorogenic acid/kainic acid rats. |
2023-11-24 |
2023-11-28 |
rat |
| Yizhou Zhang, Meiqin Chen, Huan Chen, Shixiong Mi, Chang Wang, Hongchun Zuo, Leigang Song, Juan Du, Huixian Cui, Sha L. Testosterone reduces hippocampal synaptic damage in an androgen receptor-independent manner. The Journal of endocrinology. 2023-11-22. PMID:37991884. |
our results showed that testosterone ameliorated spatial memory deficit and neuronal damage, and increased dendritic spines density and postsynaptic density protein 95 (psd95) and glutamate receptor 1 (glua1) expression in the hippocampus of tfm male mice. |
2023-11-22 |
2023-11-29 |
mouse |
| Alicja Skórkowska, Weronika Krzyżanowska, Beata Bystrowska, Roberta Torregrossa, Matthew Whiteman, Bartosz Pomierny, Bogusława Budziszewsk. The hydrogen sulfide donor AP39 reduces glutamate-mediated excitotoxicity in a rat model of brain ischemia. Neuroscience. 2023-11-22. PMID:37993086. |
the results showed a significant longitudinal decrease in extracellular glutamate concentrations in the motor cortex and hippocampus in mcao+ap39 rats compared to mcao rats. |
2023-11-22 |
2023-11-29 |
rat |
| Adriana Fernanda K Vizuete, Fernanda Fróes, Marina Seady, Fernanda Hansen, Rodrigo Ligabue-Braun, Carlos-Alberto Gonçalves, Diogo O Souz. A Mechanism of Action of Metformin in the Brain: Prevention of Methylglyoxal-Induced Glutamatergic Impairment in Acute Hippocampal Slices. Molecular neurobiology. 2023-11-18. PMID:37980327. |
we suggest a new role of metformin in the glutamate system, whereby it protects the hippocampus against the derangements of the glutamatergic system induced by mg, possibly by phosphorylation via pkc ζ (4). |
2023-11-18 |
2023-11-20 |
Not clear |
| Mauricio Quezada, Carolina Ponce, Pablo Berríos-Cárcamo, Daniela Santapau, Javiera Gallardo, Cristian De Gregorio, María Elena Quintanilla, Paola Morales, Marcelo Ezquer, Mario Herrera-Marschitz, Yedy Israel, Paula Andrés-Herrera, Lucia Hipólito, Fernando Ezque. Amelioration of morphine withdrawal syndrome by systemic and intranasal administration of mesenchymal stem cell-derived secretome in preclinical models of morphine dependence. CNS neuroscience & therapeutics. 2023-11-06. PMID:37927136. |
the morphine-induced increases in neuroinflammation, brain oxidative stress, and alteration of glutamate levels in the hippocampus and nucleus accumbens have been associated with morphine dependence and a higher severity of withdrawal symptoms. |
2023-11-06 |
2023-11-08 |
human |
| Bataa M A El-Kafoury, Enas A Abdel-Hady, Wesam El Bakly, Wael M Elayat, Ghada Galal Hamam, Samar M M Abd El Rahman, Noha N Lashee. Lipoic acid inhibits cognitive impairment induced by multiple cell phones in young male rats: role of Sirt1 and Atg7 pathway. Scientific reports. vol 13. issue 1. 2023-10-30. PMID:37898621. |
correspondingly, there was an elevation of hippocampal ach, glutamate, and mda levels; accompanied by up-regulation of hippocampal sirt1 and atg7 gene expression. |
2023-10-30 |
2023-11-08 |
rat |
| Bataa M A El-Kafoury, Enas A Abdel-Hady, Wesam El Bakly, Wael M Elayat, Ghada Galal Hamam, Samar M M Abd El Rahman, Noha N Lashee. Lipoic acid inhibits cognitive impairment induced by multiple cell phones in young male rats: role of Sirt1 and Atg7 pathway. Scientific reports. vol 13. issue 1. 2023-10-30. PMID:37898621. |
compared to the emf-exposed group, la administration improved both learning and memory, this was proved by the significant decline in hippocampal mda and ach levels, the higher hippocampal glutamate, the downregulated hippocampal sirt1 gene expression and the upregulated atg7 gene expression. |
2023-10-30 |
2023-11-08 |
rat |
| Bataa M A El-Kafoury, Enas A Abdel-Hady, Wesam El Bakly, Wael M Elayat, Ghada Galal Hamam, Samar M M Abd El Rahman, Noha N Lashee. Lipoic acid inhibits cognitive impairment induced by multiple cell phones in young male rats: role of Sirt1 and Atg7 pathway. Scientific reports. vol 13. issue 1. 2023-10-30. PMID:37898621. |
lipoic acid treatment improved both learning and memory by enhancing autophagy and hippocampal glutamate level and by the reduced ach levels and sirt1 gene expression. |
2023-10-30 |
2023-11-08 |
rat |
| Somaye Fallahnezhad, Faezeh Ghorbani-Taherdehi, Amirhossein Sahebkar, Azade Nadim, Mehrnaz Kafashzadeh, Mehrnoosh Kafashzadeh, Mahmoud Gorji-Valokol. Potential neuroprotective effect of nanomicellar curcumin on learning and memory functions following subacute exposure to bisphenol A in adult male rats. Metabolic brain disease. 2023-10-16. PMID:37843661. |
the expression of oxidative stress markers, proinflammatory cytokines, oxidative stress-scavenging enzymes, glutamate receptors, and mapk and memory-related proteins was measured in rat hippocampus and cortical tissues. |
2023-10-16 |
2023-11-08 |
rat |
| Debpali Sur, Oryan Agranyoni, Michael Kirby, Naamah Cohen, Anastasia Bagaev, Kristina Karandasheva, Elena Shmerkin, Denis Gorobets, Brajesh Kumar Savita, Raphael Avneri, Mali-Salmon Divon, Elad Lax, Izhak Michaelevski, Albert Pinhaso. Nurture outpaces nature: fostering with an attentive mother alters social dominance in a mouse model of stress sensitivity. Molecular psychiatry. 2023-10-16. PMID:37845494. |
furthermore, adult sub/d offspring exhibited increased sociability, social dominance, and hippocampal glutamate and monoamine levels resembling the neurochemical profile of dom mice. |
2023-10-16 |
2023-11-08 |
mouse |
| Gehua Wen, Xiaoni Zhan, Xiaoming Xu, Xi Xia, Shukun Jiang, Xinghua Ren, Weishu Ren, Haoyang Lou, Lei Lu, Anca Hermenean, Jun Yao, Lina Gao, Baoman Li, Yan Lu, Xu W. Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model. Molecular neurobiology. 2023-10-15. PMID:37840071. |
in this study, we investigated pyroptosis-associated protein nlrp3/caspase-1/gsdmd-n expression in the hippocampus of mice and the toxic effect of high levels of glutamate on primary astrocytes. |
2023-10-15 |
2023-11-08 |
mouse |
| Gehua Wen, Xiaoni Zhan, Xiaoming Xu, Xi Xia, Shukun Jiang, Xinghua Ren, Weishu Ren, Haoyang Lou, Lei Lu, Anca Hermenean, Jun Yao, Lina Gao, Baoman Li, Yan Lu, Xu W. Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model. Molecular neurobiology. 2023-10-15. PMID:37840071. |
treatment with 128 mm glutamate in cortical and hippocampus astrocytes increased the level of nlrp3, and gsdmd-n, and ketamine alleviated high glutamate-induced pyroptosis-associated proteins. |
2023-10-15 |
2023-11-08 |
mouse |
| Laura Mikél McNair, Jens Velde Andersen, Helle S Waagepeterse. Stable isotope tracing reveals disturbed cellular energy and glutamate metabolism in hippocampal slices of aged male mice. Neurochemistry international. 2023-10-14. PMID:37838084. |
stable isotope tracing reveals disturbed cellular energy and glutamate metabolism in hippocampal slices of aged male mice. |
2023-10-14 |
2023-11-08 |
mouse |
| Xinyu Yao, Xiaoyi Xu, Kunhua Hu, Zhaoshou Yang, Shaodong Den. BANF1 promotes glutamate-induced apoptosis of HT-22 hippocampal neurons. Molecular biology reports. 2023-10-14. PMID:37838622. |
glutamate exposure was fatal to ht-22 neuronal cells that derived from mouse hippocampus. |
2023-10-14 |
2023-11-08 |
mouse |
| Guven Akçay, Mutay Aslan, Dijle Kipmen Korgun, Tugçe Çeker, Ezgi Akan, Narin Deri. Effects of transcranial direct current stimulation on the glutamatergic pathway in the male rat hippocampus after experimental focal cerebral ischemia. Journal of neuroscience research. 2023-10-06. PMID:37800665. |
glutamate and glutamine levels, alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate receptor (ampar1), n-methyl-d-aspartate receptors (nmdar1 and nmdar2a), vesicular glutamate transporter-1 (vglut-1), and excitatory amino acid transporters (eaat1-3) mrna expressions in hippocampus tissues were measured. |
2023-10-06 |
2023-10-07 |
rat |
| Roberta Ribeiro, Emanuele Guimarães Silva, Felipe Caixeta Moreira, Giovanni Freitas Gomes, Gabriela Reis Cussat, Barbara Stehling Ramos Silva, Maria Carolina Machado da Silva, Heliana de Barros Fernandes, Carolina de Sena Oliveira, Leonardo de Oliveira Guarnieri, Victoria Lopes, Cláudia Natália Ferreira, Ana Maria Caetano de Faria, Tatiani Uceli Maioli, Fabíola Mara Ribeiro, Aline Silva de Miranda, Grace Schenatto Pereira Moraes, Antônio Carlos Pinheiro de Oliveira, Luciene Bruno Vieir. Chronic hyperpalatable diet induces impairment of hippocampal-dependent memories and alters glutamatergic and fractalkine axis signaling. Scientific reports. vol 13. issue 1. 2023-09-29. PMID:37773430. |
our results revealed that hsb diet induced a decrease in memory reconsolidation and extinction, as well as an increase in hippocampal glutamate levels. |
2023-09-29 |
2023-10-07 |
mouse |
| Hany H Arab, Ahmed H Eid, Rania Yahia, Shuruq E Alsufyani, Ahmed M Ashour, Azza A K El-Sheikh, Hany W Darwish, Muhammed A Saad, Muhammad Y Al-Shorbagy, Marwa A Masou. Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats. Pharmaceuticals (Basel, Switzerland). vol 16. issue 9. 2023-09-28. PMID:37765022. |
notably, it significantly diminished hippocampal glutamate content and enhanced acetylcholine and gaba neurotransmitters. |
2023-09-28 |
2023-10-07 |
rat |