| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prapimpun Wongchitrat, Niyada Lansubsakul, Utcharaporn Kamsrijai, Kwankanit Sae-Ung, Sujira Mukda, Piyarat Govitrapon. Melatonin attenuates the high-fat diet and streptozotocin-induced reduction in rat hippocampal neurogenesis. Neurochemistry international. vol 100. 2018-01-31. PMID:27620814. |
the present study showed that hfd-fed and stz-treated rats significantly impaired memory in the morris water maze task, reduced neurogenesis in the hippocampus shown by a reduction in nestin, doublecortin (dcx) and β-iii tubulin immunoreactivities, reduced axon terminal markers, synaptophysin, reduced dendritic marker including postsynaptic density 95 (psd-95) and the glutamate receptor subunit nr2a. |
2018-01-31 |
2023-08-13 |
rat |
| Kevin N Hascup, Erin R Hascu. Soluble Amyloid-β42 Stimulates Glutamate Release through Activation of the α7 Nicotinic Acetylcholine Receptor. Journal of Alzheimer's disease : JAD. vol 53. issue 1. 2018-01-29. PMID:27163813. |
because aβ42 binds the α7 nicotinic acetylcholine receptors (α7nachrs) located presynaptically on glutamatergic terminals, involved with hippocampal dependent learning and memory, we examined the effects of the human, monomeric isoform of aβ42 on glutamate release in the dentate gyrus (dg), ca3, and ca1, of isoflurane anesthetized, 6-9 month old male c57bl/6j mice. |
2018-01-29 |
2023-08-13 |
mouse |
| Kevin N Hascup, Erin R Hascu. Soluble Amyloid-β42 Stimulates Glutamate Release through Activation of the α7 Nicotinic Acetylcholine Receptor. Journal of Alzheimer's disease : JAD. vol 53. issue 1. 2018-01-29. PMID:27163813. |
local application of aβ42 (0.01, 0.1, 1.0, and 10.0μm; ∼150 nl; 1-2 seconds) elicited robust, reproducible glutamate signals in all hippocampal subfields studied. |
2018-01-29 |
2023-08-13 |
mouse |
| Kevin N Hascup, Erin R Hascu. Soluble Amyloid-β42 Stimulates Glutamate Release through Activation of the α7 Nicotinic Acetylcholine Receptor. Journal of Alzheimer's disease : JAD. vol 53. issue 1. 2018-01-29. PMID:27163813. |
this study demonstrates that the human, monomeric aβ42 isoform evokes glutamate release through the α7nachr and varies across hippocampal subfields. |
2018-01-29 |
2023-08-13 |
mouse |
| S L Zup, N S Edwards, M M McCarth. Sex- and age-dependent effects of androgens on glutamate-induced cell death and intracellular calcium regulation in the developing hippocampus. Neuroscience. vol 281. 2018-01-26. PMID:25264034. |
we observed that glutamate did not induce robust or sexually dimorphic apoptosis in cultured hippocampal neurons at an early neonatal time point, but did 5days later - only in males. |
2018-01-26 |
2023-08-13 |
Not clear |
| Xiaoli Guo, Ginny G Farías, Rafael Mattera, Juan S Bonifacin. Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 36. 2018-01-25. PMID:27559088. |
we show that inactivation or depletion of rab5 in rat hippocampal neurons abrogates the somatodendritic polarity of the transferrin receptor and several glutamate receptor types, resulting in their appearance in the axon. |
2018-01-25 |
2023-08-13 |
rat |
| Roberto I Melendez, Cristina Roman, Coral M Capo-Velez, Jose A Lasalde-Dominicc. Decreased glial and synaptic glutamate uptake in the striatum of HIV-1 gp120 transgenic mice. Journal of neurovirology. vol 22. issue 3. 2018-01-24. PMID:26567011. |
moreover, immunoblot analysis showed that the protein expression of glutamate transporter subtype-1 (glt-1), the predominant brain glutamate transporter, was significantly reduced in the striatum but not in the hippocampus of gp120 mice. |
2018-01-24 |
2023-08-13 |
mouse |
| Holly C Hunsberger, Sharay E Setti, Ryan T Heslin, Jorge E Quintero, Greg A Gerhardt, Miranda N Ree. Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models. Journal of visualized experiments : JoVE. issue 123. 2018-01-23. PMID:28518111. |
as such, the method described here has been used to assess potential hippocampal disruptions in glutamate in a transgenic mouse model of alzheimer's disease. |
2018-01-23 |
2023-08-13 |
mouse |
| Tao Wu, Jianguo Jiang, Luna Yang, Haifeng Li, Wanjing Zhang, Yangyang Chen, Binggong Zhao, Boda Kong, Ping Lu, Zhenzhen Zhao, Jiawei Zhu, Zhengwei F. Timing of glucocorticoid administration determines severity of lipid metabolism and behavioral effects in rats. Chronobiology international. vol 34. issue 1. 2018-01-18. PMID:27791398. |
in addition, the expression of glutamate aspartate transporter, glial fibrillary acidic protein and glutamate transporter-1, astrocyte-related genes important for maintaining nervous system functions, was drastically decreased in the hippocampus of dex-treated rats, especially when dex was given at zt0. |
2018-01-18 |
2023-08-13 |
rat |
| S Singh, P Rana, P Kumar, L R Shankar, S Khush. Hippocampal Neurometabolite Changes in Hypothyroidism: An In Vivo (1) H Magnetic Resonance Spectroscopy Study Before and After Thyroxine Treatment. Journal of neuroendocrinology. vol 28. issue 9. 2018-01-16. PMID:27203419. |
our results revealed a significant decrease of glutamate (glu) (p = 0.045) and myo-inositol (mi) (p = 0.002) levels in the hippocampus of hypothyroid patients compared to controls. |
2018-01-16 |
2023-08-13 |
human |
| Tingting Chen, Conghui Wang, Sha Sha, Libin Zhou, Lei Chen, Ling Che. Simvastatin Enhances Spatial Memory and Long-Term Potentiation in Hippocampal CA1 via Upregulation of α7 Nicotinic Acetylcholine Receptor. Molecular neurobiology. vol 53. issue 6. 2018-01-15. PMID:26198568. |
in hippocampal slices obtained from sv mice, acute perfusion of mla blocked the increased glutamate release, whereas foh, pi3k inhibitor ly294002, or mek inhibitor u0126 could not. |
2018-01-15 |
2023-08-13 |
mouse |
| Johannes Vogt, Sergei Kirischuk, Petr Unichenko, Leslie Schlüter, Assunta Pelosi, Heiko Endle, Jenq-Wei Yang, Nikolai Schmarowski, Jin Cheng, Carine Thalman, Ulf Strauss, Alexey Prokudin, B Suman Bharati, Junken Aoki, Jerold Chun, Beat Lutz, Heiko J Luhmann, Robert Nitsc. Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 1. 2018-01-15. PMID:27909001. |
altered synaptic bioactive lipid signaling has been recently shown to augment neuronal excitation in the hippocampus of adult animals by activation of presynaptic lpa2-receptors leading to increased presynaptic glutamate release. |
2018-01-15 |
2023-08-13 |
Not clear |
| Holly C Hunsberger, James E Hickman, Miranda N Ree. Riluzole rescues alterations in rapid glutamate transients in the hippocampus of rTg4510 mice. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26744018. |
riluzole rescues alterations in rapid glutamate transients in the hippocampus of rtg4510 mice. |
2018-01-12 |
2023-08-13 |
mouse |
| Holly C Hunsberger, James E Hickman, Miranda N Ree. Riluzole rescues alterations in rapid glutamate transients in the hippocampus of rTg4510 mice. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26744018. |
here, we used enzyme-based ceramic microelectrode array technology to measure real-time phasic glutamate release and uptake events in the hippocampal subregions of taup301l mice. |
2018-01-12 |
2023-08-13 |
mouse |
| Christopher R Dorsett, Jennifer L McGuire, Tracy L Niedzielko, Erica A K DePasquale, Jaroslaw Meller, Candace L Floyd, Robert E McCullumsmit. Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression. Journal of neurotrauma. vol 34. issue 1. 2018-01-12. PMID:27312729. |
in the ipsilateral cortex and hippocampus, we found no differences in expression of the primary glutamate transporter in the brain (glt-1) 24 h after tbi. |
2018-01-12 |
2023-08-13 |
rat |
| Christopher R Dorsett, Jennifer L McGuire, Tracy L Niedzielko, Erica A K DePasquale, Jaroslaw Meller, Candace L Floyd, Robert E McCullumsmit. Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression. Journal of neurotrauma. vol 34. issue 1. 2018-01-12. PMID:27312729. |
in contrast, we found a decrease in glutamate uptake in the cortex, but not the hippocampus, 24 h after injury. |
2018-01-12 |
2023-08-13 |
rat |
| Qian Zhang, Chuang Zhang, Jia-Yin Zhang, Hui-Zhen Zhang, Xiao-Feng Li, Hong-Ling Xiao, Yan-Hui Sun, Hai-Jiao Xing, Xiao-Kang Xu, Yu-Lei Liang, Xin Zhang, Xiao-Qi Zhang, Ai-Ying L. [Influence of Electroacupuncture Intervention on Glutamic Acid and Ca Zhen ci yan jiu = Acupuncture research. vol 41. issue 6. 2018-01-11. PMID:29071893. |
[influence of electroacupuncture intervention on glutamic acid and ca to observe the influence of electroacupuncture (ea) intervention on hippocampal glutamate (glu) and ca |
2018-01-11 |
2023-08-13 |
Not clear |
| Ana Contreras, Danila Del Rio, Ana Martínez, Carmen Gil, Lidia Morales, Mariano Ruiz-Gayo, Nuria Del Olm. Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3? Neuroreport. vol 28. issue 6. 2018-01-10. PMID:28328738. |
high-fat diets (hfd) impair hippocampal-dependent learning and memory and produce important changes in synaptic transmission by enhancing glutamate uptake, decreasing synaptic efficacy, and inhibiting plasticity mechanisms such as n-methyl-d-aspartate-mediated long-term depression (ltd) within the hippocampus. |
2018-01-10 |
2023-08-13 |
mouse |
| Gitte B Christiansen, Katrine H Andersen, Sarah Riis, Anders Nykjaer, Ulrik Bolcho, Morten S Jensen, Mai Marie Hol. The sorting receptor SorCS3 is a stronger regulator of glutamate receptor functions compared to GABAergic mechanisms in the hippocampus. Hippocampus. vol 27. issue 3. 2018-01-09. PMID:27935149. |
the sorting receptor sorcs3 is a stronger regulator of glutamate receptor functions compared to gabaergic mechanisms in the hippocampus. |
2018-01-09 |
2023-08-13 |
mouse |
| Rachelle Crescenzi, Catherine DeBrosse, Ravi P R Nanga, Matthew D Byrne, Guruprasad Krishnamoorthy, Kevin D'Aquilla, Hari Nath, Knashawn H Morales, Michiyo Iba, Hari Hariharan, Virginia M Y Lee, John A Detre, Ravinder Redd. Longitudinal imaging reveals subhippocampal dynamics in glutamate levels associated with histopathologic events in a mouse model of tauopathy and healthy mice. Hippocampus. vol 27. issue 3. 2018-01-09. PMID:27997993. |
previously, glutamate chemical exchange saturation transfer (glucest) magnetic resonance imaging (mri) demonstrated that glutamate levels are reduced in regions of synapse loss in the hippocampus of a mouse model of late-stage tauopathy. |
2018-01-09 |
2023-08-13 |
mouse |