| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroki Shiwaku, Asami Umino, Masakazu Umino, Toru Nishikaw. Phencyclidine-induced dysregulation of primary cilia in the rodent brain. Brain research. vol 1674. 2018-05-22. PMID:28842124. |
using an immunohistochemical technique, we found that a subcutaneous injection of phencyclidine, an nmda type glutamate receptor (nmdar) antagonist, caused a reduction in the long axis length of a primary cilium in the ca1 region of the hippocampus without affecting that in the dentate gyrus and medial prefrontal cortex of rats and mice. |
2018-05-22 |
2023-08-13 |
mouse |
| Dainan Zhang, Alexandra J Mably, Dominic M Walsh, Michael J Rowa. Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid β- and TNFα- Mediated Synaptic Plasticity Disruption in the Rat Hippocampus. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 7. 2018-05-21. PMID:27390019. |
peripheral interventions enhancing brain glutamate homeostasis relieve amyloid β- and tnfα- mediated synaptic plasticity disruption in the rat hippocampus. |
2018-05-21 |
2023-08-13 |
rat |
| Débora Lanznaster, Josiel M Mack, Victor Coelho, Marcelo Ganzella, Roberto F Almeida, Tharine Dal-Cim, Gisele Hansel, Eduardo R Zimmer, Diogo O Souza, Rui D Prediger, Carla I Tasc. Guanosine Prevents Anhedonic-Like Behavior and Impairment in Hippocampal Glutamate Transport Following Amyloid-β Molecular neurobiology. vol 54. issue 7. 2018-05-18. PMID:27599498. |
guanosine prevents anhedonic-like behavior and impairment in hippocampal glutamate transport following amyloid-β amyloid-beta (aβ) peptides are the major neuropathological hallmarks related with alzheimer's disease (ad). |
2018-05-18 |
2023-08-13 |
mouse |
| Theresa Currier Thomas, Joshua A Beitchman, Francois Pomerleau, Teresa Noel, Paiboon Jungsuwadee, D Allan Butterfield, Daret K St Clair, Mary Vore, Greg A Gerhard. Acute treatment with doxorubicin affects glutamate neurotransmission in the mouse frontal cortex and hippocampus. Brain research. vol 1672. 2018-05-18. PMID:28705715. |
acute treatment with doxorubicin affects glutamate neurotransmission in the mouse frontal cortex and hippocampus. |
2018-05-18 |
2023-08-13 |
mouse |
| Theresa Currier Thomas, Joshua A Beitchman, Francois Pomerleau, Teresa Noel, Paiboon Jungsuwadee, D Allan Butterfield, Daret K St Clair, Mary Vore, Greg A Gerhard. Acute treatment with doxorubicin affects glutamate neurotransmission in the mouse frontal cortex and hippocampus. Brain research. vol 1672. 2018-05-18. PMID:28705715. |
cognitive function is presumed to be primarily mediated by neuronal circuitry in the frontal cortex (fc) and hippocampus, where glutamate is the primary excitatory neurotransmitter. |
2018-05-18 |
2023-08-13 |
mouse |
| Theresa Currier Thomas, Joshua A Beitchman, Francois Pomerleau, Teresa Noel, Paiboon Jungsuwadee, D Allan Butterfield, Daret K St Clair, Mary Vore, Greg A Gerhard. Acute treatment with doxorubicin affects glutamate neurotransmission in the mouse frontal cortex and hippocampus. Brain research. vol 1672. 2018-05-18. PMID:28705715. |
using novel glutamate-selective microelectrode arrays, amperometric recordings measured parameters of extracellular glutamate clearance and potassium-evoked release of glutamate within the medial fc and dentate gyrus (dg) of the hippocampus. |
2018-05-18 |
2023-08-13 |
mouse |
| Suzan G Rosa, Ana P Pesarico, Carolina F Tagliapietra, Sônia Ca da Luz, Cristina W Nogueir. Opioid system contribution to the antidepressant-like action of m-trifluoromethyl-diphenyl diselenide in mice: A compound devoid of tolerance and withdrawal syndrome. Journal of psychopharmacology (Oxford, England). vol 31. issue 9. 2018-05-17. PMID:28857657. |
treatment with m-trifluoromethyl-diphenyl diselenide induced neither tolerance to the antidepressant-like action nor physical signs of withdrawal, which could be associated with the fact that m-trifluoromethyl-diphenyl diselenide did not change the mouse cortical and hippocampal glutamate uptake and release. |
2018-05-17 |
2023-08-13 |
mouse |
| Nadezhda A Dorofeeva, Yuliya S Grigorieva, Liubov S Nikitina, Elena A Lavrova, Elizaveta V Nasluzova, Margarita V Glazova, Elena V Chernigovskay. Effects of ERK1/2 kinases inactivation on the nigrostriatal system of Krushinsky-Molodkina rats genetically prone to audiogenic seizures. Neurological research. vol 39. issue 10. 2018-05-15. PMID:28738742. |
recently, we demonstrated that inhibition of erk1/2 activity by sl-327 treatment blocks seizure behavior in krushinsky-molodkina (km) rats, which was mediated by altering of gaba and glutamate release mechanism in the hippocampus. |
2018-05-15 |
2023-08-13 |
rat |
| Michelangelo Colavita, Geoffrey Terral, Clement E Lemercier, Filippo Drago, Giovanni Marsicano, Federico Mass. Layer-specific potentiation of network GABAergic inhibition in the CA1 area of the hippocampus. Scientific reports. vol 6. 2018-05-14. PMID:27345695. |
using voltage sensitive dye imaging (vsdi) in mouse hippocampal slices, we demonstrate that gabaa-mediated field inhibitory postsynaptic potentials undergo layer-specific potentiation upon activation of metabotropic glutamate receptors (mglu). |
2018-05-14 |
2023-08-13 |
mouse |
| Eva Punzón, Fernanda García-Alvarado, Marcos Maroto, Cristina Fernández-Mendívil, Patrycja Michalska, Isabel García-Álvarez, Juan Alberto Arranz-Tagarro, Izaskun Buendia, Manuela G López, Rafael León, Luis Gandía, Alfonso Fernández-Mayoralas, Antonio G Garcí. Novel sulfoglycolipid IG20 causes neuroprotection by activating the phase II antioxidant response in rat hippocampal slices. Neuropharmacology. vol 116. 2018-05-09. PMID:28007500. |
here we have shown that ig20 at 0.3-10 μm afforded neuroprotection in rat hippocampal slices stressed with veratridine, glutamate or with oxygen plus glucose deprivation followed by reoxygenation (ogd/reox). |
2018-05-09 |
2023-08-13 |
rat |
| Eva Punzón, Fernanda García-Alvarado, Marcos Maroto, Cristina Fernández-Mendívil, Patrycja Michalska, Isabel García-Álvarez, Juan Alberto Arranz-Tagarro, Izaskun Buendia, Manuela G López, Rafael León, Luis Gandía, Alfonso Fernández-Mayoralas, Antonio G Garcí. Novel sulfoglycolipid IG20 causes neuroprotection by activating the phase II antioxidant response in rat hippocampal slices. Neuropharmacology. vol 116. 2018-05-09. PMID:28007500. |
excess production of reactive oxygen species (ros) elicited by glutamate or odg/reox was prevented by ig20 that also restored the depressed tissue levels of gsh and atp in hippocampal slices subjected to ogd/reox. |
2018-05-09 |
2023-08-13 |
rat |
| Kentaro Tokudome, Takahiro Okumura, Saki Shimizu, Tomoji Mashimo, Akiko Takizawa, Tadao Serikawa, Ryo Terada, Shizuka Ishihara, Naofumi Kunisawa, Masashi Sasa, Yukihiro Ohn. Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission. Scientific reports. vol 6. 2018-05-02. PMID:27265781. |
neurochemical studies revealed that the sv2a(l174q) mutation specifically reduced depolarization-induced gaba, but not glutamate, release in the hippocampus without affecting basal release or the sv2a expression level in gabaergic neurons. |
2018-05-02 |
2023-08-13 |
rat |
| T Fuchsberger, S Martínez-Bellver, E Giraldo, V Teruel-Martí, A Lloret, J Viñ. Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival. Scientific reports. vol 6. 2018-05-02. PMID:27514492. |
we confirmed the main findings in vivo using microinjection of either aβ or glutamate in the ca1 region of the rat hippocampus. |
2018-05-02 |
2023-08-13 |
rat |
| Jens Velde Andersen, Jakob Dahl Nissen, Sofie Kjellerup Christensen, Kia Hjulmand Markussen, Helle Sønderby Waagepeterse. Impaired Hippocampal Glutamate and Glutamine Metabolism in the db/db Mouse Model of Type 2 Diabetes Mellitus. Neural plasticity. vol 2017. 2018-04-23. PMID:28695014. |
impaired hippocampal glutamate and glutamine metabolism in the db/db mouse model of type 2 diabetes mellitus. |
2018-04-23 |
2023-08-13 |
mouse |
| Baomei Xia, Chang Chen, Hailou Zhang, Wenda Xue, Juanjuan Tang, Weiwei Tao, Ruyan Wu, Li Ren, Wei Wang, Gang Che. Chronic stress prior to pregnancy potentiated long-lasting postpartum depressive-like behavior, regulated by Akt-mTOR signaling in the hippocampus. Scientific reports. vol 6. 2018-04-19. PMID:27756905. |
chronic stress induced transient decrease in akt-mtor signaling and altered expressions of glutamate receptor subunits nr1 and glur1, in contrast to long-term deficits in akt-mtor signaling, glur1/nr1 ratio, and hippocampal neurogenesis in ppd-like mice. |
2018-04-19 |
2023-08-13 |
mouse |
| Carlos Manlio Díaz-García, Rebecca Mongeon, Carolina Lahmann, Dorothy Koveal, Hannah Zucker, Gary Yelle. Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake. Cell metabolism. vol 26. issue 2. 2018-04-17. PMID:28768175. |
using metabolic biosensors in acute hippocampal slices and brains of awake mice, we find that neuronal metabolic responses to stimulation do not depend on astrocytic stimulation by glutamate release, nor do they require neuronal uptake of lactate; instead they reflect increased direct glucose consumption by neurons. |
2018-04-17 |
2023-08-13 |
mouse |
| Taekyung Kwon, Masayuki Sakamoto, Darcy S Peterka, Rafael Yust. Attenuation of Synaptic Potentials in Dendritic Spines. Cell reports. vol 20. issue 5. 2018-04-17. PMID:28768195. |
here, we study spine electrical properties in cultured hippocampal neurons using an improved genetically encoded voltage indicator (arclight) and two-photon glutamate uncaging. |
2018-04-17 |
2023-08-13 |
Not clear |
| Yukihiro Ohno, Kentaro Tokudom. Therapeutic Role of Synaptic Vesicle Glycoprotein 2A (SV2A) in Modulating Epileptogenesis. CNS & neurological disorders drug targets. vol 16. issue 4. 2018-04-16. PMID:28393712. |
although the functional mechanisms of sv2a in regulating epileptogenesis remain unknown, studies using animals carrying the sv2a missense mutation showed that the dysfunction of sv2a preferentially disrupts action potential-induced γ-aminiobutyric acid (gaba), but not glutamate, released in the limbic regions (i.e., hippocampus and amygdala) and markedly facilitates kindling epileptogenesis. |
2018-04-16 |
2023-08-13 |
mouse |
| Chih-Ming Chen, Lauren L Orefice, Shu-Ling Chiu, Tara A LeGates, Samer Hattar, Richard L Huganir, Haiqing Zhao, Baoji Xu, Rejji Kuruvill. Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 4. 2018-04-12. PMID:28069946. |
wnt5a expression in hippocampal neurons begins postnatally, and its deletion attenuated camkii and rac1 activity, reduced glun1 glutamate receptor expression, and impaired synaptic plasticity and spatial learning and memory in 3-mo-old mice. |
2018-04-12 |
2023-08-13 |
mouse |
| Piyaporn Thorajak, Wanassanun Pannangrong, Jariya Umka Welbat, Wunnee Chaijaroonkhanarak, Kittisak Sripanidkulchai, Bungorn Sripanidkulcha. Effects of Aged Garlic Extract on Cholinergic, Glutamatergic and GABAergic Systems with Regard to Cognitive Impairment in Aβ-Induced Rats. Nutrients. vol 9. issue 7. 2018-04-09. PMID:28671572. |
the rats were then euthanized to investigate any changes to the cholinergic neurons, vesicular glutamate transporter 1 and 2 proteins (vglut1 and vglut2), and glutamate decarboxylase (gad) in the hippocampus. |
2018-04-09 |
2023-08-13 |
rat |