| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Márcio S Baptista, Carlos V Melo, Mário Armelão, Dennis Herrmann, Diogo O Pimentel, Graciano Leal, Margarida V Caldeira, Ben A Bahr, Mário Bengtson, Ramiro D Almeida, Carlos B Duart. Role of the proteasome in excitotoxicity-induced cleavage of glutamic acid decarboxylase in cultured hippocampal neurons. PloS one. vol 5. issue 4. 2011-06-16. PMID:20405034. |
we found that excitotoxic stimulation of cultured hippocampal neurons with glutamate leads to a time-dependent cleavage of gad65 and gad67 in the n-terminal region of the proteins, and decrease the corresponding mrnas. |
2011-06-16 |
2023-08-12 |
Not clear |
| Julie M Ziobro, Laxmikant S Deshpande, Robert J Delorenz. An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges. Brain research. vol 1371. 2011-06-14. PMID:21111720. |
the objective of this study was to develop an in vitro model of epileptogenesis induced by glutamate injury in organotypic hippocampal slice cultures (ohscs), as observed in stroke-induced acquired epilepsy. |
2011-06-14 |
2023-08-12 |
rat |
| Julie M Ziobro, Laxmikant S Deshpande, Robert J Delorenz. An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges. Brain research. vol 1371. 2011-06-14. PMID:21111720. |
glutamate exposure produced a subset of hippocampal neurons that died acutely and a larger population of injured but surviving neurons. |
2011-06-14 |
2023-08-12 |
rat |
| Stoyan G Popkirov, Denise Manahan-Vaugha. Involvement of the metabotropic glutamate receptor mGluR5 in NMDA receptor-dependent, learning-facilitated long-term depression in CA1 synapses. Cerebral cortex (New York, N.Y. : 1991). vol 21. issue 3. 2011-06-13. PMID:20525770. |
the metabotropic glutamate receptor subtype 5 (mglur5) is critically involved in enabling the persistency of multiple forms of hippocampal synaptic plasticity. |
2011-06-13 |
2023-08-12 |
rat |
| Dimitri De Bundel, Anneleen Schallier, Ellen Loyens, Ruani Fernando, Hirohisa Miyashita, Joeri Van Liefferinge, Katia Vermoesen, Shiro Bannai, Hideyo Sato, Yvette Michotte, Ilse Smolders, Ann Massi. Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 15. 2011-06-13. PMID:21490221. |
loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility. |
2011-06-13 |
2023-08-12 |
mouse |
| Dimitri De Bundel, Anneleen Schallier, Ellen Loyens, Ruani Fernando, Hirohisa Miyashita, Joeri Van Liefferinge, Katia Vermoesen, Shiro Bannai, Hideyo Sato, Yvette Michotte, Ilse Smolders, Ann Massi. Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 15. 2011-06-13. PMID:21490221. |
interestingly, we observed significantly lower extracellular hippocampal glutamate concentrations in xct(-/-) mice compared to wild-type littermates. |
2011-06-13 |
2023-08-12 |
mouse |
| Dimitri De Bundel, Anneleen Schallier, Ellen Loyens, Ruani Fernando, Hirohisa Miyashita, Joeri Van Liefferinge, Katia Vermoesen, Shiro Bannai, Hideyo Sato, Yvette Michotte, Ilse Smolders, Ann Massi. Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 15. 2011-06-13. PMID:21490221. |
moreover, intrahippocampal perfusion with system x(c)- inhibitors lowered extracellular glutamate, whereas the system x(c)- activator n-acetylcysteine elevated extracellular glutamate in the rat hippocampus. |
2011-06-13 |
2023-08-12 |
mouse |
| Dimitri De Bundel, Anneleen Schallier, Ellen Loyens, Ruani Fernando, Hirohisa Miyashita, Joeri Van Liefferinge, Katia Vermoesen, Shiro Bannai, Hideyo Sato, Yvette Michotte, Ilse Smolders, Ann Massi. Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 15. 2011-06-13. PMID:21490221. |
this indicates that system x(c)- may be an interesting target for pathologies associated with excessive extracellular glutamate release in the hippocampus. |
2011-06-13 |
2023-08-12 |
mouse |
| Dimitri De Bundel, Anneleen Schallier, Ellen Loyens, Ruani Fernando, Hirohisa Miyashita, Joeri Van Liefferinge, Katia Vermoesen, Shiro Bannai, Hideyo Sato, Yvette Michotte, Ilse Smolders, Ann Massi. Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 15. 2011-06-13. PMID:21490221. |
these novel findings sustain that system x(c)-) is an important source of extracellular glutamate in the hippocampus. |
2011-06-13 |
2023-08-12 |
mouse |
| Veronica Musante, Maria Summa, Rodrigo A Cunha, Maurizio Raiteri, Anna Pittalug. Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions. Journal of neurochemistry. vol 117. issue 3. 2011-06-10. PMID:21348870. |
rat hippocampal glutamatergic terminals possess nmda autoreceptors whose activation by low micromolar nmda elicits glutamate exocytosis in the presence of physiological mg(2+) (1.2 mm), the release of glutamate being significantly reduced when compared to that in mg(2+)-free condition. |
2011-06-10 |
2023-08-12 |
rat |
| W Dimpfel, J A Hoffman. Effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro. BMC pharmacology. vol 11. 2011-06-06. PMID:21338509. |
effects of rasagiline, its metabolite aminoindan and selegiline on glutamate receptor mediated signalling in the rat hippocampus slice in vitro. |
2011-06-06 |
2023-08-12 |
rat |
| Ling Zhong, Kanwardeep S Kaleka, Nashaat Z Gerge. Neurogranin phosphorylation fine-tunes long-term potentiation. The European journal of neuroscience. vol 33. issue 2. 2011-06-01. PMID:21198977. |
learning-related potentiation of synaptic strength at cornu ammonis subfield 1 (ca1) hippocampal excitatory synapses is dependent on neuronal activity and the activation of glutamate receptors. |
2011-06-01 |
2023-08-12 |
rat |
| Lech Kiedrowsk. Cytosolic zinc release and clearance in hippocampal neurons exposed to glutamate--the role of pH and sodium. Journal of neurochemistry. vol 117. issue 2. 2011-05-27. PMID:21255017. |
cytosolic zinc release and clearance in hippocampal neurons exposed to glutamate--the role of ph and sodium. |
2011-05-27 |
2023-08-12 |
Not clear |
| Lech Kiedrowsk. Cytosolic zinc release and clearance in hippocampal neurons exposed to glutamate--the role of pH and sodium. Journal of neurochemistry. vol 117. issue 2. 2011-05-27. PMID:21255017. |
the present work addressed these mechanisms in cultured hippocampal neurons exposed to glutamate and glycine (glu/gly). |
2011-05-27 |
2023-08-12 |
Not clear |
| João R Gomes, Andrea C Lobo, Carlos V Melo, Ana R Inácio, Jiro Takano, Nobuhisa Iwata, Takaomi C Saido, Luís P de Almeida, Tadeusz Wieloch, Carlos B Duart. Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 12. 2011-05-27. PMID:21430162. |
we found that vgat is cleaved by calpains following excitotoxic stimulation of hippocampal neurons with glutamate, giving rise to a stable truncated cleavage product (tvgat). |
2011-05-27 |
2023-08-12 |
mouse |
| Christopher G Thomas, Hua Tian, Jeffrey S Diamon. The relative roles of diffusion and uptake in clearing synaptically released glutamate change during early postnatal development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 12. 2011-05-27. PMID:21430173. |
both factors change greatly in the rodent hippocampus during the second postnatal week when most synapses become established and begin to mature, processes that are influenced by synaptically released glutamate. |
2011-05-27 |
2023-08-12 |
mouse |
| Christopher G Thomas, Hua Tian, Jeffrey S Diamon. The relative roles of diffusion and uptake in clearing synaptically released glutamate change during early postnatal development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 12. 2011-05-27. PMID:21430173. |
we investigated whether these competing changes influence the glutamate concentration time course and postsynaptic responses in the ca1 region of the mouse hippocampus during this critical period of synaptic development. |
2011-05-27 |
2023-08-12 |
mouse |
| Taku Doi, Yuto Ueda, Mayuko Takaki, L James Willmor. Differential molecular regulation of glutamate in kindling resistant rats. Brain research. vol 1375. 2011-05-23. PMID:21138736. |
using pentylenetetrazol (ptz) kindling, we collected hippocampal tissue from standard response and kindling resistant animals, measuring hippocampal mrna with real-time pcr of glutamate transporters glast, glt-1, and eaac1 and the sodium-coupled neutral amino acid transporter (snat) 1, snat2, and snat3. |
2011-05-23 |
2023-08-12 |
rat |
| Marcos Roberto de Oliveira, Ricardo Fagundes da Rocha, Laura Stertz, Gabriel Rodrigo Fries, Diogo Losch de Oliveira, Flávio Kapczinski, José Cláudio Fonseca Moreir. Total and mitochondrial nitrosative stress, decreased brain-derived neurotrophic factor (BDNF) levels and glutamate uptake, and evidence of endoplasmic reticulum stress in the hippocampus of vitamin A-treated rats. Neurochemical research. vol 36. issue 3. 2011-05-19. PMID:21188516. |
total and mitochondrial nitrosative stress, decreased brain-derived neurotrophic factor (bdnf) levels and glutamate uptake, and evidence of endoplasmic reticulum stress in the hippocampus of vitamin a-treated rats. |
2011-05-19 |
2023-08-12 |
rat |
| Marcos Roberto de Oliveira, Ricardo Fagundes da Rocha, Laura Stertz, Gabriel Rodrigo Fries, Diogo Losch de Oliveira, Flávio Kapczinski, José Cláudio Fonseca Moreir. Total and mitochondrial nitrosative stress, decreased brain-derived neurotrophic factor (BDNF) levels and glutamate uptake, and evidence of endoplasmic reticulum stress in the hippocampus of vitamin A-treated rats. Neurochemical research. vol 36. issue 3. 2011-05-19. PMID:21188516. |
then, we performed the present work to investigate the effects of vitamin a supplementation at clinical doses (1,000-9,000 iu/kg day(-1)) for 28 days on rat hippocampal nitrosative stress levels (both total and mitochondrial), bioenergetics states, brain-derived neurotrophic factor (bdnf), alpha- and beta-synucleins, bip and dopamine receptor 2 (d2 receptor) contents, and glutamate uptake. |
2011-05-19 |
2023-08-12 |
rat |