| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Júlio Santos-Terra, Iohanna Deckmann, Giovanna Carello-Collar, Gustavo Della-Flora Nunes, Guilherme Bauer-Negrini, Gustavo Brum Schwingel, Mellanie Fontes-Dutra, Rudimar Riesgo, Carmem Gottfrie. Resveratrol Prevents Cytoarchitectural and Interneuronal Alterations in the Valproic Acid Rat Model of Autism. International journal of molecular sciences. vol 23. issue 8. 2022-04-23. PMID:35456893. |
we evaluated the effect of prenatal treatment with resveratrol (rsv) on the neuronal organization and quantity of parvalbumin-positive (pv+), somatostatin-positive (som+), and calbindin-positive (cb+) gabaergic interneurons, besides the levels of synaptic proteins and gaba receptors in the medial prefrontal cortex (mpfc) and hippocampus (hc) of the asd model induced by valproic acid (vpa). |
2022-04-23 |
2023-08-13 |
rat |
| Maria Bove, Stefania Schiavone, Paolo Tucci, Vladyslav Sikora, Stefania Dimonte, Anna Laura Colia, Maria Grazia Morgese, Luigia Trabac. Ketamine administration in early postnatal life as a tool for mimicking Autism Spectrum Disorders core symptoms. Progress in neuro-psychopharmacology & biological psychiatry. 2022-04-23. PMID:35460811. |
moreover, by using this mouse model, we performed neurochemical and biomolecular analyses, quantifying neurotransmitters belonging to excitatory-inhibitory pathways, such as glutamate, glutamine and gamma-aminobutyric acid (gaba), as well as immune activation biomarkers related to asd, such as cd11b and glial fibrillary acidic protein (gfap), in the hippocampus and amygdala. |
2022-04-23 |
2023-08-13 |
mouse |
| Maria Bove, Stefania Schiavone, Paolo Tucci, Vladyslav Sikora, Stefania Dimonte, Anna Laura Colia, Maria Grazia Morgese, Luigia Trabac. Ketamine administration in early postnatal life as a tool for mimicking Autism Spectrum Disorders core symptoms. Progress in neuro-psychopharmacology & biological psychiatry. 2022-04-23. PMID:35460811. |
in addition, we found decreased bdnf and enhanced gfap hippocampal expression levels, accompanied by elevations in glutamate amount, as well as reduction in gaba content in amygdala and hippocampus. |
2022-04-23 |
2023-08-13 |
mouse |
| Jia-Xing Liu, Jia-Han Li, Chen-Hui DU, Yan Ya. [Metabonomic study of biochemical changes in serum of PCPA-induced insomnia rats after treatment with Suanzaoren Decoction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 6. 2022-03-29. PMID:35347962. |
then pathological changes of the liver and brain were observed and biochemical indexes such as 5-hydroxytryptamine(5-ht), dopamine(da), glutamate(glu), γ-aminobutyric acid(gaba), and norepinephrine(ne) in the hippocampus and prostaglandin d2(pgd2), tumor necrosis factor-α(tnf-α), interleukin-1β(il-1β), and il-6 in the serum of rats were detected. |
2022-03-29 |
2023-08-13 |
rat |
| Jia-Xing Liu, Jia-Han Li, Chen-Hui DU, Yan Ya. [Metabonomic study of biochemical changes in serum of PCPA-induced insomnia rats after treatment with Suanzaoren Decoction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 6. 2022-03-29. PMID:35347962. |
the results showed that szrd could improve the pathological changes of brain and liver tissues, increase the levels of neurotransmitters 5-ht, da, and gaba in hippocampus and the level of pgd2 in hypothalamic-pituitary-adrenal axis(hpa axis), and reduce the levels of il-1β and tnf-α in serum of insomnia rats. |
2022-03-29 |
2023-08-13 |
rat |
| Josh Allen, Raquel Romay-Tallon, Milann A Mitchell, Kyle J Brymer, Jenessa Johnston, Carla L Sánchez-Lafuente, Graziano Pinna, Lisa E Kalynchuk, Hector J Carunch. Reelin has antidepressant-like effects after repeated or singular peripheral injections. Neuropharmacology. 2022-03-28. PMID:35341790. |
injections of reelin were effective in rescuing the cort-induced increases in forced-swim-test immobility in male and female rats, decreases in reelin-immunopositive cells in the dentate gyrus subgranular zone, and expression of hippocampal gaba |
2022-03-28 |
2023-08-13 |
rat |
| Bartłomiej Szulczyk, Anna Spyrk. Menthol exerts TRPM8-independent antiepileptic effects in prefrontal cortex pyramidal neurons. Brain research. 2022-03-01. PMID:35227652. |
it has been shown previously that menthol exerts antiepileptic effects in hippocampal neurons by enhancing gaba receptors. |
2022-03-01 |
2023-08-13 |
Not clear |
| Daniele C Wolf, Nathalie T Sanon, Alexandra O S Cunha, Jia-Shu Chen, Tarek Shaker, Abdul-Rahman Elhassan, Antônia Sâmia Fernandes do Nascimento, Graziella Di Cristo, Alexander G Wei. Sex-specific differences in KCC2 localisation and inhibitory synaptic transmission in the rat hippocampus. Scientific reports. vol 12. issue 1. 2022-02-25. PMID:35210456. |
in the hippocampus, mrna levels of proteins associated with gaba signaling were not significantly affected at postnatal day (p) 7 or p40. |
2022-02-25 |
2023-08-13 |
rat |
| B Spurny-Dworak, P Handschuh, M Spies, U Kaufmann, R Seiger, M Klöbl, M E Konadu, M B Reed, V Ritter, P Baldinger-Melich, W Bogner, G S Kranz, R Lanzenberge. Effects of sex hormones on brain GABA and glutamate levels in a cis- and transgender cohort. Psychoneuroendocrinology. vol 138. 2022-02-17. PMID:35176535. |
mean gaba+ (combination of gaba and macromolecules) and glx (combination of glutamate and glutamine) ratios to total creatine (gaba+/tcr, glx/tcr) were calculated in five predefined regions-of-interest (hippocampus, insula, pallidum, putamen and thalamus). |
2022-02-17 |
2023-08-13 |
human |
| Meinrad Drexel, Sadegh Rahimi, Günther Sper. Silencing of hippocampal somatostatin interneurons induces recurrent spontaneous limbic seizures in mice. Neuroscience. 2022-02-15. PMID:35167940. |
we now investigated whether impairing this type of feed-back inhibition by selectively inhibiting gaba release from sst expressing interneurons in hippocampal sector ca1 and subiculum may be sufficient to induce spontaneous recurrent seizures. |
2022-02-15 |
2023-08-13 |
mouse |
| Xiaoyue Wei, Kezhu Wang, Jinfeng Gao, Shijian Chen, Siying Zeng, Yuhong Zha. FG7142 combined with restraint stress induces anxiogenic-like effects via downregulation gamma-aminobutyric acid type A receptor subunit alpha1 and 5-hydroxytryptamine 1A receptors expression in the hippocampus. Neuroreport. vol 33. issue 3. 2022-02-09. PMID:35139062. |
fg7142 combined with restraint stress induces anxiogenic-like effects via downregulation gamma-aminobutyric acid type a receptor subunit alpha1 and 5-hydroxytryptamine 1a receptors expression in the hippocampus. |
2022-02-09 |
2023-08-13 |
Not clear |
| Yosra A Hussien, Dina F Mansour, Somaia A Nada, Sahar S Abd El-Rahman, Rania M Abdelsalam, Amina S Attia, Dalia M El-Tanboul. Linagliptin attenuates thioacetamide-induced hepatic encephalopathy in rats: Modulation of C/EBP-β and CX3CL1/Fractalkine, neuro-inflammation, oxidative stress and behavioral defects. Life sciences. 2022-02-08. PMID:35134437. |
lng modulated taa-induced disturbances in hippocampal amino acids; glutamate, and gaba with a significant increase in hippocampal bdnf. |
2022-02-08 |
2023-08-13 |
rat |
| Haicong Zhou, Shibo Zhang, Xueqi Zhang, Hong Zhou, Tieqiao Wen, Jiao Wan. Depression-like symptoms due to Dcf1 deficiency are alleviated by intestinal transplantation of Lactobacillus murine and Lactobacillus reuteri. Biochemical and biophysical research communications. vol 593. 2022-01-23. PMID:35066403. |
in the present study, we found that dcf1 knockout (ko) mice had depression-like symptoms and disruptive changes in gamma-aminobutyric acid (gaba) concentration and gaba receptor expression were found in the hippocampus of dcf1 ko and wt mice. |
2022-01-23 |
2023-08-13 |
mouse |
| Wen-Long Xie, Hui-Ling Zheng, Hou-Hong Li, Jia-Jing Lu, Shi-Ge Xue, Yi Luo, Cong Ma, Jian-Feng Liu, Zhuang-Li Hu, Lan Ni, You Jin, Fang Wang, Jian-Guo Che. Deficiency of Glycosylated α-Dystroglycan in Ventral Hippocampus Bridges the Destabilization of Gamma-Aminobutyric Acid Type A Receptors With the Depressive-like Behaviors of Male Mice. Biological psychiatry. 2022-01-22. PMID:35063187. |
deficiency of glycosylated α-dystroglycan in ventral hippocampus bridges the destabilization of gamma-aminobutyric acid type a receptors with the depressive-like behaviors of male mice. |
2022-01-22 |
2023-08-13 |
mouse |
| Caifeng Shao, Jiaxue Dong, Mingwei Zhao, Shenhao Liu, Xue Wang, Yang Yu, Lingyan Fang, Ziying Zhu, Qian Chen, Xu Xiao, Wei-Ning Zhang, Kun Yan. Presynaptic GABA Neuroscience letters. 2022-01-13. PMID:35026332. |
presynaptic gaba combining cell type-specific optogenetics and whole cell recordings on mouse acute hippocampal slices, we compared gaba release from cholecystokinin-expressing (cck) and parvalbumin-expressing (pv) interneurons onto ca1 pyramidal neurons. |
2022-01-13 |
2023-08-13 |
mouse |
| Tania López-Hernández, Koh-Ichiro Takenaka, Yasunori Mori, Pornparn Kongpracha, Shushi Nagamori, Volker Haucke, Shigeo Takamor. Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses. eLife. vol 11. 2022-01-11. PMID:35014951. |
we report on the comprehensive survey of six major sv proteins to show that sv endocytosis in mouse hippocampal neurons at physiological temperature occurs independent of clathrin while the endocytic retrieval of a subset of sv proteins including the vesicular transporters for glutamate and gaba depend on sorting by the clathrin adaptor ap-2. |
2022-01-11 |
2023-08-13 |
mouse |
| Alberto Marcos, Inmaculada Ballesteros-Yáñez, Carlos A Castillo-Sarmiento, Felipe Pardo, David Roura-Martínez, José Ramón Muñoz-Rodríguez, Alejandro Higuera-Matas, Emilio Ambrosi. The interactions of alcohol and cocaine regulate the expression of genes involved in the GABAergic, glutamatergic and endocannabinoid systems of male and female rats. Neuropharmacology. 2021-12-29. PMID:34965406. |
brain samples from the medial prefrontal cortex, nucleus accumbens, hippocampus and amygdala were extracted to analyse the mrna expression of genes encoding subunits of the gaba, nmda and ampa receptors, as well as the expression of the cb1 receptor, and that of enzymes related to the biosynthesis and degradation of endocannabinoids. |
2021-12-29 |
2023-08-13 |
rat |
| Francesca Logiacco, Pengfei Xia, Svilen Veselinov Georgiev, Celeste Franconi, Yi-Jen Chang, Bilge Ugursu, Anje Sporbert, Ralf Kühn, Helmut Kettenmann, Marcus Semtne. Microglia sense neuronal activity via GABA in the early postnatal hippocampus. Cell reports. vol 37. issue 13. 2021-12-29. PMID:34965412. |
microglia sense neuronal activity via gaba in the early postnatal hippocampus. |
2021-12-29 |
2023-08-13 |
Not clear |
| Paulina Kazmierska-Grebowska, Marcin Siwiec, Joanna Ewa Sowa, Bartosz Caban, Tomasz Kowalczyk, Renata Bocian, M Bruce MacIve. Lamotrigine Attenuates Neuronal Excitability, Depresses GABA Synaptic Inhibition, and Modulates Theta Rhythms in Rat Hippocampus. International journal of molecular sciences. vol 22. issue 24. 2021-12-24. PMID:34948401. |
lamotrigine attenuates neuronal excitability, depresses gaba synaptic inhibition, and modulates theta rhythms in rat hippocampus. |
2021-12-24 |
2023-08-13 |
rat |
| Shijia Chen, Fengpei Chen, Nashwa Amin, Qiannan Ren, Shan Ye, Zhiying Hu, Xiaoning Tan, Mizu Jiang, Marong Fan. Defects of parvalbumin-positive interneurons in the ventral dentate gyrus region are implicated depression-like behavior in mice. Brain, behavior, and immunity. vol 99. 2021-12-11. PMID:34562597. |
fast-spiking parvalbumin-positive interneurons (pvis), a subpopulation of gabaergic interneurons (gaba, g-aminobutyric acid), exhibit a widespread distribution throughout the hippocampus, and has been reported to play an important role in a variety of mental disorders. |
2021-12-11 |
2023-08-13 |
mouse |