| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Y Reyes-Bravo, P Villalobos-Aguilera, J T Almonte-Zepeda, M S Mendoza-Trejo, M Giordano, A Orozco, V M Rodrígue. Chronic atrazine exposure increases the expression of genes associated with GABAergic and glutamatergic systems in the brain of male albino rat. Frontiers in toxicology. vol 4. 2022-09-08. PMID:36071823. |
at the end of the atr treatment, the levels of mrna of several genes involved in the production, vesiculation, reuptake, and receptors of gaba and glu in the striatum (str), nucleus accumbens (nacc), prefrontal cortex (pfc), ventral midbrain (vmid) and hippocampus (hipp) were evaluated by absolute qpcr. |
2022-09-08 |
2023-08-14 |
rat |
| Alba García-Baos, Ines Gallego-Landin, Irene Ferreres-Álvarez, Xavier Puig-Reyne, Adriana Castro-Zavala, Olga Valverde, Ana Martín-Sánche. Effects of fast-acting antidepressant drugs on a postpartum depression mice model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 154. 2022-08-27. PMID:36029538. |
such symptoms are accompanied by lower allopregnanolone serum levels, reduction of vesicular transporters of gaba (vgat) and glutamate (vglut1) in the infralimbic cortex (il), as well as decreased hippocampal cellular proliferation. |
2022-08-27 |
2023-08-14 |
mouse |
| Nikita S Persaud, Hannah M Cate. The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review. eNeuro. 2022-08-23. PMID:35998298. |
in this review, we summarize and discuss a plethora of dna methylation, histone modification, and associated gene expression differences underscoring the anxiety phenotype.findings we outline include expression changes of various dmnts and changes in histone modifications that affect the hypothalamic pituitary adrenal axis and stress response as well as gaba, glutamate, and bdnf signaling in the pfc, amygdala, hypothalamus, and hippocampus. |
2022-08-23 |
2023-08-14 |
Not clear |
| Wenfei Wang, Yichun Wang, Qiuting Guo, Huiting Li, Zhaoqiang Wang, Jia Li, Taotao Li, Tiantian Tang, Yujiao Wang, Yanzhuo Jia, Yao Wang, Junbo Zou, Yajun Shi, Dongyan Guo, Ming Yang, Xiaofei Zhang, Jing Su. Valerian essential oil for treating insomnia Frontiers in nutrition. vol 9. 2022-08-22. PMID:35990355. |
valerian essential oil was given orally for treatment and the contents of 5-hydroxytryptamine receptor 1 a (5-ht1ar), γ-aminobutyric acid (gaba), cyclic adenosine monophosphate (camp), and protein kinase a (pka) in the hippocampus of rats in each group were detected by enzyme-linked immunosorbent assay (elisa), western blot, polymerase chain reaction (pcr), and immunohistochemistry. |
2022-08-22 |
2023-08-14 |
rat |
| Zhiqian Yu, Mai Sakai, Hotaka Fukushima, Chiaki Ono, Yoshie Kikuchi, Ryuta Koyama, Ko Matsui, Tomoyuki Furuyashiki, Satoshi Kida, Hiroaki Tomit. Contextual fear conditioning regulates synapse-related gene transcription in mouse microglia. Brain research bulletin. 2022-08-20. PMID:35987296. |
furthermore, in the hippocampal microglia, we found that the expression of neurotransmitter release regulators, γ-aminobutyric acid (gaba) receptor gabrb3 and synapsin 1/2, increased under fear memory consolidation and restored (decreased) after extinction. |
2022-08-20 |
2023-08-14 |
mouse |
| Mohieldin M M Youssef, Hiro Taiyo Hamada, Esther Suk King Lai, Yuji Kiyama, Mohamed El-Tabbal, Hiroshi Kiyonari, Kohei Nakano, Bernd Kuhn, Tadashi Yamamot. TOB is an effector of the hippocampus-mediated acute stress response. Translational psychiatry. vol 12. issue 1. 2022-07-29. PMID:35906220. |
electrophysiological recordings in hippocampal slices showed increased postsynaptic ampar-mediated neurotransmission, accompanied by decreased gaba neurotransmission and subsequently altered excitatory/inhibitory balance after tob deletion. |
2022-07-29 |
2023-08-14 |
mouse |
| Gergana Mincheva, Carla Gimenez-Garzo, Paula Izquierdo-Altarejos, Mar Martinez-Garcia, Magnus Doverskog, Thomas P Blackburn, Anneli Hällgren, Torbjörn Bäckström, Marta Llansola, Vicente Felip. Golexanolone, a GABA CNS neuroscience & therapeutics. 2022-07-26. PMID:35880480. |
golexanolone, a gaba hyperammonemic rats show peripheral inflammation, increased gabaergic neurotransmission and neuroinflammation in cerebellum and hippocampus which induce motor incoordination and cognitive impairment. |
2022-07-26 |
2023-08-14 |
rat |
| Dalia A Nawwar, Hala F Zaki, Rabab H Saye. Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia-like behaviors in rats. Inflammopharmacology. 2022-07-25. PMID:35876932. |
they also increased the gamma-aminobutyric acid and glutamate levels and glutamate decarboxylase 67 and parvalbumin mrna expression in the hippocampus. |
2022-07-25 |
2023-08-14 |
rat |
| Xuechun Cai, Lili Qiu, Chaoran Wang, Hang Yang, Zhenhui Zhou, Meng Mao, Yunqing Zhu, Yazhou Wen, Wenlan Cai, Wei Zhu, Jie Su. Hippocampal Inhibitory Synapsis Deficits Induced by α5-Containing GABA Molecular neurobiology. 2022-07-18. PMID:35849280. |
hippocampal inhibitory synapsis deficits induced by α5-containing gaba chronic neuropathic pain often leads to cognitive impairment, but the exact mechanism remains unclear. |
2022-07-18 |
2023-08-14 |
Not clear |
| Hitomi Shikano, Akari Ikeda, Yuko Maejima, Shoko Kobayashi, Tsutomu Terauchi, Jun Yokoyama, Kenju Shimomura, Shu Tair. Optimization of the use of Py-Tag for next generation derivatization reagents in imaging mass spectrometry. Journal of bioscience and bioengineering. 2022-07-05. PMID:35781190. |
brain sections of unilateral 6-ohda lesioned parkinson's disease model rats showed py-tag da (m/z 328.3) in the unilateral striatum and py-tag gaba (m/z 278.3) in the cerebral cortex, striatum, hippocampus and hypothalamus. |
2022-07-05 |
2023-08-14 |
rat |
| b' Ivana Peri\\xc4\\x87, Marija Lje\\xc5\\xa1evi\\xc4\\x87, Vladimir Be\\xc5\\xa1koski, Milan Nikoli\\xc4\\x87, Dragana Filipovi\\xc4\\x8. Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats. Psychopharmacology. 2022-07-01. PMID:35776189.' |
metabolomic profiling relates tianeptine effectiveness with hippocampal gaba, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats. |
2022-07-01 |
2023-08-14 |
rat |
| Tessa J Helman, John P Headrick, Jason N Peart, Nicolas J C Stapelber. Central and cardiac stress resiliences consistently linked to integrated immuno-neuroendocrine responses across stress models in male mice. The European journal of neuroscience. 2022-06-28. PMID:35763309. |
highly integrated expression of hpa axis, neuro-inflammatory, bdnf, monoamine, gaba, cannabinoid and opioid signalling genes was confirmed across conditions, and consistent/potentially causal correlations identified for: i) locomotor activity (noradrenaline, ghrelin; fc crhr1, tnfrsf1b, il33, nfkb1, maoa, gabra1; hippocampal il33); ii) thigmotaxis (adrenaline, leptin); iii) anxiety-like behaviour (adrenaline, leptin; fc tnfrsf1a; hippocampal il33); iv) depressive-like behaviour (ghrelin; fc/hippocampal s100a8); and v) cardiac stress-resistance (noradrenaline, leptin; fc il33, tnfrsf1b, htr1a, gabra1, gabrg2; hippocampal il33, tnfrsf1a, maoa, drd2). |
2022-06-28 |
2023-08-14 |
mouse |
| Yuki Onishi, Yusuke Yamamura, Misa Hosogi, Hiroshi Higashi, Kiyokazu Ogita, Toshihiko Kinjo, Kyosuke Uno, Yukio Yoneda, Nobuyuki Kuramot. Delayed Expression of Both GABA Neurochemical research. 2022-06-23. PMID:35737203. |
delayed expression of both gaba trimethyltin (tmt) has been used as a cytotoxin to neurons rather than glial cells in the mammalian hippocampus. |
2022-06-23 |
2023-08-14 |
mouse |
| Maxime Lévesque, Siyan Wang, Guillaume Etter, Sylvain Williams, Massimo Avol. Bilateral optogenetic activation of inhibitory cells favors ictogenesis. Neurobiology of disease. 2022-06-19. PMID:35718264. |
our findings reveal that bilateral activation of pv-interneurons in the hippocampus (leading to a presumptive increase in gaba signaling) favors ictogenesis. |
2022-06-19 |
2023-08-14 |
mouse |
| Malwina Lisek, Joanna Mackiewicz, Marta Sobolczyk, Bozena Ferenc, Feng Guo, Ludmila Zylinska, Tomasz Bocze. Early Developmental PMCA2b Expression Protects From Ketamine-Induced Apoptosis and GABA Impairments in Differentiating Hippocampal Progenitor Cells. Frontiers in cellular neuroscience. vol 16. 2022-06-09. PMID:35677757. |
early developmental pmca2b expression protects from ketamine-induced apoptosis and gaba impairments in differentiating hippocampal progenitor cells. |
2022-06-09 |
2023-08-14 |
Not clear |
| Qin Zhou, Qiong Wang, Baomei He, Haibo Kong, Huanjun Luo, Xiaowei Wang, Wenlan Wan. MicroRNA 322-5p reduced neuronal inflammation via the TLR4/TRAF6/NF-κB axis in a rat epilepsy model. Open medicine (Warsaw, Poland). vol 17. issue 1. 2022-06-01. PMID:35647304. |
exogenous mir-322-5p reduced the expression of inflammatory molecules and increased the gaba levels in se rats, and also reduced hippocampal neuronal cell apoptosis caused by epilepsy. |
2022-06-01 |
2023-08-13 |
rat |
| Hardy Hagena, Mirko Feldmann, Denise Manahan-Vaugha. Lifelong changes of neurotransmitter receptor expression and debilitation of hippocampal synaptic plasticity following early postnatal blindness. Scientific reports. vol 12. issue 1. 2022-06-01. PMID:35650390. |
two fundamental characteristics comprise widespread changes in the relative expression of gaba and glutamate receptors and debilitation of hippocampal synaptic plasticity. |
2022-06-01 |
2023-08-13 |
mouse |
| Lin-Ru Zhao, Pan He, Jie Li, Ya-Jun Zhang, Jing-Xing Jiang, Ying-Ru Wu, Yue Zhang, Jia Li, Cong Liu, Xu-Liang Ha. [Sleep-improving mechanism of Chaiqin Ningshen Granules in insomnia rats: based on hippocampal metabonomics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 7. 2022-05-09. PMID:35534263. |
the results show that the drugs can significantly improve the mental state, liver depression, and blood stasis of rats, significantly increase the content of 5-hydroxytryptamine(5-ht) and gamma aminobutyric acid(gaba) in hippocampus(except low-dose cng), and significantly reduce the content of glucose(glu)(except low-dose cng). |
2022-05-09 |
2023-08-13 |
rat |
| Amaya Austrich-Olivares, María Salud García-Gutiérrez, Lucía Illescas, Ani Gasparyan, Jorge Manzanare. Cannabinoid CB1 Receptor Involvement in the Actions of CBD on Anxiety and Coping Behaviors in Mice. Pharmaceuticals (Basel, Switzerland). vol 15. issue 4. 2022-04-23. PMID:35455470. |
relative gene expression analyses of cnr1 and cnr2, gpr55 and gaba(a)α2 and γ2 receptor subunits were performed in the amygdala (amy) and hippocampus (hipp) of cd1 mice. |
2022-04-23 |
2023-08-13 |
mouse |
| Amaya Austrich-Olivares, María Salud García-Gutiérrez, Lucía Illescas, Ani Gasparyan, Jorge Manzanare. Cannabinoid CB1 Receptor Involvement in the Actions of CBD on Anxiety and Coping Behaviors in Mice. Pharmaceuticals (Basel, Switzerland). vol 15. issue 4. 2022-04-23. PMID:35455470. |
real-time pcr studies revealed a significant reduction in cnr1 and gaba(a)α2 and γ2 gene expression in the hipp and amy of cd1 mice treated with cbd. |
2022-04-23 |
2023-08-13 |
mouse |