| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J S Sprouse, G K Aghajania. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse (New York, N.Y.). vol 1. issue 1. 1989-02-21. PMID:3505364. |
in intracellular studies, ipsapirone and ly 165163, when added to the media bathing brain slices, mimicked the actions of 5-ht in hyperpolarizing dorsal raphe cell membranes and decreasing input resistance; however, the maximal effects of the 5-ht1a compounds on these membrane properties exceeded those of 5-ht. |
1989-02-21 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse (New York, N.Y.). vol 1. issue 1. 1989-02-21. PMID:3505364. |
in summary, dorsal raphe 5-ht neurons appear highly responsive to 5-ht1a, but not to 5-ht1b compounds; these findings are discussed with regard to the 5-ht receptor subtypes as candidates for the somatodendritic autoreceptor of dorsal raphe neurons. |
1989-02-21 |
2023-08-11 |
rat |
| L Lanfumey, J Adrie. Adaptive changes of beta-adrenergic receptors after neonatal locus coeruleus lesion: regulation of serotoninergic unit activity. Synapse (New York, N.Y.). vol 2. issue 6. 1989-02-13. PMID:2850635. |
spontaneous activity of 5-hydroxytryptamine (5-ht) neurons in the dorsal raphe nucleus (drn) was recorded in adult rats that had undergone a bilateral locus coeruleus (lc) lesion during the neonatal period. |
1989-02-13 |
2023-08-11 |
rat |
| B Costall, M E Kelly, R J Naylor, E S Onaiv. Actions of buspirone in a putative model of anxiety in the mouse. The Journal of pharmacy and pharmacology. vol 40. issue 7. 1989-02-08. PMID:2904990. |
in contrast, the injection of 5-hydroxytryptamine and 2-methyl-5-hydroxytryptamine into the dorsal raphe nucleus increased exploratory behaviour in the black section with decreased activity in the white area: the effects of 2-methyl-5-hydroxytryptamine were antagonized by buspirone administered peripherally. |
1989-02-08 |
2023-08-11 |
mouse |
| B Costall, M E Kelly, R J Naylor, E S Onaiv. Actions of buspirone in a putative model of anxiety in the mouse. The Journal of pharmacy and pharmacology. vol 40. issue 7. 1989-02-08. PMID:2904990. |
it is concluded that in the mouse model the ability of buspirone to reduce the aversive response to a brightly illuminated area may reflect an anxiolytic action, that the dorsal raphe nucleus may be an important locus of action, and that the effects of buspirone may reflect an interaction at 5-hydroxytryptamine receptors. |
1989-02-08 |
2023-08-11 |
mouse |
| M J Villar, M L Vitale, T Hökfelt, A A Verhofsta. Dorsal raphe serotoninergic branching neurons projecting both to the lateral geniculate body and superior colliculus: a combined retrograde tracing-immunohistochemical study in the rat. The Journal of comparative neurology. vol 277. issue 1. 1989-01-25. PMID:3198794. |
these results support a role of the serotoninergic dorsal raphe projection to the lateral geniculate body and to the superior colliculus in the processing of visual information, and they suggest that serotonin may have a coordinating influence on primary visual centers. |
1989-01-25 |
2023-08-11 |
rat |
| A C Scallet, G W Lipe, S F Ali, R R Holson, C H Frith, W Slikke. Neuropathological evaluation by combined immunohistochemistry and degeneration-specific methods: application to methylenedioxymethamphetamine. Neurotoxicology. vol 9. issue 3. 1989-01-19. PMID:2904668. |
four months after two 40 mg/kg oral doses per day for four days, rats had a reduced neurochemical content of 5-ht in the hippocampus, and fewer immunostainable 5-ht axons per unit area in the hippocampal stratum lacunosum but no change in brain-stem neurochemical 5-ht content or in the numeric density of 5-ht-positive cell bodies in the dorsal raphe nucleus. |
1989-01-19 |
2023-08-11 |
rat |
| L A Mamounas, M E Mollive. Evidence for dual serotonergic projections to neocortex: axons from the dorsal and median raphe nuclei are differentially vulnerable to the neurotoxin p-chloroamphetamine (PCA). Experimental neurology. vol 102. issue 1. 1988-12-07. PMID:2846339. |
moreover, a recent anterograde transport study suggests that fine and beaded 5-ht axons arise from the dorsal raphe (dr) and median raphe (mr) nuclei, respectively. |
1988-12-07 |
2023-08-11 |
rat |
| L A Mamounas, M E Mollive. Evidence for dual serotonergic projections to neocortex: axons from the dorsal and median raphe nuclei are differentially vulnerable to the neurotoxin p-chloroamphetamine (PCA). Experimental neurology. vol 102. issue 1. 1988-12-07. PMID:2846339. |
since the mood-altering substances mda, mdma, and pca act specifically upon 5-ht axon terminals from the dorsal raphe nucleus, dr neurons may be preferentially involved in the control of affective state. |
1988-12-07 |
2023-08-11 |
rat |
| R B Innis, E J Nestler, G K Aghajania. Evidence for G protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons. Brain research. vol 459. issue 1. 1988-11-21. PMID:3139262. |
in vitro intracellular recording techniques in the rat brain slice preparation demonstrate that both serotonin (5-ht) and baclofen (a gabab-receptor agonist) inhibit 5-ht neurons in the dorsal raphe nucleus by inducing a hyperpolarization of membrane potential and a decrease in apparent input resistance (rin). |
1988-11-21 |
2023-08-11 |
rat |
| R B Innis, E J Nestler, G K Aghajania. Evidence for G protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons. Brain research. vol 459. issue 1. 1988-11-21. PMID:3139262. |
in slices from rats that had previously received a local injection of pertussis toxin (0.5 microgram) immediately rostral to the dorsal raphe nucleus, there was a virtually complete blockade of inhibition induced by both the serotonin autoreceptor and the gabab-receptor. |
1988-11-21 |
2023-08-11 |
rat |
| R B Innis, E J Nestler, G K Aghajania. Evidence for G protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons. Brain research. vol 459. issue 1. 1988-11-21. PMID:3139262. |
in summary, these results provide evidence for the role of a g protein(s) in the mediation of the camp-independent increase in potassium conductance in 5-ht neurons of dorsal raphe nucleus induced by both 5-ht1a- and gabab-receptors. |
1988-11-21 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology. vol 27. issue 7. 1988-10-24. PMID:2901680. |
responses of hippocampal pyramidal cells to putative serotonin 5-ht1a and 5-ht1b agonists: a comparative study with dorsal raphe neurons. |
1988-10-24 |
2023-08-11 |
rat |
| J S Sprouse, G K Aghajania. Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology. vol 27. issue 7. 1988-10-24. PMID:2901680. |
conversely, using identical ejection parameters, ipsapirone and ly 165163 (previously reported) and 8-oh-dpat were as effective as 5-ht in inhibiting markedly the baseline activity of serotonergic dorsal raphe neurons; mcpp and tfmpp (previously reported) were only weakly active. |
1988-10-24 |
2023-08-11 |
rat |
| F Crespi, K F Martin, C A Marsde. Simultaneous in vivo voltammetric measurement of striatal extracellular DOPAC and 5-HIAA levels: effect of electrical stimulation of DA and 5-HT neuronal pathways. Neuroscience letters. vol 90. issue 3. 1988-10-20. PMID:2458556. |
electrical stimulation of the dorsal raphe (drn) increased 5ht and decreased da metabolism in the striatum. |
1988-10-20 |
2023-08-11 |
rat |
| T M Dawson, P Barone, A Sidhu, J K Wamsley, T N Chas. The D1 dopamine receptor in the rat brain: quantitative autoradiographic localization using an iodinated ligand. Neuroscience. vol 26. issue 1. 1988-10-20. PMID:2971144. |
[125i]sch 23982 binding to serotonin receptors was concentrated in the cortices, dorsal raphe, central gray, anterior hypothalamic area and the molecular cell layer of the cerebellum. |
1988-10-20 |
2023-08-11 |
rat |
| T M Burlhis, G K Aghajania. Pacemaker potentials of serotonergic dorsal raphe neurons: contribution of a low-threshold Ca2+ conductance. Synapse (New York, N.Y.). vol 1. issue 6. 1988-10-20. PMID:3455563. |
the purposes of this study, carried out in the rat dorsal raphe nucleus brain slice preparation, were to 1) determine the ionic nature of the pp, 2) investigate its time- and voltage-dependent properties, and 3) investigate the possible modulation of the underlying conductance by the alpha 1-agonist phenylephrine and by serotonin (5-ht), agents that modify dorsal raphe pacemaker activity. |
1988-10-20 |
2023-08-11 |
rat |
| J T Lum, M F Pierce. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. European journal of pharmacology. vol 149. issue 1-2. 1988-08-31. PMID:2969339. |
the neuroleptic spiperone, which binds to 5-ht1a, 5-ht2 and dopamine (da) receptors, was studied for its effects on serotonin (5-ht) and da neurons in dorsal raphe nucleus and substantia nigra pars compacta, respectively. |
1988-08-31 |
2023-08-11 |
Not clear |
| A L Frankhuijzen, G Wardeh, F Hogenboom, A H Mulde. Alpha 2-adrenoceptor mediated inhibition of the release of radiolabelled 5-hydroxytryptamine and noradrenaline from slices of the dorsal region of the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 337. issue 3. 1988-08-22. PMID:2839776. |
possible local interactions between noradrenergic and serotonergic systems in the dorsal raphe region of the rat were investigated by studying the effects of various drugs on depolarization (20 mmol/l k+)-induced release of [3h]5-hydroxytryptamine (5-ht) and [3h]noradrenaline (na) in vitro using a superfusion method. |
1988-08-22 |
2023-08-11 |
human |
| A L Frankhuijzen, G Wardeh, F Hogenboom, A H Mulde. Alpha 2-adrenoceptor mediated inhibition of the release of radiolabelled 5-hydroxytryptamine and noradrenaline from slices of the dorsal region of the rat brain. Naunyn-Schmiedeberg's archives of pharmacology. vol 337. issue 3. 1988-08-22. PMID:2839776. |
it is concluded that the release of both 5-ht and na in the dorsal raphe region may be subject to presynaptic inhibition by na via activation of alpha 2-adrenoceptors. |
1988-08-22 |
2023-08-11 |
human |