| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D G Standaert, C M Testa, G D Rudolf, Z R Hollingswort. Inhibition of N-methyl-D-aspartate glutamate receptor subunit expression by antisense oligonucleotides reveals their role in striatal motor regulation. The Journal of pharmacology and experimental therapeutics. vol 276. issue 1. 1996-02-26. PMID:8558453. |
n-methyl-d-aspartate (nmda) glutamate receptors have an established role in the regulation of motor behavior by the basal ganglia. |
1996-02-26 |
2023-08-12 |
rat |
| Y P Maneuf, I J Mitchell, A R Crossman, G N Woodruff, J M Brotchi. Functional implications of kappa opioid receptor-mediated modulation of glutamate transmission in the output regions of the basal ganglia in rodent and primate models of Parkinson's disease. Brain research. vol 683. issue 1. 1995-11-03. PMID:7552334. |
functional implications of kappa opioid receptor-mediated modulation of glutamate transmission in the output regions of the basal ganglia in rodent and primate models of parkinson's disease. |
1995-11-03 |
2023-08-12 |
rat |
| M S Star. Glutamate/dopamine D1/D2 balance in the basal ganglia and its relevance to Parkinson's disease. Synapse (New York, N.Y.). vol 19. issue 4. 1995-07-26. PMID:7792721. |
this review will focus on the ways in which glutamate receptor blockade facilitates motor recovery with l-dopa and will examine whether the basis for this beneficial effect can be traced to a specific interaction with dopamine at d1 or d2 receptors, and therefore to discrete motor pathways within the basal ganglia. |
1995-07-26 |
2023-08-12 |
Not clear |
| A E Johnson, U Liminga, A Lidén, N Lindefors, L M Gunne, F A Wiese. Chronic treatment with a classical neuroleptic alters excitatory amino acid and GABAergic neurotransmission in specific regions of the rat brain. Neuroscience. vol 63. issue 4. 1995-05-01. PMID:7535390. |
the neuroleptic dependent increases in glutamate decarboxylase mrna levels in the entopeduncular nucleus may reflect changes in neurotransmission in the indirect pathway connecting the major input and output nuclei of the basal ganglia. |
1995-05-01 |
2023-08-12 |
rat |
| E F Ball, P J Shaw, P G Ince, M Johnso. The distribution of excitatory amino acid receptors in the normal human midbrain and basal ganglia with implications for Parkinson's disease: a quantitative autoradiographic study using [3H]MK-801, [3H]glycine, [3H]CNQX and [3H]kainate. Brain research. vol 658. issue 1-2. 1995-03-02. PMID:7834343. |
detailed knowledge of the anatomy and subtype specificity of glutamate receptors is important both in understanding the normal physiology of basal ganglia neurotransmission and the pathophysiological changes occurring in diseases affecting the basal ganglia such as parkinson's disease (pd). |
1995-03-02 |
2023-08-12 |
human |
| E F Ball, P J Shaw, P G Ince, M Johnso. The distribution of excitatory amino acid receptors in the normal human midbrain and basal ganglia with implications for Parkinson's disease: a quantitative autoradiographic study using [3H]MK-801, [3H]glycine, [3H]CNQX and [3H]kainate. Brain research. vol 658. issue 1-2. 1995-03-02. PMID:7834343. |
in addition, perturbation of glutamate neurotransmission resulting from dopamine depletion in the basal ganglia is likely to contribute to the clinical manifestations of motor dysfunction. |
1995-03-02 |
2023-08-12 |
human |
| R H Porter, J G Greene, D S Higgins, J T Greenamyr. Polysynaptic regulation of glutamate receptors and mitochondrial enzyme activities in the basal ganglia of rats with unilateral dopamine depletion. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 11 Pt 2. 1994-12-02. PMID:7965108. |
because stn uses glutamate as a transmitter, we examined whether there are regulatory changes in glutamate receptor binding in the basal ganglia. |
1994-12-02 |
2023-08-12 |
rat |
| Z H Qin, L W Zhou, B Weis. D2 dopamine receptor messenger RNA is altered to a greater extent by blockade of glutamate receptors than by blockade of dopamine receptors. Neuroscience. vol 60. issue 1. 1994-09-08. PMID:8052421. |
to study further the molecular mechanisms by which glutamate and dopamine interact to regulate the functions of the basal ganglia, the effects of persistently inhibiting dopamine receptors and glutamate n-methyl-d-aspartate receptors on the density of d1 and d2 dopamine receptors and on the level of their transcripts were examined in mouse brain. |
1994-09-08 |
2023-08-12 |
mouse |
| D G Standaert, C M Testa, A B Young, J B Penne. Organization of N-methyl-D-aspartate glutamate receptor gene expression in the basal ganglia of the rat. The Journal of comparative neurology. vol 343. issue 1. 1994-08-10. PMID:8027428. |
glutamate is an important neurotransmitter in the circuitry of the basal ganglia. |
1994-08-10 |
2023-08-12 |
rat |
| J Sánchez-Prieto, I Herrero, M T Miras-Portugal, F Mor. Unchanged exocytotic release of glutamic acid in cortex and neostriatum of the rat during aging. Brain research bulletin. vol 33. issue 3. 1994-03-03. PMID:7904891. |
the ca(2+)-dependent release of glutamate induced by 4-aminopyridine in synaptosomes prepared both from the cerebral cortex and basal ganglia was unchanged in aged rats (27-30 months) when compared to adults rats (3 months). |
1994-03-03 |
2023-08-12 |
rat |
| J Sánchez-Prieto, I Herrero, M T Miras-Portugal, F Mor. Unchanged exocytotic release of glutamic acid in cortex and neostriatum of the rat during aging. Brain research bulletin. vol 33. issue 3. 1994-03-03. PMID:7904891. |
the results suggest that during aging the nerve terminals from the cerebral cortex and basal ganglia maintain an intact ability to release glutamate by exocytosis. |
1994-03-03 |
2023-08-12 |
rat |
| T Klockgether, L Tursk. Toward an understanding of the role of glutamate in experimental parkinsonism: agonist-sensitive sites in the basal ganglia. Annals of neurology. vol 34. issue 4. 1993-11-12. PMID:7692810. |
toward an understanding of the role of glutamate in experimental parkinsonism: agonist-sensitive sites in the basal ganglia. |
1993-11-12 |
2023-08-12 |
rat |
| T Klockgether, L Tursk. Toward an understanding of the role of glutamate in experimental parkinsonism: agonist-sensitive sites in the basal ganglia. Annals of neurology. vol 34. issue 4. 1993-11-12. PMID:7692810. |
therefore, we examined whether the glutamate agonists n-methyl-d-aspartate (nmda), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (ampa), kainate, and trans-(+/-)-1-amino-1,3-cyclopentanedicarboxylate produce parkinsonism in rats after microapplication into different subregions of the basal ganglia. |
1993-11-12 |
2023-08-12 |
rat |
| T Klockgether, L Tursk. Toward an understanding of the role of glutamate in experimental parkinsonism: agonist-sensitive sites in the basal ganglia. Annals of neurology. vol 34. issue 4. 1993-11-12. PMID:7692810. |
these observations suggest that the activation of glutamate receptor subtypes in the basal ganglia may be differentially involved in the expression of parkinsonian symptoms. |
1993-11-12 |
2023-08-12 |
rat |
| R C Pierce, G V Rebe. Intraneostriatal administration of glutamate antagonists increases behavioral activation and decreases neostriatal ascorbate via nondopaminergic mechanisms. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 13. issue 10. 1993-11-12. PMID:8105039. |
in order to assess glutamate-ascorbate interactions and their influence on the behavioral output of the basal ganglia, glutamate and homocysteic acid (a glutamate reuptake blocker) as well as nmda antagonists were infused into the neostriatum of freely moving rats while extracellular neostriatal ascorbate was monitored via electrochemically modified carbon-fiber electrodes. |
1993-11-12 |
2023-08-12 |
rat |
| J Kornhuber, M Welle. Amantadine and the glutamate hypothesis of schizophrenia. Experiences in the treatment of neuroleptic malignant syndrome. Journal of neural transmission. General section. vol 92. issue 1. 1993-08-17. PMID:8101093. |
our observations support the glutamate hypothesis of schizophrenia which suggests that reduced glutamatergic transmission causes a relative dopaminergic excess in the basal ganglia and the limbic system. |
1993-08-17 |
2023-08-12 |
Not clear |
| L J Martin, C D Blackstone, A I Levey, R L Huganir, D L Pric. AMPA glutamate receptor subunits are differentially distributed in rat brain. Neuroscience. vol 53. issue 2. 1993-06-11. PMID:8388083. |
immunocytochemistry shows that glutamate receptor subunits are distributed abundantly and differentially within neuronal cell bodies and processes in cerebral cortex, basal ganglia, limbic system, thalamus, cerebellum and brainstem. |
1993-06-11 |
2023-08-12 |
rat |
| W J Schmidt, M Bubser, W Haube. Behavioural pharmacology of glutamate in the basal ganglia. Journal of neural transmission. Supplementum. vol 38. 1993-02-26. PMID:1491249. |
behavioural pharmacology of glutamate in the basal ganglia. |
1993-02-26 |
2023-08-11 |
Not clear |
| S Berretta, H A Robertson, A M Graybie. Dopamine and glutamate agonists stimulate neuron-specific expression of Fos-like protein in the striatum. Journal of neurophysiology. vol 68. issue 3. 1992-11-27. PMID:1359024. |
the monoamine dopamine and the amino acid glutamate are major neurotransmitters in the basal ganglia implicated in the normal functions of the striatum and in extrapyramidal disease states. |
1992-11-27 |
2023-08-11 |
rat |
| M D Simpson, P Slater, M C Royston, J F Deaki. Regionally selective deficits in uptake sites for glutamate and gamma-aminobutyric acid in the basal ganglia in schizophrenia. Psychiatry research. vol 42. issue 3. 1992-09-10. PMID:1353892. |
regionally selective deficits in uptake sites for glutamate and gamma-aminobutyric acid in the basal ganglia in schizophrenia. |
1992-09-10 |
2023-08-11 |
human |