| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E F Ball, P J Shaw, P G Ince, M Johnso. The distribution of excitatory amino acid receptors in the normal human midbrain and basal ganglia with implications for Parkinson's disease: a quantitative autoradiographic study using [3H]MK-801, [3H]glycine, [3H]CNQX and [3H]kainate. Brain research. vol 658. issue 1-2. 1995-03-02. PMID:7834343. |
in addition, perturbation of glutamate neurotransmission resulting from dopamine depletion in the basal ganglia is likely to contribute to the clinical manifestations of motor dysfunction. |
1995-03-02 |
2023-08-12 |
human |
| G Schlaug, H Hefter, B Nebeling, V Engelbrecht, P Weiss, G Stöcklin, R J Seit. Dopamine D2 receptor binding and cerebral glucose metabolism recover after D-penicillamine-therapy in Wilson's disease. Journal of neurology. vol 241. issue 10. 1995-02-27. PMID:7836960. |
it is hypothesized that recovery of motor functions due to copper trapping therapy was associated with an increase in basal ganglia activity and a re-expression or upregulation of dopamine d2 receptors. |
1995-02-27 |
2023-08-12 |
Not clear |
| A E Johnson, H Coirini, L Källström, F A Wiese. Characterization of dopamine receptor binding sites in the subthalamic nucleus. Neuroreport. vol 5. issue 14. 1995-02-22. PMID:7827344. |
experiments were undertaken to determine the distribution and binding profile of dopamine (da) receptors within a key extra-striatal region of the rat basal ganglia, the subthalamic nucleus (sth). |
1995-02-22 |
2023-08-12 |
rat |
| J N Joyc. The dopamine hypothesis of schizophrenia: limbic interactions with serotonin and norepinephrine. Psychopharmacology. vol 112. issue 1 Suppl. 1995-02-22. PMID:7831438. |
thus, evidence for the dopamine hypothesis has been derived from studies of the basal ganglia in schizophrenic cases and infrequently from other (e.g. |
1995-02-22 |
2023-08-12 |
human |
| R M Ridle. The psychology of perserverative and stereotyped behaviour. Progress in neurobiology. vol 44. issue 2. 1995-02-17. PMID:7831478. |
it is supposed that the level of dopamine activity in the basal ganglia affects the baseline level of behavioural activation such that excess activation results in the excessive execution of the most probable response to the environment to the exclusion of other possibilities (i.e. |
1995-02-17 |
2023-08-12 |
Not clear |
| R M Ridle. The psychology of perserverative and stereotyped behaviour. Progress in neurobiology. vol 44. issue 2. 1995-02-17. PMID:7831478. |
the symptoms of pd result from inadequate levels of dopamine in the basal ganglia while the stimulant psychoses result from excessive availability of dopamine. |
1995-02-17 |
2023-08-12 |
Not clear |
| R M Wu, K P Mohanakumar, D L Murphy, C C Chiue. Antioxidant mechanism and protection of nigral neurons against MPP+ toxicity by deprenyl (selegiline). Annals of the New York Academy of Sciences. vol 738. 1995-02-17. PMID:7832430. |
these findings indicate that the cytotoxic hydroxyl radical generated from dopamine oxidation in the iron-rich basal ganglia may contribute to the mechanism underlying the selective a9 melanized nigral degeneration in mptp-parkinsonism and possibly in idiopathic parkinson's disease. |
1995-02-17 |
2023-08-12 |
rat |
| C C Chiueh, R M Wu, K P Mohanakumar, L M Sternberger, G Krishna, T Obata, D L Murph. In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia. Annals of the New York Academy of Sciences. vol 738. 1995-02-17. PMID:7832434. |
these results indicate that nonenzymatic and/or enzymatic oxidation of the dopamine released by mptp analogues in the extracellular fluid may play a key role in the generation of .oh free radicals in the iron-rich basal ganglia. |
1995-02-17 |
2023-08-12 |
Not clear |
| M Kato, N Miyashita, O Hikosaka, M Matsumura, S Usui, A Kor. Eye movements in monkeys with local dopamine depletion in the caudate nucleus. I. Deficits in spontaneous saccades. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 1 Pt 2. 1995-02-16. PMID:7823189. |
dopamine is known to exert powerful modulatory effects on the basal ganglia function, but its nature and mechanism are still unclear, especially in relation to voluntary behavior. |
1995-02-16 |
2023-08-12 |
monkey |
| C A Altar, C B Boylan, M Fritsche, C Jackson, C Hyman, R M Lindsa. The neurotrophins NT-4/5 and BDNF augment serotonin, dopamine, and GABAergic systems during behaviorally effective infusions to the substantia nigra. Experimental neurology. vol 130. issue 1. 1995-02-14. PMID:7821394. |
this has prompted the in vivo study of their effects on behavior and neuro-chemical parameters associated with dopamine, serotonin, and gabaergic neurons in the basal ganglia. |
1995-02-14 |
2023-08-12 |
rat |
| M B Youdim, J P Finber. Pharmacological actions of l-deprenyl (selegiline) and other selective monoamine oxidase B inhibitors. Clinical pharmacology and therapeutics. vol 56. issue 6 Pt 2. 1995-01-18. PMID:7995014. |
although not all features of its antiparkinson action are known, studies that used brains obtained at autopsy from patients who took l-deprenyl show that the selective inhibition of mao-b with a concomitant increase of phenylethylamine and dopamine, but not of serotonin or noradrenaline, in the basal ganglia may be responsible for its mode of action. |
1995-01-18 |
2023-08-12 |
Not clear |
| K W Lange, P Riederer, M B Youdi. Biochemical actions of l-deprenyl (selegiline). Clinical pharmacology and therapeutics. vol 56. issue 6 Pt 2. 1995-01-18. PMID:7995015. |
because parkinson's disease is characterized by a decrease in dopaminergic neurotransmission in the basal ganglia, the selective inhibition of mao-b should lead to diminished metabolism of dopamine in the nigrostriatal system and a significant increase in the concentration of the neurotransmitter. |
1995-01-18 |
2023-08-12 |
human |
| K X Huang, J R Walter. Electrophysiological effects of SKF 38393 in rats with reserpine treatment and 6-hydroxydopamine-induced nigrostriatal lesions reveal two types of plasticity in D1 dopamine receptor modulation of basal ganglia output. The Journal of pharmacology and experimental therapeutics. vol 271. issue 3. 1995-01-17. PMID:7996456. |
to examine the role of d1 dopamine receptors in modulating basal ganglia output and how this role may be altered by changes in dopaminergic transmission, the effects of a d1 dopamine agonist on firing rates of substantia nigra pars reticulata (snpr) neurons were determined in reserpine-treated rats and compared with effects observed in nigrostriatal-lesioned and normal rats. |
1995-01-17 |
2023-08-12 |
rat |
| K X Huang, J R Walter. Electrophysiological effects of SKF 38393 in rats with reserpine treatment and 6-hydroxydopamine-induced nigrostriatal lesions reveal two types of plasticity in D1 dopamine receptor modulation of basal ganglia output. The Journal of pharmacology and experimental therapeutics. vol 271. issue 3. 1995-01-17. PMID:7996456. |
current models of basal ganglia function predict that d1 dopamine agonists should reduce activity in the snpr, because d1 dopamine receptors on striatonigral neurons are thought to stimulate striatonigral firing rates and to enhance the release of tau-aminobutyric acid in the snpr. |
1995-01-17 |
2023-08-12 |
rat |
| G Arnold, K Tatsch, W H Oertel, T Vogl, J Schwarz, E Kraft, C M Kirsc. Clinical progressive supranuclear palsy: differential diagnosis by IBZM-SPECT and MRI. Journal of neural transmission. Supplementum. vol 42. 1994-12-22. PMID:7964681. |
specific striatal dopamine d2 receptor binding in ibzm-spect, as calculated by a basal ganglia to frontal cortex ratio (bg/fc) was reduced in 5 patients, but normal in 3 patients. |
1994-12-22 |
2023-08-12 |
Not clear |
| E F Walke. Developmentally moderated expressions of the neuropathology underlying schizophrenia. Schizophrenia bulletin. vol 20. issue 3. 1994-12-20. PMID:7526447. |
specifically, it is suggested that the diathesis for schizophrenia involves a functional excess of dopamine activity in the basal ganglia that serves to disrupt these circuits. |
1994-12-20 |
2023-08-12 |
Not clear |
| J Kornhuber, M Welle. Neuroleptic malignant syndrome. Current opinion in neurology. vol 7. issue 4. 1994-12-20. PMID:7952245. |
the neurochemical key features in all these conditions are probably functional dopamine deficiency and ensuing hyperactivity of excitatory amino acid neurotransmission in the basal ganglia and hypothalamus. |
1994-12-20 |
2023-08-12 |
Not clear |
| C C Chiueh, S J Huang, D L Murph. Suppression of hydroxyl radical formation by MAO inhibitors: a novel possible neuroprotective mechanism in dopaminergic neurotoxicity. Journal of neural transmission. Supplementum. vol 41. 1994-11-23. PMID:7931226. |
thus, .oh generation evoked by mptp analogues may be due mainly to a burst increase in iron-catalyzed autoxidation of released dopamine in the basal ganglia where high levels of iron and oxygen are present. |
1994-11-23 |
2023-08-12 |
Not clear |
| L Shao, J Billings, N Pfeiffer, H F Kun. Concentration recovery for SPECT CNS dopamine-receptor studies for monkeys. Medical physics. vol 21. issue 5. 1994-10-28. PMID:7935203. |
a series of images were taken with different concentration ratios between the basal ganglia and the other brain compartments to simulate the dynamic imaging study of the dopamine d2 receptor in a monkey brain. |
1994-10-28 |
2023-08-12 |
monkey |
| B M Pedro, L S Pilowsky, D C Costa, D R Hemsley, P J Ell, N P Verhoeff, R W Kerwin, N S Gra. Stereotypy, schizophrenia and dopamine D2 receptor binding in the basal ganglia. Psychological medicine. vol 24. issue 2. 1994-10-13. PMID:8084937. |
stereotypy, schizophrenia and dopamine d2 receptor binding in the basal ganglia. |
1994-10-13 |
2023-08-12 |
human |