| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P A Lapchak, S Jiao, F Collins, P J Mille. Glial cell line-derived neurotrophic factor: distribution and pharmacology in the rat following a bolus intraventricular injection. Brain research. vol 747. issue 1. 1997-05-14. PMID:9042532. |
this study shows that intraventricularly injected gdnf can access basal ganglia structures, most notably the midbrain dopamine cell body region, and remains present in this area for at least 7 days following a single administration. |
1997-05-14 |
2023-08-12 |
rat |
| H Moukhles, O Bosler, J P Bolam, A Vallée, D Umbriaco, M Geffard, G Douce. Quantitative and morphometric data indicate precise cellular interactions between serotonin terminals and postsynaptic targets in rat substantia nigra. Neuroscience. vol 76. issue 4. 1997-04-29. PMID:9027876. |
they indicate that this dense serotonin input to the substantia nigra is very precisely organized, acting through both "non-junctional" and "junctional" modes of neurotransmission in the pars compacta, which projects to the neostriatum and the limbic system, whereas the predominant mode of serotonin transmission appears to be of the "junctional" type in the pars reticulata, where serotonin can finely control the motor output of the basal ganglia by acting on the gaba projection neurons either directly or through the local release of dopamine by dopaminergic dendrites. |
1997-04-29 |
2023-08-12 |
rat |
| S Ferre, P Popoli, B Tinner-Staines, K Fux. Adenosine A1 receptor-dopamine D1 receptor interaction in the rat limbic system: modulation of dopamine D1 receptor antagonist binding sites. Neuroscience letters. vol 208. issue 2. 1997-04-11. PMID:8859902. |
antagonistic interactions between adenosine a2a and dopamine d2 receptors and between adenosine a1 and dopamine d1 receptors have been previously found in the basal ganglia. |
1997-04-11 |
2023-08-12 |
rat |
| L García-Larrea, E Brousolle, M F Gravejat, G Chazot, F Mauguièr. Brain responses to detection of right or left somatic targets are symmetrical in unilateral Parkinson's disease: a case against the concept of "parkinsonian neglect'. Cortex; a journal devoted to the study of the nervous system and behavior. vol 32. issue 4. 1997-03-14. PMID:8954246. |
such deficits have been attributed to dopamine loss in basal ganglia and cortical targets. |
1997-03-14 |
2023-08-12 |
Not clear |
| L B Wilson, A M Woodward, J J Ferrar. An acute dystonic reaction with long-term use of ranitidine in an intensive care unit patient. The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society. vol 149. issue 1. 1997-03-10. PMID:9033194. |
dystonic reactions produce twisting and repetitive movements or abnormal posturing; this sign is considered an extrapyramidal sequela that is most typically thought to arise from decreased dopamine activity in the basal ganglia. |
1997-03-10 |
2023-08-12 |
Not clear |
| H F Kung, H J Kim, M P Kung, S K Meegalla, K Plössl, H K Le. Imaging of dopamine transporters in humans with technetium-99m TRODAT-1. European journal of nuclear medicine. vol 23. issue 11. 1997-03-06. PMID:8854853. |
the specific uptake of [99mtc]trodat-1 in dopamine transporter sites located in the basal ganglia area was confirmed: the best contrast between the basal ganglia and the occipital area, which is devoid of dopamine transporters, was achieved at 120-140 min following injection. |
1997-03-06 |
2023-08-12 |
rat |
| b' P Popoli, L Gim\\xc3\\xa9nez-Llort, A Pezzola, R Reggio, E Mart\\xc3\\xadnez, K Fuxe, S Ferr\\xc3\\xa. Adenosine A1 receptor blockade selectively potentiates the motor effects induced by dopamine D1 receptor stimulation in rodents. Neuroscience letters. vol 218. issue 3. 1997-03-04. PMID:8945765.' |
an antagonistic interaction between adenosine a1 and dopamine d1 receptors has previously been found in the basal ganglia. |
1997-03-04 |
2023-08-12 |
mouse |
| S K Meegalla, K Plössl, M P Kung, S Chumpradit, D A Stevenson, S A Kushner, W T McElgin, P D Mozley, H F Kun. Synthesis and characterization of technetium-99m-labeled tropanes as dopamine transporter-imaging agents. Journal of medicinal chemistry. vol 40. issue 1. 1997-03-04. PMID:9016323. |
after an iv injection of 9 mci of [99mtc]trodat-1 (13), in vivo images of baboon brain using single-photon emission-computed tomography exhibited excellent localization in striatum (basal ganglia), where dopamine neurons are known to be concentrated. |
1997-03-04 |
2023-08-12 |
rat |
| A Takahashi, J Todoroki, M Murasak. [Neuroleptic malignant syndrome, syndrome malin]. Nihon rinsho. Japanese journal of clinical medicine. vol 54. issue 3. 1997-02-28. PMID:8904246. |
nms is thought to occur from central dopamine depletion in the hypothalamus and basal ganglia. |
1997-02-28 |
2023-08-12 |
Not clear |
| P K Morrish, G V Sawle, D J Brook. Regional changes in [18F]dopa metabolism in the striatum in Parkinson's disease. Brain : a journal of neurology. vol 119 ( Pt 6). 1997-02-18. PMID:9010013. |
we have investigated regional changes in dopamine metabolism within the basal ganglia with clinical progression of idiopathic parkinson's disease, using coregistration of [18f]dopa-pet and mri images and comparing six normal subjects with 15 parkinson's disease patients in a cross-sectional study. |
1997-02-18 |
2023-08-12 |
human |
| K S Raevskiĭ, T D Sotnikova, R R Gaĭnetdino. [The brain dopaminergic systems: receptor heterogeneity, functional role and pharmacological regulation]. Uspekhi fiziologicheskikh nauk. vol 27. issue 4. 1997-02-12. PMID:9019922. |
it is hypothesized that dopamine d3 autoreceptor is preferentially involved in the regulation of dopamine release while d2 one is responsible for the control of dopamine synthesis and metabolism in rat basal ganglia in vivo. |
1997-02-12 |
2023-08-12 |
rat |
| L P Martin, B L Waszcza. Dopamine D2, receptor-mediated modulation of the GABAergic inhibition of substantia nigra pars reticulata neurons. Brain research. vol 729. issue 2. 1997-02-07. PMID:8876984. |
collectively these results suggest that dendritically released dopamine may act via nigral d2 receptors, perhaps located on pars reticulata neurons themselves, to regulate basal ganglia output from the substantia nigra. |
1997-02-07 |
2023-08-12 |
Not clear |
| E Arenas, P Akerud, V Wong, C Boylan, H Persson, R M Lindsay, C A Alta. Effects of BDNF and NT-4/5 on striatonigral neuropeptides or nigral GABA neurons in vivo. The European journal of neuroscience. vol 8. issue 8. 1997-02-06. PMID:8921261. |
these results suggest that bdnf or nt-4/5 may modify the output of the basal ganglia not only through effects on dopamine neurons but also by increasing neurotransmission in striatonigral peptidergic and nigral gabaergic pathways. |
1997-02-06 |
2023-08-12 |
rat |
| M Gilbert, C M Counsell, C Snivel. Pallidotomy: a surgical intervention for control of Parkinson's disease. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses. vol 28. issue 4. 1997-01-29. PMID:8880595. |
parkinson's disease results from chronic degeneration of cells in the basal ganglia that produce dopamine. |
1997-01-29 |
2023-08-12 |
Not clear |
| R K Schwarting, J P Husto. Unilateral 6-hydroxydopamine lesions of meso-striatal dopamine neurons and their physiological sequelae. Progress in neurobiology. vol 49. issue 3. 1997-01-16. PMID:8878304. |
with respect to the study of dopamine neurons in the brain, especially within the basal ganglia, the neurotoxin 6-hydroxydopamine (6-ohda) provides an important tool. |
1997-01-16 |
2023-08-12 |
human |
| R K Schwarting, J P Husto. Unilateral 6-hydroxydopamine lesions of meso-striatal dopamine neurons and their physiological sequelae. Progress in neurobiology. vol 49. issue 3. 1997-01-16. PMID:8878304. |
this approach has contributed to neuroscientific knowledge at the basic and clinical levels, since it has been used to clarify the neuroanatomy, neurochemistry, and electrophysiology of mesencephalic dopamine neurons and their relationships with the basal ganglia. |
1997-01-16 |
2023-08-12 |
human |
| M Gerlach, M B Youdim, P Riedere. Pharmacology of selegiline. Neurology. vol 47. issue 6 Suppl 3. 1997-01-15. PMID:8959982. |
although not all features of its anti-pd action are known, studies using brain obtained at autopsy from patients who had been treated with 10 mg of selegiline showed that selective inhibition of mao-b, with the concomitant increase of phenylethylamine and dopamine (da) but not of serotonin or noradrenaline, in the basal ganglia may be regarded as its mode of action. |
1997-01-15 |
2023-08-12 |
Not clear |
| W Timmerman, E D Abercrombi. Amphetamine-induced release of dendritic dopamine in substantia nigra pars reticulata: D1-mediated behavioral and electrophysiological effects. Synapse (New York, N.Y.). vol 23. issue 4. 1997-01-07. PMID:8855513. |
dopamine (da) released from dendrites of substantia nigra dopaminergic neurons potentially is in a position to modulate basal ganglia outputs from the substantia nigra pars reticulata (snr) via stimulation of d1 receptors on the terminals of striatonigral afferents. |
1997-01-07 |
2023-08-12 |
rat |
| D Ebert, H Feistel, T Loew, A Pirne. Dopamine and depression--striatal dopamine D2 receptor SPECT before and after antidepressant therapy. Psychopharmacology. vol 126. issue 1. 1996-12-23. PMID:8853222. |
the changes observed might be the result of increased tonic dopamine release in the basal ganglia, but several other explanations exist. |
1996-12-23 |
2023-08-12 |
Not clear |
| K Kuwabara, S Hitoshi, N Nukina, K Ishii, T Momose, S Kubota, Y Seyama, I Kanazaw. PET analysis of a case of cerebrotendinous xanthomatosis presenting hemiparkinsonism. Journal of the neurological sciences. vol 138. issue 1-2. 1996-12-03. PMID:8791252. |
although mri studies could not detect any abnormality in the basal ganglia or midbrain, pet analysis using [18f]-6-fluoro-l-dopa revealed reduced uptake of dopamine into the putamen, suggesting the impairment of presynaptic dopaminergic neurons. |
1996-12-03 |
2023-08-12 |
Not clear |