Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
G Heimer, M Rivlin, Z Israel, H Bergma. Synchronizing activity of basal ganglia and pathophysiology of Parkinson's disease. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017503. |
we conclude that the normal fluctuation of basal ganglia dopamine levels combined with local cortico-striatal learning rules lead to noncorrelated activity in the pallidum. |
2006-10-24 |
2023-08-12 |
human |
J V Jacobs, F B Hora. Abnormal proprioceptive-motor integration contributes to hypometric postural responses of subjects with Parkinson's disease. Neuroscience. vol 141. issue 2. 2006-10-04. PMID:16713110. |
medication did not consistently improve the length and accuracy of the parkinson's disease subjects' compensatory steps, suggesting that degeneration of dopamine circuits within the basal ganglia is not responsible for the proprioceptive-motor deficit that degrades compensatory steps in parkinson's disease subjects. |
2006-10-04 |
2023-08-12 |
human |
Agnes Nadjar, Jonathan M Brotchie, Celine Guigoni, Qin Li, Shao-Bo Zhou, Gui-Jie Wang, Paula Ravenscroft, François Georges, Alan R Crossman, Erwan Bezar. Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 34. 2006-09-28. PMID:16928853. |
the classic view of anatomofunctional organization of the basal ganglia is that striatopallidal neurons of the "indirect" pathway express d2 dopamine receptors and corelease enkephalin with gaba, whereas striatopallidal neurons of the "direct" pathway bear d1 dopamine receptors and corelease dynorphin and substance p with gaba. |
2006-09-28 |
2023-08-12 |
Not clear |
Agnes Nadjar, Jonathan M Brotchie, Celine Guigoni, Qin Li, Shao-Bo Zhou, Gui-Jie Wang, Paula Ravenscroft, François Georges, Alan R Crossman, Erwan Bezar. Phenotype of striatofugal medium spiny neurons in parkinsonian and dyskinetic nonhuman primates: a call for a reappraisal of the functional organization of the basal ganglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 34. 2006-09-28. PMID:16928853. |
although many studies have investigated the pathophysiology of the basal ganglia after dopamine denervation and subsequent chronic levodopa (l-dopa) treatment, none has ever considered the possibility of plastic changes leading to profound reorganization and/or biochemical phenotype modifications of medium spiny neurons. |
2006-09-28 |
2023-08-12 |
Not clear |
Genela Morris, Alon Nevet, David Arkadir, Eilon Vaadia, Hagai Bergma. Midbrain dopamine neurons encode decisions for future action. Nature neuroscience. vol 9. issue 8. 2006-09-27. PMID:16862149. |
current models of the basal ganglia and dopamine neurons emphasize their role in reinforcement learning. |
2006-09-27 |
2023-08-12 |
monkey |
Genela Morris, Alon Nevet, David Arkadir, Eilon Vaadia, Hagai Bergma. Midbrain dopamine neurons encode decisions for future action. Nature neuroscience. vol 9. issue 8. 2006-09-27. PMID:16862149. |
because dopamine neurons do not have spatial or motor properties, we conclude that immediate decisions are likely to be generated elsewhere and conveyed to the dopamine neurons, which play a role in shaping long-term decision policy through dynamic modulation of the efficacy of basal ganglia synapses. |
2006-09-27 |
2023-08-12 |
monkey |
C Warren Olanow, José A Obeso, Fabrizio Stocch. Drug insight: Continuous dopaminergic stimulation in the treatment of Parkinson's disease. Nature clinical practice. Neurology. vol 2. issue 7. 2006-09-15. PMID:16932589. |
dopaminergic neurons in the basal ganglia normally fire in a random but continuous manner, so that striatal dopamine concentrations are maintained at a relatively constant level. |
2006-09-15 |
2023-08-12 |
Not clear |
Gali Heimer, Michal Rivlin-Etzion, Izhar Bar-Gad, Joshua A Goldberg, Suzanne N Haber, Hagai Bergma. Dopamine replacement therapy does not restore the full spectrum of normal pallidal activity in the 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine primate model of Parkinsonism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 31. 2006-09-05. PMID:16885224. |
we therefore suggest that this imbalance reflects additional abnormal organization of the basal ganglia networks in response to dopamine replacement and may constitute the physiological substrate of the limitations and side effects of chronic drt. |
2006-09-05 |
2023-08-12 |
monkey |
C J Zeis. Neuroanatomical phenotyping in the mouse: the dopaminergic system. Veterinary pathology. vol 42. issue 6. 2006-08-01. PMID:16301571. |
one of these resides in the basal nuclei and their associated projections and utilizes dopamine as a neurotransmitter. |
2006-08-01 |
2023-08-12 |
mouse |
J L Short, C Ledent, E Borrelli, J Drago, A J Lawrenc. Genetic interdependence of adenosine and dopamine receptors: evidence from receptor knockout mice. Neuroscience. vol 139. issue 2. 2006-07-31. PMID:16476524. |
dopamine and adenosine receptors are known to share a considerable overlap in their regional distribution, being especially rich in the basal ganglia. |
2006-07-31 |
2023-08-12 |
mouse |
Aaron J Gruber, Peter Dayan, Boris S Gutkin, Sara A Soll. Dopamine modulation in the basal ganglia locks the gate to working memory. Journal of computational neuroscience. vol 20. issue 2. 2006-06-30. PMID:16699839. |
dopamine modulation in the basal ganglia locks the gate to working memory. |
2006-06-30 |
2023-08-12 |
human |
Aaron J Gruber, Peter Dayan, Boris S Gutkin, Sara A Soll. Dopamine modulation in the basal ganglia locks the gate to working memory. Journal of computational neuroscience. vol 20. issue 2. 2006-06-30. PMID:16699839. |
dopamine in the basal ganglia effectively locks this gate by influencing the stability of up and down states in the striatum. |
2006-06-30 |
2023-08-12 |
human |
R M Kostrzewa, P Nowak, J P Kostrzewa, R A Kostrzewa, R Bru. Peculiarities of L: -DOPA treatment of Parkinson's disease. Amino acids. vol 28. issue 2. 2006-05-24. PMID:15750845. |
l-dihydroxyphenylalanine (l: -dopa), the anti-parkinsonian drug affording the greatest symptomatic relief of parkinsonian symptoms, is still misunderstood in terms of its neurotoxic potential and the mechanism by which generated dopamine (da) is able to exert an effect despite the absence of da innervation of target sites in basal ganglia. |
2006-05-24 |
2023-08-12 |
rat |
Kendall H Lee, Charles D Blaha, Brent T Harris, Shannon Cooper, Frederick L Hitti, James C Leiter, David W Roberts, Uhnoh Ki. Dopamine efflux in the rat striatum evoked by electrical stimulation of the subthalamic nucleus: potential mechanism of action in Parkinson's disease. The European journal of neuroscience. vol 23. issue 4. 2006-05-09. PMID:16519665. |
taken together, these results suggest that enhanced dopamine release within the basal ganglia may be an important mechanism whereby high-frequency stimulation of the subthalamic nucleus improves motor symptoms of parkinson's disease. |
2006-05-09 |
2023-08-12 |
rat |
Jonathan W Min. Neurobiology of basal ganglia and Tourette syndrome: basal ganglia circuits and thalamocortical outputs. Advances in neurology. vol 99. 2006-05-09. PMID:16536354. |
in summary, the scheme of basal ganglia function presented here, in conjunction with known features of anatomical organization and dopamine neurotransmission provides a hypothesis for the pathophysiology of tics. |
2006-05-09 |
2023-08-12 |
Not clear |
Roger L Albi. Neurobiology of basal ganglia and Tourette syndrome: striatal and dopamine function. Advances in neurology. vol 99. 2006-05-09. PMID:16536355. |
neurobiology of basal ganglia and tourette syndrome: striatal and dopamine function. |
2006-05-09 |
2023-08-12 |
Not clear |
I G Sil'ki. [Role of the basal ganglia in the occurrence of paradoxical sleep dreams (hypothetical mechanism)]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 56. issue 1. 2006-05-03. PMID:16583673. |
this disinhibition is promoted by activation of dopaminergic cells by pedunculopontine neurons, subsequent rise in dopamine concentration in the input basal ganglia structure. |
2006-05-03 |
2023-08-12 |
Not clear |
I G Sil'ki. [Role of the basal ganglia in the occurrence of paradoxical sleep dreams (hypothetical mechanism)]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 56. issue 1. 2006-05-03. PMID:16583673. |
this selection is caused by modifiable action of dopamine on long-term changes in the efficacy of synaptic transmission during circulation of signals in closed interconnected loops, each of which includes one of the visual cortical areas (motor cortex), one of the thalamic nuclei, limbic and one of the visual areas (motor area) of the basal ganglia. |
2006-05-03 |
2023-08-12 |
Not clear |
Nicolas Mallet, Bérangère Ballion, Catherine Le Moine, François Gono. Cortical inputs and GABA interneurons imbalance projection neurons in the striatum of parkinsonian rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 14. 2006-04-26. PMID:16597742. |
therefore, dopamine degeneration induces a cascade of imbalances that spread out of the basal ganglia and affect the whole basal ganglia-thalamo-cortical circuits. |
2006-04-26 |
2023-08-12 |
rat |
Reidun Torp, Preet Bano Singh, Dag R Sørensen, Espen Dietrichs, Henry Hirschber. [Growth factors as neuroprotective treatment in Parkinson disease?]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. vol 126. issue 7. 2006-04-11. PMID:16554879. |
the study reported here evaluates the ability of externally applied growth factors to protect the dopamine fibres in the basal ganglia in a toxin-induced animal model of the disease. |
2006-04-11 |
2023-08-12 |
Not clear |