| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D Domenger, R K W Schwartin. Effects of neostriatal 6-OHDA lesion on performance in a rat sequential reaction time task. Neuroscience letters. vol 444. issue 3. 2008-12-03. PMID:18760328. |
work in humans and monkeys has provided evidence that the basal ganglia, and the neurotransmitter dopamine therein, play an important role for sequential learning and performance. |
2008-12-03 |
2023-08-12 |
human |
| Okihide Hikosaka, Ethan Bromberg-Martin, Simon Hong, Masayuki Matsumot. New insights on the subcortical representation of reward. Current opinion in neurobiology. vol 18. issue 2. 2008-12-02. PMID:18674617. |
midbrain dopamine neurons modulate these basal ganglia neurons differentially using signals related to reward-prediction error. |
2008-12-02 |
2023-08-12 |
Not clear |
| Colleen M Niswender, Kari A Johnson, C David Weaver, Carrie K Jones, Zixiu Xiang, Qingwei Luo, Alice L Rodriguez, Joy E Marlo, Tomas de Paulis, Analisa D Thompson, Emily L Days, Tasha Nalywajko, Cheryl A Austin, Michael Baxter Williams, Jennifer E Ayala, Richard Williams, Craig W Lindsley, P Jeffrey Con. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Molecular pharmacology. vol 74. issue 5. 2008-11-17. PMID:18664603. |
parkinson's disease (pd) is caused by the death of dopamine neurons in the basal ganglia and results in motor symptoms such as tremor and bradykinesia. |
2008-11-17 |
2023-08-12 |
human |
| Massimiliano Di Filippo, Barbara Picconi, Alessandro Tozzi, Veronica Ghiglieri, Aroldo Rossi, Paolo Calabres. The endocannabinoid system in Parkinson's disease. Current pharmaceutical design. vol 14. issue 23. 2008-11-17. PMID:18781984. |
the evidence that ecbs play a central role in regulating basal ganglia physiology and motor function and the profound modifications occurring in ecb signaling after dopamine depletion in both experimental models of pd and patients suffering from the disease, provide support for the development of pharmacological compounds targeting the ecb system as symptomatic and neuroprotective therapeutic strategies for pd. |
2008-11-17 |
2023-08-12 |
Not clear |
| Kenta Sato, Chiho Sumi-Ichinose, Ryuji Kaji, Kazuhisa Ikemoto, Takahide Nomura, Ikuko Nagatsu, Hiroshi Ichinose, Masayuki Ito, Wataru Sako, Shinji Nagahiro, Ann M Graybiel, Satoshi Got. Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 34. 2008-10-24. PMID:18713855. |
the mechanisms underlying the genesis of dystonia in drd present a challenge to models of basal ganglia movement control, given that striatal dopamine deficiency is the hallmark of parkinson's disease. |
2008-10-24 |
2023-08-12 |
mouse |
| Bhooma R Aravamuthan, Debra A Bergstrom, Robin A French, Joseph J Taylor, Louise C Parr-Brownlie, Judith R Walter. Altered neuronal activity relationships between the pedunculopontine nucleus and motor cortex in a rodent model of Parkinson's disease. Experimental neurology. vol 213. issue 2. 2008-10-08. PMID:18601924. |
the anesthetized rat is a useful model for investigating the effects of dopamine loss on the transmission of oscillatory cortical activity through basal ganglia structures. |
2008-10-08 |
2023-08-12 |
rat |
| Bhooma R Aravamuthan, Debra A Bergstrom, Robin A French, Joseph J Taylor, Louise C Parr-Brownlie, Judith R Walter. Altered neuronal activity relationships between the pedunculopontine nucleus and motor cortex in a rodent model of Parkinson's disease. Experimental neurology. vol 213. issue 2. 2008-10-08. PMID:18601924. |
to investigate the impact of dopamine cell lesion-induced changes in basal ganglia output on activity in the ppn, this study examines ppn spike timing with reference to motor cortex (mcx) local field potential (lfp) activity in urethane- or ketamine-anesthetized rats. |
2008-10-08 |
2023-08-12 |
rat |
| Bhooma R Aravamuthan, Debra A Bergstrom, Robin A French, Joseph J Taylor, Louise C Parr-Brownlie, Judith R Walter. Altered neuronal activity relationships between the pedunculopontine nucleus and motor cortex in a rodent model of Parkinson's disease. Experimental neurology. vol 213. issue 2. 2008-10-08. PMID:18601924. |
these observations suggest that dopamine loss alters ppn spike timing by increasing inhibitory oscillatory input to the ppn from basal ganglia output nuclei, a phenomenon that may be relevant to motor dysfunction and ppn dbs efficacy in pd patients. |
2008-10-08 |
2023-08-12 |
rat |
| Ana Belén Martín, Emilio Fernandez-Espejo, Belén Ferrer, Miguel Angel Gorriti, Ainhoa Bilbao, Miguel Navarro, Fernando Rodriguez de Fonseca, Rosario Moratall. Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 7. 2008-09-24. PMID:17957223. |
this study indicates that the endocannabinoid system is a relevant negative modulator of both dopamine d1 and d2 receptor-mediated behaviors, a finding that may contribute to our understanding of basal ganglia motor disorders. |
2008-09-24 |
2023-08-12 |
mouse |
| Daniel Kondziella, Ursula Sonnewald, Mats Tullberg, Carsten Wikkels. Brain metabolism in adult chronic hydrocephalus. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18419769. |
compromised periventricular blood flow, decreased dopamine levels in the substantia nigra and damaged striatal gabaergic interneurons may reflect basal ganglia symptoms. |
2008-09-12 |
2023-08-12 |
human |
| Adriana Galvan, Thomas Wichman. Pathophysiology of parkinsonism. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 119. issue 7. 2008-08-20. PMID:18467168. |
the motor signs of parkinson's disease are thought to result in large part from a reduction of the level of dopamine in the basal ganglia. |
2008-08-20 |
2023-08-12 |
Not clear |
| Adriana Galvan, Thomas Wichman. Pathophysiology of parkinsonism. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. vol 119. issue 7. 2008-08-20. PMID:18467168. |
over the last few years, many of the functional and anatomical consequences of dopamine loss in these structures have been identified, both in the basal ganglia and in related areas in thalamus and cortex. |
2008-08-20 |
2023-08-12 |
Not clear |
| John G Kerns, Keith H Nuechterlein, Todd S Braver, Deanna M Barc. Executive functioning component mechanisms and schizophrenia. Biological psychiatry. vol 64. issue 1. 2008-08-15. PMID:18549874. |
executive functioning refers to a set of processes involved in complex, goal-directed thought and behavior involving multiple brain regions (e.g., prefrontal cortex, parietal cortex, basal ganglia) and multiple neurotransmitters (e.g., dopamine, glutamate, gamma-aminobutyric acid). |
2008-08-15 |
2023-08-12 |
Not clear |
| Samuel D Gale, Abigail L Person, David J Perke. A novel basal ganglia pathway forms a loop linking a vocal learning circuit with its dopaminergic input. The Journal of comparative neurology. vol 508. issue 5. 2008-08-01. PMID:18398824. |
in songbirds, dopamine may act on the basal ganglia nucleus area x to influence the neural activity that contributes to vocal learning and contextual changes in song variability. |
2008-08-01 |
2023-08-12 |
Not clear |
| Liming Luan, Feng Ding, Yi Ai, Anders Andersen, Peter Hardy, Eric Forman, Greg A Gerhardt, Don M Gash, Richard Grondin, Zhiming Zhan. Pharmacological MRI (phMRI) monitoring of treatment in hemiparkinsonian rhesus monkeys. Cell transplantation. vol 17. issue 4. 2008-07-29. PMID:18522244. |
here we report the monitoring of gdnf-induced functional changes of the basal ganglia in hemiparkinsonian monkeys via pharmacological mri measuring the blood oxygenation level-dependent (bold) response to a direct dopamine agonist (apomorphine, apo). |
2008-07-29 |
2023-08-12 |
monkey |
| R G Thorne, L R Hanson, T M Ross, D Tung, W H Fre. Delivery of interferon-beta to the monkey nervous system following intranasal administration. Neuroscience. vol 152. issue 3. 2008-07-21. PMID:18304744. |
our study suggests both ifn-beta and ifn-alpha, which share the same receptor, may be bound with relatively high affinity in these structures, possibly offering new insight into a neurovegetative syndrome induced by ifn-alpha therapy and suspected to involve altered dopamine neurotransmission in the basal ganglia. |
2008-07-21 |
2023-08-12 |
rat |
| J C Lewers, I Ceballos-Picot, T L Shirley, L Mockel, K Egami, H A Jinna. Consequences of impaired purine recycling in dopaminergic neurons. Neuroscience. vol 152. issue 3. 2008-07-21. PMID:18313225. |
in the brains of humans or mice with inherited defects of the purine recycling enzyme hypoxanthine-guanine phosphoribosyltransferase (hprt), the most prominent defect is loss of basal ganglia dopamine. |
2008-07-21 |
2023-08-12 |
mouse |
| Heiko Braak, Kelly Del Tredic. Cortico-basal ganglia-cortical circuitry in Parkinson's disease reconsidered. Experimental neurology. vol 212. issue 1. 2008-07-17. PMID:18501351. |
the model has undergone refinement, but the emphasis on the basal ganglia side of the equation (dopamine deficiency in the dorsal striatum) remains. |
2008-07-17 |
2023-08-12 |
Not clear |
| Helen J Chenery, Anthony J Angwin, David A Coplan. The basal ganglia circuits, dopamine, and ambiguous word processing: a neurobiological account of priming studies in Parkinson's disease. Journal of the International Neuropsychological Society : JINS. vol 14. issue 3. 2008-07-15. PMID:18419834. |
the basal ganglia circuits, dopamine, and ambiguous word processing: a neurobiological account of priming studies in parkinson's disease. |
2008-07-15 |
2023-08-12 |
Not clear |
| Helen J Chenery, Anthony J Angwin, David A Coplan. The basal ganglia circuits, dopamine, and ambiguous word processing: a neurobiological account of priming studies in Parkinson's disease. Journal of the International Neuropsychological Society : JINS. vol 14. issue 3. 2008-07-15. PMID:18419834. |
research into the processing of lexical ambiguities has provided a valuable paradigm for investigating the functional architecture of the language processing system in normal and neurologically impaired populations and specifically, how basal ganglia circuits and the neurotransmitter dopamine may act to enhance and/or suppress various meanings relative to the context in which the lexical ambiguity appears. |
2008-07-15 |
2023-08-12 |
Not clear |