| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ya Wang, Yang Liu, Jianwei Xiong, Tingting Di, Zihao Yuan, Jie Wu, Ling Che. Reduced serotonin impairs long-term depression in basolateral amygdala complex and causes anxiety-like behaviors in a mouse model of perimenopause. Experimental neurology. vol 321. 2020-02-28. PMID:31377402. |
serotonin (5-ht) synthesis in dorsal raphe nucleus (drn) and serotonergic afferents to basolateral amygdala complex (bla) were reduced in vcd-mice, which were recovered by the supplement e2. |
2020-02-28 |
2023-08-13 |
mouse |
| Lavanya P Sharma, Y C Janardhan Redd. Obsessive-compulsive disorder comorbid with schizophrenia and bipolar disorder. Indian journal of psychiatry. vol 61. issue Suppl 1. 2020-02-25. PMID:30745688. |
when ocd presents in the context of schizophrenia, management may include treatment with atypical antipsychotics with limited serotonergic properties, changing the antipsychotic, reduction in the dose of the antipsychotic, addition of cognitive-behavior therapy (cbt), or a specific serotonin reuptake inhibitor (ssri). |
2020-02-25 |
2023-08-13 |
Not clear |
| Jin Zhang, Shuxuan Lv, Guoyi Tang, Guanyun Bian, Yaxin Yang, Ruotong Li, Jie Yang, Jian Li. Activation of calcium-impermeable GluR2-containing AMPA receptors in the lateral habenula produces antidepressant-like effects in a rodent model of Parkinson's disease. Experimental neurology. vol 322. 2020-02-24. PMID:31499061. |
we further found that intra-lhb injection of (s)-ampa excited dopaminergic neurons in the anterior ventral tegmental area (avta) and serotonergic neurons in the dorsal raphe nucleus (drn), which increased release of da and 5-ht in the medial prefrontal cortex (mpfc), while nbqx induced the opposite effects. |
2020-02-24 |
2023-08-13 |
rat |
| Jin Zhang, Shuxuan Lv, Guoyi Tang, Guanyun Bian, Yaxin Yang, Ruotong Li, Jie Yang, Jian Li. Activation of calcium-impermeable GluR2-containing AMPA receptors in the lateral habenula produces antidepressant-like effects in a rodent model of Parkinson's disease. Experimental neurology. vol 322. 2020-02-24. PMID:31499061. |
collectively, antidepressant-like effects produced by (s)-ampa attribute to activation of lhb neurons expressing ci-ampar, which excites avta dopaminergic neurons and drn serotonergic neurons via the direct projection, thereby increasing release of mpfc da and 5-ht. |
2020-02-24 |
2023-08-13 |
rat |
| Jui-Hu Shih, Chuang-Hsin Chiu, Kuo-Hsing Ma, Yuahn-Sieh Huang, Chyng-Yann Shiue, Ting-Yin Yeh, Li-Ting Kao, Yang-Yi Lin, I-Hsun L. Autophagy inhibition plays a protective role against 3, 4-methylenedioxymethamphetamine (MDMA)-induced loss of serotonin transporters and depressive-like behaviors in rats. Pharmacological research. vol 142. 2020-02-13. PMID:30826457. |
the 3,4-methylenedioxymethamphetamine (mdma) is a popular recreational drug, which ultimately leads to serotonergic (5-ht) neurotoxicity and psychiatric disorders. |
2020-02-13 |
2023-08-13 |
rat |
| Tatiana O Kolesnikova, Sergey L Khatsko, Konstantin A Demin, Vadim A Shevyrin, Allan V Kaluef. DARK Classics in Chemical Neuroscience: α-Pyrrolidinovalerophenone ("Flakka"). ACS chemical neuroscience. vol 10. issue 1. 2020-02-06. PMID:30384587. |
its interesting pharmacological profile (co-inhibition of dopamine and norepinephrine, but not serotonin, transporters) also calls for further studies of α-pvp in animal models, to dissect serotonergic from other monoaminergic mechanisms of action of drugs of abuse. |
2020-02-06 |
2023-08-13 |
Not clear |
| Yuan-Qiang Wang, Wei-Wei Lin, Nan Wu, Si-Yi Wang, Mao-Zi Chen, Zhi-Hua Lin, Xiang-Qun Xie, Zhi-Wei Fen. Structural insight into the serotonin (5-HT) receptor family by molecular docking, molecular dynamics simulation and systems pharmacology analysis. Acta pharmacologica Sinica. vol 40. issue 9. 2020-02-05. PMID:30814658. |
however, due to a high sequence similarity/identity among 5-ht receptors and the unavailability of the 3d structure of the different 5-ht receptor, no report was available so far regarding the systematical comparison of the key and selective residues involved in the binding pocket, making it difficult to design subtype-selective serotonergic drugs. |
2020-02-05 |
2023-08-13 |
Not clear |
| Saikat Chakraborty, Jack C Lennon, Sridhar A Malkaram, Yan Zeng, Daniel W Fisher, Hongxin Don. Serotonergic system, cognition, and BPSD in Alzheimer's disease. Neuroscience letters. vol 704. 2020-02-05. PMID:30946928. |
though differences in overall serotonergic transmission occur in ad, circuit-specific alterations in individual 5-ht receptors (5-htrs) are likely linked to the heterogeneous presentation of bpsd in ad. |
2020-02-05 |
2023-08-13 |
Not clear |
| Sergio Vegas-Suarez, Elena Paredes-Rodriguez, Asier Aristieta, Jose V Lafuente, Cristina Miguelez, Luisa Uged. Dysfunction of serotonergic neurons in Parkinson's disease and dyskinesia. International review of neurobiology. vol 146. 2020-02-03. PMID:31349930. |
evidence indicates that the pathophysiology of both pd and lid disorders is also associated with the dysfunctional activity of the serotonergic (5-ht) neurons that may be responsible for motor and non-motor disturbances. |
2020-02-03 |
2023-08-13 |
Not clear |
| Ibrahim M Shokry, Connor J Shields, John J Callanan, Zhiyuan Ma, Rui Ta. Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats. BMC pharmacology & toxicology. vol 20. issue 1. 2020-02-03. PMID:31383036. |
mdma causes serotonin (5-ht) syndrome immediately after administration and serotonergic injury in a few days or weeks. |
2020-02-03 |
2023-08-13 |
rat |
| Ibrahim M Shokry, Connor J Shields, John J Callanan, Zhiyuan Ma, Rui Ta. Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats. BMC pharmacology & toxicology. vol 20. issue 1. 2020-02-03. PMID:31383036. |
however, a serotonin syndrome is not always followed by serotonergic injury, indicating different mechanisms responsible for two adverse effects. |
2020-02-03 |
2023-08-13 |
rat |
| Minoru Miyazato, Asuka Ashikar. [Therapeutic new targets for stress urinary incontinence in the central nervous system]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 155. issue 1. 2020-01-24. PMID:31902839. |
therapeutic targets include adrenergic and serotonergic (5-ht) receptors in the spinal cord, which stimulate pudendal nerve innervating the external urethral sphincter and/or sympathetic nerve innervating urethral smooth muscle. |
2020-01-24 |
2023-08-13 |
rat |
| Balaji Krishna. Amygdala-Hippocampal Phospholipase D (PLD) Signaling As Novel Mechanism of Cocaine-Environment Maladaptive Conditioned Responses. The international journal of neuropsychopharmacology. vol 19. issue 6. 2020-01-23. PMID:26802567. |
in the present study, 1 of the 2 known upstream serotonergic targets of phospholipase d, the serotonin (5-hydroxytryptamine) 2c receptor, was investigated for its role in recruiting phospholipase d signaling in cocaine-conditioned behaviors altered in the rat amygdala and dorsal hippocampus. |
2020-01-23 |
2023-08-13 |
rat |
| Lisa van de Wijer, Lidiane P Garcia, Sabrina I Hanswijk, Juliette Rando, Anthonieke Middelman, Rob Ter Heine, Quirijn de Mast, Gerard J M Martens, André J A M van der Ven, Sharon M Kolk, Arnt F A Schellekens, Judith R Homber. Neurodevelopmental and behavioral consequences of perinatal exposure to the HIV drug efavirenz in a rodent model. Translational psychiatry. vol 9. issue 1. 2020-01-15. PMID:30745561. |
the neurotransmitter serotonin exerts neurotrophic effects during neurodevelopment and antenatal exposure to serotonergic agents has been linked to developmental delay. |
2020-01-15 |
2023-08-13 |
human |
| Radwa Khalil, Ben Godde, Ahmed A Kari. The Link Between Creativity, Cognition, and Creative Drives and Underlying Neural Mechanisms. Frontiers in neural circuits. vol 13. 2020-01-13. PMID:30967763. |
however, the current literature on neural systems and circuits underlying creative cognition, and on how creative drives such as motivation, mood states, and reward could shape our creative mind through the associated neuromodulatory systems [i.e., the dopaminergic (da), the noradrenergic (ne) and the serotonergic (5-ht) system] seems to be insufficient to explain the creative ideation and production process. |
2020-01-13 |
2023-08-13 |
Not clear |
| Simon D Brandt, Pierce V Kavanagh, Folker Westphal, Alexander Stratford, Simon P Elliott, Geraldine Dowling, Jason Wallach, Adam L Halberstad. Return of the lysergamides. Part V: Analytical and behavioural characterization of 1-butanoyl-d-lysergic acid diethylamide (1B-LSD). Drug testing and analysis. vol 11. issue 8. 2020-01-13. PMID:31083768. |
lsd and other serotonergic hallucinogens induce the head-twitch response (htr) in rats and mice, which is believed to be mediated largely by 5-ht |
2020-01-13 |
2023-08-13 |
mouse |
| Sofi da Cunha-Bang, Anders Ettrup, Brenda Mc Mahon, Anine Persson Skibsted, Martin Schain, Szabolcs Lehel, Agnete Dyssegaard, Louise Møller Jørgensen, Kirsten Møller, Nic Gillings, Claus Svarer, Gitte M Knudse. Measuring endogenous changes in serotonergic neurotransmission with [ Translational psychiatry. vol 9. issue 1. 2020-01-09. PMID:30975977. |
measuring endogenous changes in serotonergic neurotransmission with [ developing positron emission tomography (pet) radioligands for the detection of endogenous serotonin release will enable the investigation of serotonergic deficits in many neuropsychiatric disorders. |
2020-01-09 |
2023-08-13 |
Not clear |
| Kazue Hisaoka-Nakashima, Sayaka Taki, Shintaro Watanabe, Yoki Nakamura, Yoshihiro Nakata, Norimitsu Moriok. Mirtazapine increases glial cell line-derived neurotrophic factor production through lysophosphatidic acid 1 receptor-mediated extracellular signal-regulated kinase signaling in astrocytes. European journal of pharmacology. vol 860. 2020-01-08. PMID:31306636. |
the antidepressant mirtazapine is a noradrenaline and specific serotonergic antidepressant (nassa) and does not block reuptake of catecholamines and serotonin. |
2020-01-08 |
2023-08-13 |
rat |
| Brian A Baldo, Michael A Ros. The anaesthetist, opioid analgesic drugs, and serotonin toxicity: a mechanistic and clinical review. British journal of anaesthesia. vol 124. issue 1. 2020-01-06. PMID:31653394. |
most cases of serotonin toxicity are provoked by therapeutic doses of a combination of two or more serotonergic drugs, defined as drugs affecting the serotonin neurotransmitter system. |
2020-01-06 |
2023-08-13 |
Not clear |
| Jodi L Pawluski, Ming Li, Joseph S Lonstei. Serotonin and motherhood: From molecules to mood. Frontiers in neuroendocrinology. vol 53. 2020-01-02. PMID:30878665. |
therefore, the main goals of this review are to detail: (1) how the serotonin system of the female brain changes across pregnancy and postpartum; (2) the role of the central serotonergic system in maternal caregiving and maternal aggression; and (3) how the serotonin system and selective serotonin reuptake inhibitor medications (ssris) are involved in the treatment of maternal mental illness. |
2020-01-02 |
2023-08-13 |
Not clear |