| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P McCleary, J D Leande. Meperidine-induced hypothermia in the rat. Neuropharmacology. vol 21. issue 12. 1983-03-11. PMID:6984142. |
the results indicate that the hypothermic effect of meperidine is not a result of an opioid action, and that although it may be mediated through serotonergic systems, inhibition of serotonin reuptake is probably not the primary mechanism. |
1983-03-11 |
2023-08-12 |
rat |
| J M Lauder, J A Wallace, H Krebs, P Petrusz, K McCarth. In vivo and in vitro development of serotonergic neurons. Brain research bulletin. vol 9. issue 1-6. 1983-02-25. PMID:6129049. |
the first part of this paper describes the normal ontogeny of the serotonergic (5-ht) system in the rat brain as studied using long survival 3h-thymidine autoradiography (time of neuronal genesis, time of origin) and the falck-hillarp histofluorescence method, electron microscopy, and immunocytochemistry (anti-5-ht). |
1983-02-25 |
2023-08-12 |
rat |
| J A Finkelstein, W T Chance, J E Fische. Brain serotonergic activity and plasma amino acid levels in genetically obese Zucker rats. Pharmacology, biochemistry, and behavior. vol 17. issue 5. 1983-02-25. PMID:6184736. |
in order to test the hypothesis that serotonergic activity is abnormal in the brains of genetically obese zucker rats, levels of serotonin (5-ht); its amino acid precursor, tryptophan (trp), and its major metabolite, 5-hydroxyindoleacetic acid (5-hiaa) were measured in eight brain regions in groups of obese and non-obese male rats. |
1983-02-25 |
2023-08-12 |
rat |
| A Gratto. Time course analysis of para-chlorophenylalanine induced suppression of self-stimulation behavior. Pharmacology, biochemistry, and behavior. vol 17. issue 4. 1983-02-25. PMID:6217466. |
the hypothesis of a serotonergic basis of reward rests partly on data showing that serotonin (5-ht) depletion by para-chlorophenylalanine (p-cpa) causes depression of self-stimulation (ss) rates. |
1983-02-25 |
2023-08-12 |
Not clear |
| M Weiss, J Pelle. Raphe - cerebellum interactions. I. Effects of cerebellar stimulation and harmaline administration on single unit activity of midbrain raphe neurons in the rat. Experimental brain research. vol 48. issue 2. 1983-02-25. PMID:6293860. |
from a total sample of 160 cells, 106 (66%) presenting a slow regular discharge pattern were classified as serotonergic (5-ht cells), whereas 35 (22%), having a faster firing rate, were considered non serotonergic (ns cells). |
1983-02-25 |
2023-08-12 |
rat |
| J A Wallace, P Petrusz, J M Laude. Serotonin immunocytochemistry in the adult and developing rat brain: methodological and pharmacological considerations. Brain research bulletin. vol 9. issue 1-6. 1983-02-25. PMID:6756548. |
rather, since the staining could be inhibited by pretreatment with the catecholaminergic uptake blocker desmethylimipramine, it is postulated that this effect may be due to either (1) the non-specific uptake of 5-ht or 5-hydroxytryptophan (5-htp) into the dopaminergic cells of a9 and a10 due to elevated levels of these substances in the dense serotonergic axonal plexus passing through this region or (2) to an increased uptake of circulating l-tryptophan by these a9 and a10 cells followed by conversion of this amino acid to tryptamine by aromatic amine decarboxylase, an enzyme common to both 5-ht and dopaminergic neurons. |
1983-02-25 |
2023-08-12 |
rat |
| R M Bowker, K N Westlund, J D Coulte. Origins of serotonergic projections to the lumbar spinal cord in the monkey using a combined retrograde transport and immunocytochemical technique. Brain research bulletin. vol 9. issue 1-6. 1983-02-25. PMID:6756550. |
with this technique the brainstem origins of descending serotonergic (5ht) pathways to the lumbar spinal cord have been determined in the monkey. |
1983-02-25 |
2023-08-12 |
monkey |
| H G Lidov, M E Mollive. Immunohistochemical study of the development of serotonergic neurons in the rat CNS. Brain research bulletin. vol 9. issue 1-6. 1983-02-25. PMID:6756556. |
in this study the development of serotonergic (5-ht) neurons is followed from their initiation of transmitter synthesis until the establishment of an essentially mature morphology. |
1983-02-25 |
2023-08-12 |
rat |
| H G Baumgarten, H P Klemm, J Sievers, H G Schlossberge. Dihydroxytryptamines as tools to study the neurobiology of serotonin. Brain research bulletin. vol 9. issue 1-6. 1983-02-25. PMID:7172024. |
the neurotoxins 5,6- and 5,7-dihydroxytryptamine are accepted tools for "chemical degeneration" of serotonergic (5-ht) axons in the cns (for reviews, see [11, 12, 15, 20] ). |
1983-02-25 |
2023-08-12 |
Not clear |
| T Di Paolo, B Gagné, P Poyet, F Labri. [3H]Apomorphine binding to a GTP-sensitive dopaminergic site in bovine anterior pituitary gland. Canadian journal of biochemistry. vol 60. issue 11. 1983-02-25. PMID:7172091. |
by contrast, adrenergic (phentolamine, propranolol, and clonidine) and serotonergic (serotonin, cyproheptadine, and methysergide) agonists and antagonists do not compete or are weak competitors at micromolar concentrations. |
1983-02-25 |
2023-08-12 |
cattle |
| J B Appel, F J White, A M Holohea. Analyzing mechanism(s) of hallucinogenic drug action with drug discrimination procedures. Neuroscience and biobehavioral reviews. vol 6. issue 4. 1983-02-14. PMID:7177512. |
with reference to lsd, many dd experiments suggest: (1) that while hallucinogens substitute for (mimic) lsd (in rats), such substitution does not predict hallucinogenic potency (in humans) but does predict similarities in mechanism(s) of action; (2) the behavioral (in vivo) effects of lsd, unlike those of some of its congeners, are mediated primarily by central, serotonergic (5-ht) neuronal mechanism although lsd may also have (secondary) dopamine (da) agonist properties; (3) both the locus and the nature of these lsd-5-ht interactions are unclear: cells arising from b-7, b-8 and b-9 regions of the dorsal-medial raphe may be involved; pretreatment with agents that deplete 5-ht and increase the stereospecific binding of 3h-lsd in vitro (p-chlorophenylalanine; 5,7-dihydroxytryptamine) enhance sensitivity to lsd in vivo. |
1983-02-14 |
2023-08-12 |
rat |
| A Sietnieks, B J Meyerso. Enhancement by progesterone of 5-hydroxytryptophan inhibition of the copulatory response in the female rat. Neuroendocrinology. vol 35. issue 5. 1983-01-27. PMID:6983043. |
possible mechanisms underlying the observed interactive effect of progesterone and serotonin on lordosis behavior, such as a progesterone-induced alteration of serotonergic transmission, are discussed. |
1983-01-27 |
2023-08-12 |
rat |
| M Hadjiconstantinou, P E Potter, N H Nef. Trans-synaptic modulation via muscarinic receptors of serotonin-containing small intensely fluorescent cells of superior cervical ganglion. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 2. issue 12. 1983-01-19. PMID:6183414. |
reserpine, p-chlorophenylalanine, or fluoxetine treatment reduces the content of serotonin in the ganglion, suggesting that the sif cell system has properties similar to those of serotonergic neurons of the brain. |
1983-01-19 |
2023-08-12 |
rat |
| R A Shephard, D A Buxton, P L Broadhurs. Drug interactions do not support reduction in serotonin turnover as the mechanism of action of benzodiazepines. Neuropharmacology. vol 21. issue 10. 1983-01-19. PMID:6216416. |
these findings are discussed in the context of the serotonin hypothesis of benzodiazepine action, with the conclusion that benzodiazepines act at a site distal to that of serotonergic drugs on conflict behaviour. |
1983-01-19 |
2023-08-12 |
Not clear |
| E J Catapan. Demonstration of denervation supersensitivity: a pharmacological approach. Comparative biochemistry and physiology. C: Comparative pharmacology. vol 72. issue 2. 1983-01-07. PMID:6128156. |
this may be due in part to the difficulties associated with producing specific lesions of serotonergic systems and with quantifying physiological responses of the cns due to serotonin. |
1983-01-07 |
2023-08-12 |
Not clear |
| M A Ruda, J Coffield, H W Steinbusc. Immunocytochemical analysis of serotonergic axons in laminae I and II of the lumbar spinal cord of the cat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 2. issue 11. 1983-01-07. PMID:7143045. |
serotonergic axons in the superficial dorsal horn were examined at the light and electron microscopic levels using an antibody specific for serotonin (5-ht). |
1983-01-07 |
2023-08-12 |
cat |
| F de Clerck, J L David, P A Jansse. Inhibition of 5-hydroxytryptamine-induced and -amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist. Agents and actions. vol 12. issue 3. 1982-12-21. PMID:6215842. |
this amplification by 5-hydroxytryptamine results in a platelet response typical for the potentiated agonist; for the combination of the monoamine with collagen, the serotonergic amplification results in enhanced aggregation, release of beta-tg and pf4 and excessive formation of txb2. |
1982-12-21 |
2023-08-12 |
human |
| M Vergnes, E Kemp. Effect of hypothalamic injections of 5,7-dihydroxytryptamine on elicitation of mouse-killing in rats. Behavioural brain research. vol 5. issue 4. 1982-12-18. PMID:6889881. |
in order to further investigate the topography of the 5-ht pathways and terminals though to be involved in an inhibitory control over this behavior, localized lesions of the serotonergic system(s) were performed by means of bilateral 5,7-dihydroxytryptamine (5,7-dht) injections (5 microgram/microliter) into the hypothalamus in naive rats. |
1982-12-18 |
2023-08-12 |
rat |
| G Maura, A Gemignani, M Raiter. Noradrenaline inhibits central serotonin release through alpha 2-adrenoceptors located on serotonergic nerve terminals. Naunyn-Schmiedeberg's archives of pharmacology. vol 320. issue 3. 1982-12-16. PMID:6290904. |
noradrenaline inhibits central serotonin release through alpha 2-adrenoceptors located on serotonergic nerve terminals. |
1982-12-16 |
2023-08-12 |
rat |
| G Maura, A Gemignani, M Raiter. Noradrenaline inhibits central serotonin release through alpha 2-adrenoceptors located on serotonergic nerve terminals. Naunyn-Schmiedeberg's archives of pharmacology. vol 320. issue 3. 1982-12-16. PMID:6290904. |
the results indicate that, in rat brain, the inhibition of 5-hydroxytryptamine release by noradrenaline is mediated by adrenoceptors of the alpha 2-type localized on the terminal serotonergic fibres. |
1982-12-16 |
2023-08-12 |
rat |