| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N N Osborne, S Pate. Postnatal development of serotonin-accumulating neurones in the rabbit retina and an immunohistochemical analysis of the uptake and release of serotonin. Experimental eye research. vol 38. issue 6. 1984-10-17. PMID:6381078. |
the serotonin accumulated by the serotonergic neurones can be released by potassium depolarization in a calcium-dependent manner. |
1984-10-17 |
2023-08-12 |
rabbit |
| P M Vanhoutte, R A Cohen, J M Van Nuete. Serotonin and arterial vessels. Journal of cardiovascular pharmacology. vol 6 Suppl 2. 1984-09-24. PMID:6206351. |
the vasoconstrictor effects of serotonin can be explained by (a) activation of serotonergic receptors on vascular smooth muscle, (b) activation, directly or indirectly, of postjunctional alpha-adrenoceptors, and (c) amplification of the response to other vasoactive agonists. |
1984-09-24 |
2023-08-12 |
Not clear |
| H Y Tsa. Further evidence for the possible relationship between neuropeptides and serotonergic neurones in rat spinal cord. Japanese journal of pharmacology. vol 35. issue 2. 1984-09-20. PMID:6205198. |
these findings may infer a possible mechanism by which neuroactive peptides regulate 5-ht release from serotonergic neurones in the spinal cord. |
1984-09-20 |
2023-08-12 |
rat |
| F De Clerck, B Xhonneux, J Leysen, P A Jansse. Evidence for functional 5-HT2 receptor sites on human blood platelets. Biochemical pharmacology. vol 33. issue 17. 1984-09-19. PMID:6466388. |
the 5-ht induced platelet reaction is inhibited in a concentration-dependent way by various serotonergic antagonists; the potency of these compounds in this respect correlates strongly with their potential to inhibit the specific binding of [3h] ketanserin, a selective label for 5-ht2 binding sites, to rat prefrontal cortex and striatum and to cat platelet membranes. |
1984-09-19 |
2023-08-12 |
human |
| G K Aghajanian, J M Lakosk. Hyperpolarization of serotonergic neurons by serotonin and LSD: studies in brain slices showing increased K+ conductance. Brain research. vol 305. issue 1. 1984-09-14. PMID:6331598. |
hyperpolarization of serotonergic neurons by serotonin and lsd: studies in brain slices showing increased k+ conductance. |
1984-09-14 |
2023-08-12 |
rat |
| G K Aghajanian, J M Lakosk. Hyperpolarization of serotonergic neurons by serotonin and LSD: studies in brain slices showing increased K+ conductance. Brain research. vol 305. issue 1. 1984-09-14. PMID:6331598. |
serotonin and lsd hyperpolarized serotonergic dorsal raphe neurons in rat midbrain slices; the hyperpolarizations were accompanied by a decrease in input resistance, suggesting an increase in potassium conductance as one possible mechanism. |
1984-09-14 |
2023-08-12 |
rat |
| L A Kamal, K H Le Quan-Bui, P Meye. Decreased uptake of 3H-serotonin and endogenous content of serotonin in blood platelets in hypertensive patients. Hypertension (Dallas, Tex. : 1979). vol 6. issue 4. 1984-09-14. PMID:6746086. |
the reduced number of carriers of serotonin uptake and the slight decrease in the affinity constant observed in platelets of patients with essential hypertension suggest that serotonin metabolism is altered in essential hypertension and that blood platelets may be a useful model in studying the serotonergic modifications at the molecular level. |
1984-09-14 |
2023-08-12 |
human |
| M Jouve. [Neuromediators and hypnogenic factors]. Revue neurologique. vol 140. issue 6-7. 1984-09-07. PMID:6147008. |
the serotonergic system of the raphe was considered first as a true hypnogenic system since its inactivation by lesion or inhibition of 5ht biosynthesis with pcpa led to a total insomnia which could be reversed into physiological sleep by a secondary injection of 5htp (the direct precursor of 5ht). |
1984-09-07 |
2023-08-12 |
rat |
| C Barbieri, M Sala, G Bigatti, W G Rauhe, A Guffanti, A Diena, D Scorza, M Bevilacqua, G Norbiat. Serotonergic regulation of cortisol secretion in dogs. Endocrinology. vol 115. issue 2. 1984-09-05. PMID:6745178. |
a significant rise in corticosteroids was observed after 1.5 and 3 mg/kg (p less than 0.01) iv fenfluramine, an indirect serotonergic agonist, as well as after 2 (p less than 0.05) and 3 mg/kg (p less than 0.01) iv quipazine, a direct agonist of 5-ht receptors. |
1984-09-05 |
2023-08-12 |
Not clear |
| J M Aletta, D J Goldber. Routing of transmitter and other changes in fast axonal transport after transection of one branch of the bifurcate axon of an identified neuron. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 4. issue 7. 1984-08-20. PMID:6204021. |
transport of [3h]fucosyl glycoprotein, which normally is associated with the serotonergic vesicle in this axon, decreases to the same extent as transport of [3h]serotonin following proximal transection. |
1984-08-20 |
2023-08-12 |
Not clear |
| S B Freedman, S Chierchia, L Rodriguez-Plaza, R Bugiardini, G Smith, A Maser. Ergonovine-induced myocardial ischemia: no role for serotonergic receptors? Circulation. vol 70. issue 2. 1984-08-20. PMID:6733873. |
because ergonovine appears to produce coronary contractions by a serotonergic (5-ht) mechanism, we attempted to prevent ergonovine-induced ischemia in patients with vasospastic angina by pretreatment with ketanserin, a new selective 5-ht blocker. |
1984-08-20 |
2023-08-12 |
human |
| M Warnhof. Simultaneous determination of norepinephrine, dopamine, 5-hydroxytryptamine and their main metabolites in rat brain using high-performance liquid chromatography with electrochemical detection. Enzymatic hydrolysis of metabolites prior to chromatography. Journal of chromatography. vol 307. issue 2. 1984-08-13. PMID:6203923. |
in order to measure turnover rates of the noradrenergic, dopaminergic, and serotonergic transmitter systems in rat brain, a method was developed by which norepinephrine, dopamine, and 5-hydroxytryptamine, and their main metabolites 3-methoxy-4-hydroxyphenylglycol, 3,4-dihydroxyphenylacetic acid, 3-methoxy-4-hydroxyphenylacetic acid, and 5-hydroxyindole-3-acetic acid, could be measured simultaneously. |
1984-08-13 |
2023-08-12 |
rat |
| L D Van de Kar, C W Wilkinson, Y Skrobik, M S Brownfield, W F Ganon. Evidence that serotonergic neurons in the dorsal raphe nucleus exert a stimulatory effect on the secretion of renin but not of corticosterone. Brain research. vol 235. issue 2. 1984-08-13. PMID:6765221. |
the data support the hypothesis that serotonergic neurons in the dorsal raphe nucleus are part of a neural pathway mediating increased renin secretion, and that the stimulatory effect of serotonin on corticosterone secretion is mediated by a different pathway. |
1984-08-13 |
2023-08-12 |
rat |
| F Belardetti, M Brunelli, G Demontis, D Sonett. Serotonin and Retzius cell depress the hyperpolarization following impulses of leech touch cell. Brain research. vol 300. issue 1. 1984-08-07. PMID:6329431. |
intracellular stimulation of giant serotonergic neurons (retzius cells, rz) mimicked serotonin perfusion: the effect was proportional to the number of spikes fired by retzius cells. |
1984-08-07 |
2023-08-12 |
Not clear |
| J Carlton, N Rowlan. Anorexia and brain serotonin: development of tolerance to the effects of fenfluramine and quipazine in rats with serotonin-depleting lesions. Pharmacology, biochemistry, and behavior. vol 20. issue 5. 1984-08-07. PMID:6610879. |
the acute and chronic effects of the "serotonergic anorectics" quipazine and dl-fenfluramine were examined in rats with substantial and specific depletions of brain 5-hydroxytryptamine (5-ht) induced by 5,7-dihydroxytryptamine (5,7-dht). |
1984-08-07 |
2023-08-12 |
rat |
| J M Van Nueten, W De Ridder, P M Vanhoutt. Ketanserin and vascular contractions in response to cooling. European journal of pharmacology. vol 99. issue 4. 1984-08-07. PMID:6734731. |
5-hydroxytryptamine caused contractions which were enhanced by cooling from 37 to 29 degrees c. both the contractions induced by 5-hydroxytryptamine and their augmentation by cooling were inhibited by similar concentrations of the serotonergic 5-ht2 antagonist ketanserin. |
1984-08-07 |
2023-08-12 |
rabbit |
| J M Van Nueten, W De Ridder, P M Vanhoutt. Ketanserin and vascular contractions in response to cooling. European journal of pharmacology. vol 99. issue 4. 1984-08-07. PMID:6734731. |
these experiments demonstrate that cooling augments the responsiveness of peripheral arteries to 5-hydroxytryptamine and that the augmentation is mediated by 5-ht2 serotonergic receptors. |
1984-08-07 |
2023-08-12 |
rabbit |
| E Glusa, F Markward. Inhibition of 5-hydroxytryptamine-potentiated aggregation of human blood platelets by 5-hydroxytryptamine receptor-blocking agents. Biomedica biochimica acta. vol 43. issue 2. 1984-07-18. PMID:6732757. |
our results indicate a certain similarity between the 5-ht receptors on platelets and the 5-ht receptors on serotonergic neurons and vascular smooth muscle which belong to the 5-ht2 receptor type. |
1984-07-18 |
2023-08-12 |
human |
| O Gandolfi, M L Barbaccia, E Cost. Comparison of iprindole, imipramine and mianserin action on brain serotonergic and beta adrenergic receptors. The Journal of pharmacology and experimental therapeutics. vol 229. issue 3. 1984-07-16. PMID:6327970. |
whereas the attenuation of noradrenergic receptor function elicited by imipramine can be antagonized by lesions of serotonergic axons, the inhibition of norepinephrine-induced stimulation of adenylate cyclase elicited by iprindole or mianserin is not inhibited by serotonin axon lesions. |
1984-07-16 |
2023-08-12 |
Not clear |
| W J McBride, P V Hall, E Chernet, J T Patrick, S Shapir. Alterations of amino acid transmitter systems in spinal cords of chronic paraplegic dogs. Journal of neurochemistry. vol 42. issue 6. 1984-07-13. PMID:6144726. |
eadie-hofstee analysis of [3h]serotonin uptake showed a 90% reduction in vmax for the paraplegic group relative to control values, thereby indicating the expected loss of descending serotonergic pathways. |
1984-07-13 |
2023-08-12 |
Not clear |