| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P R Albert, P Lembo, J M Storring, A Charest, C Saucie. The 5-HT1A receptor: signaling, desensitization, and gene transcription. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 1. 1996-09-20. PMID:8719026. |
the hypothesis that antianxiety or antidepressant agents (e.g., 5-ht1a agonists, 5-ht uptake blockers) exert their clinical actions via enhancement of serotonergic neurotransmission due to desensitization of 5-ht1a autoreceptors predicts that regulation of this receptor plays a crucial role in the therapeutic actions of these agents. |
1996-09-20 |
2023-08-12 |
Not clear |
| D Zhou, G Huether, J Wiltfang, G Hajak, E Rüthe. Serotonin transporters in the rat frontal cortex: lack of circadian rhythmicity but down-regulation by food restriction. Journal of neurochemistry. vol 67. issue 2. 1996-09-19. PMID:8764592. |
by means of [3h]paroxetine binding to rat cortical membranes, we studied the influence of two physiological variables that are clearly associated with altered serotonergic activity--circadian rhythm and semistarvation--on k(d)and bmax values of the serotonin transporter of the rat frontal cortex. |
1996-09-19 |
2023-08-12 |
human |
| C A Fornal, C W Metzler, R A Gallegos, S C Veasey, A C McCreary, B L Jacob. WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135. The Journal of pharmacology and experimental therapeutics. vol 278. issue 2. 1996-09-18. PMID:8768728. |
we reported previously that pharmacological blockade of somatodendritic 5-hydroxytryptamine (5-ht)1a autoreceptors with spiperone, a nonselective 5-ht1a antagonist, increases the spontaneous firing rate of central serotonergic neurons in awake cats. |
1996-09-18 |
2023-08-12 |
Not clear |
| E V Gurevich, J N Joyc. Comparison of [3H]paroxetine and [3H]cyanoimipramine for quantitative measurement of serotonin transporter sites in human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 5. 1996-09-12. PMID:8703300. |
there is a good correlation between the regional distribution of 5-ht transporter sites labeled with either [3h]paroxetine or [3h]cn-imi and the density of serotonergic innervation. |
1996-09-12 |
2023-08-12 |
human |
| T Ishigaki, D W Xie, J C Liu, Y Nakamura, H Y Zhang, K Tani, Y Shimazu, K Chen, J C Shih, K Miyasato, K Ohara, K Ohar. Intact 5-HT2A receptor exons and the adjoining intron regions in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 5. 1996-09-12. PMID:8703302. |
genes that regulate serotonergic (5-ht) systems may underlie the etiology of schizophrenia. |
1996-09-12 |
2023-08-12 |
Not clear |
| L S Lin, M T Li. Hypothalamic serotonin release and raised blood pressure after raphe nuclei stimulation in rats. Brain research bulletin. vol 39. issue 5. 1996-09-11. PMID:8705318. |
the dr stimulation-induced hypertension, tachycardia, or increased hypothalamic 5-ht release were attenuated by prior destruction of the ascending serotonergic system produced by icv injection of 5,7-dihydroxytryptamine and by prior blockade of postsynaptic serotonergic receptors produced by intrahypothalamic injection of 5-ht2 antagonists, cyproheptadine and ketanserin. |
1996-09-11 |
2023-08-12 |
rat |
| G B Varty, G A Higgin. Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs. Psychopharmacology. vol 122. issue 1. 1996-09-11. PMID:8711060. |
there is also evidence to suggest a role of serotonergic (5-ht) and glutamatergic systems in schizophrenia, and accordingly ppi can be disrupted by the 5-ht2 agonist doi, and the non-competitive nmda antagonist, dizocilpine. |
1996-09-11 |
2023-08-12 |
rat |
| A Mar, P Drapea. Modulation of conduction block in leech mechanosensory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 14. 1996-08-30. PMID:8699244. |
we have examined whether the duration of conduction block could be modulated by the serotonergic retzius neurons or by application of serotonin (5-ht). |
1996-08-30 |
2023-08-12 |
Not clear |
| M J Eaton, S R Whittemor. Autocrine BDNF secretion enhances the survival and serotonergic differentiation of raphe neuronal precursor cells grafted into the adult rat CNS. Experimental neurology. vol 140. issue 2. 1996-08-27. PMID:8690054. |
brain-derived neurotrophic factor (bdnf) regulates the in vitro survival and serotonergic phenotype of rn46a cells, and we hypothesized that expression of bdnf in rn46a cells would potentiate their survival and serotonin (5ht) expression in vivo. |
1996-08-27 |
2023-08-12 |
rat |
| Q P Han, G Dryhurs. Influence of glutathione on the oxidation of 1-methyl-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline: chemistry of potential relevance to the addictive and neurodegenerative consequences of ethanol use. Journal of medicinal chemistry. vol 39. issue 7. 1996-08-26. PMID:8691480. |
within the cytoplasm of serotonergic neurons, these metabolic processes would thus provide acetaldehyde, which would react with unbound 5-hydroxytryptamine (5-ht) to give 1-methyl-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline (1), known to be formed at elevated levels in the brain following ethanol drinking, and ho. |
1996-08-26 |
2023-08-12 |
Not clear |
| Q P Han, G Dryhurs. Influence of glutathione on the oxidation of 1-methyl-6-hydroxy-1,2,3,4-tetrahydro-beta-carboline: chemistry of potential relevance to the addictive and neurodegenerative consequences of ethanol use. Journal of medicinal chemistry. vol 39. issue 7. 1996-08-26. PMID:8691480. |
furthermore, deficiencies of 5-ht and loss of certain serotonergic pathways in the brain have been linked to the preference for and addiction to ethanol. |
1996-08-26 |
2023-08-12 |
Not clear |
| A Adell, R D Myer. Selective destruction of midbrain raphe nuclei by 5,7-DHT: is brain 5-HT involved in alcohol drinking in Sprague-Dawley rats? Brain research. vol 693. issue 1-2. 1996-07-31. PMID:8653423. |
explanations of our findings include: (1) a compensatory neurochemical change in pre- or postsynaptic 5-ht receptors subsequent to the dysfunction of serotonergic neurons in the forebrain; (2) a unique characteristic of the sprague-dawley strain of rat; and (3) residual quanta of 5-ht which sustains the pattern of alcohol drinking. |
1996-07-31 |
2023-08-12 |
rat |
| M Sandrini, G Vitale, A V Vergoni, A Ottani, A Bertolin. Effect of acute and chronic treatment with triiodothyronine on serotonin levels and serotonergic receptor subtypes in the rat brain. Life sciences. vol 58. issue 18. 1996-07-25. PMID:8649184. |
effect of acute and chronic treatment with triiodothyronine on serotonin levels and serotonergic receptor subtypes in the rat brain. |
1996-07-25 |
2023-08-12 |
rat |
| E F Coccaro, R J Kavoussi, Y I Sheline, J D Lish, J G Csernansk. Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet. Archives of general psychiatry. vol 53. issue 6. 1996-07-10. PMID:8639036. |
to examine the relationship between binding parameters of the platelet central serotonergic (5-ht) transporter and measures of aggression and impulsivity in adult human subjects. |
1996-07-10 |
2023-08-12 |
human |
| A Heils, A Teufel, S Petri, G Stöber, P Riederer, D Bengel, K P Lesc. Allelic variation of human serotonin transporter gene expression. Journal of neurochemistry. vol 66. issue 6. 1996-07-01. PMID:8632190. |
by directing the magnitude and duration of postsynaptic responses, carrier-facilitated 5-ht transport into and release from the presynaptic neuron are essential for the fine tuning of serotonergic neurotransmission. |
1996-07-01 |
2023-08-12 |
human |
| J García-Colunga, R Miled. Serotonergic modulation of muscle acetylcholine receptors of different subunit composition. Proceedings of the National Academy of Sciences of the United States of America. vol 93. issue 9. 1996-07-01. PMID:8633003. |
modulation of muscle acetylcholine (accho) receptors (acchors) by serotonin [5-hydroxytryptamine (5ht)] and other serotonergic compounds was studied in xenopus laevis oocytes. |
1996-07-01 |
2023-08-12 |
xenopus_laevis |
| C P Chen, J T Alder, D M Bowen, M M Esiri, B McDonald, T Hope, K A Jobst, P T Franci. Presynaptic serotonergic markers in community-acquired cases of Alzheimer's disease: correlations with depression and neuroleptic medication. Journal of neurochemistry. vol 66. issue 4. 1996-06-25. PMID:8627315. |
presynaptic serotonergic markers, serotonin uptake sites, and concentrations of serotonin and 5-hydroxyindoleacetic acid were studied in the frontal and temporal cortex of 20 community-acquired cases of alzheimer's disease and 16 controls matched for age, sex, postmortem delay, and storage. |
1996-06-25 |
2023-08-12 |
human |
| T E Hunt, W Wu, V K Zbuze. Ondansetron blocks nifedipine-induced analgesia in rats. Anesthesia and analgesia. vol 82. issue 3. 1996-06-14. PMID:8623950. |
the serotonergic system is involved in pain transmission and the 5-hydroxytryptamine (5-ht3) receptor subtype mediates some of these effects at the spinal level. |
1996-06-14 |
2023-08-12 |
rat |
| M Fujita, K Takatoku, Y Matoba, M Nishiura, K Kobayashi, O Inoue, T Nishimur. Differential kinetics of [123I]beta-CIT binding to dopamine and serotonin transporters. European journal of nuclear medicine. vol 23. issue 4. 1996-06-06. PMID:8612664. |
iodine-123-labelled 3beta-(4-iodophenyl)tropane-2beta-carboxylic acid ([123i]beta-cit) labels both the dopamine transporter (dat) and the serotonin transporter (5-htt) and this ligand is able to clarify pathological changes in both dopaminergic and serotonergic systems. |
1996-06-06 |
2023-08-12 |
rat |
| L A Mamounas, M E Blue, J A Siuciak, C A Alta. Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 12. 1996-06-06. PMID:8613731. |
a pathology of brain serotonergic (5-ht) systems has been found in psychiatric disturbances, normal aging and in neurodegenerative disorders including alzheimer's and parkinson's disease. |
1996-06-06 |
2023-08-12 |
rat |