| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R A Glennon, S S Hong, M Bondarev, H Law, M Dukat, S Rakhi, P Power, E Fan, D Kinneau, R Kamboj, M Teitler, K Herrick-Davis, C Smit. Binding of O-alkyl derivatives of serotonin at human 5-HT1D beta receptors. Journal of medicinal chemistry. vol 39. issue 1. 1996-03-01. PMID:8568822. |
to identify novel serotonergic agents with enhanced 5-ht1d versus 5-ht1a selectivity, we attempted to take advantage of possible differences in the regions of bulk tolerance associated with the 5-position of the 5-ht binding sites for these two populations of receptors. |
1996-03-01 |
2023-08-12 |
human |
| N Zec, J J Filiano, A Panigrahy, W F White, H C Kinne. Developmental changes in [3H]lysergic acid diethylamide ([3H]LSD) binding to serotonin receptors in the human brainstem. Journal of neuropathology and experimental neurology. vol 55. issue 1. 1996-02-28. PMID:8558166. |
the ontogeny of serotonin receptors in the human brainstem is largely unknown, despite the putative roles of serotonin in neural development, synaptic transmission, brainstem modulation of vegetative functions, and clinical disorders of serotonergic function. |
1996-02-28 |
2023-08-12 |
human |
| N Zec, J J Filiano, A Panigrahy, W F White, H C Kinne. Developmental changes in [3H]lysergic acid diethylamide ([3H]LSD) binding to serotonin receptors in the human brainstem. Journal of neuropathology and experimental neurology. vol 55. issue 1. 1996-02-28. PMID:8558166. |
tissue autoradiography was used with [3h]lsd for total serotonergic receptor binding and [3h]lsd and serotonin for nonspecific binding; computer-based quantitation was applied. |
1996-02-28 |
2023-08-12 |
human |
| N Zec, J J Filiano, A Panigrahy, W F White, H C Kinne. Developmental changes in [3H]lysergic acid diethylamide ([3H]LSD) binding to serotonin receptors in the human brainstem. Journal of neuropathology and experimental neurology. vol 55. issue 1. 1996-02-28. PMID:8558166. |
the fetal peak in [3h]lsd binding to 5-ht receptors is consistent with a trophic role of serotonin in immature human brainstem, and a decrease, between midgestation and infancy, in serotonergic modulation of vegetative functions controlled by the brainstem. |
1996-02-28 |
2023-08-12 |
human |
| R D Trifunović, M S Brodi. The effects of clomipramine on the excitatory action of ethanol on dopaminergic neurons of the ventral tegmental area in vitro. The Journal of pharmacology and experimental therapeutics. vol 276. issue 1. 1996-02-26. PMID:8558452. |
these results may have some implications for the development of serotonergic drugs, including serotonin uptake inhibitors, for the treatment of alcoholism. |
1996-02-26 |
2023-08-12 |
Not clear |
| N C Aggelopoulos, M J Burton, R W Clarke, S A Edgle. Characterization of a descending system that enables crossed group II inhibitory reflex pathways in the cat spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 2. 1996-02-22. PMID:8551355. |
to examine whether serotonergic fibers were involved, the effects of agents selective for 5-hydroxytryptamine (5-ht)1a receptors were examined. |
1996-02-22 |
2023-08-12 |
cat |
| D D Maskall, A P Zis, R W Lam, C M Clark, A J Kua. Prolactin response to buspirone challenge in the presence of dopaminergic blockade. Biological psychiatry. vol 38. issue 4. 1996-02-20. PMID:8547445. |
buspirone-stimulated prolactin release has been employed as an indirect measure of central serotonin activity; however, it is not clear whether serotonergic or dopaminergic systems are responsible for this response. |
1996-02-20 |
2023-08-12 |
human |
| S K Yeghiayan, A E Kelle. Serotonergic stimulation of the ventrolateral striatum induces orofacial stereotypy. Pharmacology, biochemistry, and behavior. vol 52. issue 3. 1996-02-14. PMID:8545465. |
in addition to dopaminergic projections from the substantia nigra, the striatum receives serotonergic (5-ht) inputs arising from the raphe nuclei. |
1996-02-14 |
2023-08-12 |
Not clear |
| R W Fulle. Serotonin uptake inhibitors: uses in clinical therapy and in laboratory research. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. vol 45. 1996-02-13. PMID:8545537. |
the result is a limit on the degree to which extracellular serotonin and serotonergic neurotransmission are increased. |
1996-02-13 |
2023-08-12 |
Not clear |
| R McQuade, T Shar. Release of cerebral 5-hydroxytryptamine evoked by electrical stimulation of the dorsal and median raphe nuclei: effect of a neurotoxic amphetamine. Neuroscience. vol 68. issue 4. 1996-02-12. PMID:8544983. |
in summary, our data show that electrical stimulation of the dorsal or median raphe nucleus releases 5-hydroxytryptamine in a regionally specific manner (hippocampus versus frontal cortex), suggesting that serotonergic nerve terminals of the dorsal and median raphe pathways were being activated selectively. |
1996-02-12 |
2023-08-12 |
rat |
| J M Moorman, A Jackson, D G Grahame-Smith, R A Lesli. Induction of c-fos in rat forebrain by pharmacological manipulation of 5-hydroxytryptamine levels. Neuroscience. vol 68. issue 4. 1996-02-12. PMID:8544984. |
it is well known that 5-hydroxytryptamine mediates mood and affect, and this study indicates potential brain loci of action of serotonergic drugs. |
1996-02-12 |
2023-08-12 |
rat |
| K E Sabol, J B Richards, K Layton, L S Seide. Amphetamine analogs have differential effects on DRL 36-s schedule performance. Psychopharmacology. vol 121. issue 1. 1996-02-07. PMID:8539341. |
consistent with in vitro and in vivo release studies, the differential results of these five drugs on drl 36-s schedule performance suggest a predominant dopamine role for amph and meth, a predominant serotonin role for fen, and different degrees of combined dopaminergic and serotonergic roles for mdma and pca in the mediation of the task. |
1996-02-07 |
2023-08-12 |
Not clear |
| J H Krystal, E Webb, N L Cooney, H R Kranzler, S W Southwick, G R Heninger, D S Charne. Serotonergic and noradrenergic dysregulation in alcoholism: m-chlorophenylpiperazine and yohimbine effects in recently detoxified alcoholics and healthy comparison subjects. The American journal of psychiatry. vol 153. issue 1. 1996-02-06. PMID:8540598. |
this study compared serotonergic (5-ht) and noradrenergic reactivity in recently detoxified alcoholic patients and healthy comparison subjects. |
1996-02-06 |
2023-08-12 |
human |
| L L Howell, L D Byr. Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey. The Journal of pharmacology and experimental therapeutics. vol 275. issue 3. 1996-02-01. PMID:8531128. |
the pharmacological profile of effects of selective 5ht uptake inhibitors and direct agonists indicates that the behavioral-stimulant and reinforcing effects of cocaine do not depend on inhibition of 5ht uptake, whereas the drug interactions suggest that the serotonergic system can modulate specific behavioral effects of cocaine. |
1996-02-01 |
2023-08-12 |
monkey |
| C Sánche. Serotonergic mechanisms involved in the exploratory behaviour of mice in a fully automated two-compartment black and white text box. Pharmacology & toxicology. vol 77. issue 1. 1996-01-29. PMID:8532615. |
an overall increase of serotonergic activity by means of 5-ht uptake inhibition (citalopram), 5-ht release (fenfluramine) or administration of a 5-ht precursor (1-5-htp) facilitated exploratory activity in the white compartment. |
1996-01-29 |
2023-08-12 |
mouse |
| C Sánche. Serotonergic mechanisms involved in the exploratory behaviour of mice in a fully automated two-compartment black and white text box. Pharmacology & toxicology. vol 77. issue 1. 1996-01-29. PMID:8532615. |
reduction of serotonergic activity by treatment with the 5-ht depletor p-chloro-phenylalanine methyl ester (pcpa) did not change the exploratory behaviour, but attenuated the response to fenfluramine significantly. |
1996-01-29 |
2023-08-12 |
mouse |
| G G Kinney, B Kocsis, R P Verte. Injections of muscimol into the median raphe nucleus produce hippocampal theta rhythm in the urethane anesthetized rat. Psychopharmacology. vol 120. issue 3. 1996-01-19. PMID:8524970. |
it has previously been shown that serotonergic [5-hydroxytryptamine (5-ht)] neurons of the median raphe nucleus (mr) are critically involved in the control of the hippocampal electroencephalogram (eeg). |
1996-01-19 |
2023-08-12 |
rat |
| Z Cohen, K Tsuiki, A Takada, A Beaudet, M Diksic, E Hame. In vivo-synthesized radioactively labelled alpha-methyl serotonin as a selective tracer for visualization of brain serotonin neurons. Synapse (New York, N.Y.). vol 21. issue 1. 1996-01-19. PMID:8525458. |
to investigate the use of alpha-[3h]methyl tryptophan (alpha-[3h]mtrp) as a tracer for the in vivo study of brain serotonergic neurons, we examined whether alpha-[3h]mtrp and its metabolite alpha-[3h]methyl serotonin (alpha-[3h]m5-ht) selectively label serotonergic neurons and whether once accumulated in these neurons, the radioactive metabolite behaves like endogenous serotonin. |
1996-01-19 |
2023-08-12 |
rat |
| Z Cohen, K Tsuiki, A Takada, A Beaudet, M Diksic, E Hame. In vivo-synthesized radioactively labelled alpha-methyl serotonin as a selective tracer for visualization of brain serotonin neurons. Synapse (New York, N.Y.). vol 21. issue 1. 1996-01-19. PMID:8525458. |
tissue sections in which serotonergic neurons had been immunostained for 5-ht or its synthesizing enzyme, tryptophan hydroxylase, were processed for radioautography at the light and electron microscopic level. |
1996-01-19 |
2023-08-12 |
rat |
| P T Wong, H Feng, W L Te. Interaction of the dopaminergic and serotonergic systems in the rat striatum: effects of selective antagonists and uptake inhibitors. Neuroscience research. vol 23. issue 1. 1996-01-18. PMID:7501296. |
the selectivity of these drugs and the time course of their effects on hva and 5-hiaa suggested that the dopaminergic drugs may affect the serotonergic systems primarily via changes in extraneuronal da and conversely, serotonergic drugs affect the dopaminergic systems via changes in extraneuronal 5-ht. |
1996-01-18 |
2023-08-12 |
rat |