| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Madhusmita P Sahu, Yago Pazos-Boubeta, Anna Steinzeig, Katja Kaurinkoski, Michela Palmisano, Olgierd Borowecki, Timo Petteri Piepponen, Eero Castré. Depletion of TrkB Receptors From Adult Serotonergic Neurons Increases Brain Serotonin Levels, Enhances Energy Metabolism and Impairs Learning and Memory. Frontiers in molecular neuroscience. vol 14. 2021-05-04. PMID:33935645. |
depletion of trkb receptors from adult serotonergic neurons increases brain serotonin levels, enhances energy metabolism and impairs learning and memory. |
2021-05-04 |
2023-08-13 |
mouse |
| Daisuke Matsunaga, Hikaru Nakagawa, Takayuki Ishiwat. Difference in the brain serotonin and its metabolite level and anxiety-like behavior between forced and voluntary exercise conditions in rats. Neuroscience letters. vol 744. 2021-04-30. PMID:33373674. |
after 4 weeks, rats either underwent the open field test (oft) or their 5-ht and 5-hiaa levels were measured in the major serotonergic neural cell bodies and projection areas. |
2021-04-30 |
2023-08-13 |
rat |
| Jinling Chu, Satoshi Deyama, Xueting Li, Mei Motono, Atsuki Otoda, Atsushi Saito, Hirohito Esaki, Naoya Nishitani, Katsuyuki Kaned. Role of 5-HT Neuroscience letters. vol 743. 2021-04-29. PMID:33352288. |
this study aimed to examine the role of serotonergic transmission in the medial prefrontal cortex (mpfc) in cocaine cpp enhancement by acute restraint stress, which increases extracellular serotonin (5-ht) levels in the mpfc. |
2021-04-29 |
2023-08-13 |
mouse |
| Claudia Fuchs, Laura Gennaccaro, Elisa Ren, Giuseppe Galvani, Stefania Trazzi, Giorgio Medici, Manuela Loi, Erin Conway, Orrin Devinsky, Roberto Rimondini, Elisabetta Cian. Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder. Neuropharmacology. vol 167. 2021-04-23. PMID:31469994. |
here we show a dysregulation of hippocampal and cortical serotonergic (5-ht) receptor expression in heterozygous cdkl5 knockout (ko) female mice, suggesting that impaired 5-ht neurotransmission contributes to cdd. |
2021-04-23 |
2023-08-13 |
mouse |
| Adam L Halberstadt, Muhammad Chatha, Adam K Klein, Jason Wallach, Simon D Brand. Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species. Neuropharmacology. vol 167. 2021-04-23. PMID:31917152. |
serotonergic hallucinogens such as lysergic acid diethylamide (lsd) induce head twitches in rodents via 5-ht |
2021-04-23 |
2023-08-13 |
mouse |
| Ria Fisher, Atsuko Hikima, Rebecca Morris, Michael J Jackson, Sarah Rose, Mark A Varney, Ronan Depoortere, Adrian Newman-Tancred. The selective 5-HT Neuropharmacology. vol 167. 2021-04-23. PMID:32057799. |
the selective 5-ht l-dopa is the gold-standard pharmacotherapy for treatment of parkinson's disease (pd) but can lead to the appearance of troubling dyskinesia which are attributable to 'false neurotransmitter' release of dopamine by serotonergic neurons. |
2021-04-23 |
2023-08-13 |
Not clear |
| Edward T Wargent, Malgorzata S Martin-Gronert, Roselle L Cripps, Lora K Heisler, Giles S H Yeo, Susan E Ozanne, Jonathan R S Arch, Claire J Stocke. Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity. International journal of obesity (2005). vol 44. issue 9. 2021-04-21. PMID:32719434. |
food consumption and food-seeking behaviour are directly modulated by central serotonergic (5-hydroxytryptamine, 5-ht) pathways. |
2021-04-21 |
2023-08-13 |
rat |
| Qiang Lu, Chiaki Murakami, Yuki Murakami, Fumi Hoshino, Maho Asami, Takako Usuki, Hiromichi Sakai, Fumio Sakan. 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain. FEBS letters. vol 594. issue 11. 2021-04-16. PMID:32134507. |
serotonin transporter (sert) is involved in serotonergic system regulation and in the pathophysiology/therapeutics of serotonin-/sert-related diseases such as obsessive-compulsive disorder, depression, autism, and schizophrenia. |
2021-04-16 |
2023-08-13 |
mouse |
| Rosa M Leon, Tito Borner, Lauren M Stein, Norma A Urrutia, Bart C De Jonghe, Heath D Schmidt, Matthew R Haye. Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats. Neuropharmacology. vol 187. 2021-04-14. PMID:33581143. |
we hypothesized that the serotonergic modulation of glp-1-producing neurons (i.e., ppg neurons) is stimuli-specific and that stressed-induced ppg activity is one of the modalities in which 5-ht plays a role. |
2021-04-14 |
2023-08-13 |
rat |
| Dagmar N van Deursen, Odile A van den Heuvel, Jan Booij, Henk W Berendse, Chris Vrien. Autonomic failure in Parkinson's disease is associated with striatal dopamine deficiencies. Journal of neurology. vol 267. issue 7. 2021-04-12. PMID:32162062. |
dopamine and serotonin are known to play a role in autonomic regulation, and, therefore, pd-related degeneration of serotonergic and dopaminergic neurons in these regions may be associated with autonomic dysfunction. |
2021-04-12 |
2023-08-13 |
Not clear |
| Takuto Ishida, Hiroyuki Uchida, Satoru Kaneko, Kazuhiro Sugiyama, Yuichi Hamabe, Masaru Mimura, Takefumi Suzuk. Life-Threatening Serotonin Syndrome Precipitated by Discontinuation of Serotonin-Dopamine Antagonist in the Presence of Serotonergic Agents: A Case Report. Clinical neuropharmacology. vol 43. issue 3. 2021-04-12. PMID:32217863. |
life-threatening serotonin syndrome precipitated by discontinuation of serotonin-dopamine antagonist in the presence of serotonergic agents: a case report. |
2021-04-12 |
2023-08-13 |
Not clear |
| Kristina Loy, Julie Fourneau, Ning Meng, Carmen Denecke, Giuseppe Locatelli, Florence M Bareyr. Semaphorin 7A restricts serotonergic innervation and ensures recovery after spinal cord injury. Cellular and molecular life sciences : CMLS. vol 78. issue 6. 2021-04-07. PMID:33128105. |
descending serotonergic (5-ht) projections originating from the raphe nuclei form an important input to the spinal cord that control basic locomotion. |
2021-04-07 |
2023-08-13 |
mouse |
| David A Nielsen, Huiqiong Deng, Michelle A Patriquin, Mark J Harding, John Oldham, Ramiro Salas, J Christopher Fowler, B Christopher Frue. Association of TPH1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study. European archives of psychiatry and clinical neuroscience. vol 270. issue 5. 2021-04-05. PMID:30923939. |
variants in three genes coding for components of the serotonergic system, the tryptophan hydroxylase 1 (tph1) rs1799913, serotonin transporter (slc6a4) 5-httlpr, and serotonin receptor 2a (htr2a) rs6311, were evaluated for association with suicidal ideation (si) and with recovery from si in a psychiatric inpatient population. |
2021-04-05 |
2023-08-13 |
Not clear |
| Mathieu Boudier-Revéret, Min Cheol Chan. Serotonin syndrome in a patient with chronic pain taking analgesic drugs mistaken for psychogenic nonepileptic seizure. Yeungnam University journal of medicine. 2021-04-05. PMID:33813810. |
serotonin syndrome (ss) is a potentially life-threatening condition that is caused by the administration of drugs that increase serotonergic activity in the central nervous system. |
2021-04-05 |
2023-08-13 |
Not clear |
| Yuko Yoshimura, Mitsuru Kikuchi, Daisuke N Saito, Tetsu Hirosawa, Tetsuya Takahashi, Toshio Munesue, Hirotaka Kosaka, Nobushige Naito, Yasuomi Ouchi, Yoshio Minab. Markers for the central serotonin system correlate to verbal ability and paralinguistic social voice processing in autism spectrum disorder. Scientific reports. vol 10. issue 1. 2021-03-25. PMID:32883965. |
to estimate the brain serotonergic condition, we measured the serotonin transporter nondisplaceable binding potential cerebrum-wide using positron emission tomography with [11c]n,n-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine ([11c] dasb). |
2021-03-25 |
2023-08-13 |
human |
| Rachel A Daut, J Russell Ravenel, Linda R Watkins, Steven F Maier, Laura K Fonke. The behavioral and neurochemical effects of an inescapable stressor are time of day dependent. Stress (Amsterdam, Netherlands). vol 23. issue 4. 2021-03-24. PMID:31868091. |
anxiety- and fear-related behavioral changes produced by is are driven by sensitization of serotonergic (5-hydroxytryptamine, 5-ht) neurons in the dorsal raphe nucleus (drn). |
2021-03-24 |
2023-08-13 |
rat |
| C Abuin-Martínez, R Vidal, M D Gutiérrez-López, M Pérez-Hernández, P Giménez-Gómez, N Morales-Puerto, E O'Shea, M I Colad. Increased kynurenine concentration attenuates serotonergic neurotoxicity induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats through activation of aryl hydrocarbon receptor. Neuropharmacology. vol 187. 2021-03-23. PMID:33607146. |
autoradiographic quantification of serotonin transporters showed that both the tdo inhibitor 680c91 and the ahr antagonist ch-223191 potentiated the neurotoxicity induced by mdma, while administration of exogenous l-kynurenine or of the ahr positive modulator 3,3'-diindolylmethane (dim) partially prevented the serotonergic damage induced by the drug. |
2021-03-23 |
2023-08-13 |
rat |
| Nabil Benzin. [New pathophysiological approaches to obsessive-compulsive disorder]. La Revue du praticien. vol 70. issue 7. 2021-03-23. PMID:33739728. |
while serotonin was the first to be incriminated due to the efficacy of serotonergic antidepressants, it turns out that years of research in genetics and neuroimaging have invalidated this hypothesis in favour of a new target: glutamate. |
2021-03-23 |
2023-08-13 |
Not clear |
| Boglárka Emese Skopkó, Ádám Deák, Clara Matesz, Barna Kelentey, Tímea Bácska. Pefloxacin induced changes in serotonergic innervation and mast cell number in rat salivary glands. Drug and chemical toxicology. vol 43. issue 5. 2021-03-19. PMID:30257570. |
we found that a three-day treatment significantly increased the number of immunoreactive serotonergic nerve fibers, but after a seven-day treatment the number of serotonin positive nerve fibers decreased almost to values of the control group. |
2021-03-19 |
2023-08-13 |
rat |
| Boglárka Emese Skopkó, Ádám Deák, Clara Matesz, Barna Kelentey, Tímea Bácska. Pefloxacin induced changes in serotonergic innervation and mast cell number in rat salivary glands. Drug and chemical toxicology. vol 43. issue 5. 2021-03-19. PMID:30257570. |
the background of this process is the altered serotonergic innervation and the increased number of activated mast cells releasing different mediators for example histamine, which can finally lead to reduced number of serotonin positive nerve fibers after a seven-day treatment of pefloxacin leading to atrophy and hypofunction of the salivary glands. |
2021-03-19 |
2023-08-13 |
rat |