| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen R Baldassarri, Eunkyung Park, Sjoerd J Finnema, Beata Planeta, Nabeel Nabulsi, Soheila Najafzadeh, Jim Ropchan, Yiyun Huang, Jonas Hannestad, Kathleen Maloney, Zubin Bhagwagar, Richard E Carso. Inverse changes in raphe and cortical 5-HT Synapse (New York, N.Y.). vol 74. issue 10. 2021-08-10. PMID:32324935. |
inverse changes in raphe and cortical 5-ht serotonergic neurotransmission plays a key role in the pathophysiology and treatment of various neuropsychiatric diseases. |
2021-08-10 |
2023-08-13 |
Not clear |
| Neeranjali S Jain, Claire W Ruan, Shanil R Dhanji, Richard J Syme. Psychotropic Drug-Induced Glaucoma: A Practical Guide to Diagnosis and Management. CNS drugs. vol 35. issue 3. 2021-08-09. PMID:33604881. |
selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, monoamine oxidase inhibitors and antipsychotics may trigger angle closure by influencing pupil configuration through adrenergic, anticholinergic, serotonergic or dopaminergic mechanisms. |
2021-08-09 |
2023-08-13 |
Not clear |
| Joana Pereira-Sousa, Bruna Ferreira-Lomba, Aina Bellver-Sanchis, Daniela Vilasboas-Campos, Jorge H Fernandes, Marta D Costa, Mark A Varney, Adrian Newman-Tancredi, Patrícia Maciel, Andreia Teixeira-Castr. Identification of the 5-HT Neurobiology of disease. vol 152. 2021-07-30. PMID:33516872. |
previous studies pinpointed the modulation of serotonergic signaling, through pharmacological inhibition of the serotonin transporter sert, as a promising therapeutic approach for mjd/sca3. |
2021-07-30 |
2023-08-13 |
Not clear |
| Manting D Chiang, Karen Frey, Chris Lee, Evan D Kharasch, Dani Tallchief, Christopher Sawyer, Jane Blood, Hyunmoon Back, Leonid Kagan, Simon Haroutounia. Plasma and cerebrospinal fluid pharmacokinetics of ondansetron in humans. British journal of clinical pharmacology. vol 87. issue 2. 2021-07-28. PMID:32495990. |
changes in serotonergic sensory modulation associated with overexpression of 5-ht |
2021-07-28 |
2023-08-13 |
Not clear |
| Gwenn S Smith, Hiroto Kuwabara, Neda F Gould, Najilla Nassery, Alena Savonenko, Jin Hui Joo, Kristin L Bigos, Michael Kraut, James Brasic, Daniel P Holt, Andrew W Hall, William B Mathews, Robert F Dannals, Ayon Nandi, Clifford I Workma. Molecular imaging of the serotonin transporter availability and occupancy by antidepressant treatment in late-life depression. Neuropharmacology. vol 194. 2021-07-28. PMID:33450276. |
degeneration of the serotonergic system and lower occupancy of the initial target for antidepressant medications, the serotonin transporter (5-htt), may contribute to variability in treatment response. |
2021-07-28 |
2023-08-13 |
Not clear |
| Kinga Sałat, Anna Furgała-Wojas, Robert Sała. The Microglial Activation Inhibitor Minocycline, Used Alone and in Combination with Duloxetine, Attenuates Pain Caused by Oxaliplatin in Mice. Molecules (Basel, Switzerland). vol 26. issue 12. 2021-07-28. PMID:34208184. |
since activated microglia, impaired serotonergic and noradrenergic neurotransmission and overexpressed sodium channels are implicated in oxaliplatin-induced pain, this in vivo study assessed the effect of minocycline, a microglial activation inhibitor used alone or in combination with ambroxol, a sodium channel blocker, or duloxetine, a serotonin and noradrenaline reuptake inhibitor, on oxaliplatin-induced tactile allodynia and cold hyperalgesia. |
2021-07-28 |
2023-08-13 |
mouse |
| Sun A Ki. 5-HT1A and 5-HT2A Signaling, Desensitization, and Downregulation: Serotonergic Dysfunction and Abnormal Receptor Density in Schizophrenia and the Prodrome. Cureus. vol 13. issue 6. 2021-07-27. PMID:34306878. |
the significant role of serotonin (5-hydroxytryptamine [5-ht]) in the pathogenesis and early development of schizophrenia has been established by contemporary research through the assessment of structural and pharmacological neuroimaging, blood metabolites, cerebrospinal fluid, genome polymorphisms, and other valid indicators of abnormal serotonergic activity in prodromal, ultra-high-risk, and schizophrenic patient groups. |
2021-07-27 |
2023-08-13 |
Not clear |
| Giulia Sbrini, Paola Brivio, Kari Bosch, Judith Regina Homberg, Francesca Calabres. Enrichment Environment Positively Influences Depression- and Anxiety-Like Behavior in Serotonin Transporter Knockout Rats through the Modulation of Neuroplasticity, Spine, and GABAergic Markers. Genes. vol 11. issue 11. 2021-07-23. PMID:33114023. |
the serotonin transporter (5-htt in humans, sert in rodents) is the main regulator of serotonergic transmission in the brain. |
2021-07-23 |
2023-08-13 |
rat |
| Sultana Jaha. Can Low Dose Sertraline Cause Serotonin Syndrome in Pediatric Patients? 2 Case Reports. CNS spectrums. vol 26. issue 2. 2021-07-23. PMID:34127119. |
serotonin syndrome is a potentially life-threatening condition associated with increased serotonergic activity in the central nervous system. |
2021-07-23 |
2023-08-13 |
Not clear |
| Sultana Jaha. Can Low Dose Sertraline Cause Serotonin Syndrome in Pediatric Patients? 2 Case Reports. CNS spectrums. vol 26. issue 2. 2021-07-23. PMID:34127119. |
the hunter criteria for serotonin syndrome (ss) are fulfilled if the patient has taken a serotonergic agent and has one of the following symptoms: 1) spontaneous clonus, 2) inducible clonus and agitation or diaphoresis, 3) ocular clonus and agitation or diaphoresis, 4) tremor and hyperreflexia, 5) hypertonia, or 6) temperature above 38 c and ocular clonus or inducible clonus. |
2021-07-23 |
2023-08-13 |
Not clear |
| Maria Willadsen, Metin Üngör, Anna Sługocka, Rainer K W Schwarting, Judith R Homberg, Markus Wöh. Fear Extinction and Predictive Trait-Like Inter-Individual Differences in Rats Lacking the Serotonin Transporter. International journal of molecular sciences. vol 22. issue 13. 2021-07-21. PMID:34209318. |
the serotonergic system (5-hydroxytryptamine, 5-ht) with the 5-ht transporter (5-htt, sert) is strongly implicated in the regulation of anxiety and fear. |
2021-07-21 |
2023-08-13 |
rat |
| Yi Cheng, Nan Song, Renkai Ge, Yue Da. Serotonergic Modulation of Persistent Inward Currents in Serotonergic Neurons of Medulla in ePet-EYFP Mice. Frontiers in neural circuits. vol 15. 2021-07-16. PMID:33889077. |
serotonergic (5-ht) neurons in the medulla play multiple functional roles associated with many symptoms and motor activities. |
2021-07-16 |
2023-08-13 |
mouse |
| Melissa Faria, Eva Prats, Marina Bellot, Cristian Gomez-Canela, Demetrio Raldú. Pharmacological Modulation of Serotonin Levels in Zebrafish Larvae: Lessons for Identifying Environmental Neurotoxicants Targeting the Serotonergic System. Toxics. vol 9. issue 6. 2021-07-14. PMID:34070577. |
pharmacological modulation of serotonin levels in zebrafish larvae: lessons for identifying environmental neurotoxicants targeting the serotonergic system. |
2021-07-14 |
2023-08-13 |
zebrafish |
| Melissa Faria, Eva Prats, Marina Bellot, Cristian Gomez-Canela, Demetrio Raldú. Pharmacological Modulation of Serotonin Levels in Zebrafish Larvae: Lessons for Identifying Environmental Neurotoxicants Targeting the Serotonergic System. Toxics. vol 9. issue 6. 2021-07-14. PMID:34070577. |
modulation of larvae serotonergic system was accomplished by 24 h exposure to single and opposite pharmacodynamics co-exposure to three model psychopharmaceuticals with antagonistic and agonistic serotonin signaling properties: 2.5 mm 4-chloro-dl-phenylalanine (pcpa) and 5 µm deprenyl and 0.5 µm fluoxetine, respectively. |
2021-07-14 |
2023-08-13 |
zebrafish |
| Anne R de Kort, Elbert A J Joosten, Jacob Patijn, Dick Tibboel, Nynke J van den Hooge. The development of descending serotonergic modulation of the spinal nociceptive network: a life span perspective. Pediatric research. 2021-07-14. PMID:34257402. |
descending serotonergic modulation switches from facilitation in early life to bimodal control in adulthood, masking an already functional 5-ht inhibitory system at early ages. |
2021-07-14 |
2023-08-13 |
human |
| Chenxuan Huang, Yifan Chen, Qiaoxian Yue, Erying Hao, Dehe Wang, Rongyan Zhou, Guoxian Zhao, Hui Che. Effect of in ovo injection of serotonin on the behavior and hormone level in laying hens. General and comparative endocrinology. vol 310. 2021-07-13. PMID:34048728. |
the changes of these hormone concentrations and gene expressions suggested that 5-ht accumulation in early embryonic stages may alter both the adrenergic and serotonergic systems, which could further regulate the isolation behavior and improve birds' growth performance to a certain extent. |
2021-07-13 |
2023-08-13 |
Not clear |
| William D Gwynne, Mirza S Shakeel, Adele Girgis-Gabardo, John A Hassel. The Role of Serotonin in Breast Cancer Stem Cells. Molecules (Basel, Switzerland). vol 26. issue 11. 2021-07-12. PMID:34073226. |
we identified compounds including selective antagonists of multiple serotonergic system pathway components required for serotonin biosynthesis, transport, activity via multiple 5-ht receptors (5-htrs), and catabolism that reduce the viability of breast cancer stem cells of both mouse and human origin using multiple orthologous assays. |
2021-07-12 |
2023-08-13 |
mouse |
| Benjamin Malcolm, Kelan Thoma. Serotonin toxicity of serotonergic psychedelics. Psychopharmacology. 2021-07-12. PMID:34251464. |
psychiatric disorders targeted by these psychedelic-assisted therapies are managed with serotonergic drugs like selective serotonin reuptake inhibitors (ssris) as the current standard of care, so it is important to evaluate the potential risks of drug-drug interactions and serotonin toxicity (st) between these agents. |
2021-07-12 |
2023-08-13 |
Not clear |
| Erica Schlichting, Chris Welter, Tammi Schaeffer, Tania D Strou. Serotonin Syndrome Associated With Vilazodone Overdose in a 22-Month-Old Treated With Dexmedetomidine. The Journal of emergency medicine. vol 60. issue 2. 2021-07-08. PMID:33158691. |
vilazodone blocks the serotonin reuptake pump and desensitizes serotonin receptors (especially 5ht1a autoreceptors), therefore increasing serotonergic neurotransmission. |
2021-07-08 |
2023-08-13 |
Not clear |
| Brian P Murray, Joseph E Carpenter, Joshua Sayers, Michael Yeh, Jordan Beau, Emily A Kiernan, Matthew J Wolf, Tonya A Bolton, Ziad Kazz. Two Cases of Serotonin Syndrome After Bupropion Overdose Treated With Cyproheptadine. The Journal of emergency medicine. vol 60. issue 4. 2021-07-08. PMID:33308914. |
we highlight two cases of single-agent bupropion overdose that subsequently met the diagnosis of serotonin syndrome by the hunter criteria, despite the absence of direct serotonergic agents. |
2021-07-08 |
2023-08-13 |
Not clear |