| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Charline Jansch, Georg C Ziegler, Andrea Forero, Sina Gredy, Sina Wäldchen, Maria Rosaria Vitale, Evgeniy Svirin, Johanna E M Zöller, Jonas Waider, Katharina Günther, Frank Edenhofer, Markus Sauer, Erhard Wischmeyer, Klaus-Peter Lesc. Serotonin-specific neurons differentiated from human iPSCs form distinct subtypes with synaptic protein assembly. Journal of neural transmission (Vienna, Austria : 1996). vol 128. issue 2. 2021-10-15. PMID:33560471. |
differentiated hipscs synthesize 5-ht, express specific markers, such as tryptophan hydroxylase 2 and 5-ht transporter, and exhibit an electrophysiological signature characteristic of serotonergic neurons, with spontaneous rhythmic activities, broad action potentials and large afterhyperpolarization potentials. |
2021-10-15 |
2023-08-13 |
human |
| Shami Kanekar, Chandni Sheth, Hendrick Ombach, Jadeda Brown, Michael Hoffman, Robert Ettaro, Perry Rensha. Sex-based changes in rat brain serotonin and behavior in a model of altitude-related vulnerability to treatment-resistant depression. Psychopharmacology. vol 238. issue 10. 2021-10-15. PMID:34159421. |
depression and ssri resistance are linked to disrupted serotonergic function, and hypobaric hypoxia may reduce the oxygen-dependent synthesis of serotonin. |
2021-10-15 |
2023-08-13 |
rat |
| B Spurny, T Vanicek, R Seiger, M B Reed, M Klöbl, V Ritter, J Unterholzner, G M Godbersen, L R Silberbauer, D Pacher, S Klug, M E Konadu, G Gryglewski, S Trattnig, W Bogner, R Lanzenberge. Effects of SSRI treatment on GABA and glutamate levels in an associative relearning paradigm. NeuroImage. vol 232. 2021-10-14. PMID:33657450. |
treatment with selective serotonin reuptake inhibitors (ssris) does not solely affect the serotonergic system but shows downstream effects on gaba- and glutamatergic neurotransmission, potentially helping to restore cognitive function via neuroplastic effects. |
2021-10-14 |
2023-08-13 |
human |
| Osama Y Alshogran, Laith N Al-Eitan, Shoroq M Altawalbeh, Hatem A Ama. Association of DRD4 exon III and 5-HTTLPR VNTR genetic polymorphisms with psychiatric symptoms in hemodialysis patients. PloS one. vol 16. issue 3. 2021-10-13. PMID:33784353. |
given that the dopaminergic and serotonergic pathways are involved in the etiology of psychiatric disease, this study evaluated the genetic association of dopamine d4 receptor (drd4) and serotonin transporter (slc6a4) genes with psychiatric symptom susceptibility among hd patients. |
2021-10-13 |
2023-08-13 |
Not clear |
| Nako Nakatsuka, Kelly J Heard, Alix Faillétaz, Dmitry Momotenko, János Vörös, Fred H Gage, Krishna C Vadodari. Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes. Molecular psychiatry. vol 26. issue 7. 2021-10-12. PMID:33767349. |
sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes. |
2021-10-12 |
2023-08-13 |
human |
| Nako Nakatsuka, Kelly J Heard, Alix Faillétaz, Dmitry Momotenko, János Vörös, Fred H Gage, Krishna C Vadodari. Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes. Molecular psychiatry. vol 26. issue 7. 2021-10-12. PMID:33767349. |
while ipsc-derived human serotonergic neurons offer the possibility to study serotonin (5-ht) release and uptake, particularly by 5-ht-modulating drugs such as selective serotonin reuptake inhibitors (ssris), a major limitation is the inability to reliably quantify 5-ht secreted from neurons in vitro. |
2021-10-12 |
2023-08-13 |
human |
| Nako Nakatsuka, Kelly J Heard, Alix Faillétaz, Dmitry Momotenko, János Vörös, Fred H Gage, Krishna C Vadodari. Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes. Molecular psychiatry. vol 26. issue 7. 2021-10-12. PMID:33767349. |
we generated human serotonergic neurons in vitro and detected secreted 5-ht using aptamer-coated nanopipettes in a low nanomolar range, with the possibility of detecting significantly lower (picomolar) concentrations. |
2021-10-12 |
2023-08-13 |
human |
| Nako Nakatsuka, Kelly J Heard, Alix Faillétaz, Dmitry Momotenko, János Vörös, Fred H Gage, Krishna C Vadodari. Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes. Molecular psychiatry. vol 26. issue 7. 2021-10-12. PMID:33767349. |
furthermore, as a proof of concept, we treated human serotonergic neurons in vitro with the ssri citalopram and detected a significant increase in extracellular 5-ht using the aptamer-modified nanopipettes. |
2021-10-12 |
2023-08-13 |
human |
| Mauro Chivite, Esther Leal, Jesús M Míguez, Jose Miguel Cerdá-Reverte. Distribution of two isoforms of tryptophan hydroxylase in the brain of rainbow trout (Oncorhynchus mykiss). An in situ hybridization study. Brain structure & function. vol 226. issue 7. 2021-10-05. PMID:34213591. |
a large number of neurons are also considered to be serotonergic or "pseudo-serotonergic" as they accumulate and release 5-ht yet do not produce it as no amine-synthetic enzymes are expressed, yet a combination of 5-ht transporters is observed. |
2021-10-05 |
2023-08-13 |
Not clear |
| Aurélie Flaive, Maxime Fougère, Cornelis Immanuel van der Zouwen, Dimitri Ryczk. Serotonergic Modulation of Locomotor Activity From Basal Vertebrates to Mammals. Frontiers in neural circuits. vol 14. 2021-10-04. PMID:33224027. |
during the last 50 years, the serotonergic (5-ht) system was reported to exert a complex modulation of locomotor activity. |
2021-10-04 |
2023-08-13 |
Not clear |
| Ibrahim Mohammed Badamasi, Munn Sann Lye, Normala Ibrahim, Nurul Asyikin Abdul Razaq, King Hwa Ling, Johnson Stansla. Serotonergic receptor gene polymorphism and response to selective serotonin reuptake inhibitors in ethnic Malay patients with first episode of major depressive disorder. The pharmacogenomics journal. vol 21. issue 4. 2021-10-04. PMID:33731884. |
serotonergic receptor gene polymorphism and response to selective serotonin reuptake inhibitors in ethnic malay patients with first episode of major depressive disorder. |
2021-10-04 |
2023-08-13 |
Not clear |
| Xiaohong Huang, Shihuan Kuang, Todd J Applegate, Tsang-Long Lin, Heng-Wei Chen. Prenatal Serotonin Fluctuation Affects Serotoninergic Development and Related Neural Circuits in Chicken Embryos. Neuroscience. vol 473. 2021-10-01. PMID:34425158. |
these findings indicate that the 5-ht exposure effect can be achieved via different paths by modifying the embryonic serotonergic (5-htergic) and daergic systems and altering fetal 5-htergic influence on the thalamocortical circuit and hypothalamic-pituitary-adrenal axis. |
2021-10-01 |
2023-08-13 |
chicken |
| Felipe de Jesus Jiménez Vásquez, Diana Méndez Guerrero, Moisés Rubio Osornio, María Del Carmen Rubio Osornio, Sandra Orozco Suárez, Socorro Retana-Márque. Decreased serotonin content and release in the ventral hippocampus of prenatally stressed male rats in response to forced swim test. Acta neurobiologiae experimentalis. vol 80. issue 4. 2021-09-30. PMID:33350985. |
prenatal stress modifies the serotonergic system by altering the synthesis, metabolism, receptors and serotonin content in the hippocampus. |
2021-09-30 |
2023-08-13 |
rat |
| Paul Andrews, Jay Amsterda. A hormetic approach to understanding antidepressant effectiveness and the development of antidepressant tolerance - A conceptual view. Psychiatria polska. vol 54. issue 6. 2021-09-29. PMID:33740797. |
specifically, the serotonin system adapts to ssris by suppressing the firing of serotonergic neurons, inhibiting the synthesis of serotonin, and reducing the overall content of serotonin in the brain. |
2021-09-29 |
2023-08-13 |
Not clear |
| Grzegorz Ślifirski, Marek Król, Jadwiga Turł. 5-HT Receptors and the Development of New Antidepressants. International journal of molecular sciences. vol 22. issue 16. 2021-09-28. PMID:34445721. |
the complex nature of the serotonergic system and interactions with other neurochemical systems indicate that the development of depression may be mediated by various pathomechanisms, the common denominator of which is undoubtedly the disturbed transmission in central 5-ht synapses. |
2021-09-28 |
2023-08-13 |
human |
| Rui-Si Cui, Heng Ruan, Li-Yuan Liu, Xin-Wang L. Involvement of noradrenergic and serotonergic systems in risk-based decisions between options of equivalent expected value in rats. Neurobiology of learning and memory. vol 175. 2021-09-27. PMID:32890758. |
risk perception is an important factor that may mediate risk-based decision-making processes regulated by noradrenergic (na) and serotonergic (5-ht) systems. |
2021-09-27 |
2023-08-13 |
rat |
| Yohei Kawano, Maho Katsuyama, Masashi Nagata, Maki Obana, Satoshi Nakamatsu, Ayano Mori, Namiki Sakamoto, Yasunari Mano, Kenichi Negishi, Shuji Shimada, Takao Aoyam. Antiplatelet Effect of Mirtazapine via Co-blocking of the 5-HT Biological & pharmaceutical bulletin. vol 44. issue 2. 2021-09-27. PMID:33518675. |
antiplatelet effect of mirtazapine via co-blocking of the 5-ht mirtazapine (mtz) is a noradrenergic and specific serotonergic antidepressant. |
2021-09-27 |
2023-08-13 |
mouse |
| Lucien Roulet, Victoria Rollason, Jules Desmeules, Valérie Pigue. Tapentadol Versus Tramadol: A Narrative and Comparative Review of Their Pharmacological, Efficacy and Safety Profiles in Adult Patients. Drugs. vol 81. issue 11. 2021-09-24. PMID:34196947. |
the safety of tapentadol in real-world conditions remains poorly documented, particularly in at-risk patient subgroups and also in the ability to assess the risk associated with its residual serotonergic activity (serotonin syndrome, seizures). |
2021-09-24 |
2023-08-13 |
Not clear |
| Marissa C Ciesla, Yasin B Seven, Latoya L Allen, Kristin N Smith, Zachary A Asa, Alec K Simon, Ashley E Holland, Juliet V Santiago, Kelsey Stefan, Ashley Ross, Elisa J Gonzalez-Rothi, Gordon S Mitchel. Serotonergic innervation of respiratory motor nuclei after cervical spinal injury: Impact of intermittent hypoxia. Experimental neurology. vol 338. 2021-09-17. PMID:33460645. |
since serotonin contributes to functional recovery post-injury, treatments to restore or accelerate serotonergic reinnervation are of considerable interest. |
2021-09-17 |
2023-08-13 |
rat |
| Marissa C Ciesla, Yasin B Seven, Latoya L Allen, Kristin N Smith, Zachary A Asa, Alec K Simon, Ashley E Holland, Juliet V Santiago, Kelsey Stefan, Ashley Ross, Elisa J Gonzalez-Rothi, Gordon S Mitchel. Serotonergic innervation of respiratory motor nuclei after cervical spinal injury: Impact of intermittent hypoxia. Experimental neurology. vol 338. 2021-09-17. PMID:33460645. |
however, serotonergic structures were larger after c2hx in both motor nuclei, and total serotonin immunolabeling area was increased in the phrenic motor nucleus but reduced in the intercostal motor nucleus. |
2021-09-17 |
2023-08-13 |
rat |