| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Ciccocioppo, I Panocka, C Polidori, C T Dourish, M Mass. Blockade of pre- and post-synaptic 5-HT1A receptors does not modify the effect of fluoxetine or 5-hydroxytryptophan on ethanol and food intake in rats. Psychopharmacology. vol 134. issue 1. 1998-01-27. PMID:9399367. |
however, these agents can also increase 5-ht levels at somatodendritic 5-ht1a autoreceptors, with negative effects on serotonergic transmission. |
1998-01-27 |
2023-08-12 |
rat |
| L G Schmidt, P Dufeu, A Heinz, S Kuhn, H Rommelspache. Serotonergic dysfunction in addiction: effects of alcohol, cigarette smoking and heroin on platelet 5-HT content. Psychiatry research. vol 72. issue 3. 1998-01-27. PMID:9406907. |
serotonergic dysfunction in addiction: effects of alcohol, cigarette smoking and heroin on platelet 5-ht content. |
1998-01-27 |
2023-08-12 |
Not clear |
| K Rasmussen, J F Czachur. Nicotine withdrawal leads to increased sensitivity of serotonergic neurons to the 5-HT1A agonist 8-OH-DPAT. Psychopharmacology. vol 133. issue 4. 1998-01-22. PMID:9372532. |
rats were anesthetized on various days of the procedure and the effect of the 5-hydroxytryptamine (5-ht)-1a agonist 8-oh-dpat on the single-unit activity of serotonergic neurons in the dorsal raphe nucleus was examined. |
1998-01-22 |
2023-08-12 |
rat |
| D C Chugani, O Muzik, P Chakraborty, T Mangner, H T Chugan. Human brain serotonin synthesis capacity measured in vivo with alpha-[C-11]methyl-L-tryptophan. Synapse (New York, N.Y.). vol 28. issue 1. 1998-01-20. PMID:9414016. |
[c-11]amt is an analog of tryptophan, the precursor for serotonin synthesis, and is converted to alpha-[c-11]methyl-serotonin ([c-11]am-5ht), which is trapped in serotonergic neurons because [c-11]am-5ht is not degraded by monoamine oxidase. |
1998-01-20 |
2023-08-12 |
human |
| T R Summers, A L Hunter, C H Summer. Female social reproductive roles affect central monoamines. Brain research. vol 767. issue 2. 1998-01-15. PMID:9367258. |
reproductively dominant females had significantly greater telencephalic 5-hiaa, and serotonergic activation, as indicated by the ratio of 5-hiaa to 5-ht. |
1998-01-15 |
2023-08-12 |
Not clear |
| J Beiko, L Candusso, D P Cai. The effect of nonspatial water maze pretraining in rats subjected to serotonin depletion and muscarinic receptor antagonism: a detailed behavioural assessment of spatial performance. Behavioural brain research. vol 88. issue 2. 1998-01-14. PMID:9404629. |
the results showed that: (a) depletion of serotonin with pcpa had no effect on water maze performance and produced no sensorimotor disturbances; (b) antagonism of muscarinic receptors produced impairments in spatial and sensorimotor function in naive rats but neither effect was observed in rats first given nsp; (c) combined disruption of muscarinic and serotonergic function produced a severe deficit in spatial performance that was only partially alleviated by nsp; and (d) there was an association between poor maze acquisition scores and a high incidence of sensorimotor dysfunction. |
1998-01-14 |
2023-08-12 |
rat |
| J Tiihonen, J T Kuikka, K A Bergström, J Karhu, H Viinamäki, J Lehtonen, T Hallikainen, J Yang, P Hakol. Single-photon emission tomography imaging of monoamine transporters in impulsive violent behaviour. European journal of nuclear medicine. vol 24. issue 10. 1998-01-13. PMID:9323266. |
several studies have shown that impulsive violent and suicidal behaviour is associated with a central serotonin deficit, but until now it has not been possible to use laboratory tests with high sensitivity and specificity to study this kind of deficit or to localize the sites of serotonergic abnormalities in the living human brain. |
1998-01-13 |
2023-08-12 |
human |
| J M Halperin, J H Newcorn, I Kopstein, K E McKay, S T Schwartz, L J Siever, V Sharm. Serotonin, aggression, and parental psychopathology in children with attention-deficit hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry. vol 36. issue 10. 1998-01-12. PMID:9334552. |
to explore the relationship between central serotonergic (5-ht) function and history of parental aggression in aggressive and nonaggressive boys with attention-deficit hyperactivity disorder (adhd). |
1998-01-12 |
2023-08-12 |
Not clear |
| J E Smith, J M Lakosk. Electrophysiological study of the effects of the reuptake inhibitor duloxetine on serotonergic responses in the aging hippocampus. Pharmacology. vol 55. issue 2. 1998-01-09. PMID:9323306. |
the pharmacological effects of the dual serotonin (5-hydroxy-tryptamine, 5-ht) and norepinephrine reuptake inhibitor, duloxetine, on serotonergic function in the aging hippocampus were studied using an in vivo chloral hydrate-anesthetized preparation in the female fischer 344 rate across the life-span (3-8, 11-14, 18-22 and 24-27 months). |
1998-01-09 |
2023-08-12 |
Not clear |
| J M Gorma. The use of newer antidepressants for panic disorder. The Journal of clinical psychiatry. vol 58 Suppl 14. 1998-01-08. PMID:9418747. |
data from research trials as well as clinical experience are accumulating to indicate that the serotonin selective reuptake inhibitors (ssris)--fluoxetine, fluvoxamine, paroxetine, and sertraline--and perhaps venlafaxine, which inhibits both serotonergic and noradrenergic reuptake, are useful antipanic medications. |
1998-01-08 |
2023-08-12 |
Not clear |
| E F Coccaro, R J Kavouss. Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Archives of general psychiatry. vol 54. issue 12. 1997-12-23. PMID:9400343. |
evidence of an inverse relationship between central serotonergic (serotonin [5-hydroxytryptamine]) system function and impulsive aggressive behavior has been accumulating for more than 2 decades. |
1997-12-23 |
2023-08-12 |
human |
| L Uphous. Multiple serotonin receptors: too many, not enough, or just the right number? Neuroscience and biobehavioral reviews. vol 21. issue 5. 1997-12-22. PMID:9353798. |
serotonergic regulation of female reproduction and regulation of glucocorticoid release are used to illustrate the integrative potential deriving from the existence of multiple 5-ht receptors. |
1997-12-22 |
2023-08-12 |
Not clear |
| L L McMahon, J A Kaue. Hippocampal interneurons are excited via serotonin-gated ion channels. Journal of neurophysiology. vol 78. issue 5. 1997-12-22. PMID:9356400. |
as our results indicate that 5-ht may mediate fast excitatory synaptic transmission onto these interneurons, serotonergic inputs can simultaneously modulate the output of both hippocampus and dentate gyrus. |
1997-12-22 |
2023-08-12 |
Not clear |
| K M Ogilvie, M H Stetso. The neuroendocrine control of clock-timed gonadotropin release in the female Syrian hamster: role of serotonin. The Journal of endocrinology. vol 155. issue 1. 1997-12-17. PMID:9390013. |
the correlation of high 5ht turnover in the scn of die but not pro and pia animals suggested that elevated serotonergic activity in the scn is part of the mechanism by which the gonadotropin surge is prevented on die. |
1997-12-17 |
2023-08-12 |
Not clear |
| L Imeri, S Bianchi, M Manci. Muramyl dipeptide and IL-1 effects on sleep and brain temperature after inhibition of serotonin synthesis. The American journal of physiology. vol 273. issue 5. 1997-12-16. PMID:9374807. |
these results suggest that 1) mdp effects on both sleep-wake activity and brain cortical temperature are mediated by the serotonergic system; 2) the mechanisms mediating the first and the second phases of il-1-induced sws excess are different: 5-ht could be involved in the first phase, but not in the second one; and 3) the 5-ht system does not appear to be involved in il-1-induced fever. |
1997-12-16 |
2023-08-12 |
rat |
| C Montiel, C J Herrero, E García-Palomero, J Renart, A G García, R B Loma. Serotonergic effects of dotarizine in coronary artery and in oocytes expressing 5-HT2 receptors. European journal of pharmacology. vol 332. issue 2. 1997-12-15. PMID:9286620. |
contrary to flunarizine that blocks equally well the serotonergic and the k+ vascular responses, dotarizine exhibits 17-fold higher affinity for vascular 5-ht receptors. |
1997-12-15 |
2023-08-12 |
xenopus_laevis |
| L E Rueter, C A Fornal, B L Jacob. A critical review of 5-HT brain microdialysis and behavior. Reviews in the neurosciences. vol 8. issue 2. 1997-12-08. PMID:9344182. |
since electrophysiological studies have shown that behavioral arousal is the primary determinant of brain serotonergic neuronal activity, we suggest that the increase in 5-ht release seen during a wide variety of experimental conditions is largely due to one factor, namely an increase in behavioral arousal/motor activity associated with the manipulation. |
1997-12-08 |
2023-08-12 |
Not clear |
| J W Gibb, L Bush, G R Hanso. Exacerbation of methamphetamine-induced neurochemical deficits by melatonin. The Journal of pharmacology and experimental therapeutics. vol 283. issue 2. 1997-12-08. PMID:9353379. |
methamphetamine (meth), administered in large, repeated doses, compromises the dopaminergic and serotonergic systems as indicated by prolonged suppression of tyrosine hydroxylase and tryptophan hydroxylase activity and concurrent decreases in the content of dopamine and 5-hydroxytryptamine. |
1997-12-08 |
2023-08-12 |
rat |
| J Cerdà, T R Petrino, M J Greenberg, R A Wallac. Pharmacology of the serotonergic inhibition of steroid-induced reinitiation of oocyte meiosis in the teleost Fundulus heteroclitus. Molecular reproduction and development. vol 48. issue 2. 1997-12-02. PMID:9291479. |
the response of oocytes to 5-ht was characterized pharmacologically, i.e., the capacity of serotonergic agonists and antagonists to mimic or block the 5-ht inhibition of the steroid-induced oocyte maturation was assessed by the changes in the percentage of oocyte germinal vesicle breakdown (gvbd). |
1997-12-02 |
2023-08-12 |
Not clear |
| S Kasper, N Praschak-Rieder, J Tauscher, R Wol. A risk-benefit assessment of mirtazapine in the treatment of depression. Drug safety. vol 17. issue 4. 1997-12-02. PMID:9352961. |
its antidepressant effect appears to be related to its dual enhancement of central noradrenergic and serotonin 5-ht1 receptor-mediated serotonergic neurotransmission. |
1997-12-02 |
2023-08-12 |
Not clear |