| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Z Wrona, G Dryhurs. Oxidation of serotonin by superoxide radical: implications to neurodegenerative brain disorders. Chemical research in toxicology. vol 11. issue 6. 1998-07-16. PMID:9625732. |
this raises the possibility that t-4,5-d and perhaps other putative intraneuronal metabolites formed by the o2*-/h2o2/oxo-iron-mediated oxidations of 5-ht might be endotoxins that contribute to neurodegeneration in brain regions innervated by serotonergic neurons caused by ma, ischemia-reperfusion, and other neurodegenerative brain disorders. |
1998-07-16 |
2023-08-12 |
Not clear |
| J W Jahng, T A Houpt, T H Joh, J H So. Differential expression of monoamine oxidase A, serotonin transporter, tyrosine hydroxylase and norepinephrine transporter mRNA by anorexia mutation and food deprivation. Brain research. Developmental brain research. vol 107. issue 2. 1998-07-13. PMID:9593916. |
decreased 5htt expression in the anx rn is consistent with upregulation of serotonergic neurotransmission that may accompany 5ht hyperinnervation. |
1998-07-13 |
2023-08-12 |
mouse |
| G Rozas, I Liste, M J Guerra, J L Labandeira-Garci. Sprouting of the serotonergic afferents into striatum after selective lesion of the dopaminergic system by MPTP in adult mice. Neuroscience letters. vol 245. issue 3. 1998-07-10. PMID:9605478. |
neonatal destruction of the nigrostrial dopaminergic (da) system with 6-hydroxydopamine leads to serotonergic (5-ht) hyperinnervation of the striatum. |
1998-07-10 |
2023-08-12 |
mouse |
| L Buydens-Branchey, M Branchey, J Hudson, M Rothman, P Fergeson, C McKerni. Effect of fenfluramine challenge on cocaine craving in addicted male users. The American journal on addictions. vol 7. issue 2. 1998-07-09. PMID:9598218. |
the authors studied the effects of a challenging dose of the serotonin (5-ht)-releaser/reuptake inhibitor d,l-fenfluramine (fen) on spontaneous cocaine craving in a group of cocaine-addicted users in order to evaluate the involvement of serotonergic pathways in the modulation of craving for cocaine. |
1998-07-09 |
2023-08-12 |
Not clear |
| L Buydens-Branchey, M Branchey, J Hudson, M Rothman, P Fergeson, C McKerni. Effect of fenfluramine challenge on cocaine craving in addicted male users. The American journal on addictions. vol 7. issue 2. 1998-07-09. PMID:9598218. |
these data suggest that 5-ht releasers/reuptake inhibitors and serotonergic agents with greater postsynaptic activity should be further examined. |
1998-07-09 |
2023-08-12 |
Not clear |
| T E Dudley, L A DiNardo, J D Glas. Endogenous regulation of serotonin release in the hamster suprachiasmatic nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 13. 1998-07-02. PMID:9634570. |
collectively, these results show that the daily rhythm in output of 5-ht in the scn is generated endogenously, and that behavioral state can strongly influence serotonergic activity in the circadian clock in a phase-dependent manner. |
1998-07-02 |
2023-08-12 |
Not clear |
| O Rilke, D Freier, M Jähkel, J Oehle. Dynamic alterations of serotonergic metabolism and receptors during social isolation of low- and high-active mice. Pharmacology, biochemistry, and behavior. vol 59. issue 4. 1998-06-26. PMID:9586845. |
serotonergic systems of ham were found to be more reactive to environmental disturbances, and their serotonin metabolism was more affected by social isolation. |
1998-06-26 |
2023-08-12 |
mouse |
| b' A Kankaanp\\xc3\\xa4\\xc3\\xa4, E Meririnne, P Lillsunde, T Sepp\\xc3\\xa4l\\xc3\\xa. The acute effects of amphetamine derivatives on extracellular serotonin and dopamine levels in rat nucleus accumbens. Pharmacology, biochemistry, and behavior. vol 59. issue 4. 1998-06-26. PMID:9586861.' |
the strong effects of mda and mdma on levels of 5-ht indicate that their actions on serotonergic mechanisms are different from those of the hallucinogens. |
1998-06-26 |
2023-08-12 |
rat |
| H C Dringenberg, C H Vanderwol. Involvement of direct and indirect pathways in electrocorticographic activation. Neuroscience and biobehavioral reviews. vol 22. issue 2. 1998-06-24. PMID:9579316. |
recent evidence indicates that neocortical electrocorticographic (ecog) activation depends critically on cholinergic (ach) inputs from the basal forebrain and serotonergic (5-hydroxytryptamine, 5-ht) inputs from the midbrain raphe to the neocortex. |
1998-06-24 |
2023-08-12 |
Not clear |
| H C Dringenberg, C H Vanderwol. Involvement of direct and indirect pathways in electrocorticographic activation. Neuroscience and biobehavioral reviews. vol 22. issue 2. 1998-06-24. PMID:9579316. |
concurrent blockade of cholinergic and serotonergic inputs to the cortex abolishes all ecog activation, suggesting that: (a) together, ach and 5-ht are essential for cortical activation to occur; and (b) other systems cannot maintain cortical activation in the absence of the cholinergic and serotonergic inputs. |
1998-06-24 |
2023-08-12 |
Not clear |
| J D Higley, M Linnoil. Low central nervous system serotonergic activity is traitlike and correlates with impulsive behavior. A nonhuman primate model investigating genetic and environmental influences on neurotransmission. Annals of the New York Academy of Sciences. vol 836. 1998-06-24. PMID:9616793. |
we have used nonhuman primates to examine developmental and behavioral correlates of cns serotonergic activity, as measured by concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-hiaa) in the cerebrospinal fluid (csf). |
1998-06-24 |
2023-08-12 |
Not clear |
| G N Pande. Altered serotonin function in suicide. Evidence from platelet and neuroendocrine studies. Annals of the New York Academy of Sciences. vol 836. 1998-06-24. PMID:9616799. |
several strategies have been used to examine the serotonergic system in suicidal behavior, which include the determination of serotonin and its metabolites in csf and postmortem brain tissues as well as serotonin receptor subtypes in postmortem brain tissues, and in platelets of suicidal patients. |
1998-06-24 |
2023-08-12 |
human |
| M Muraoka, H Hayakawa, A Kagaya, T Kojima, S Yamawak. Effects of carbon monoxide exposure on serotonergic neuronal systems in rat brain. Life sciences. vol 62. issue 23. 1998-06-24. PMID:9627089. |
these findings indicated that co exposure caused presynaptic serotonergic neuronal dysfunctions that consisted mainly of decreased concentration of 5-ht in the frontal cortex or a decrease of 5-ht synthesis in all six regions, without compensatory hyperfunction of 5-ht2a receptors. |
1998-06-24 |
2023-08-12 |
rat |
| J P Rénéric, I Luck. Antidepressant behavioral effects by dual inhibition of monoamine reuptake in the rat forced swimming test. Psychopharmacology. vol 136. issue 2. 1998-06-18. PMID:9551776. |
the combination of higher doses of desipramine with fluoxetine, or compounds with mixed activity at inhibiting ne and 5-ht reuptake, demonstrated effects similar to those of desipramine alone and may reflect inhibition of the expression of serotonergic antidepressant behavioral effects by selective ne reuptake inhibitors. |
1998-06-18 |
2023-08-12 |
rat |
| H Jones, V A Curtis, P Wright, J V Luce. Neuroendocrine evidence that clozapine's serotonergic antagonism is relevant to its efficacy in treating hallucinations and other positive schizophrenic symptoms. The American journal of psychiatry. vol 155. issue 6. 1998-06-18. PMID:9619161. |
the authors examined the effect of prolonged clozapine treatment on central serotonergic (5-ht) function in schizophrenia. |
1998-06-18 |
2023-08-12 |
Not clear |
| D L Hammond, V Nelson, D A Thoma. Intrathecal methysergide antagonizes the antinociception, but not the hyperalgesia produced by microinjection of baclofen in the ventromedial medulla of the rat. Neuroscience letters. vol 244. issue 2. 1998-06-16. PMID:9572593. |
these data support the idea that the antinociceptive effect of low doses of baclofen in the tail-flick test is mediated by disinhibition of a bulbospinal serotonergic projection and release of serotonin in the spinal cord. |
1998-06-16 |
2023-08-12 |
rat |
| K Kaneko, A Kurumaji, A Watanabe, S Yamada, M Tor. Changes in high K+-evoked serotonin release and serotonin 2A/2C receptor binding in the frontal cortex of rats with thioacetamide-induced hepatic encephalopathy. Journal of neural transmission (Vienna, Austria : 1996). vol 105. issue 1. 1998-06-12. PMID:9588757. |
these results suggest that there is no change in basal 5-ht release in the cortex of rats with taa-induced he despite the increase in intraneuronal 5-ht metabolism and in the size of releasable 5-ht pool, and that serotonergic neurotransmission via 5-ht2a receptor is altered in the brain area of rats with he. |
1998-06-12 |
2023-08-12 |
rat |
| C Martin, V Roman, D Agay, M Fatôm. Anti-emetic effect of ondansetron and granisetron after exposure to mixed neutron and gamma irradiation. Radiation research. vol 149. issue 6. 1998-06-11. PMID:9611102. |
two deliveries of 5-ht3 receptor antagonists seem to disrupt serotonergic transmission at the brain stem structures and to affect the peripheral release of serotonin from the gut, thus completely preventing radiation-induced vomiting. |
1998-06-11 |
2023-08-12 |
Not clear |
| M J Mijnster, Y Galis-de Graaf, P Voor. Serotonergic regulation of neuropeptide and glutamic acid decarboxylase mRNA levels in the rat striatum and globus pallidus: studies with fluoxetine and DOI. Brain research. Molecular brain research. vol 54. issue 1. 1998-06-10. PMID:9526047. |
the serotonergic regulation of neuropeptide and glutamic acid decarboxylase (gad) mrna level in the rat basal ganglia was investigated by determining the effects of chronic treatment with the serotonin uptake blocker fluoxetine and the serotonin 5-ht2 agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrobromide (doi). |
1998-06-10 |
2023-08-12 |
rat |
| K Krebs-Thomson, V Lehmann-Masten, S Naiem, M P Paulus, M A Geye. Modulation of phencyclidine-induced changes in locomotor activity and patterns in rats by serotonin. European journal of pharmacology. vol 343. issue 2-3. 1998-06-09. PMID:9570460. |
to test the hypothesis that serotonergic modulation of the effects of phencyclidine (pcp) are due to circuit- rather than receptor-based interactions between glutamatergic and serotonergic systems, multivariate profiles of rat behavior were assessed after treatments with the 5-hydroxytryptamine (5-ht) 5-ht2 receptor antagonist ketanserin (1.0 mg/kg), the 5-ht2 receptor agonist (1(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) (doi; 0.27 mg/kg), various doses of pcp (0.75 to 10.125 mg/kg), or combinations thereof. |
1998-06-09 |
2023-08-12 |
rat |