| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M D Bauman, D G Amara. The distribution of serotonergic fibers in the macaque monkey amygdala: an immunohistochemical study using antisera to 5-hydroxytryptamine. Neuroscience. vol 136. issue 1. 2006-02-14. PMID:16182456. |
the distribution of serotonergic fibers in the macaque monkey amygdala: an immunohistochemical study using antisera to 5-hydroxytryptamine. |
2006-02-14 |
2023-08-12 |
monkey |
| Ying Qu, Nelly Villacreses, Dennis L Murphy, Stanley I Rapopor. 5-HT2A/2C receptor signaling via phospholipase A2 and arachidonic acid is attenuated in mice lacking the serotonin reuptake transporter. Psychopharmacology. vol 180. issue 1. 2006-02-13. PMID:15834538. |
the serotonin reuptake transporter (sert) helps to regulate brain serotonergic transmission and is the target of some antidepressants. |
2006-02-13 |
2023-08-12 |
mouse |
| C-J Hong, T-J Chen, Y W-Y Yu, S-J Tsa. Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder. The pharmacogenomics journal. vol 6. issue 1. 2006-02-13. PMID:16302021. |
the firing rate of dorsal raphe serotonergic neurons is controlled by somatodendritic 5-hydroxytryptamine 1a (htr1a) autoreceptors, and desensitization of these receptors is implicated in the antidepressant mechanism of selective serotonin reuptake inhibitors. |
2006-02-13 |
2023-08-12 |
Not clear |
| René Hurlemann, Christian Boy, Philipp T Meyer, Harald Scherk, Michael Wagner, Hans Herzog, Heinz H Coenen, Kai Vogeley, Peter Falkai, Karl Zilles, Wolfgang Maier, Andreas Baue. Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia. Anatomy and embryology. vol 210. issue 5-6. 2006-02-10. PMID:16187138. |
distribution volume ratios (dvrs) as a proxy for 5-ht(2a)r availability were significantly reduced in prefrontal cortex regions of at-risk subjects, implicating early abnormalities of serotonergic neurotransmission that antecede the onset of schizophrenia. |
2006-02-10 |
2023-08-12 |
human |
| G Koller, R R Engel, U W Preuss, A Karakesisoglou, P Zill, B Bondy, M Soyk. Tryptophan hydroxylase gene 1 polymorphisms are not associated with suicide attempts in alcohol-dependent individuals. Addiction biology. vol 10. issue 3. 2006-02-08. PMID:16109589. |
tryptophan hydroxylase (tph), the rate-limiting enzyme in serotonin biosynthesis, is a significant regulating factor in the serotonergic system. |
2006-02-08 |
2023-08-12 |
human |
| J Balaji, R Desai, S K Kaushalya, M J Eaton, S Mait. Quantitative measurement of serotonin synthesis and sequestration in individual live neuronal cells. Journal of neurochemistry. vol 95. issue 5. 2006-02-07. PMID:16269014. |
we use multiphoton microscopy to directly observe intracellular and intravesicular serotonin in the serotonergic neuronal cell line rn46a. |
2006-02-07 |
2023-08-12 |
Not clear |
| M Al-Fayez, D Russell, R Wayne Davies, P G Shiels, P J Baker, A P Payn. Deficits in the mid-brain raphe nuclei and striatum of the AS/AGU rat, a protein kinase C-gamma mutant. The European journal of neuroscience. vol 22. issue 11. 2006-02-07. PMID:16324113. |
the present study examines another midbrain aminergic system with input to the basal ganglia, the serotonergic (5-ht) raphe-striatal system originating in the dorsal raphe nucleus. |
2006-02-07 |
2023-08-12 |
rat |
| R B D'Eath, E Ormandy, A B Lawrence, B E H Sumner, S L Meddl. Resident-intruder trait aggression is associated with differences in lysine vasopressin and serotonin receptor 1A (5-HT1A) mRNA expression in the brain of pre-pubertal female domestic pigs (Sus scrofa). Journal of neuroendocrinology. vol 17. issue 10. 2006-02-03. PMID:16159381. |
because there is evidence for the involvement of the vasopressin and serotonergic systems in the regulation of aggressive behaviour in male mammals, we sought differences using quantitative in situ hybridisation of vasopressin and serotonin 1a receptor (5-ht1a) mrna expression within specific brain regions of aggressive and nonaggressive prepubertal female pigs. |
2006-02-03 |
2023-08-12 |
Not clear |
| Brian D Burrell, Christie L Sahle. Serotonin mediates learning-induced potentiation of excitability. Journal of neurophysiology. vol 94. issue 6. 2006-01-25. PMID:16120666. |
serotonin (5-ht) also increases s-cell excitability, and serotonergic modulation is known to be critical for sensitization of whole-body shortening, suggesting that 5-ht mediates learning-induced enhancement of s-cell excitability. |
2006-01-25 |
2023-08-12 |
Not clear |
| S Ueda, S Sakakibara, K Yoshimot. Effect of long-lasting serotonin depletion on environmental enrichment-induced neurogenesis in adult rat hippocampus and spatial learning. Neuroscience. vol 135. issue 2. 2006-01-25. PMID:16125851. |
intracisternal administration of the serotonergic neurotoxin, 5,7-dihydroxytryptamine, on postnatal day 3 apparently reduced serotonin content in the adult hippocampus without regeneration. |
2006-01-25 |
2023-08-12 |
rat |
| Rie Suzuki, Wahida Rahman, Lars J Rygh, Mark Webber, Stephen P Hunt, Anthony H Dickenso. Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. Pain. vol 117. issue 3. 2006-01-25. PMID:16150546. |
substance p-saporin (sp-sap) was used to selectively ablate superficial dorsal horn neurons expressing the neurokinin-1 receptor for substance p. these neurons project to the brain as shown by retrograde labelling and engage descending brainstem serotonergic influences that enhance spinal excitability via a facilitatory action on 5ht(3) receptors. |
2006-01-25 |
2023-08-12 |
Not clear |
| Cindy K J Lieben, Arjan Blokland, Ayhan Sik, Eric Sung, Petra van Nieuwenhuizen, Rudy Schreibe. The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 12. 2006-01-24. PMID:15957009. |
in conclusion, although ro4368554 did not improve a time-related retention deficit, it reversed a cholinergic and a serotonergic memory deficit, suggesting that both mechanisms may be involved in the facilitation of object memory by ro4368554 and, possibly, other 5-ht(6) receptor antagonists. |
2006-01-24 |
2023-08-12 |
rat |
| Bruno P Guiard, Nicolas Froger, Michel Hamon, Alain M Gardier, Laurence Lanfume. Sustained pharmacological blockade of NK1 substance P receptors causes functional desensitization of dorsal raphe 5-HT 1A autoreceptors in mice. Journal of neurochemistry. vol 95. issue 6. 2006-01-20. PMID:16219031. |
recording of drn serotonergic neurons in brainstem slices showed that gr 205171 treatment reduced (by approximately 1.5 fold) the potency of the 5-ht 1a receptor agonist, ipsapirone, to inhibit cell firing. |
2006-01-20 |
2023-08-12 |
mouse |
| Kyoji Morita, Hideki Arimochi, Song He. Serotonergic 5-HT2A receptor stimulation induces steroid 5alpha-reductase gene expression in rat C6 glioma cells via transcription factor Egr-1. Brain research. Molecular brain research. vol 139. issue 2. 2006-01-17. PMID:15936112. |
these results indicate that serotonin may stimulate 5alpha-r gene expression via transcription factor egr-1 in glial cells, thus suggesting that serotonin flowing out of the serotonergic synapse may be implicated in ssri-induced changes in neurosteroid metabolism in brain. |
2006-01-17 |
2023-08-12 |
rat |
| Jeanine I H Keuker, Jan N Keijser, Csaba Nyakas, Paul G M Luiten, Eberhard Fuch. Aging is accompanied by a subfield-specific reduction of serotonergic fibers in the tree shrew hippocampal formation. Journal of chemical neuroanatomy. vol 30. issue 4. 2006-01-13. PMID:16169187. |
we applied immunocytochemistry with an antibody against serotonin to assess serotonergic fiber densities in the various hippocampal subfields of adult (0.9-1.3 years) and old (5-7 years) tree shrews. |
2006-01-13 |
2023-08-12 |
rat |
| Tokumitsu Wakabayashi, Takashi Osada, Ryuzo Shinga. Serotonin deficiency shortens the duration of forward movement in Caenorhabditis elegans. Bioscience, biotechnology, and biochemistry. vol 69. issue 9. 2006-01-12. PMID:16195598. |
mutants with defective serotonin biosynthesis or worms with ablated serotonergic neurons showed a markedly decreased duration of forward movement, suggesting involvement of this neuromodulator in the regulation of the duration of worm locomotion. |
2006-01-12 |
2023-08-12 |
caenorhabditis_elegans |
| Giampiero Giovacchini, Lixin Lang, Ying Ma, Peter Herscovitch, William C Eckelman, Richard E Carso. Differential effects of paroxetine on raphe and cortical 5-HT1A binding: a PET study in monkeys. NeuroImage. vol 28. issue 1. 2006-01-11. PMID:15993625. |
few studies, however, have sought to demonstrate that variations in 5-ht concentration can be closely tracked with available serotonergic ligands. |
2006-01-11 |
2023-08-12 |
rat |
| Giampiero Giovacchini, Lixin Lang, Ying Ma, Peter Herscovitch, William C Eckelman, Richard E Carso. Differential effects of paroxetine on raphe and cortical 5-HT1A binding: a PET study in monkeys. NeuroImage. vol 28. issue 1. 2006-01-11. PMID:15993625. |
microdialysis studies in rats have shown a maximal increase in 5-ht concentration in raphe nuclei after systemic infusion of selective serotonergic re-uptake inhibitors (ssris). |
2006-01-11 |
2023-08-12 |
rat |
| Tiffany W Cho. Treatment approaches to symptoms associated with frontotemporal degeneration. Current psychiatry reports. vol 7. issue 5. 2006-01-10. PMID:16216158. |
although there is evidence to support a serotonergic deficit, and clinicians frequently prescribe selective serotonin reuptake inhibitors to patients with ftd, only paroxetine and trazodone have been studied. |
2006-01-10 |
2023-08-12 |
Not clear |
| E Calama, A V Ortíz de Urbina, A Morán, M L Martín, L San Romá. Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat. Clinical and experimental pharmacology & physiology. vol 32. issue 10. 2006-01-05. PMID:16173953. |
in the present study, we analysed the effect of different doses of 5-hydroxytryptamine (5-ht; intravenous infusions of 0.001-40 microg/kg per min) in the autoperfused hindquarters of the rat subjected to electrical stimulation (frequencies of 0.5-20 hz) of the lumbar chains, investigating the relationship between the adrenergic and serotonergic systems in this vascular bed. |
2006-01-05 |
2023-08-12 |
rat |