| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melissa A Mahgoub, Yildirim Sara, Ege T Kavalali, Lisa M Monteggi. Reciprocal interaction of serotonin and neuronal activity in regulation of cAMP-responsive element-dependent gene expression. The Journal of pharmacology and experimental therapeutics. vol 317. issue 1. 2006-05-25. PMID:16382023. |
the ability of 5-ht to stimulate creb phosphorylation in the absence of neuronal activity or inhibit creb phosphorylation during activity was due to a tight balance between protein kinases and phosphatases that could be physiologically tilted by different serotonergic receptors or exogenously influenced by phosphatase and kinase inhibitors. |
2006-05-25 |
2023-08-12 |
human |
| Kirsten Nielsen, Dorte Brask, Gitte M Knudsen, Susana Azna. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16408260. |
immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. |
2006-05-25 |
2023-08-12 |
rat |
| Kirsten Nielsen, Dorte Brask, Gitte M Knudsen, Susana Azna. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16408260. |
tracking serotonergic pathways in the brain through immunodetection of serotonin has widely been used for the anatomical characterization of the serotonergic system. |
2006-05-25 |
2023-08-12 |
rat |
| Kirsten Nielsen, Dorte Brask, Gitte M Knudsen, Susana Azna. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16408260. |
immunostaining for serotonin is also frequently applied for the visualization of individual serotonin containing fibers and quantification of serotonin positive fibers has been widely used to detect changes in the serotonergic innervation. |
2006-05-25 |
2023-08-12 |
rat |
| Kirsten Nielsen, Dorte Brask, Gitte M Knudsen, Susana Azna. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16408260. |
however, particularly in conditions with enhanced serotonin metabolism the detection level of serotonin may lead to an underestimation of the true number of serotonergic fibers. |
2006-05-25 |
2023-08-12 |
rat |
| Kirsten Nielsen, Dorte Brask, Gitte M Knudsen, Susana Azna. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16408260. |
the serotonin transporter (sert) protein, on the other hand, is less liable to metabolism and for that reason we hypothetized that sert immunostaining is a more stable marker of serotonergic fibers. |
2006-05-25 |
2023-08-12 |
rat |
| Kirsten Nielsen, Dorte Brask, Gitte M Knudsen, Susana Azna. Immunodetection of the serotonin transporter protein is a more valid marker for serotonergic fibers than serotonin. Synapse (New York, N.Y.). vol 59. issue 5. 2006-05-25. PMID:16408260. |
we conclude that the rapid metabolism of serotonin leads to an underestimation of immunodetected serotonergic fibers and that in many instances, sert immunostaining may be a better indicator of serotonergic fibers. |
2006-05-25 |
2023-08-12 |
rat |
| C Mehler-Wex, A Warnk. [Dysmorphophobia]. MMW Fortschritte der Medizin. vol 148. issue 10. 2006-05-24. PMID:16612948. |
since an involvement of the serotonergic system is assumed, selective serotonin reuptake inhibitors are considered to be the medication of first choice. |
2006-05-24 |
2023-08-12 |
Not clear |
| Claudia Somme. Is serotonin hyperalgesic or analgesic? Current pain and headache reports. vol 10. issue 2. 2006-05-18. PMID:16539862. |
in the central nervous system, 5-ht is involved in descending inhibition, but facilitatory serotonergic pathways may be functionally more important. |
2006-05-18 |
2023-08-12 |
Not clear |
| Madhuri Roy, Nadia K David, Jean V Danao, Helene Baribault, Hui Tian, Marco Giorgett. Genetic inactivation of melanin-concentrating hormone receptor subtype 1 (MCHR1) in mice exerts anxiolytic-like behavioral effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 1. 2006-05-12. PMID:15988472. |
baseline dialysate 5-ht levels were significantly lower in mchr1 knockout mice as compared with wild-type controls (9.53+/-0.24 fmol for wild types vs 6.91+/-0.36 fmol for knockouts) in the prefrontal cortex (pfc), one of the main target structures of the serotonergic system and one that is highly associated with the control of emotional processes. |
2006-05-12 |
2023-08-12 |
mouse |
| Michael J Minzenberg, Robert Grossman, Antonia S New, Vivian Mitropoulou, Rachel Yehuda, Marianne Goodman, Diedre A Reynolds, Jeremy M Silverman, Emil F Coccaro, Sue Marcus, Larry J Sieve. Blunted hormone responses to Ipsapirone are associated with trait impulsivity in personality disorder patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 1. 2006-05-12. PMID:16123761. |
impulsivity is related to impaired function at (or downstream to) postsynaptic 5-ht(1a) receptors, and this relationship may be partly responsible for the association of impaired serotonergic function with diagnoses such as bpd and ied-r. |
2006-05-12 |
2023-08-12 |
human |
| David S Paterson, Eric G Thompson, Hannah C Kinne. Serotonergic and glutamatergic neurons at the ventral medullary surface of the human infant: Observations relevant to central chemosensitivity in early human life. Autonomic neuroscience : basic & clinical. vol 124. issue 1-2. 2006-05-12. PMID:16458076. |
the ventral surface of the medulla oblongata (vms) of animals has long been recognized as a site of chemosensitivity, culminating in the recent identification of chemosensitive serotonergic (5-ht) and glutamatergic (glut) neurons in this region. |
2006-05-12 |
2023-08-12 |
human |
| Peter Gaszner, Ildikó Mikly. Major depression and the synthetic enhancer substances, (-)-deprenyl and R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane. Progress in neuro-psychopharmacology & biological psychiatry. vol 30. issue 1. 2006-05-08. PMID:16023777. |
the finding that phenylethylamine and tryptamine are endogenous enhancers of the impulse propagation mediated release of catecholamines and serotonin in the brain, and the development of synthetic enhancer substances opened the possibility to stimulate catecholaminergic and serotonergic neurons in the brain stem via a previously unknown mechanism. |
2006-05-08 |
2023-08-12 |
Not clear |
| Julie G Hensle. Serotonergic modulation of the limbic system. Neuroscience and biobehavioral reviews. vol 30. issue 2. 2006-05-05. PMID:16157378. |
serotonin projections to these structures, which arise from serotonergic cell body groups in the midbrain, form a dense plexus of axonal processes. |
2006-05-05 |
2023-08-12 |
Not clear |
| Julie G Hensle. Serotonergic modulation of the limbic system. Neuroscience and biobehavioral reviews. vol 30. issue 2. 2006-05-05. PMID:16157378. |
in many areas of the limbic system, serotonergic neurotransmission can best be described as paracrine or volume transmission, and thus serotonin is believed to play a neuromodulatory role in the brain. |
2006-05-05 |
2023-08-12 |
Not clear |
| J D K Uys, C J F Muller, L Marais, B H Harvey, D J Stein, W M U Daniel. Early life trauma decreases glucocorticoid receptors in rat dentate gyrus upon adult re-stress: reversal by escitalopram. Neuroscience. vol 137. issue 2. 2006-05-03. PMID:16310967. |
given interactions between the neuroendocrine and central serotonergic systems, we hypothesized that exposure to early trauma would lead to abnormal hypothalamic-adrenal axis activity that would be normalized by pretreatment with a selective serotonin re-uptake inhibitor. |
2006-05-03 |
2023-08-12 |
rat |
| B Schurad, R Horowski, S Jähnichen, T Görnemann, J Tack, H H Pert. Proterguride, a highly potent dopamine receptor agonist promising for transdermal administration in Parkinson's disease: interactions with alpha(1)-, 5-HT(2)- and H(1)-receptors. Life sciences. vol 78. issue 20. 2006-05-02. PMID:16310806. |
in contrast, at serotonergic receptors (5-ht(2a), 5-ht(2b)) proterguride acted as a partial agonist. |
2006-05-02 |
2023-08-12 |
rat |
| Gisèle Pickering, Marie-Anne Loriot, Frédéric Libert, Alain Eschalier, Philippe Beaune, Claude Dubra. Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism. Clinical pharmacology and therapeutics. vol 79. issue 4. 2006-05-02. PMID:16580905. |
preclinical studies have suggested that the mechanism of the analgesic action of acetaminophen (inn, paracetamol) is linked to the serotonergic system and that it is inhibited by tropisetron, a 5-hydroxytryptamine type 3 antagonist. |
2006-05-02 |
2023-08-12 |
Not clear |
| Sadamu Nakai, Wataru Matsunaga, Kenichi Isobe, Tetsuya Shirokaw. Age-dependent interactive changes in serotonergic and noradrenergic cortical axon terminals in F344 rats. Neuroscience research. vol 54. issue 3. 2006-04-28. PMID:16406149. |
the serotonergic (5-ht) axons originating from the dorsal raphe (dr) share the same cortical area and their age-dependent changes and interactions with na axons were still unclear. |
2006-04-28 |
2023-08-12 |
rat |
| Pinhas N Dannon, Katherine Lowengrub, I Iancu, Moshe Kotle. Paroxetine in panic disorder: clinical management and long-term follow-up. Expert review of neurotherapeutics. vol 4. issue 2. 2006-04-25. PMID:15853560. |
paroxetine is unique among the selective serotonin reuptake inhibitors since, in addition to its effect on the cns serotonergic neurotransmission, it also has mild noradrenergic properties demonstrated to be effective in the treatment of anxiety disorders and depression. |
2006-04-25 |
2023-08-12 |
Not clear |