| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eliza Koros, Przemyslaw Bienkowski, Wojciech Kostowsk. Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on ethanol discrimination in the rat. Alcohol (Fayetteville, N.Y.). vol 36. issue 2. 2006-04-19. PMID:16396744. |
it has been shown that ethanol produces a complex interoceptive cue in rodents with distinct gabaergic, glutamatergic, and serotonergic (5-hydroxytryptamine, 5-ht) components. |
2006-04-19 |
2023-08-12 |
rat |
| Byung-Joo Ham, Min-Soo Lee, Heon-Jeong Lee, Rhee-Hun Kang, Chang-Su Han, Myoung-Jin Choi, Seung-Hwan Lee, Seung-Ho Ry. No association between the tryptophan hydroxylase gene polymorphism and major depressive disorders and antidepressant response in a Korean population. Psychiatric genetics. vol 15. issue 4. 2006-04-14. PMID:16314762. |
tryptophan hydroxylase (tph) is the rate-limiting enzyme in serotonin biosynthesis, and selective serotonin re-uptake inhibitors exert their activity enhancing the general serotonergic tone. |
2006-04-14 |
2023-08-12 |
Not clear |
| Mads Breum Larsen, Anja Winther Fjorback, Ove Wibor. The C-terminus is critical for the functional expression of the human serotonin transporter. Biochemistry. vol 45. issue 4. 2006-04-14. PMID:16430230. |
the plasma membrane serotonin transporter (sert) has an important role in terminating serotonergic neurotransmission by re-uptake of 5-ht from the synaptic cleft. |
2006-04-14 |
2023-08-12 |
human |
| Alexis Evrard, Nicolas Barden, Michel Hamon, Joëlle Adrie. Glucocorticoid receptor-dependent desensitization of 5-HT1A autoreceptors by sleep deprivation: studies in GR-i transgenic mice. Sleep. vol 29. issue 1. 2006-04-14. PMID:16453979. |
sleep deprivation for one night induces mood improvement in depressed patients, an action that probably involves the serotonergic (5-ht) system. |
2006-04-14 |
2023-08-12 |
mouse |
| Christopher A Lowry, Frank L Moor. Regulation of behavioral responses by corticotropin-releasing factor. General and comparative endocrinology. vol 146. issue 1. 2006-04-13. PMID:16426606. |
crf-related neuropeptides increase swimming behaviors in amphibians and fish, apparently by activating brainstem serotonergic systems because the administration of fluoxetine (a selective serotonin re-uptake inhibitor) greatly enhances crf-induced locomotor activity. |
2006-04-13 |
2023-08-12 |
Not clear |
| Bettina Bert, Heidrun Fink, Heide Hörtnagl, Rüdiger W Veh, Ben Davies, Franz Theuring, Heike Kussero. Mice over-expressing the 5-HT(1A) receptor in cortex and dentate gyrus display exaggerated locomotor and hypothermic response to 8-OH-DPAT. Behavioural brain research. vol 167. issue 2. 2006-04-04. PMID:16256213. |
the serotonin 1a (5-ht(1a)) receptor is one of the best described receptor subtypes of the serotonergic system. |
2006-04-04 |
2023-08-12 |
mouse |
| Jaime M Monti, Héctor Janto. Effects of the 5-HT(7) receptor antagonist SB-269970 microinjected into the dorsal raphe nucleus on REM sleep in the rat. Behavioural brain research. vol 167. issue 2. 2006-04-04. PMID:16290281. |
our results indicate that the 5-ht(7) receptor is involved in the effect of drn serotonergic (5-ht) neurons on brainstem structures that act to promote and induce rem sleep. |
2006-04-04 |
2023-08-12 |
rat |
| B D Cash, W D Che. Review article: The role of serotonergic agents in the treatment of patients with primary chronic constipation. Alimentary pharmacology & therapeutics. vol 22. issue 11-12. 2006-04-03. PMID:16305718. |
as the role of serotonin in gastrointestinal function is further elucidated and additional candidate drugs are developed, it is likely that serotonergic agents will afford additional treatment options for patients with chronic constipation. |
2006-04-03 |
2023-08-12 |
Not clear |
| B D Cash, W D Che. Review article: The role of serotonergic agents in the treatment of patients with primary chronic constipation. Alimentary pharmacology & therapeutics. vol 22. issue 11-12. 2006-04-03. PMID:16305718. |
this article provides a concise review of the evidence supporting a role for serotonin in the pathogenesis of chronic constipation and a summary of the currently available evidence supporting the use of serotonergic agents for this disorder. |
2006-04-03 |
2023-08-12 |
Not clear |
| Mary M Niblock, Catherine J Luce, Richard A Belliveau, David S Paterson, Michelle L Kelly, Lynn A Sleeper, James J Filiano, Hannah C Kinne. Comparative anatomical assessment of the piglet as a model for the developing human medullary serotonergic system. Brain research. Brain research reviews. vol 50. issue 1. 2006-03-30. PMID:16043226. |
because the piglet is frequently used as a model for developmental disorders of the medullary serotonergic (5-ht) system in the human infant, this review compares the topography and developmental profile of selected 5-ht markers between humans in the first year of life and piglets in the first 60 days of life. |
2006-03-30 |
2023-08-12 |
human |
| John C Talpos, Lawrence S Wilkinson, Trevor W Robbin. A comparison of multiple 5-HT receptors in two tasks measuring impulsivity. Journal of psychopharmacology (Oxford, England). vol 20. issue 1. 2006-03-29. PMID:16204332. |
to test this hypothesis, behavioural effects of three partially selective serotonergic (5-ht) ligands, ketanserin (5-ht2(a, c) receptor antagonist), ser-082 (5-ht2(c, b) receptor antagonist) and sb-270146-a (5-ht6 receptor antagonist) were compared in two tests of impulsivity. |
2006-03-29 |
2023-08-12 |
Not clear |
| A E Frampton, J C H Andrews, A Parfitt, I A Jagroop, D P Mikhailidis, J A Henr. Does meta-chlorophenylpiperazine (mCPP) activate human platelets? Platelets. vol 17. issue 1. 2006-03-29. PMID:16308184. |
mcpp (meta-chlorophenylpiperazine), an agonist at serotonin (5-hydroxytryptamine, 5-ht) 5-ht2 receptors, has been used as a probe of serotonergic function. |
2006-03-29 |
2023-08-12 |
human |
| Annie Daszuta, Mounira Ban, Amélie Soumier, Micheline Hery, Elisabeth Mocae. [Depression and neuroplasticity: implication of serotoninergic systems]. Therapie. vol 60. issue 5. 2006-03-28. PMID:16433011. |
interestingly, serotonergic (5-ht) systems play a major role both as antidepressants and by increasing hippocampal neurogenesis through various receptor subtypes. |
2006-03-28 |
2023-08-12 |
Not clear |
| Alain Gardie. [Mechanism of action of antidepressant drugs: importance of genetically modified mice in the pharmacological in vivo approach]. Therapie. vol 60. issue 5. 2006-03-28. PMID:16433012. |
thus, we found that indirect activation of 5-ht1b autoreceptors limits the effects of ssris on dialysate 5-ht levels at serotonergic nerve terminals such as the ventral hippocampus. |
2006-03-28 |
2023-08-12 |
mouse |
| László Lakatos, Zoltán Rihme. [1+1 or 2x1? Another form of dual antidepressive mechanism of action]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 7. issue 3. 2006-03-28. PMID:16493875. |
the good clinical efficacy data of escitalopram may be explained by its unique dual serotonergic effect on serotonin transporter protein. |
2006-03-28 |
2023-08-12 |
Not clear |
| Eija Koponen, Tomi Rantamäki, Vootele Voikar, Tommi Saarelainen, Ewen MacDonald, Eero Castré. Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines. Cellular and molecular neurobiology. vol 25. issue 6. 2006-03-27. PMID:16392030. |
brain-derived neurotrophic factor (bdnf) influences the growth and plasticity of serotonergic (5-ht) neurons via the activation of trkb receptor. |
2006-03-27 |
2023-08-12 |
mouse |
| Viktor Roman, Irene Walstra, Paul G M Luiten, Peter Meerl. Too little sleep gradually desensitizes the serotonin 1A receptor system. Sleep. vol 28. issue 12. 2006-03-21. PMID:16408408. |
one of the proposed neurobiological mechanisms underlying depression is a disturbance in the brain's serotonergic neurotransmission, particularly a desensitization of the serotonin (5-ht)1a receptor system. |
2006-03-21 |
2023-08-12 |
Not clear |
| Roberto Mandrioli, Maria A Ragg. Advances in the enantioseparation of second-generation antidepressant drugs by electrodriven methods. Electrophoresis. vol 27. issue 1. 2006-03-17. PMID:16421952. |
in particular, the following pharmacological classes of antidepressants will be considered: selective serotonin reuptake inhibitors (fluoxetine, citalopram, paroxetine, sertraline); norepinephrine reuptake inhibitors (reboxetine); serotonin and norepinephrine reuptake inhibitors (venlafaxine, milnacipran, duloxetine); and noradrenergic and specific serotonergic antidepressants (mirtazapine). |
2006-03-17 |
2023-08-12 |
Not clear |
| b' Saveta Dragani\\xc4\\x87-Raji\\xc4\\x87, Dusica Leci\\xc4\\x87-Tosevski, Vladimir R Paunovi\\xc4\\x87, Vesna Cveji\\xc4\\x87, Dragan Svraki\\xc4\\x8. [Panic disorder--psychobiological aspects of personality dimensions]. Srpski arhiv za celokupno lekarstvo. vol 133. issue 3-4. 2006-03-16. PMID:16206699.' |
evidence of the importance of serotonergic (5-ht) system in panic disorder (pd), however, has substanti ally increased in recent years. |
2006-03-16 |
2023-08-12 |
Not clear |
| Gabriel Manjarrez, Edgar Hernandez, Alejandro Robles, Jorge Hernande. N1/P2 component of auditory evoked potential reflect changes of the brain serotonin biosynthesis in rats. Nutritional neuroscience. vol 8. issue 4. 2006-03-16. PMID:16491646. |
it is known that l-tryptophan stimulates serotonin synthesis in the brain and serotonergic neuronal activity. |
2006-03-16 |
2023-08-12 |
rat |