| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Pratuangdejkul, B Schneider, P Jaudon, V Rosilio, E Baudoin, S Loric, M Conti, J-M Launay, P Manive. Definition of an uptake pharmacophore of the serotonin transporter through 3D-QSAR analysis. Current medicinal chemistry. vol 12. issue 20. 2005-12-05. PMID:16181139. |
since the plasma membrane 5-ht transporter (sert) is the major protagonist in regulating extracellular 5-ht concentration, sert is the target of most drugs interacting with the serotonergic system. |
2005-12-05 |
2023-08-12 |
Not clear |
| Sarah E Hopwood, Stefan Trap. TASK-like K+ channels mediate effects of 5-HT and extracellular pH in rat dorsal vagal neurones in vitro. The Journal of physiology. vol 568. issue Pt 1. 2005-11-28. PMID:16020457. |
dorsal vagal neurones (dvn) receive serotonergic projections from the medullary raphé nuclei, suggesting that 5-ht modulates vagal activity. |
2005-11-28 |
2023-08-12 |
rat |
| Silvia Racca, Angela Spaccamiglio, Paola Esculapio, Giuliana Abbadessa, Luigi Cangemi, Francesco DiCarlo, Paolo Portaleon. Effects of swim stress and alpha-MSH acute pre-treatment on brain 5-HT transporter and corticosterone receptor. Pharmacology, biochemistry, and behavior. vol 81. issue 4. 2005-11-28. PMID:16023186. |
moreover, serotonergic pathways in various brain areas are activated by stressors, a feature that suggests a role for serotonin in both stress-induced hpaa disregulation and depressive physiopathology. |
2005-11-28 |
2023-08-12 |
rat |
| b' Marta Kubera, Michael Maes, Gunter Kenis, Yong-Ku Kim, W\\xc5\\x82adys\\xc5\\x82aw Laso\\xc5\\x8. Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6. Psychiatry research. vol 134. issue 3. 2005-11-25. PMID:15892984.' |
effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6. |
2005-11-25 |
2023-08-12 |
human |
| Joseph D DiBattista, Hymie Anisman, Megan Whitehead, Kathleen M Gilmou. The effects of cortisol administration on social status and brain monoaminergic activity in rainbow trout Oncorhynchus mykiss. The Journal of experimental biology. vol 208. issue Pt 14. 2005-11-21. PMID:16000540. |
significant increases of serotonergic activity ([5-hiaa]/[5-ht] ratio) were detected in the telencephalon with cortisol treatment, an effect that was eliminated by simultaneous administration of ru486. |
2005-11-21 |
2023-08-12 |
Not clear |
| P K Gillma. Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British journal of anaesthesia. vol 95. issue 4. 2005-11-15. PMID:16051647. |
serotonergic side-effects occur with serotonergic drugs, and overdoses of serotonin re-uptake inhibitors (sris) frequently produce marked serotonergic side-effects, and in 15% of cases, moderate serotonergic toxicity, but not to a severe degree, which produces hyperthermia and risk of death. |
2005-11-15 |
2023-08-12 |
Not clear |
| P K Gillma. Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity. British journal of anaesthesia. vol 95. issue 4. 2005-11-15. PMID:16051647. |
it is only combinations of serotonergic drugs acting by different mechanisms that are capable of raising intra-synaptic serotonin to a level that is life threatening. |
2005-11-15 |
2023-08-12 |
Not clear |
| D J De Silva, S J French, N Y Cheung, A K Swinson, C Bendotti, M Rattra. Rat brain serotonin neurones that express neuronal nitric oxide synthase have increased sensitivity to the substituted amphetamine serotonin toxins 3,4-methylenedioxymethamphetamine and p-chloroamphetamine. Neuroscience. vol 134. issue 4. 2005-11-15. PMID:16054768. |
using double-labeling immunocytochemistry and double in situ hybridization for nitric oxide synthase and the serotonin transporter, it was confirmed that about two thirds of serotonergic cell bodies in the dorsal raphé nucleus expressed nitric oxide synthase, however few if any serotonin transporter immunoreactive axons in striatum expressed nitric oxide synthase at detectable levels. |
2005-11-15 |
2023-08-12 |
rat |
| C A Olsson, G B Byrnes, M Lotfi-Miri, V Collins, R Williamson, C Patton, R J L Anne. Association between 5-HTTLPR genotypes and persisting patterns of anxiety and alcohol use: results from a 10-year longitudinal study of adolescent mental health. Molecular psychiatry. vol 10. issue 9. 2005-11-08. PMID:15852063. |
the serotonin transporter gene (5-htt) encodes a transmembrane protein that plays an important role in regulating serotonergic neurotransmission and related aspects of mood and behaviour. |
2005-11-08 |
2023-08-12 |
human |
| b' Pascal Amireault, Fran\\xc3\\xa7ois Dub\\xc3\\xa. Serotonin and its antidepressant-sensitive transport in mouse cumulus-oocyte complexes and early embryos. Biology of reproduction. vol 73. issue 2. 2005-11-08. PMID:15858217.' |
to clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-ht itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (tph1); and the 5-ht-specific transporter (slc6a4) required for modulating its cellular effects. |
2005-11-08 |
2023-08-12 |
mouse |
| b' Pascal Amireault, Fran\\xc3\\xa7ois Dub\\xc3\\xa. Serotonin and its antidepressant-sensitive transport in mouse cumulus-oocyte complexes and early embryos. Biology of reproduction. vol 73. issue 2. 2005-11-08. PMID:15858217.' |
all together, our results show that 5-ht may be produced locally by cumulus cells and that it can be actively taken up by mammalian oocytes and embryos as part of a likely larger serotonergic network possibly regulating various developmental processes much earlier than previously thought. |
2005-11-08 |
2023-08-12 |
mouse |
| L C Reis, A C Almeida, P L Cedraz-Mercez, E L Olivares, A Marinho, C M Thoma. Evidence indicating participation of the serotonergic system in controlling feeding behavior in Coturnix japonica (Galliformes: Aves). Brazilian journal of biology = Revista brasleira de biologia. vol 65. issue 2. 2005-11-08. PMID:16097739. |
we investigated participation of the brain serotonergic system in food intake control by using oral and systemic administration of serotonin precursors in quails (coturnix japonica). |
2005-11-08 |
2023-08-12 |
Not clear |
| L C Reis, A C Almeida, P L Cedraz-Mercez, E L Olivares, A Marinho, C M Thoma. Evidence indicating participation of the serotonergic system in controlling feeding behavior in Coturnix japonica (Galliformes: Aves). Brazilian journal of biology = Revista brasleira de biologia. vol 65. issue 2. 2005-11-08. PMID:16097739. |
the results suggest the involvement of serotonergic pathways in food intake control in quails and also show, for the first time, hypnogenic action induced by serotonin and a hyperdipsic effect elicited by hydroxytryptophan. |
2005-11-08 |
2023-08-12 |
Not clear |
| Hina Mehta, Reena Haobam, Rajamma Usha, Kochupurackal P Mohanakuma. Evidence for the involvement of central serotonergic mechanisms in cholinergic tremor induced by tacrine in Balb/c mice. Behavioural brain research. vol 163. issue 2. 2005-11-07. PMID:15990178. |
these results indicate that the cholinergic tremor produced by tacrine in balb/c mice is mediated via central serotonergic mechanisms, and stimulation of 5-ht(2a/2c) receptors plays a pivotal role in this motor dysfunction. |
2005-11-07 |
2023-08-12 |
mouse |
| Mustafa M Husain, Diane Stegman, Kenneth Trevin. Pregnancy and delivery while receiving vagus nerve stimulation for the treatment of major depression: a case report. Annals of general psychiatry. vol 4. 2005-10-26. PMID:16168055. |
the use of selective serotonin reuptake inhibitors (ssris) during pregnancy may induce serotonergic symptoms in the infant after delivery. |
2005-10-26 |
2023-08-12 |
Not clear |
| Jonathan M Brotchi. Nondopaminergic mechanisms in levodopa-induced dyskinesia. Movement disorders : official journal of the Movement Disorder Society. vol 20. issue 8. 2005-10-19. PMID:16007614. |
at the cellular level, an appreciation of abnormal signaling by, among others, glutamatergic (nmda and ampa receptors in particular), alpha2 adrenergic, serotonergic (5ht), cannabinoid and opioid mechanisms in both priming and expression of lid has begun to emerge over the last decade. |
2005-10-19 |
2023-08-12 |
Not clear |
| O Zivanović, E Til. [Serotonin syndrome--a case account]. Medicinski pregled. vol 45. issue 3-4. 2005-10-19. PMID:16104086. |
beside a large number of pharmaceuticals available on our market having an impact on serotonergic transmission, selective serotonin reuptake blocker inhibitors (fluvoxamine, fluoxetine) and a selective reversible monoaminooxidase inhibitor (moclobemide), have been included recently. |
2005-10-19 |
2023-08-12 |
Not clear |
| Hannah C Kinney, Michael M Myers, Richard A Belliveau, Leslie L Randall, Felicia L Trachtenberg, Sherri Ten Fingers, Mitzi Youngman, Donald Habbe, William P Fife. Subtle autonomic and respiratory dysfunction in sudden infant death syndrome associated with serotonergic brainstem abnormalities: a case report. Journal of neuropathology and experimental neurology. vol 64. issue 8. 2005-10-19. PMID:16106217. |
previously, we reported abnormalities in the serotonergic (5-ht) system of the medulla in sids cases in 2 independent datasets, including in the northern plains american indians. |
2005-10-19 |
2023-08-12 |
Not clear |
| Zeina S Malek, Hugues Dardente, Paul Pevet, Sylvie Raiso. Tissue-specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profiles. The European journal of neuroscience. vol 22. issue 4. 2005-10-18. PMID:16115212. |
these data show that the circadian 5-ht synthesis within the serotonergic neurons projecting to the circadian system might be explained by the rhythmic transcription of the tph2 gene in raphe nuclei. |
2005-10-18 |
2023-08-12 |
rat |
| L Arboreliu. 5-HT1A receptor antagonists as putative adjuvants to antidepressants: preclinical and clinical evidence. IDrugs : the investigational drugs journal. vol 2. issue 2. 2005-10-13. PMID:16160947. |
this hypothesis is based on preclinical findings showing that the purported increase in 5-ht concentrations in terminal regions produced by acute administration of ssris is hampered by a concomitant increase in 5-ht levels in cell body area leading to decreased serotonergic cell firing due to increased stimulation of inhibitory 5-ht1a autoreceptors. |
2005-10-13 |
2023-08-12 |
Not clear |