| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susanne Nikolaus, Christina Antke, Hans-Wilhelm Mülle. In vivo imaging of synaptic function in the central nervous system: II. Mental and affective disorders. Behavioural brain research. vol 204. issue 1. 2009-12-01. PMID:19523495. |
the majority of in vivo findings suggest no alterations (25 out of a total of 50 reports on serotonin synthesis, transporter as well as receptor binding) rather than a deficiency (merely 13 out of these 50 reports) of cortical serotonergic neurotransmission in major depression, whereas a decrease of cortical serotonergic neurotransmission (3 out of a total on 5 reports) can be assumed in bipolar illness. |
2009-12-01 |
2023-08-12 |
human |
| A Schmitt, J Benninghoff, R Moessner, M Rizzi, E Paizanis, C Doenitz, S Gross, M Hermann, A Gritti, L Lanfumey, S Fritzen, A Reif, M Hamon, D L Murphy, A Vescovi, K-P Lesc. Adult neurogenesis in serotonin transporter deficient mice. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 9. 2009-11-27. PMID:17510734. |
the 5-ht transporter (5-htt, slc6a4) mediates high-affinity reuptake of 5-ht into presynaptic terminals and thereby fine-tunes serotonergic neurotransmission. |
2009-11-27 |
2023-08-12 |
mouse |
| Ana M Galan, Irene Lopez-Vilchez, Maribel Diaz-Ricart, Fulgencio Navalon, Esther Gomez, Cristobal Gasto, Gines Escola. Serotonergic mechanisms enhance platelet-mediated thrombogenicity. Thrombosis and haemostasis. vol 102. issue 3. 2009-11-25. PMID:19718472. |
although it is generally acknowledged that serotonin (5-ht) is a weak agonist for human platelets, recent information suggests an association between serotonergic mechanisms and cardiovascular risk. |
2009-11-25 |
2023-08-12 |
human |
| Tomoko Hibino, Mitsutoshi Yuzurihara, Yoshio Kase, Atsushi Taked. synephrine, a component of Evodiae Fructus, constricts isolated rat aorta via adrenergic and serotonergic receptors. Journal of pharmacological sciences. vol 111. issue 1. 2009-11-25. PMID:19721332. |
because the constrictive effects of both evodiae fructus and synephrine were exerted via adrenergic alpha(1)-receptors and serotonergic (5-ht(1d) and 5-ht(2a)) receptors, synephrine may be one of the important components in the constrictive effects of evodiae fructus. |
2009-11-25 |
2023-08-12 |
rat |
| Eva Real, Mònica Gratacòs, Virginia Soria, Geòrgia Escaramís, Pino Alonso, Cinto Segalàs, Mònica Bayés, Rafael de Cid, José M Menchón, Xavier Estivil. A brain-derived neurotrophic factor haplotype is associated with therapeutic response in obsessive-compulsive disorder. Biological psychiatry. vol 66. issue 7. 2009-11-23. PMID:19589503. |
furthermore, there is strong evidence of a role for the serotonergic system in the pathophysiology and treatment of ocd, and upregulation of bdnf has been observed with various classes of antidepressants, including selective serotonin reuptake inhibitors (ssri). |
2009-11-23 |
2023-08-12 |
Not clear |
| K S Gomes, R L Nunes-De-Souz. Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 7. 2009-11-17. PMID:19625008. |
given that intra-dpag injections of a wide range of serotonergic 5-ht(1a), 5-ht(2a) and 5-ht(2c) receptor agonists produce anxiolytic-like effects in maze-naïve rodents, the present study examined the effects of the 5-ht(1a) receptor agonist 8-oh-dpat (5.6 and 10.0nmol in 0.15microl) the preferential 5-ht(2a) receptor agonist doi (2.0 and 8.0nmol in 0.1microl) and the preferential 5-ht(2c) receptor agonist mk-212 (21.2 and 63.6nmol in 0.1microl) microinjected into the dpag prior to trial 1 and trial 2 on the behaviour of mice in the epm. |
2009-11-17 |
2023-08-12 |
mouse |
| Michael V Baratta, Christina M Zarza, Devan M Gomez, Serge Campeau, Linda R Watkins, Steven F Maie. Selective activation of dorsal raphe nucleus-projecting neurons in the ventral medial prefrontal cortex by controllable stress. The European journal of neuroscience. vol 30. issue 6. 2009-11-17. PMID:19686468. |
the serotonergic (5-ht) dorsal raphe nucleus (drn) has come to be viewed as a critical structure in mediating the behavioral effects of uncontrollable stress. |
2009-11-17 |
2023-08-12 |
rat |
| Jesper T Andreasen, Elsebet O Nielsen, John P Redrob. Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test. Psychopharmacology. vol 205. issue 3. 2009-11-16. PMID:19452140. |
nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. |
2009-11-16 |
2023-08-12 |
mouse |
| Anissa Abi-Dargha. Alterations of serotonin transmission in schizophrenia. International review of neurobiology. vol 78. 2009-11-13. PMID:17349860. |
a role for serotonin alterations in the pathophysiology of schizophrenia has long been suspected because of the psychotogenic effects of serotonergic agonists and the therapeutic effects of 5-ht(2) antagonism. |
2009-11-13 |
2023-08-12 |
Not clear |
| A N Iniushkin, N A Merkulova, A O Orlova, E M Iniushkin. [Local GABA-ergic modulation of serotonergic neuron activity in the nucleus raphe magnus]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 95. issue 7. 2009-11-12. PMID:19803461. |
in voltage-clamp experimental on slices of the rat brainstem the effects of 5-ht and gaba on serotonergic neurons of nucleus raphe magnus were investigated. |
2009-11-12 |
2023-08-12 |
rat |
| A N Iniushkin, N A Merkulova, A O Orlova, E M Iniushkin. [Local GABA-ergic modulation of serotonergic neuron activity in the nucleus raphe magnus]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 95. issue 7. 2009-11-12. PMID:19803461. |
local applications of 5-ht induced an increase in ipcss frequency and amplitude in 45% of serotonergic cells. |
2009-11-12 |
2023-08-12 |
rat |
| Gongliang Zhang, Swapna Krishnamoorthy, Zhiyuan Ma, Nick P Vukovich, Xupei Huang, Rui Ta. Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome. European journal of pharmacology. vol 615. issue 1-3. 2009-11-10. PMID:19464285. |
serotonin (5-hydroxytryptamine; 5-ht)-toxicity syndrome, an iatrogenic brain disorder induced by excessive efflux of 5-ht, has received much attention because of increasing incidents of serotonergic antidepressants. |
2009-11-10 |
2023-08-12 |
rat |
| Y Le Strat, P Gorwoo. Agomelatine, an innovative pharmacological response to unmet needs. Journal of psychopharmacology (Oxford, England). vol 22. issue 7 Suppl. 2009-11-05. PMID:18753276. |
this consideration has led to the synthesis of agomelatine, a novel antidepressant combining melatonergic mt(1) and mt(2) agonism and serotonergic 5-ht(2c) antagonism. |
2009-11-05 |
2023-08-12 |
Not clear |
| R W La. Addressing circadian rhythm disturbances in depressed patients. Journal of psychopharmacology (Oxford, England). vol 22. issue 7 Suppl. 2009-11-05. PMID:18753278. |
evidence suggests that melatonergic (mt(1) and mt(2)) and the 5-ht(2c) serotonergic receptor subtypes are important modulators of circadian rhythmicity. |
2009-11-05 |
2023-08-12 |
Not clear |
| Marat G Uzbeko. Antidepressant action of tianeptine is connected with acceleration of serotonin turnover in the synapse: a hypothesis. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 11. issue 2. 2009-11-04. PMID:19827315. |
based on the results of our investigation of patients with anxious depression under the treatment with serotonergic antidepressants with different mechanism of action on serotonin reuptake we, the first time in the literature, propose the hypothesis about neurochemical mechanism of tianeptine action. |
2009-11-04 |
2023-08-12 |
Not clear |
| Nadja Osterberg, Eleni Rouss. Characterization of primary neurospheres generated from mouse ventral rostral hindbrain. Cell and tissue research. vol 336. issue 1. 2009-11-03. PMID:19224248. |
serotonergic (5-ht) neurons of the reticular formation play a key role in the modulation of behavior, and their dysfunction is associated with severe neurological and psychiatric disorders, such as depression and schizophrenia. |
2009-11-03 |
2023-08-12 |
mouse |
| Barbara E Musolf, Nadja Spitzer, Brian L Antonsen, Donald H Edward. Serotonergic modulation of crayfish hindgut. The Biological bulletin. vol 217. issue 1. 2009-11-02. PMID:19679722. |
the crayfish hindgut is a morphologically differentiated tube that varies along its length in the distribution of muscles and glands, contractile properties, serotonergic innervation, patterns of 5-ht receptor expression, and sensitivity to serotonin (5-ht). |
2009-11-02 |
2023-08-12 |
Not clear |
| Ilona Klejbor, Aaron Kucinski, Scott R Wersinger, Thomas Corso, Jan H Spodnik, Jerzy Dziewiatkowski, Janusz Moryś, Renae A Hesse, Kenner C Rice, Robert Miletich, Ewa K Stachowiak, Michal K Stachowia. Serotonergic hyperinnervation and effective serotonin blockade in an FGF receptor developmental model of psychosis. Schizophrenia research. vol 113. issue 2-3. 2009-10-29. PMID:19570652. |
serotonergic hyperinnervation and effective serotonin blockade in an fgf receptor developmental model of psychosis. |
2009-10-29 |
2023-08-12 |
mouse |
| Ilona Klejbor, Aaron Kucinski, Scott R Wersinger, Thomas Corso, Jan H Spodnik, Jerzy Dziewiatkowski, Janusz Moryś, Renae A Hesse, Kenner C Rice, Robert Miletich, Ewa K Stachowiak, Michal K Stachowia. Serotonergic hyperinnervation and effective serotonin blockade in an FGF receptor developmental model of psychosis. Schizophrenia research. vol 113. issue 2-3. 2009-10-29. PMID:19570652. |
we show in th(tk-)/th(tk-) mice that hypoplastic development of da systems induces serotonergic hyperinnervation of midbrain da nuclei, demonstrating the co-developmental relationship between da and 5-ht systems. |
2009-10-29 |
2023-08-12 |
mouse |
| Minoru Miyazato, Yasuhiro Kaiho, Izumi Kamo, Takeya Kitta, Michael B Chancellor, Kimio Sugaya, Yoichi Arai, William C de Groat, Naoki Yoshimur. Role of spinal serotonergic pathways in sneeze-induced urethral continence reflex in rats. American journal of physiology. Renal physiology. vol 297. issue 4. 2009-10-27. PMID:19640898. |
to clarify the role of spinal serotonergic mechanisms in preventing stress urinary incontinence (sui) during sneezing, we investigated the effect of intrathecal (it) application of 8-oh-dpat (a 5-ht(1a) agonist), mcpp (a 5-ht(2b/2c) agonist), and fluoxetine (a serotonin reuptake inhibitor) using a rat model that can examine the neurally evoked continence reflex during sneezing. |
2009-10-27 |
2023-08-12 |
rat |