| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvia Navailles, Abdelhamid Benazzouz, Bernard Bioulac, Christian Gross, Philippe De Deurwaerdèr. High-frequency stimulation of the subthalamic nucleus and L-3,4-dihydroxyphenylalanine inhibit in vivo serotonin release in the prefrontal cortex and hippocampus in a rat model of Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 6. 2010-03-05. PMID:20147561. |
these neurochemical data show that stn-hfs inhibits 5-ht release by modulating serotonergic neuron activity, while the decrease in 5-ht levels induced by l-dopa may include its direct action inside serotonergic neurons. |
2010-03-05 |
2023-08-12 |
rat |
| Soo-Hyun Park, Yun-Beom Sim, Seung-Min Choi, Young-Jun Seo, Min-Soo Kwon, Jin-Koo Lee, Hong-Won Su. Antinociceptive profiles and mechanisms of orally administered vanillin in the mice. Archives of pharmacal research. vol 32. issue 11. 2010-03-04. PMID:20091280. |
however, phentolamine (alpha1-adrenergic receptor antagonist) or methysergide (5-ht serotonergic receptor antagonist) did not affect antinociception induced by vanillin in the writhing test. |
2010-03-04 |
2023-08-12 |
mouse |
| Yun Li, Xu-Feng Huang, Chao Deng, Barbara Meyer, Aimin Wu, Yinghua Yu, Weihai Ying, Guo-Yuan Yang, Midori A Yenari, Qing Wan. Alterations in 5-HT2A receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats. Synapse (New York, N.Y.). vol 64. issue 3. 2010-03-02. PMID:19862688. |
the downregulation of 5-ht(2a) receptor binding in this study also provides indirect evidence for plasticity in the serotonergic system in the rat brains. |
2010-03-02 |
2023-08-12 |
rat |
| Emil F Coccaro, Royce Lee, Richard J Kavouss. Aggression, suicidality, and intermittent explosive disorder: serotonergic correlates in personality disorder and healthy control subjects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 2. 2010-03-01. PMID:19776731. |
central serotonergic (5-ht) activity has long been implicated in the regulation of impulsive aggressive behavior. |
2010-03-01 |
2023-08-12 |
human |
| Shaoyong Su, Jinying Zhao, J Douglas Bremner, Andrew H Miller, Weining Tang, Mark Bouzyk, Harold Snieder, Olga Novik, Nadeem Afzal, Jack Goldberg, Viola Vaccarin. Serotonin transporter gene, depressive symptoms, and interleukin-6. Circulation. Cardiovascular genetics. vol 2. issue 6. 2010-03-01. PMID:20031642. |
we explored the relationship of genetic variants of the serotonin transporter gene slc6a4, a key regulator of the serotonergic neurotransmission, with both depressive symptoms and plasma interleukin-6 (il-6) levels. |
2010-03-01 |
2023-08-12 |
Not clear |
| Sandra Dehning, Norbert Müller, Judith Matz, Andreas Bender, Irina Kerle, Jens Benninghoff, Richard Musil, Ilja Spellmann, Brigitta Bondy, Hans-Juergen Möller, Michael Riedel, Peter Zil. A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome. Psychiatric genetics. vol 20. issue 1. 2010-02-24. PMID:20010450. |
as neuroimaging studies allude to dopaminergic and serotonergic dysfunction in gts and serotonin as an important factor for dopamine release, genotyping of common polymorphisms in the serotonergic receptor (htr1a: c-1019g; htr2a: t102c, his452tyr, a-1438g; htr2c: c-759t, g-697c) and transporter genes (slc6a4) was carried out in 87 patients with gts, compared with 311 matched controls. |
2010-02-24 |
2023-08-12 |
Not clear |
| Jacobus J Dudok, Alexander J A Groffen, Menno P Witter, Pieter Voorn, Matthijs Verhag. Chronic activation of the 5-HT(2) receptor reduces 5-HT neurite density as studied in organotypic slice cultures. Brain research. vol 1302. 2010-02-23. PMID:19728996. |
here we studied the effect of serotonin and serotonin pharmacological compounds on the outgrowth of serotonergic projections using organotypic slice co-cultures of hippocampus and dorsal raphe nuclei. |
2010-02-23 |
2023-08-12 |
Not clear |
| Jacobus J Dudok, Alexander J A Groffen, Menno P Witter, Pieter Voorn, Matthijs Verhag. Chronic activation of the 5-HT(2) receptor reduces 5-HT neurite density as studied in organotypic slice cultures. Brain research. vol 1302. 2010-02-23. PMID:19728996. |
chronic application of a 5-ht(2) agonist reduced the serotonergic neurite density, without effects on survival of serotonergic neurons. |
2010-02-23 |
2023-08-12 |
Not clear |
| Jacobus J Dudok, Alexander J A Groffen, Menno P Witter, Pieter Voorn, Matthijs Verhag. Chronic activation of the 5-HT(2) receptor reduces 5-HT neurite density as studied in organotypic slice cultures. Brain research. vol 1302. 2010-02-23. PMID:19728996. |
in contrast, application of a 5-ht(1a) agonist or the serotonin transporter inhibitor fluoxetine did not affect serotonergic neurite density. |
2010-02-23 |
2023-08-12 |
Not clear |
| Jacobus J Dudok, Alexander J A Groffen, Menno P Witter, Pieter Voorn, Matthijs Verhag. Chronic activation of the 5-HT(2) receptor reduces 5-HT neurite density as studied in organotypic slice cultures. Brain research. vol 1302. 2010-02-23. PMID:19728996. |
we conclude that serotonergic connectivity was reproduced in vitro and that the serotonin neurite density is inhibited by chronic activation of the 5-ht(2) receptor. |
2010-02-23 |
2023-08-12 |
Not clear |
| Harold E Bay. Lorcaserin and adiposopathy: 5-HT2c agonism as a treatment for 'sick fat' and metabolic disease. Expert review of cardiovascular therapy. vol 7. issue 11. 2010-02-23. PMID:19900026. |
this review examines: the mechanisms by which serotonergic pathways improve adiposity and adiposopathy; historical data and perspective regarding the efficacy and safety of prior 5-ht agonists; speculation regarding future paradigms in treating adiposopathy; and why lorcaserin may prove to be a safe and generally well-tolerated agent that not only improves the weight of patients, but also improves the health of patients. |
2010-02-23 |
2023-08-12 |
Not clear |
| Sean D Hood, Dana A Hince, Simon J C Davies, Spilios Argyropoulos, Hayley Robinson, John Potokar, David J Nut. Effects of acute tryptophan depletion in serotonin reuptake inhibitor-remitted patients with generalized anxiety disorder. Psychopharmacology. vol 208. issue 2. 2010-02-23. PMID:19936713. |
serotonergic antidepressants [selective serotonin reuptake inhibitor (ssri)] are first-line treatments for generalised anxiety disorder (gad); however, it is not known if synaptic serotonin (5-ht) availability is important for ssri efficacy. |
2010-02-23 |
2023-08-12 |
Not clear |
| T L Schaefer, C V Vorhees, M T William. Mouse plasmacytoma-expressed transcript 1 knock out induced 5-HT disruption results in a lack of cognitive deficits and an anxiety phenotype complicated by hypoactivity and defensiveness. Neuroscience. vol 164. issue 4. 2010-02-19. PMID:19786075. |
although pharmacological, neurotoxin, and dietary manipulation of 5-ht and tryptophan hydroxylase has added to our understanding of the serotonergic system, the results are complicated by multiple factors. |
2010-02-19 |
2023-08-12 |
mouse |
| T M Clark, J L Lawecki, J J Shepherd, A N Hirschler, T R Samand. Effects of serotonergic agents on survival and hemolymph composition of the larval mosquito Aedes aegypti (Diptera: Culicidae, L.) in vivo: does serotonin regulate hemolymph acid-base homeostasis? The Journal of experimental biology. vol 212. issue Pt 22. 2010-02-17. PMID:19880735. |
effects of serotonergic agents on survival and hemolymph composition of the larval mosquito aedes aegypti (diptera: culicidae, l.) in vivo: does serotonin regulate hemolymph acid-base homeostasis? |
2010-02-17 |
2023-08-12 |
Not clear |
| Y Hayashi, S Jacob-Vadakot, E A Dugan, S McBride, R Olexa, K Simansky, M Murray, J S Shumsk. 5-HT precursor loading, but not 5-HT receptor agonists, increases motor function after spinal cord contusion in adult rats. Experimental neurology. vol 221. issue 1. 2010-02-16. PMID:19840787. |
serotonergic (5-ht) receptors are upregulated following spinal cord transection. |
2010-02-16 |
2023-08-12 |
rat |
| H Tilleman, O Kofman, L Nashelsky, U Livneh, N Roz, I Sillaber, A Biegon, M Rehavi, C Brodsk. Critical role of the embryonic mid-hindbrain organizer in the behavioral response to amphetamine and methylphenidate. Neuroscience. vol 163. issue 4. 2010-02-12. PMID:19635527. |
transmitter measurements, dopamine and serotonin transporter binding assays and autoradiography, indicated a subtle increase in striatal dopaminergic innervation and a marked general decrease of serotonergic innervation in mutants. |
2010-02-12 |
2023-08-12 |
mouse |
| H Haghir, S Kovac, E-J Speckmann, K Zilles, A Gorj. Patterns of neurotransmitter receptor distributions following cortical spreading depression. Neuroscience. vol 163. issue 4. 2010-02-12. PMID:19665048. |
in addition to up-regulation of ionotropic glutamate receptors, receptor binding sites of gaba(a), muscarinic m1 and m2, adrenergic alpha(1) and alpha(2), and serotonergic 5-ht(2) receptors were increased in the hippocampus. |
2010-02-12 |
2023-08-12 |
rat |
| H Haghir, S Kovac, E-J Speckmann, K Zilles, A Gorj. Patterns of neurotransmitter receptor distributions following cortical spreading depression. Neuroscience. vol 163. issue 4. 2010-02-12. PMID:19665048. |
cortical sd also upregulated nmda, ampa, kainate, gaba(a), serotonergic 5-ht(2), adrenergic alpha(2) and dopaminergic d1 receptor binding sites in the striatum. |
2010-02-12 |
2023-08-12 |
rat |
| J D A Olivier, L A W Jans, A Blokland, N J Broers, J R Homberg, B A Ellenbroek, A R Cool. Serotonin transporter deficiency in rats contributes to impaired object memory. Genes, brain, and behavior. vol 8. issue 8. 2010-02-10. PMID:19740092. |
the serotonin transporter (sert) has an essential role in serotonergic neurotransmission as it determines the magnitude and duration of the serotonin signal in the synaptic cleft. |
2010-02-10 |
2023-08-12 |
human |
| Erica Z McAuley, Janice M Fullerton, Ian P Blair, Jennifer A Donald, Philip B Mitchell, Peter R Schofiel. Association between the serotonin 2A receptor gene and bipolar affective disorder in an Australian cohort. Psychiatric genetics. vol 19. issue 5. 2010-02-09. PMID:19584773. |
the serotonin 2a receptor gene (htr2a) is involved in serotonergic neurotransmission, and has been targeted as a functional candidate for mood disorders because of the extensive support for the involvement of serotonin in mood regulation. |
2010-02-09 |
2023-08-12 |
Not clear |