| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sandra Boom, Krishna Talluri, Luc Janssens, Bart Remmerie, Marc De Meulder, Stefaan Rossenu, Nancy van Osselaer, Marielle Eerdekens, Adriaan Cleto. Single- and multiple-dose pharmacokinetics and dose proportionality of the psychotropic agent paliperidone extended release. Journal of clinical pharmacology. vol 49. issue 11. 2010-01-07. PMID:19713555. |
paliperidone extended-release tablet (paliperidone er) is a centrally active dopamine d(2)- and serotonergic 5-ht(2a)-receptor antagonist that is registered for the treatment of schizophrenia. |
2010-01-07 |
2023-08-12 |
Not clear |
| Anika Hennings, Peter Zill, Winfried Rie. Serotonin transporter gene promoter polymorphism and somatoform symptoms. The Journal of clinical psychiatry. vol 70. issue 11. 2010-01-05. PMID:19538902. |
symptoms of somatoform and affective disorders are thought to be connected to serotonergic neurotransmission because serotonin is known to regulate the functions relevant in these disorders, such as pain and mood. |
2010-01-05 |
2023-08-12 |
Not clear |
| Anika Hennings, Peter Zill, Winfried Rie. Serotonin transporter gene promoter polymorphism and somatoform symptoms. The Journal of clinical psychiatry. vol 70. issue 11. 2010-01-05. PMID:19538902. |
previous studies have reported associations of these disorders with a functional polymorphism in the promoter region of the serotonin transporter gene, a limiting factor of the serotonergic neuronal system, as its alleles have been associated with differences in levels of synthesized transporter and therefore differences in reuptake efficiency. |
2010-01-05 |
2023-08-12 |
Not clear |
| Nora Schiwy, Nicole Brazda, Hans Werner Mülle. Enhanced regenerative axon growth of multiple fibre populations in traumatic spinal cord injury following scar-suppressing treatment. The European journal of neuroscience. vol 30. issue 8. 2010-01-05. PMID:19817844. |
treatment yielded significantly enhanced regrowth of descending serotonergic (5-ht), catecholaminergic (tyrosine hydroxylase; th), corticospinal and rubrospinal axons into the lesion zone, as assessed by anterograde tracing and immunohistochemistry followed by quantification of axon profiles at 5 and 12 weeks post-injury. |
2010-01-05 |
2023-08-12 |
rat |
| Ryohei Matsumoto, Masanori Ichise, Hiroshi Ito, Tomomichi Ando, Hidehiko Takahashi, Yoko Ikoma, Jun Kosaka, Ryosuke Arakawa, Yota Fujimura, Miho Ota, Akihiro Takano, Kenji Fukui, Kazuhiko Nakayama, Tetsuya Suhar. Reduced serotonin transporter binding in the insular cortex in patients with obsessive-compulsive disorder: a [11C]DASB PET study. NeuroImage. vol 49. issue 1. 2010-01-04. PMID:19660554. |
the serotonin transporter (5-htt) and other markers of the serotonergic system have been of interest in the pathophysiology of obsessive-compulsive disorder (ocd). |
2010-01-04 |
2023-08-12 |
human |
| Asunción Morán, Ana-Vega Ortiz de Urbina, María-Luisa Martín, Alicia Rodríguez-Barbero, Luis San Romá. Characterization of the contractile 5-hydroxytryptamine receptor in the autoperfused kidney of L-NAME hypertensive rats. European journal of pharmacology. vol 620. issue 1-3. 2009-12-31. PMID:19699736. |
our data suggest that the serotonergic vasoconstrictor response induced in the in-situ autoperfused hypertensive rat kidney would be mediated by local activation of the 5-ht(2a) receptor. |
2009-12-31 |
2023-08-12 |
rat |
| Benoit Labonte, Francis Rodriguez Bambico, Gabriella Gobb. Potentiation of excitatory serotonergic responses by MK-801 in the medial prefrontal cortex. Naunyn-Schmiedeberg's archives of pharmacology. vol 380. issue 5. 2009-12-29. PMID:19727675. |
new atypical antipsychotics show a greater affinity to serotonergic rather than to dopamine receptors, suggesting that serotonin (5-ht) has a major role in the pathophysiology and treatment of schizophrenia. |
2009-12-29 |
2023-08-12 |
rat |
| Britta Haenisch, Karoline Linsel, Michael Brüss, Ralf Gilsbach, Peter Propping, Markus M Nöthen, Marcella Rietschel, Rolf Fimmers, Wolfgang Maier, Astrid Zobel, Susanne Höfels, Vera Guttenthaler, Manfred Göthert, Heinz Bönisc. Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 7. 2009-12-28. PMID:19105200. |
as shown previously, variations in the human net and 5-ht(1a) receptor genes can alter noradrenergic and serotonergic signaling in the brain: a single nucleotide polymorphism (snp) in the coding region of the net gene resulting in a f528c substitution increased plasma membrane expression of this net variant, and a snp in the human 5-ht(1a) receptor gene leading to the r219l receptor variant almost abolished cellular signal transduction subsequent to receptor activation. |
2009-12-28 |
2023-08-12 |
human |
| J Jochem, A Zak, R Rybczyk, T Irman-Florjan. Interactions between the serotonergic and histaminergic systems in the central cardiovascular regulation in haemorrhage-shocked rats: involvement of 5-HT(1A) receptors. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 58 Suppl 1. 2009-12-22. PMID:19274431. |
interactions between the serotonergic and histaminergic systems in the central cardiovascular regulation in haemorrhage-shocked rats: involvement of 5-ht(1a) receptors. |
2009-12-22 |
2023-08-12 |
rat |
| Zhen Tao, Yuan-Wei Zhang, Alice Agyiri, Gary Rudnic. Ligand effects on cross-linking support a conformational mechanism for serotonin transport. The Journal of biological chemistry. vol 284. issue 49. 2009-12-22. PMID:19837674. |
serotonin transporter (sert) is responsible for the re-uptake of 5-hydroxytryptamine (5-ht) from the synaptic cleft after release from serotonergic neurons. |
2009-12-22 |
2023-08-12 |
Not clear |
| Zachary Bencan, Damiyon Sledge, Edward D Levi. Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety. Pharmacology, biochemistry, and behavior. vol 94. issue 1. 2009-12-17. PMID:19643124. |
buspirone, a serotonergic (5ht(1a) receptor agonist) anxiolytic drug with some d(2) dopaminergic effect, had a pronounced anxiolytic-like effect in the zebrafish diving model at doses that did not have sedative effects. |
2009-12-17 |
2023-08-12 |
zebrafish |
| Andrew P Ray, Seetha Chebolu, Nissar A Darman. Receptor-selective agonists induce emesis and Fos expression in the brain and enteric nervous system of the least shrew (Cryptotis parva). Pharmacology, biochemistry, and behavior. vol 94. issue 1. 2009-12-17. PMID:19699757. |
we used cisplatin and specific agonists to 5-ht(3) serotonergic, d(2)/d(3) dopaminergic, and nk(1) tachykininergic receptors to induce vomiting in the least shrew (cryptotis parva), and quantified the resulting fos expression. |
2009-12-17 |
2023-08-12 |
human |
| P Dergham, M Ancti. Distribution of serotonin uptake and binding sites in the cnidarian Renilla koellikeri: an autoradiographic study. Tissue & cell. vol 30. issue 2. 2009-12-16. PMID:18627840. |
no subsets of cells, including serotonergic neurons, appeared to retain label preferentially, thus suggesting that removal of 5-ht and its chemical conversion is a general property of sea pansy tissues. |
2009-12-16 |
2023-08-12 |
Not clear |
| Mateus Dalbem Ferreira, Leda Menescal-de-Oliveir. Role of dorsal raphe nucleus 5-HT(1A) and 5-HT(2) receptors in tonic immobility modulation in guinea pigs. Brain research. vol 1285. 2009-12-15. PMID:19538947. |
in the current study, we investigated the influence of serotonergic 5-ht(1a) and 5-ht(2) receptor activity within the drn on the modulation of ti behavior in the guinea pig. |
2009-12-15 |
2023-08-12 |
Not clear |
| Mattie Tops, Sascha Russo, Maarten A S Boksem, Don M Tucke. Serotonin: modulator of a drive to withdraw. Brain and cognition. vol 71. issue 3. 2009-12-09. PMID:19423206. |
proposing that serotonin is involved in a drive to withdraw and seek contentment, instead of a drive to avoid, may be compatible with several lines of evidence on serotonin function and may facilitate a better understanding of serotonergic neuromodulation in human psychopathology. |
2009-12-09 |
2023-08-12 |
human |
| Ming-Ling Wu, Jou-Fang Den. Serotonin toxicity caused by moclobemide too soon after paroxetine-selegiline. Journal of the Chinese Medical Association : JCMA. vol 72. issue 8. 2009-12-09. PMID:19687003. |
serotonin toxicity is an iatrogenic complication of serotonergic drug therapy. |
2009-12-09 |
2023-08-12 |
Not clear |
| Amélie Soumier, Mounira Banasr, Sylviane Lortet, Frédérique Masmejean, Nathalie Bernard, Lydia Kerkerian-Le-Goff, Cecilia Gabriel, Mark J Millan, Elisabeth Mocaer, Annie Daszut. Mechanisms contributing to the phase-dependent regulation of neurogenesis by the novel antidepressant, agomelatine, in the adult rat hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 11. 2009-12-07. PMID:19571795. |
agomelatine is a novel antidepressant acting as a melatonergic receptor agonist and serotonergic (5-ht(2c)) receptor antagonist. |
2009-12-07 |
2023-08-12 |
rat |
| Amélie Soumier, Mounira Banasr, Sylviane Lortet, Frédérique Masmejean, Nathalie Bernard, Lydia Kerkerian-Le-Goff, Cecilia Gabriel, Mark J Millan, Elisabeth Mocaer, Annie Daszut. Mechanisms contributing to the phase-dependent regulation of neurogenesis by the novel antidepressant, agomelatine, in the adult rat hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 11. 2009-12-07. PMID:19571795. |
furthermore, as agomelatine possesses both melatonergic agonist and serotonergic (5-ht(2c)) antagonist properties, we determined whether melatonin and 5-ht(2c) receptor antagonists similarly influence cell proliferation and survival. |
2009-12-07 |
2023-08-12 |
rat |
| Andrea E Corcoran, Matthew R Hodges, Yuanming Wu, Wengang Wang, Christie J Wylie, Evan S Deneris, George B Richerso. Medullary serotonin neurons and central CO2 chemoreception. Respiratory physiology & neurobiology. vol 168. issue 1-2. 2009-12-02. PMID:19394450. |
serotonergic (5-ht) neurons are putative central respiratory chemoreceptors, aiding in the brain's ability to detect arterial changes in pco2 and implement appropriate ventilatory responses to maintain blood homeostasis. |
2009-12-02 |
2023-08-12 |
mouse |
| Susanne Nikolaus, Christina Antke, Hans-Wilhelm Mülle. In vivo imaging of synaptic function in the central nervous system: II. Mental and affective disorders. Behavioural brain research. vol 204. issue 1. 2009-12-01. PMID:19523495. |
results on both dopaminergic and serotonergic neurotransmission are inconsistent in both major depressive disorder and bipolar illness, and fail to clearly agree with the dopamine and/or serotonin hypothesis of depression. |
2009-12-01 |
2023-08-12 |
human |